Faslg

Summary

Gene Symbol: Faslg
Description: Fas ligand
Alias: Apt1Lg1, CD95-L, Fasl, Tnfsf6, Tnlg1a, tumor necrosis factor ligand superfamily member 6, Apoptosis (APO-1) antigen ligand 1 (Fas antigen ligand), CD95 ligand, CD95L protein, Fas antigen ligand, Fas ligand (TNF superfamily, member 6), Tumor necrosis factor (ligand) superfamily, member 6 (apoptosis (APO-1) antigen ligand 1) (Fas antigen ligand), tumor necrosis factor ligand 1a
Species: rat
Products:     Faslg

Top Publications

  1. Takahashi T, Tanaka M, Brannan C, Jenkins N, Copeland N, Suda T, et al. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell. 1994;76:969-76 pubmed
    ..The lpr mice have a mutation in a cell-surface protein, Fas, that mediates apoptosis. Fas ligand (FasL) is a tumor necrosis factor (TNF)-related type II membrane protein and binds to Fas...
  2. Suda T, Takahashi T, Golstein P, Nagata S. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell. 1993;75:1169-78 pubmed
    ..Northern hybridization revealed that Fas ligand is expressed in activated splenocytes and thymocytes, consistent with its involvement in T cell-mediated cytotoxicity and in several nonlymphoid tissues, such as testis. ..
  3. Vouyouka A, Lin L, Basson M. Pressure and endothelial coculture upregulate myocytic Fas-FasL pathway and induce apoptosis by way of direct and paracrine mechanisms. Am J Surg. 2005;190:780-6 pubmed
    ..SMC apoptosis SMCs through EC-derived paracrine factors and that SMC apoptosis is induced through Fas-Fas ligand (FasL) activation...
  4. Facchinetti F, Furegato S, Terrazzino S, Leon A. H(2)O(2) induces upregulation of Fas and Fas ligand expression in NGF-differentiated PC12 cells: modulation by cAMP. J Neurosci Res. 2002;69:178-88 pubmed
    ..the tumor necrosis (TNF) receptor superfamily, transduces apoptotic death upon crosslinking by its cognate ligand (FasL). As upregulation of Fas/FasL expression occurs in neuropathological conditions (e.g...
  5. Adachi K, Fujino M, Kitazawa Y, Funeshima Fuji N, Takahara S, Kimura H, et al. Exogenous expression of Fas-ligand or CrmA prolongs the survival in rat liver transplantation. Transplant Proc. 2006;38:2710-3 pubmed
    ..Fas-ligand (FasL) plays a critical role in activation-induced cell death of activated cytotoxic lymphocytes...
  6. Renna M, Correa S, Porporatto C, Figueredo C, Aoki M, Paraje M, et al. Hepatocellular apoptosis during Candida albicans colonization: involvement of TNF-alpha and infiltrating Fas-L positive lymphocytes. Int Immunol. 2006;18:1719-28 pubmed
    ..In the scenario of early liver injury, the recruited IHLs and the modulated expression of TNF-alpha, Fas-L and TLR-2 molecules could act coordinately in delivering death signals. ..
  7. Shi Q, Tian X, Zhao Y, Luo H, Tian Y, Luo A. Anti-arthritic effects of FasL gene transferred intra-articularly by an inducible lentiviral vector containing improved tet-on system. Rheumatol Int. 2014;34:51-7 pubmed publisher
    ..of this study is to construct and identify an inducible lentiviral vector containing improved tet-on system and FasL gene and observe its effects on pristane-induced arthritis (PIA)...
  8. Jayanthi S, Deng X, Ladenheim B, McCoy M, Cluster A, Cai N, et al. Calcineurin/NFAT-induced up-regulation of the Fas ligand/Fas death pathway is involved in methamphetamine-induced neuronal apoptosis. Proc Natl Acad Sci U S A. 2005;102:868-73 pubmed
    ..Because pathways linked to these factors are involved in the up-regulation of Fas ligand (FasL), FasL mRNA was quantified and found to be increased...
  9. Koncz G, Hancz A, Chakrabandhu K, Gogolak P, Kerekes K, Rajnavolgyi E, et al. Vesicles released by activated T cells induce both Fas-mediated RIP-dependent apoptotic and Fas-independent nonapoptotic cell deaths. J Immunol. 2012;189:2815-23 pubmed publisher
    Activated T cells secrete Fas ligand (FasL)-containing vesicles (secreted vesicles) that induce death of target cells...

More Information

Publications62

  1. Gratas C, Tohma Y, Barnas C, Taniere P, Hainaut P, Ohgaki H. Up-regulation of Fas (APO-1/CD95) ligand and down-regulation of Fas expression in human esophageal cancer. Cancer Res. 1998;58:2057-62 pubmed
    Fas (APO-1/CD95) is a cell surface receptor that mediates apoptosis when it reacts with Fas ligand (FasL) or Fas antibody...
  2. Liu L, Kim J, Koike M, Yoon Y, Tang X, Ma H, et al. FasL shedding is reduced by hypothermia in experimental stroke. J Neurochem. 2008;106:541-50 pubmed publisher
    ..the brain may undergo apoptotic death via extrinsic, or receptor-mediated pathways, such as that triggered by Fas/FasL. Male Sprague-Dawley rats subjected to 2 h middle cerebral artery occlusion with 2 h intraischemic mild hypothermia ..
  3. Wang W, Prince C, Mou Y, Pollman M. Notch3 signaling in vascular smooth muscle cells induces c-FLIP expression via ERK/MAPK activation. Resistance to Fas ligand-induced apoptosis. J Biol Chem. 2002;277:21723-9 pubmed
    ..both transient and constitutive Notch3 signaling promoted VSMC survival in response to the proapoptotic Fas ligand (FasL)...
  4. He P, Zhang B, Liu D, Bian X, Li D, Wang Y, et al. Hepatitis B Virus X Protein Modulates Apoptosis in NRK-52E Cells and Activates Fas/FasL Through the MLK3-MKK7-JNK3 Signaling Pathway. Cell Physiol Biochem. 2016;39:1433-43 pubmed publisher
    ..B virus X protein (HBx) contributes to HBV-induced injury of renal tubular cells and induces apoptosis via Fas/FasL up-regulation. However, the mechanism of Fas/FasL activation is unknown...
  5. Wisniewski P, Master A, Kaminska B. Cloning and purification of functionally active Fas ligand interfering protein (FIP) expressed in Escherichia coli. Acta Biochim Pol. 2008;55:51-6 pubmed
    This report presents purification and characterization of the extracellular domain of rat Fas protein, called FIP (FasL interfering protein), expressed as inclusion bodies in Escherichia coli...
  6. Ohta T, Elnemr A, Kitagawa H, Kayahara M, Takamura H, Fujimura T, et al. Fas ligand expression in human pancreatic cancer. Oncol Rep. 2004;12:749-54 pubmed
  7. Pernick N, Sarkar F, Tabaczka P, Kotcher G, Frank J, Adsay N. Fas and Fas ligand expression in pancreatic adenocarcinoma. Pancreas. 2002;25:e36-41 pubmed
    Fas and Fas ligand (FasL) mediate apoptosis of tumor cells in immune surveillance, and expression of FasL by tumors may mediate their counterattack on cytotoxic lymphocytes...
  8. Zhang W, Wang F, Wang B, Zhang J, Yu J. Intraarticular gene delivery of CTLA4-FasL suppresses experimental arthritis. Int Immunol. 2012;24:379-88 pubmed publisher
    ..Biological treatments targeting T lymphocytes may provide an efficient approach for treatment of RA. CTLA4-FasL, a fusion product of extracellular domains of CTLA4 and FasL, integrating two inhibitory elements against T cells ..
  9. Okuda Y, Sakoda S, Fujimura H, Nagata S, Yanagihara T, Bernard C. Intrathecal administration of neutralizing antibody against Fas ligand suppresses the progression of experimental autoimmune encephalomyelitis. Biochem Biophys Res Commun. 2000;275:164-8 pubmed
    A therapy aimed at blocking the Fas/Fas ligand (FasL) system was investigated using a relapsing form of experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of multiple sclerosis (MS)...
  10. Buller B, Liu X, Wang X, Zhang R, Zhang L, Hozeska Solgot A, et al. MicroRNA-21 protects neurons from ischemic death. FEBS J. 2010;277:4299-307 pubmed publisher
    ..Moreover, overexpression of miR-21 in neurons significantly reduced FASLG levels, and introduction of an miR-21 mimic into 293-HEK cells substantially reduced luciferase activity in a ..
  11. Kroon A, Delriccio V, Tseu I, Kavanagh B, Post M. Mechanical ventilation-induced apoptosis in newborn rat lung is mediated via FasL/Fas pathway. Am J Physiol Lung Cell Mol Physiol. 2013;305:L795-804 pubmed publisher
    ..caspase-3 immunochemistry) and was associated with increased expression of the apoptotic mediator Fas ligand (FasL). Fetal lung epithelial cells, but not fibroblasts, subjected to maximal (i.e...
  12. Huang X, Lu Z, Lv Z, Yu T, Yang P, Shen Y, et al. The Fas/Fas ligand death receptor pathway contributes to phenylalanine-induced apoptosis in cortical neurons. PLoS ONE. 2013;8:e71553 pubmed publisher
    ..In addition, Phe significantly increased cell surface Fas expression and formation of the Fas/FasL complex. Blocking Fas/FasL signaling using an anti-Fas antibody markedly inhibited apoptosis caused by Phe...
  13. Vrachnis N, Dalainas I, Papoutsis D, Samoli E, Rizos D, Iliodromiti Z, et al. Soluble Fas and Fas-ligand levels in mid-trimester amniotic fluid and their associations with severe small for gestational age fetuses: a prospective observational study. J Reprod Immunol. 2013;98:39-44 pubmed publisher
    We aimed to determine the second-trimester amniotic fluid (AF) levels of soluble Fas (sFas) and Fas-ligand (FasL) and investigate their association with fetal growth...
  14. Laskowska M, Laskowska K, Leszczynska Gorzelak B, Oleszczuk J. Evaluation of the maternal and umbilical vein serum sFas/sFasL system in pregnancies complicated by preeclampsia with intrauterine growth retardation. Eur J Obstet Gynecol Reprod Biol. 2006;126:155-9 pubmed
    ..Maternal and umbilical serum soluble Fas and FasL concentrations were estimated using a sandwich ELISA assay...
  15. Cosson E, Bringuier A, Paries J, Guillot R, Vaysse J, Attali J, et al. Fas/Fas-Ligand pathway is impaired in patients with type 2 diabetes. Influence of hypertension and insulin resistance. Diabetes Metab. 2005;31:47-54 pubmed
    ..Fas-mediated apoptosis is involved in type 2 diabetes and might be associated with hypertension and/or its vascular consequences. sFasL might be affected by insulin resistance. sFas and sFasL are not effective markers of SMI. ..
  16. D Abrizio P, Baldini E, Russo P, Biordi L, Graziano F, Rucci N, et al. Ontogenesis and cell specific localization of Fas ligand expression in the rat testis. Int J Androl. 2004;27:304-10 pubmed
    Over the past few years, a number of experimental evidences suggested the involvement of Fas Ligand (FasL) expressing Sertoli cells to induce apoptosis of Fas bearing germ cells...
  17. Zayas M, Lucas M, Solano F, Fernández Pérez M, Izquierdo G. Association of a CA repeat polymorphism upstream of the Fas ligand gene with multiple sclerosis. J Neuroimmunol. 2001;116:238-41 pubmed
    ..52 and 0.48 in patients vs. 0.68 and 0.32 in controls). The results suggest that chromosomes with B allele have a genetic background that reduces susceptibility to MS, particularly in the familial forms. ..
  18. Franke D, Yolcu E, Alard P, Kosiewicz M, Shirwan H. A novel multimeric form of FasL modulates the ability of diabetogenic T cells to mediate type 1 diabetes in an adoptive transfer model. Mol Immunol. 2007;44:2884-92 pubmed
    Activation induced cell death (AICD) via Fas/FasL is the primary homeostatic molecular mechanism employed by the immune system to control activated T-cell responses and promote tolerance to self-antigens...
  19. Ferrer I, Blanco R, Cutillas B, Ambrosio S. Fas and Fas-L expression in Huntington's disease and Parkinson's disease. Neuropathol Appl Neurobiol. 2000;26:424-33 pubmed
    ..The meaning of increased Fas and Fas-L expression in astrocytes is still unclear. However, the present results suggest that Fas/Fas-L signals are minimized in sensitive neurones in HD and PD. ..
  20. Song Y, Yang K. [Effect of p, p'-DDE on DNA damage and expression of FasL gene of rat Sertoli cell in vitro]. Wei Sheng Yan Jiu. 2006;35:261-3 pubmed
    To study the effects of p, p'-DDE on DNA damage and expression of FasL gene of rat Sertoli cell in vitro...
  21. Liu W, Huang Z, Ye Q, Ye S. Transfusion of endothelial cells with lentivirus-mediated expression of fas ligand prolonged survival of rat liver allograft. Transplant Proc. 2012;44:1399-403 pubmed publisher
    Immunologically privileged sites have been shown to express Fas ligand (FasL) and may protect themselves by inducing apoptosis of infiltrating inflammatory cells...
  22. Murakami M, Sasaki T, Miyata H, Yamasaki S, Kuwahara K, Chayama K. Fas and Fas ligand: Expression and soluble circulating levels in bile duct carcinoma. Oncol Rep. 2004;11:1183-6 pubmed
    Alteration of the Fas receptor (Fas)-/ligand (FasL) system including their soluble forms (sFas and sFasL) is thought to be one of the mechanisms preventing the immune system from rejecting the tumor cells...
  23. Wen T, Ren F, Liu Y, Wu Z, Zhao J. [Expression of Fas antigen and Fas ligand in acute liver injury induced by carbon tetrachloride in rat]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2006;18:417-20 pubmed
    To investigate the dynamics of expression of Fas antigen and Fas ligand (FasL) in a rat model of carbon tetrachloride-induced acute liver injury, and explore the role of apoptosis in liver injury...
  24. Durieu I, Amsellem C, Paulin C, Chambe M, Bienvenu J, Bellon G, et al. Fas and Fas ligand expression in cystic fibrosis airway epithelium. Thorax. 1999;54:1093-8 pubmed
    ..A study was undertaken to investigate the expression of Fas and Fas ligand (FasL) in CF bronchial epithelium and CF tracheal cell lines...
  25. Sabapatha A, Gercel Taylor C, Taylor D. Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences. Am J Reprod Immunol. 2006;56:345-55 pubmed
    ..The role of Fas ligand (FasL) was defined by use of Fas-blocking antibody...
  26. Zhang X, Jin Z, Da R, Dong Y, Song W, Chen X, et al. Fas/FasL-dependent apoptosis of hepatocytes induced in rat and patients with Clonorchis sinensis infection. Parasitol Res. 2008;103:393-9 pubmed publisher
    ..Furthermore, the expression of mRNA and protein of Fas, FasL, and caspase-3 was stronger in infected group than normal control using semiquantitative reverse transcriptase ..
  27. Sun N, Hao J, Li X, Yin X, Zong Y, Zhang G, et al. GluR6-FasL-Trx2 mediates denitrosylation and activation of procaspase-3 in cerebral ischemia/reperfusion in rats. Cell Death Dis. 2013;4:e771 pubmed publisher
    ..6 (GluR6) antagonist, can inhibit the denitrosylation of procaspase-3 and diminish the increased Fas ligand (FasL) and thioredoxin (Trx)-2 expression induced by cerebral I/R...
  28. C Zapico S, Menendez S, Nunez P. Cell death proteins as markers of early postmortem interval. Cell Mol Life Sci. 2014;71:2957-62 pubmed publisher
    ..analyzed the early postmortem interval (2-8 h since death) using the study of the mRNA expression of Fas Ligand (FasL) and phosphatase and tensin homologue deleted on chromosome 10 (PTEN) by Quantitative-PCR...
  29. Peng Y, Sigua C, Karsonovich C, Murr M. Protein kinase C-zeta (PKC-zeta) regulates Kupffer cell apoptosis during experimental sepsis. J Gastrointest Surg. 2007;11:1712-21 pubmed
    ..and puncture (CLP); 12 h later, livers were assayed for PKC-zeta, IKKalpha, IKKbeta, IKKgamma, NF-kappaB, Fas/FasL, Caspase-3, and DNA fragmentation...
  30. Feuk L, Prince J, Breen G, Emahazion T, Carothers A, St Clair D, et al. apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease: finding of a positive association for a polymorphism in the TNFRSF6 gene. Hum Genet. 2000;107:391-6 pubmed
    ..These results imply that TNFRSF6, in interaction with APOE4, is a genetic risk factor for sporadic EOAD. Hence, the AD risk contributed by APOE4 could be mechanistically related to a pathway in common with FAS-mediated apoptosis. ..
  31. Reinehr R, Gorg B, Höngen A, Haussinger D. CD95-tyrosine nitration inhibits hyperosmotic and CD95 ligand-induced CD95 activation in rat hepatocytes. J Biol Chem. 2004;279:10364-73 pubmed
    ..2003) FASEB J. 17, 731-733). The effect of peroxynitrite (ONOO(-)) on modulation of the hyperosmotic and CD95 ligand (CD95L)-induced CD95 activation process was studied...
  32. Baldini E, Ulisse S, Marchioni E, Di Benedetto A, Giovannetti G, Petrangeli E, et al. Expression of Fas and Fas ligand in human testicular germ cell tumours. Int J Androl. 2009;32:123-30 pubmed
    In the present study, we analysed the expression of Fas ligand (FasL) and its cognate receptor Fas in 14 seminomatous testicular germ cell tumours (TGCT) and six normal testicular tissues obtained following orchiectomy...
  33. Waetzig V, Loose K, Haeusgen W, Herdegen T. c-Jun N-terminal kinases mediate Fas-induced neurite regeneration in PC12 cells. Biochem Pharmacol. 2008;76:1476-84 pubmed publisher
    ..These findings suggest a novel signal integration from the NGF and Fas pathways in the JNK axis of MAPK signalling, where JNKs function as "physiological" mediators of normally apoptotic signals. ..
  34. Pequignot M, Provost A, Salle S, Taupin P, Sainton K, Marchant D, et al. Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina. Dev Dyn. 2003;228:231-8 pubmed
    ..Comparison of wild-type C57BL/6 mice, gld mice, defective in the death ligand fasL, and bax-/- mice, defective in the pro-apoptotic BAX protein, revealed a minor role for FAS ligand but a crucial ..
  35. Wang X, Zhang S, Chen Y, Chen Z, Huang Y, Zhang L. Effects of platelet-derived growth factor and interleukin-10 on Fas/Fas-ligand and Bcl-2/Bax mRNA expression in rat hepatic stellate cells in vitro. World J Gastroenterol. 2004;10:2706-10 pubmed
    ..polymerase chain reaction (RT-PCR) analysis was employed to compare the mRNA expression levels of Fas/FasL and Bcl-2/Bax in HSCs of each group...
  36. Bhuiyan M, Shibuya M, Shioda N, Moriguchi S, Kasahara J, Iwabuchi Y, et al. Cytoprotective effect of bis(1-oxy-2-pyridinethiolato)oxovanadiun(IV) on myocardial ischemia/reperfusion injury elicits inhibition of Fas ligand and Bim expression and elevation of FLIP expression. Eur J Pharmacol. 2007;571:180-8 pubmed
    ..These results demonstrate that treatment with VO(OPT) exerts significant cytoprotective effects along with improvement of cardiac functional recovery. ..
  37. Egeland N, Moen A, Pedersen L, Brisby H, Gjerstad J. Spinal nociceptive hyperexcitability induced by experimental disc herniation is associated with enhanced local expression of Csf1 and FasL. Pain. 2013;154:1743-8 pubmed publisher
  38. Mor G, Munoz A, Redlinger R, Silva I, Song J, Lim C, et al. The role of the Fas/Fas ligand system in estrogen-induced thymic alteration. Am J Reprod Immunol. 2001;46:298-307 pubmed
    Estrogen induces atrophy in the thymus by an unknown mechanism. Since the Fas/FasL system is one of the main pathways in T cell apoptosis, we tested the hypothesis that estrogen-induced thymic atrophy is mediated by the Fas/FasL system...
  39. Pan J, Zhao Y, Wang Z, Jin L, Sun Z, Chen S. Expression of FasL and its interaction with Fas are mediated by c-Jun N-terminal kinase (JNK) pathway in 6-OHDA-induced rat model of Parkinson disease. Neurosci Lett. 2007;428:82-7 pubmed
    ..In the present study, we examined the changes in the protein level of Fas ligand (FasL) and its interaction with Fas in a rat model of PD...
  40. Jansen T, Tyler B, Mankowski J, Recinos V, Pradilla G, Legnani F, et al. FasL gene knock-down therapy enhances the antiglioma immune response. Neuro Oncol. 2010;12:482-9 pubmed publisher
    ..components of numerous immune escape mechanisms, including immunosuppressive proteins such as TGF-beta, IL-10, and FasL. Here, we show that FasL expression can support the growth of experimental intracranial glioma...
  41. Li C, Larson D, Zhang Z, Liu Z, Strom S, Gershenwald J, et al. Polymorphisms of the FAS and FAS ligand genes associated with risk of cutaneous malignant melanoma. Pharmacogenet Genomics. 2006;16:253-63 pubmed
    The FAS/FAS ligand (FASLG) system has a key role in regulating cell growth and thus tumorigenesis...
  42. Bouchet D, Tesson L, Menoret S, Charreau B, Mathieu P, Yagita H, et al. Differential sensitivity of endothelial cells of various species to apoptosis induced by gene transfer of Fas ligand: role of FLIP levels. Mol Med. 2002;8:612-23 pubmed
    ..Genetic engineering of vascularized organs for endothelial cell (EC) expression of FasL could protect the endothelium and underlying tissues from infiltrating Fas+ leukocytes...
  43. Zhang D, Lei Y, Zhao J, Tan W. [The change of certain biochemical indexes and apotosis protein (Fas/FasL) expression in rat liver of selenium and iodine deficiency]. Wei Sheng Yan Jiu. 2008;37:682-4 pubmed
    ..the effect of selenium (Se) and iodine (I) deficiency on certain biochemical indexes and apotosis protein (Fas/FasL) expression...
  44. McKechnie N, King B, Fletcher E, Braun G. Fas-ligand is stored in secretory lysosomes of ocular barrier epithelia and released with microvesicles. Exp Eye Res. 2006;83:304-14 pubmed
    ..Here we wish to determine whether there is a concomitant loss of fas-ligand (FasL) in vivo and whether ocular epithelial cells have secretory lysosomes similar to T cells, from where FasL and hr44 ..
  45. Mullauer L, Mosberger I, Grusch M, Rudas M, Chott A. Fas ligand is expressed in normal breast epithelial cells and is frequently up-regulated in breast cancer. J Pathol. 2000;190:20-30 pubmed
    Fas (CD95/Apo-1) is a cell membrane receptor that upon binding by its ligand (FasL), triggers a signal resulting in apoptotic cell death...
  46. Li R, Xi Y, Liu X, Chen G, Wang B, Jiang L, et al. Expression of IL-1alpha, IL-6, TGF-beta, FasL and ZNF265 during sertoli cell infection by ureaplasma urealyticum. Cell Mol Immunol. 2009;6:215-21 pubmed publisher
    ..We investigated the expressions of IL-1alpha, IL-6, TGF-beta, FasL and ZNF265 at the first, second and third weeks post-infection...
  47. Dermitzaki E, Tsatsanis C, Gravanis A, Margioris A. Corticotropin-releasing hormone induces Fas ligand production and apoptosis in PC12 cells via activation of p38 mitogen-activated protein kinase. J Biol Chem. 2002;277:12280-7 pubmed
    ..Thus, CRH promotes PC12 apoptosis via the CRH type 1 receptor, which induces Fas ligand production via activation of p38. ..
  48. Satoh K, Shimosegawa T, Masamune A, Hirota M, Koizumi M, Toyota T. Fas ligand is frequently expressed in human pancreatic duct cell carcinoma. Pancreas. 1999;19:339-45 pubmed
    ..The frequent expression of Fas-L in PDCs may partly explain the notorious biologic behavior of PDCs. ..
  49. Enjoji M, Yamaguchi K, Nakashima M, Ohta S, Kotoh K, Fukushima M, et al. Serum levels of soluble molecules associated with evasion of immune surveillance: a study in biliary disease. Liver Int. 2004;24:330-4 pubmed
    Biliary carcinoma cells produce the transmembrane proteins, Fas, FasL, and RCAS1...
  50. Sayed R, Khalil W, Salem H, Kenawy S, El Sayeh B. Sulforaphane increases the survival rate in rats with fulminant hepatic failure induced by D-galactosamine and lipopolysaccharide. Nutr Res. 2014;34:982-9 pubmed publisher
    ..Moreover, SFN inhibited GalN/LPS-induced caspase-3 activation and suppressed FAS and FASL expression...
  51. Lee S, Chong S, Lee J, Kim S, Min Y, Hahn J, et al. Difference in the expression of Fas/Fas-ligand and the lymphocyte subset reconstitution according to the occurrence of acute GVHD. Bone Marrow Transplant. 1997;20:883-8 pubmed
    ..In this study, we investigated both the expression of Fas/Fas-ligand (FasL) and lymphocyte subset reconstitution in patients who underwent HLA-matched related allogeneic BMT (n = 16) and ..
  52. Li Z, Ma Q, Luo Y. [Effect of resveratrol-induced FasL up-regulation on the apoptosis of pancreatic acinar cells in rats with severe acute pancreatitis]. Nan Fang Yi Ke Da Xue Xue Bao. 2009;29:454-7 pubmed
    ..The apoptosis of the pancreatic acinar cells in the rats was detected by TUNEL assay, and the expression of Fas and FasL genes was determined by RT-PCR and Western blotting...
  53. Sapi E, Brown W, Aschkenazi S, Lim C, Munoz A, Kacinski B, et al. Regulation of Fas ligand expression by estrogen in normal ovary. J Soc Gynecol Investig. 2002;9:243-50 pubmed
    The clinical significance of the Fas/Fas ligand (FasL) system in hormone-sensitive carcinomas such as breast and ovary has been reported. However, only a few studies have investigated the potential hormonal regulation of its expression...