fatty acid binding protein


Gene Symbol: fatty acid binding protein
Description: fatty acid binding protein 1
Alias: Fabplg, L-FABP, SCP, SCP., p14, fatty acid-binding protein, liver, Z-protein, fatty acid binding protein 1, liver, liver-type fatty acid-binding protein, squalene- and sterol-carrier protein
Species: rat
Products:     fatty acid binding protein

Top Publications

  1. Thompson J, Winter N, Terwey D, Bratt J, Banaszak L. The crystal structure of the liver fatty acid-binding protein. A complex with two bound oleates. J Biol Chem. 1997;272:7140-50 pubmed
    ..The primary and secondary oleate binding sites appear to be totally interdependent, mainly because favorable hydrophobic interactions form between both aliphatic chains. ..
  2. Wang G, Chen Q, Minuk G, Gong Y, Burczynski F. Enhanced expression of cytosolic fatty acid binding protein and fatty acid uptake during liver regeneration in rats. Mol Cell Biochem. 2004;262:41-9 pubmed
    Cytoplasmic liver fatty acid binding protein (L-FABP) has been suggested to be associated with cellular mitotic activity but the changes in L-FABP mRNA and protein levels during liver regeneration following partial hepatectomy (PHx) are ..
  3. Sweetser D, Lowe J, Gordon J. The nucleotide sequence of the rat liver fatty acid-binding protein gene. Evidence that exon 1 encodes an oligopeptide domain shared by a family of proteins which bind hydrophobic ligands. J Biol Chem. 1986;261:5553-61 pubmed
    ..This suggests that the first exon may encode a shared structural and functional domain important in the interaction of these proteins with their ligands. ..
  4. Worrall A, Evans C, Wilton D. Synthesis of a gene for rat liver fatty-acid-binding protein and its expression in Escherichia coli. Biochem J. 1991;278 ( Pt 2):365-8 pubmed
    ..Induction of protein synthesis from this gene results in over expression of an FABP that is indistinguishable in its structure and binding properties with that isolated from rat liver. ..
  5. McGuire D, Chan L, Smith L, Towle H, Dempsey M. Translational control of the circadian rhythm of liver sterol carrier protein. Analysis of mRNA sequences with a specific cDNA probe. J Biol Chem. 1985;260:5435-9 pubmed
    ..However, functional SCP mRNA, measured by a cell-free translational assay, does not fluctuate in the dark-light cycle...
  6. Spann N, Kang S, Li A, Chen A, Newberry E, Davidson N, et al. Coordinate transcriptional repression of liver fatty acid-binding protein and microsomal triglyceride transfer protein blocks hepatic very low density lipoprotein secretion without hepatosteatosis. J Biol Chem. 2006;281:33066-77 pubmed
    ..Our findings show that reducing both L-FABP and MTP is an effective means to reduce VLDL secretion without causing hepatic steatosis. ..
  7. He Y, Yang X, Wang H, Estephan R, Francis F, Kodukula S, et al. Solution-state molecular structure of apo and oleate-liganded liver fatty acid-binding protein. Biochemistry. 2007;46:12543-56 pubmed
  8. Schroeder F, McIntosh A, Martin G, Huang H, Landrock D, Chung S, et al. Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias. Lipids. 2016;51:655-76 pubmed publisher
    The first discovered member of the mammalian FABP family, liver fatty acid binding protein (FABP1, L-FABP), occurs at high cytosolic concentration in liver, intestine, and in the case of humans also in kidney...
  9. Divine J, Staloch L, Haveri H, Rowley C, Heikinheimo M, Simon T. Cooperative interactions among intestinal GATA factors in activating the rat liver fatty acid binding protein gene. Am J Physiol Gastrointest Liver Physiol. 2006;291:G297-306 pubmed
    ..GATA factors were explored utilizing a transgene constructed from the proximal promoter of the rat liver fatty acid binding protein gene (Fabp1)...

Scientific Experts

More Information


  1. Newberry E, Xie Y, Kennedy S, Luo J, Davidson N. Protection against Western diet-induced obesity and hepatic steatosis in liver fatty acid-binding protein knockout mice. Hepatology. 2006;44:1191-205 pubmed
    ..We suggest that L-Fabp(-/-) mice are protected against Western diet-induced obesity and hepatic steatosis through a series of adaptations in both hepatic and extrahepatic energy substrate use. (HEPATOLOGY 2006;44:1191-1205.). ..
  2. Lagakos W, Guan X, Ho S, Sawicki L, Corsico B, Kodukula S, et al. Liver fatty acid-binding protein binds monoacylglycerol in vitro and in mouse liver cytosol. J Biol Chem. 2013;288:19805-15 pubmed publisher
    ..These results provide strong support for monoacylglycerol as a physiological ligand for LFABP and further suggest that LFABP functions in the efficient intracellular transport of MG. ..
  3. Bassuk J, Tsichlis P, Sorof S. Liver fatty acid binding protein is the mitosis-associated polypeptide target of a carcinogen in rat hepatocytes. Proc Natl Acad Sci U S A. 1987;84:7547-51 pubmed
    ..We report here that p14 is the liver fatty acid binding protein. The nucleotide sequence of p14 cDNA clones, isolated by screening a rat liver cDNA library in ..
  4. Maté S, Layerenza J, Ves Losada A. Incorporation of arachidonic and stearic acids bound to L-FABP into nuclear and endonuclear lipids from rat liver cells. Lipids. 2007;42:589-602 pubmed
  5. Neeli I, Siddiqi S, Siddiqi S, Mahan J, Lagakos W, Binas B, et al. Liver fatty acid-binding protein initiates budding of pre-chylomicron transport vesicles from intestinal endoplasmic reticulum. J Biol Chem. 2007;282:17974-84 pubmed
    ..Gene-disrupted L-FABP mouse cytosol had 60% the activity of wild type mouse cytosol. We conclude that L-FABP can select cargo for and bud PCTV from intestinal ER membranes. ..
  6. Cho K, Kim H, Kamanna V, Vaziri N. Niacin improves renal lipid metabolism and slows progression in chronic kidney disease. Biochim Biophys Acta. 2010;1800:6-15 pubmed publisher
    ..Present study sought to determine efficacy of niacin supplementation on renal tissue lipid metabolism in CRF...
  7. Yan J, Gong Y, Wang G, Gong Y, Burczynski F. Regulation of liver fatty acid binding protein expression by clofibrate in hepatoma cells. Biochem Cell Biol. 2010;88:957-67 pubmed publisher
    Peroxisome proliferator-activated receptor (PPAR) agonists such as clofibrate are known to affect liver fatty acid binding protein (L-FABP) levels, which in turn influence hepatocellular oxidant status...
  8. Bosse T, Piaseckyj C, Burghard E, Fialkovich J, Rajagopal S, Pu W, et al. Gata4 is essential for the maintenance of jejunal-ileal identities in the adult mouse small intestine. Mol Cell Biol. 2006;26:9060-70 pubmed
    ..genes normally expressed in jejunum but not in ileum, including those for the anticipated targets liver fatty acid binding protein (Fabp1) and lactase-phlorizin hydrolase (LPH), and a surprising induction of genes normally silent in ..
  9. Antonenkov V, Sormunen R, Ohlmeier S, Amery L, Fransen M, Mannaerts G, et al. Localization of a portion of the liver isoform of fatty-acid-binding protein (L-FABP) to peroxisomes. Biochem J. 2006;394:475-84 pubmed
    ..The possible role of intraperoxisomal L-FABP in lipid metabolism is discussed. ..
  10. Wang G, Gong Y, Anderson J, Sun D, Minuk G, Roberts M, et al. Antioxidative function of L-FABP in L-FABP stably transfected Chang liver cells. Hepatology. 2005;42:871-9 pubmed
    Liver fatty acid binding protein (L-FABP) contains amino acids that are known to possess antioxidant function...
  11. Ishimitsu T, Ohta S, Saito M, Teranishi M, Inada H, Yoshii M, et al. Urinary excretion of liver fatty acid-binding protein in health-check participants. Clin Exp Nephrol. 2005;9:34-9 pubmed
    ..135, P = 0.006). It is suggested that renal production and urinary excretion of L-FABP are increased in situations in which arteriosclerosis is promoted, such as hypertension, diabetes mellitus, and cardiovascular inflammation. ..
  12. Myszka D, Swenson R. Identification by photoaffinity labeling of fatty acid-binding protein as a potential warfarin receptor in rat liver. J Biol Chem. 1991;266:20725-31 pubmed
  13. Gordon J, Alpers D, Ockner R, Strauss A. The nucleotide sequence of rat liver fatty acid binding protein mRNA. J Biol Chem. 1983;258:3356-63 pubmed
    Rat liver fatty acid binding protein mRNA is present in both liver and intestinal epithelium. It is the most abundant mRNA in the small intestinal mucosa. We have determined the sequence of this mRNA from cloned cDNA...
  14. Takahashi K, Odani S, Ono T. Isolation and characterization of the three fractions (DE-I, DE-II and DE-III) of rat-liver Z-protein and the complete primary structure of DE-II. Eur J Biochem. 1983;136:589-601 pubmed
    Three fractions (DE-I, DE-II and DE-III) of Z-protein (fatty acid binding protein) have been isolated from rat liver cytosol by DEAE-cellulose chromatography and characterized...
  15. Hagan R, Davies J, Wilton D. The effect of charge reversal mutations in the alpha-helical region of liver fatty acid binding protein on the binding of fatty-acyl CoAs, lysophospholipids and bile acids. Mol Cell Biochem. 2002;239:55-60 pubmed
    Liver fatty acid binding protein (LFABP) is unique among the various types of FABPs in that it can bind a variety of ligands in addition to fatty acids...
  16. Wang L, Zheng A, Yi L, Xu C, Ding M, Deng H. Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins. Biochem Biophys Res Commun. 2004;325:302-7 pubmed
    ..The method can be used to study epigenetic modification of chromatin during nuclear reprogramming, cell differentiation, and transdifferentiation. ..
  17. He Y, Estephan R, Yang X, Vela A, Wang H, Bernard C, et al. A nuclear magnetic resonance-based structural rationale for contrasting stoichiometry and ligand binding site(s) in fatty acid-binding proteins. Biochemistry. 2011;50:1283-95 pubmed publisher
    ..A rationale based on protein sequence and electrostatics was developed to explain the stoichiometry and binding site trends for LFABPs and to put these findings into context within the larger protein family. ..
  18. Gordon J, Lowe J. Analyzing the structures, functions and evolution of two abundant gastrointestinal fatty acid binding proteins with recombinant DNA and computational techniques. Chem Phys Lipids. 1985;38:137-58 pubmed
    ..Recombinant DNA techniques combined with comparative sequence analyses offer a useful approach for defining unique as well as general structure-function relationships in this group of fatty acid binding proteins. ..
  19. Nakamura T, Sugaya T, Ebihara I, Koide H. Urinary liver-type fatty acid-binding protein: discrimination between IgA nephropathy and thin basement membrane nephropathy. Am J Nephrol. 2005;25:447-50 pubmed
    ..5 microg/g Cr to 58.8 +/- 40.5 microg/g Cr (p < 0.01). Our data suggest that the urinary L-FABP level can be used to discriminate between IgA nephropathy and thin basement membrane nephropathy in patients with microscopic hematuria. ..
  20. Alpers D, Bass N, Engle M, DeSchryver Kecskemeti K. Intestinal fatty acid binding protein may favor differential apical fatty acid binding in the intestine. Biochim Biophys Acta. 2000;1483:352-62 pubmed
    ..These data are consistent with the hypothesis that I-FABP may contribute to the metabolic compartmentalization of apically presented fatty acids in the intestine. ..
  21. Bosse T, Fialkovich J, Piaseckyj C, Beuling E, Broekman H, Grand R, et al. Gata4 and Hnf1alpha are partially required for the expression of specific intestinal genes during development. Am J Physiol Gastrointest Liver Physiol. 2007;292:G1302-14 pubmed
    ..Lactase-phlorizin hydrolase (LPH), liver fatty acid binding protein (Fabp1), and sucrase-isomaltase (SI) are well-characterized markers of these transitions...
  22. Odani S, Okazaki Y, Kato C, Uchiumi T, Takahashi Y. On the molecular origin of charge heterogeneity of rat liver fatty acid-binding protein (Z-protein). Arch Biochem Biophys. 1994;309:81-4 pubmed
    ..Since DE-III fraction carries mainly arachidonate, this post-translational modification might modulate binding specificity of fatty acid-binding protein. ..
  23. Corsico B, Liou H, Storch J. The alpha-helical domain of liver fatty acid binding protein is responsible for the diffusion-mediated transfer of fatty acids to phospholipid membranes. Biochemistry. 2004;43:3600-7 pubmed
    Intestinal fatty acid binding protein (IFABP) and liver FABP (LFABP), homologous proteins expressed at high levels in intestinal absorptive cells, employ markedly different mechanisms for the transfer of fatty acids (FAs) to acceptor ..
  24. Hostetler H, Balanarasimha M, Huang H, Kelzer M, Kaliappan A, Kier A, et al. Glucose regulates fatty acid binding protein interaction with lipids and peroxisome proliferator-activated receptor ?. J Lipid Res. 2010;51:3103-16 pubmed publisher
    ..As the liver fatty acid binding protein (L-FABP) shuttles LCFA to the nucleus, where L-FABP directly interacts with peroxisome proliferator-..
  25. Siddiqi S, Mansbach C. Phosphorylation of Sar1b protein releases liver fatty acid-binding protein from multiprotein complex in intestinal cytosol enabling it to bind to endoplasmic reticulum (ER) and bud the pre-chylomicron transport vesicle. J Biol Chem. 2012;287:10178-88 pubmed publisher
    ..We conclude that phosphorylation of Sar1b disrupts the FABP1-containing four-membered 75-kDa protein complex in cytosol enabling it to bind to the ER and generate PCTV. ..
  26. Takahashi K, Odani S, Ono T. Primary structure of rat liver Z-protein. A low-Mr cytosol protein that binds sterols, fatty acids and other small molecules. FEBS Lett. 1982;140:63-6 pubmed
  27. McIntosh A, Petrescu A, Hostetler H, Kier A, Schroeder F. Liver-type fatty acid binding protein interacts with hepatocyte nuclear factor 4?. FEBS Lett. 2013;587:3787-91 pubmed publisher
    Hepatocyte nuclear factor 4? (HNF4?) regulates liver type fatty acid binding protein (L-FABP) gene expression. Conversely as shown herein, L-FABP structurally and functionally also interacts with HNF4?...