Gene Symbol: Fcna
Description: ficolin A
Alias: Fcn1, ficolin-1, M-ficolin, collagen/fibrinogen domain-containing protein 1, ficolin (collagen/fibrinogen domain containing) 1, ficolin-alpha
Matsushita M, Kuraya M, Hamasaki N, Tsujimura M, Shiraki H, Fujita T. Activation of the lectin complement pathway by H-ficolin (Hakata antigen). J Immunol. 2002;168:3502-6 pubmed
..C4 was activated by H-ficolin preparations bound to PSA which had been coated on ELISA plates. These results indicate that H-ficolin is a second ficolin which is associated with MASPs and sMAP, and which activates the lectin pathway. ..
Kuraya M, Ming Z, Liu X, Matsushita M, Fujita T. Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation. Immunobiology. 2005;209:689-97 pubmed
..Thus, L-ficolin and H-ficolin as well as MBL participate in the clearance of apoptotic cells through complement activation. ..
Verma A, White M, Vathipadiekal V, Tripathi S, Mbianda J, Ieong M, et al
. Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses. J Immunol. 2012;189:2478-87 pubmed publisher
..H-ficolin also fixed complement to a surface coated with IAV. These findings suggest that H-ficolin contributes to host defense against IAV. ..
Endo Y, Nakazawa N, Liu Y, Iwaki D, Takahashi M, Fujita T, et al
. Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP. Immunogenetics. 2005;57:837-44 pubmed
..These results suggest that ficolin A and its variant function as recognition molecules of the lectin pathway, and ficolin B plays a distinct role through its unique carbohydrate-binding specificity. ..
Girija U, Dodds A, Roscher S, Reid K, Wallis R. Localization and characterization of the mannose-binding lectin (MBL)-associated-serine protease-2 binding site in rat ficolin-A: equivalent binding sites within the collagenous domains of MBLs and ficolins. J Immunol. 2007;179:455-62 pubmed
..Equivalent binding sites and comparable activation kinetics of MASP-2 suggest that complement activation by ficolins and MBLs proceeds by analogous mechanisms. ..
Schelenz S, Kirchhof N, Bidula S, Wallis R, Sexton D. Opsonizing properties of rat ficolin-A in the defence against Cryptococcus neoformans. Immunobiology. 2013;218:477-83 pubmed publisher
..04). We conclude that ficolin-A binds acapsular C. neoformans via their carbohydrate recognizing fibrinogen-like domains leading to enhanced uptake by lung epithelial cells in vitro. ..