Gene Symbol: Fcnb
Description: ficolin B
Alias: Fcn2, ficolin-2, L-ficolin, collagen/fibrinogen domain-containing protein 2, ficolin-beta
Endo Y, Nakazawa N, Liu Y, Iwaki D, Takahashi M, Fujita T, et al
. Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP. Immunogenetics. 2005;57:837-44 pubmed
..These results suggest that ficolin A and its variant function as recognition molecules of the lectin pathway, and ficolin B plays a distinct role through its unique carbohydrate-binding specificity. ..
Kuraya M, Ming Z, Liu X, Matsushita M, Fujita T. Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation. Immunobiology. 2005;209:689-97 pubmed
..Thus, L-ficolin and H-ficolin as well as MBL participate in the clearance of apoptotic cells through complement activation. ..
Honore C, Rørvig S, Hummelshøj T, Skjoedt M, Borregaard N, Garred P. Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain. J Leukoc Biol. 2010;88:145-58 pubmed publisher
..Moreover, rFicolin-1 bound activated but not resting T lymphocytes. Together, these results demonstrate a novel self-recognition mechanism of leukocytes mediated by the fibrinogen-like domain of Ficolin-1. ..
Zhang J, Yang L, Ang Z, Yoong S, Tran T, Anand G, et al
. Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense. J Immunol. 2010;185:6899-910 pubmed publisher
..Furthermore, our identification of the pH-sensitive interfaces of M-ficolin-CRP provides a powerful template for future design of potential immunomodulators. ..
Girija U, Mitchell D, Roscher S, Wallis R. Carbohydrate recognition and complement activation by rat ficolin-B. Eur J Immunol. 2011;41:214-23 pubmed publisher
..Mutagenesis data reveal that lack of activity in mouse ficolin-B is probably caused by a single amino acid change in the putative MASP-binding site that blocks the ficolin-MASP interaction. ..
Verma A, White M, Vathipadiekal V, Tripathi S, Mbianda J, Ieong M, et al
. Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses. J Immunol. 2012;189:2478-87 pubmed publisher
..H-ficolin also fixed complement to a surface coated with IAV. These findings suggest that H-ficolin contributes to host defense against IAV. ..