Gene Symbol: Fcna
Description: ficolin A
Alias: Fcn1, ficolin-1, M-ficolin, collagen/fibrinogen domain-containing protein 1, ficolin (collagen/fibrinogen domain containing) 1, ficolin-alpha
Species: rat
Products:     Fcna

Top Publications

  1. Matsushita M, Kuraya M, Hamasaki N, Tsujimura M, Shiraki H, Fujita T. Activation of the lectin complement pathway by H-ficolin (Hakata antigen). J Immunol. 2002;168:3502-6 pubmed
    ..C4 was activated by H-ficolin preparations bound to PSA which had been coated on ELISA plates. These results indicate that H-ficolin is a second ficolin which is associated with MASPs and sMAP, and which activates the lectin pathway. ..
  2. Kuraya M, Ming Z, Liu X, Matsushita M, Fujita T. Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation. Immunobiology. 2005;209:689-97 pubmed
    ..Thus, L-ficolin and H-ficolin as well as MBL participate in the clearance of apoptotic cells through complement activation. ..
  3. Verma A, White M, Vathipadiekal V, Tripathi S, Mbianda J, Ieong M, et al. Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses. J Immunol. 2012;189:2478-87 pubmed publisher
    ..H-ficolin also fixed complement to a surface coated with IAV. These findings suggest that H-ficolin contributes to host defense against IAV. ..
  4. Endo Y, Nakazawa N, Liu Y, Iwaki D, Takahashi M, Fujita T, et al. Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP. Immunogenetics. 2005;57:837-44 pubmed
    ..These results suggest that ficolin A and its variant function as recognition molecules of the lectin pathway, and ficolin B plays a distinct role through its unique carbohydrate-binding specificity. ..
  5. Girija U, Dodds A, Roscher S, Reid K, Wallis R. Localization and characterization of the mannose-binding lectin (MBL)-associated-serine protease-2 binding site in rat ficolin-A: equivalent binding sites within the collagenous domains of MBLs and ficolins. J Immunol. 2007;179:455-62 pubmed
    ..Equivalent binding sites and comparable activation kinetics of MASP-2 suggest that complement activation by ficolins and MBLs proceeds by analogous mechanisms. ..
  6. Schelenz S, Kirchhof N, Bidula S, Wallis R, Sexton D. Opsonizing properties of rat ficolin-A in the defence against Cryptococcus neoformans. Immunobiology. 2013;218:477-83 pubmed publisher
    ..04). We conclude that ficolin-A binds acapsular C. neoformans via their carbohydrate recognizing fibrinogen-like domains leading to enhanced uptake by lung epithelial cells in vitro. ..