Gene Symbol: Fbxl5
Description: F-box and leucine-rich repeat protein 5
Alias: F-box/LRR-repeat protein 5
Moroishi T, Nishiyama M, Takeda Y, Iwai K, Nakayama K. The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo. Cell Metab. 2011;14:339-51 pubmed publisher
..Although FBXL5 (F box and leucine-rich repeat protein 5) is thought to mediate this degradation, the role of FBXL5 in the control ..
Zhang N, Liu J, Ding X, Aikhionbare F, Jin C, Yao X. FBXL5 interacts with p150Glued and regulates its ubiquitination. Biochem Biophys Res Commun. 2007;359:34-9 pubmed
..Biophys. Res. Commun. 345 (2006) 394-402]. Here we show that F-box protein FBXL5 interacts with p150(Glued) and orchestrates its turnover via ubiquitination...
Vashisht A, Zumbrennen K, Huang X, Powers D, Durazo A, Sun D, et al
. Control of iron homeostasis by an iron-regulated ubiquitin ligase. Science. 2009;326:718-21 pubmed publisher
..We found that a SKP1-CUL1-FBXL5 ubiquitin ligase protein complex associates with and promotes the iron-dependent ubiquitination and degradation of ..
Salahudeen A, Thompson J, Ruiz J, Ma H, Kinch L, Li Q, et al
. An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis. Science. 2009;326:722-6 pubmed publisher
..We found that an E3 ubiquitin ligase complex containing the FBXL5 protein targets IRP2 for proteasomal degradation...
Lane D, Merlot A, Huang M, Bae D, Jansson P, Sahni S, et al
. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Biochim Biophys Acta. 2015;1853:1130-44 pubmed publisher
..g., Friedreich's ataxia. Increased knowledge of the molecules and their mechanisms of action in iron processing pathways (e.g., ISC biogenesis) will shape the investigation of iron metabolism in human health and disease. ..