fatty acid transport protein


Gene Symbol: fatty acid transport protein
Description: solute carrier family 27 member 1
Alias: FATP, long-chain fatty acid transport protein 1, FATP-1, fatty acid transport protein 1, solute carrier family 27 (fatty acid transporter), member 1
Species: rat

Top Publications

  1. Wu Q, Ortegon A, Tsang B, Doege H, Feingold K, Stahl A. FATP1 is an insulin-sensitive fatty acid transporter involved in diet-induced obesity. Mol Cell Biol. 2006;26:3455-67 pubmed
    b>Fatty acid transport protein 1 (FATP1), a member of the FATP/Slc27 protein family, enhances the cellular uptake of long-chain fatty acids (LCFAs) and is expressed in several insulin-sensitive tissues...
  2. Kim J, Gimeno R, Higashimori T, Kim H, Choi H, Punreddy S, et al. Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle. J Clin Invest. 2004;113:756-63 pubmed
    ..b>Fatty acid transport protein 1 (FATP1) is an acyl-CoA synthetase highly expressed in skeletal muscle and modulates fatty acid uptake ..
  3. Marotta M, Ferrer Martnez A, Parnau J, Turini M, Mace K, Gómez Foix A. Fiber type- and fatty acid composition-dependent effects of high-fat diets on rat muscle triacylglyceride and fatty acid transporter protein-1 content. Metabolism. 2004;53:1032-6 pubmed
    ..compositions (saturated, monounsaturated or n-6 polyunsaturated), on TAG levels and fatty acid transporter protein (FATP-1) expression in 2 rat muscles that differ in their fiber type, soleus, and gastrocnemius; the relationship to ..
  4. Richards M, Listenberger L, Kelly A, Lewis S, Ory D, Schaffer J. Oligomerization of the murine fatty acid transport protein 1. J Biol Chem. 2003;278:10477-83 pubmed
    The 63-kDa murine fatty acid transport protein 1 (FATP1) was cloned on the basis of its ability to augment fatty acid import when overexpressed in mammalian cells...
  5. Chabowski A, Coort S, Calles Escandon J, Tandon N, Glatz J, Luiken J, et al. The subcellular compartmentation of fatty acid transporters is regulated differently by insulin and by AICAR. FEBS Lett. 2005;579:2428-32 pubmed
  6. Schaap F, Hamers L, Van der Vusse G, Glatz J. Molecular cloning of fatty acid-transport protein cDNA from rat. Biochim Biophys Acta. 1997;1354:29-34 pubmed
    ..Several proteins, including the integral membrane protein FATP (Fatty Acid-Transport Protein), are being implicated in the process of myocardial fatty acid uptake...
  7. Liu Q, Gauthier M, Sun L, Ruderman N, Lodish H. Activation of AMP-activated protein kinase signaling pathway by adiponectin and insulin in mouse adipocytes: requirement of acyl-CoA synthetases FATP1 and Acsl1 and association with an elevation in AMP/ATP ratio. FASEB J. 2010;24:4229-39 pubmed publisher
    ..These studies demonstrate that a change in cellular energy state is associated with AMPK activation by both adiponectin and insulin, which requires the activity of FATP1 and Acsl1. ..
  8. Sebastian D, Guitart M, Garcia Martinez C, Mauvezin C, Orellana Gavaldà J, Serra D, et al. Novel role of FATP1 in mitochondrial fatty acid oxidation in skeletal muscle cells. J Lipid Res. 2009;50:1789-99 pubmed publisher
    ..Here, we demonstrate that another membrane-bound fatty acid binding protein, fatty acid transport protein 1 (FATP1), collaborates with CPT1 for fatty acid import into mitochondria...
  9. Ortegren U, Yin L, Ost A, Karlsson H, Nystrom F, Stralfors P. Separation and characterization of caveolae subclasses in the plasma membrane of primary adipocytes; segregation of specific proteins and functions. FEBS J. 2006;273:3381-92 pubmed
    ..Another class of high-density caveolae contained caveolin-1, caveolin-2 and specifically fatty acid transport protein-1, fatty acid transport protein-4, fatty acyl-CoA synthetase, hormone-sensitive lipase, perilipin, and ..

More Information


  1. Deng J, Huang J, Lu L, Hung L. Impairment of cardiac insulin signaling and myocardial contractile performance in high-cholesterol/fructose-fed rats. Am J Physiol Heart Circ Physiol. 2007;293:H978-87 pubmed
    ..The cardiac metabolic alterations that impair contractile functions may lead to the development of cardiomyopathy. ..
  2. Holloway G, Chou C, Lally J, Stellingwerff T, Maher A, Gavrilova O, et al. Increasing skeletal muscle fatty acid transport protein 1 (FATP1) targets fatty acids to oxidation and does not predispose mice to diet-induced insulin resistance. Diabetologia. 2011;54:1457-67 pubmed publisher
    We examined in skeletal muscle (1) whether fatty acid transport protein (FATP) 1 channels long-chain fatty acid (LCFA) to specific metabolic fates in rats; and (2) whether FATP1-mediated increases in LCFA uptake exacerbate the development ..
  3. Wiczer B, Lobo S, Machen G, Graves L, Bernlohr D. FATP1 mediates fatty acid-induced activation of AMPK in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2009;387:234-8 pubmed publisher
    ..b>FATP-dependent production of AMP was evaluated using FATP4 proteoliposomes, and fatty acid-dependent activation of AMP-..
  4. Mitchell R, Hatch G. Regulation of cardiolipin biosynthesis by fatty acid transport protein-1 IN HEK 293 cells. Biochim Biophys Acta. 2009;1788:2015-21 pubmed publisher
    Cardiolipin (CL) is a major phospholipid involved in energy metabolism mammalian mitochondria and fatty acid transport protein-1 (FATP-1) is a fatty acid transport protein that may regulate the intracellular level of fatty acyl-Coenzyme A'..
  5. Pohl J, Ring A, Korkmaz U, Ehehalt R, Stremmel W. FAT/CD36-mediated long-chain fatty acid uptake in adipocytes requires plasma membrane rafts. Mol Biol Cell. 2005;16:24-31 pubmed
    ..In conclusion, our data strongly suggest that FAT/CD36 mediates raft-dependent LCFA uptake. Plasma membrane lipid rafts might control LCFA uptake by regulating surface availability of FAT/CD36. ..
  6. Santos M, Perez P, Segrelles C, Ruiz S, Jorcano J, Paramio J. Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis. J Biol Chem. 2003;278:13422-30 pubmed
    ..These results confirm that keratin K10 functions in vivo include the control of many aspects of epithelial physiology, which affect the cells not only in a cell autonomous manner but also influence tissue homeostasis. ..
  7. Hirsch D, Stahl A, Lodish H. A family of fatty acid transporters conserved from mycobacterium to man. Proc Natl Acad Sci U S A. 1998;95:8625-9 pubmed
    ..Transport of LCFAs across the plasma membrane is facilitated by fatty acid transport protein (FATP), a plasma membrane protein that increases LCFA uptake when expressed in cultured mammalian cells ..
  8. DiRusso C, Darwis D, Obermeyer T, Black P. Functional domains of the fatty acid transport proteins: studies using protein chimeras. Biochim Biophys Acta. 2008;1781:135-43 pubmed publisher
    Fatty acid transport proteins (FATP) function in fatty acid trafficking pathways, several of which have been shown to participate in the transport of exogenous fatty acids into the cell...
  9. Wu Q, Kazantzis M, Doege H, Ortegon A, Tsang B, Falcon A, et al. Fatty acid transport protein 1 is required for nonshivering thermogenesis in brown adipose tissue. Diabetes. 2006;55:3229-37 pubmed
    ..How uptake of fatty acids is mediated and regulated has remained unclear. Here, we show that fatty acid transport protein (FATP)1 is expressed on the plasma membrane of BAT and is upregulated in response to cold stimuli, ..
  10. Heather L, Cole M, Lygate C, Evans R, Stuckey D, Murray A, et al. Fatty acid transporter levels and palmitate oxidation rate correlate with ejection fraction in the infarcted rat heart. Cardiovasc Res. 2006;72:430-7 pubmed
    ..translocase (FAT/CD36), plasma membrane fatty acid binding protein (FABPpm) and fatty acid transporter proteins (FATP) 1 and 6...