Fads1

Summary

Gene Symbol: Fads1
Description: fatty acid desaturase 1
Alias: fatty acid desaturase 1, D5D, delta(5) desaturase, delta(5) fatty acid desaturase
Species: rat

Top Publications

  1. ncbi Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Delta5 and Delta6 desaturases, SREBP-1, PPARalpha, and PGC-1
    Maricela Rodriguez-Cruz
    Unidad de Investigación Médica en Nutrición, Coordinacion de Investigacion en Salud, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, DF 06720 Mexico
    J Lipid Res 47:553-60. 2006
  2. doi Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion
    Audrey Extier
    Unit of Lipid Nutrition and Regulation of Brain Functions, NuReLice, UR909, INRA, F 78352 Jouy en Josas, France
    J Nutr Biochem 21:180-7. 2010
  3. doi Effect of maternal micronutrients (folic acid, vitamin B12) and omega 3 fatty acids on liver fatty acid desaturases and transport proteins in Wistar rats
    Nisha S Wadhwani
    Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune, India
    Prostaglandins Leukot Essent Fatty Acids 86:21-7. 2012
  4. ncbi Fatty acid delta 5 desaturation in rat liver cell nuclei
    A Ves-Losada
    Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, Facultad de Ciencias Medicas, UNLP CONICET, Argentina
    Mol Cell Biochem 142:163-70. 1995
  5. ncbi Psychosocial stress, catecholamines, and essential fatty acid metabolism in rats
    D E Mills
    Department of Health Studies, University of Waterloo, Ontario, Canada
    Proc Soc Exp Biol Med 205:56-61. 1994
  6. ncbi Delta 5 desaturase activity in rat kidney microsomes
    C E Irazu
    Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, Facultad de Ciencias Medicas, La Plata, Argentina
    Mol Cell Biochem 129:31-7. 1993
  7. ncbi Effect of simvastatin on desaturase activities in liver from lean and obese Zucker rats
    B Georges
    Unité de Recherche de Nutrition Cellulaire et Métabolique, Universite de Bourgogne, Dijon, France
    Lipids 28:63-5. 1993
  8. ncbi Age-related changes in delta 6 and delta 5 desaturase activities in rat liver microsomes
    C Maniongui
    Unité de Recherche de Nutrition Cellulaire et Métabolique, Universite de Bourgogne, Dijon, France
    Lipids 28:291-7. 1993
  9. ncbi Fatty acid delta(5)-desaturase mRNA is regulated by dietary vitamin A and exogenous retinoic acid in liver of adult rats
    R Zolfaghari
    Department of Nutrition, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Arch Biochem Biophys 391:8-15. 2001
  10. ncbi Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Delta-5 desaturase activity
    Shigeru Nishida
    Department of Biochemistry, Nihon University School of Medicine, Itabashi, Tokyo, Japan, Department of the Third Internal Medicine, Nihon University School of Medicine, Itabashi, Tokyo, Japan
    J Pineal Res 32:26-33. 2002

Scientific Experts

  • Rodolfo R Brenner
  • Audrey Extier
  • Nisha S Wadhwani
  • Maricela Rodriguez-Cruz
  • Thomas D Dreesen
  • Mauro A Montanaro
  • J L Savelli
  • Shigeru Nishida
  • Asmita V Kulkarni
  • Kamini D Dangat
  • R Zolfaghari
  • Sadhana R Joshi
  • Rupali R Manglekar
  • J P Poisson
  • Aaron W Adamson
  • Nimbe Torres
  • Martha Del Prado
  • Steven D Clarke
  • Berenice Palacios-González
  • M Narce
  • Armando R Tovar
  • Michael Tekle
  • Thomas W Gettys
  • Chongren Tang
  • Hyekung P Cho
  • Omar J Rimoldi
  • María S González
  • Ana M Bernasconi
  • V Fustier
  • Ichiro Murai
  • Toshiko Segawa
  • Shigeki Nakagawa
  • M D Banta
  • C J Cifelli
  • A C Ross
  • A Ves-Losada
  • C Maniongui
  • D E Mills
  • C E Irazu
  • J Bezard
  • B Georges
  • J P Blond
  • Y S Huang
  • S González-Rodríguez
  • G Durand
  • L Ulmann

Detail Information

Publications14

  1. ncbi Synthesis of long-chain polyunsaturated fatty acids in lactating mammary gland: role of Delta5 and Delta6 desaturases, SREBP-1, PPARalpha, and PGC-1
    Maricela Rodriguez-Cruz
    Unidad de Investigación Médica en Nutrición, Coordinacion de Investigacion en Salud, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, DF 06720 Mexico
    J Lipid Res 47:553-60. 2006
    ..These results indicate that the lactating mammary gland has the capacity to synthesize PUFAs and can be regulated by the lipid content in the diet...
  2. doi Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion
    Audrey Extier
    Unit of Lipid Nutrition and Regulation of Brain Functions, NuReLice, UR909, INRA, F 78352 Jouy en Josas, France
    J Nutr Biochem 21:180-7. 2010
    ..Our results support the hypothesis on hormonal regulation of PUFA metabolism, which should be taken into account for specific nutritional recommendations...
  3. doi Effect of maternal micronutrients (folic acid, vitamin B12) and omega 3 fatty acids on liver fatty acid desaturases and transport proteins in Wistar rats
    Nisha S Wadhwani
    Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune, India
    Prostaglandins Leukot Essent Fatty Acids 86:21-7. 2012
    ..Our data for the first time indicates that maternal micronutrients differentially alter the activity and expression of fatty acid desaturases in the liver...
  4. ncbi Fatty acid delta 5 desaturation in rat liver cell nuclei
    A Ves-Losada
    Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, Facultad de Ciencias Medicas, UNLP CONICET, Argentina
    Mol Cell Biochem 142:163-70. 1995
    ..This step would be essential in nuclear desaturation since when ATP and/or CoA (necessary for the acylation reaction) are omitted from the incubation mixture, the desaturation reaction does not take place...
  5. ncbi Psychosocial stress, catecholamines, and essential fatty acid metabolism in rats
    D E Mills
    Department of Health Studies, University of Waterloo, Ontario, Canada
    Proc Soc Exp Biol Med 205:56-61. 1994
    ..They also suggest that epinephrine is capable of altering the in vivo metabolism of essential fatty acids in the rat...
  6. ncbi Delta 5 desaturase activity in rat kidney microsomes
    C E Irazu
    Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, Facultad de Ciencias Medicas, La Plata, Argentina
    Mol Cell Biochem 129:31-7. 1993
    ..Contrary to a report but in accordance to others, the present results suggest that rat kidneys can synthesize arachidonic acid at least to satisfy partially their needs for eicosanoid production...
  7. ncbi Effect of simvastatin on desaturase activities in liver from lean and obese Zucker rats
    B Georges
    Unité de Recherche de Nutrition Cellulaire et Métabolique, Universite de Bourgogne, Dijon, France
    Lipids 28:63-5. 1993
    ..The changes were not reflected in the fatty acid composition of liver microsomal phospholipids when expressed as micrograms fatty acid/g of liver...
  8. ncbi Age-related changes in delta 6 and delta 5 desaturase activities in rat liver microsomes
    C Maniongui
    Unité de Recherche de Nutrition Cellulaire et Métabolique, Universite de Bourgogne, Dijon, France
    Lipids 28:291-7. 1993
    ..In particular, arachidonic acid content in old rats was slightly higher than in young rats whereas contents in linoleic and docosahexaenoic acids varied little throughout the life span.(ABSTRACT TRUNCATED AT 250 WORDS)..
  9. ncbi Fatty acid delta(5)-desaturase mRNA is regulated by dietary vitamin A and exogenous retinoic acid in liver of adult rats
    R Zolfaghari
    Department of Nutrition, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Arch Biochem Biophys 391:8-15. 2001
    Delta(5)-Desaturase (D5D) catalyzes the Delta(5,6) desaturation of dietary essential fatty acids of the n-6 and n-3 series...
  10. ncbi Long-term melatonin administration reduces hyperinsulinemia and improves the altered fatty-acid compositions in type 2 diabetic rats via the restoration of Delta-5 desaturase activity
    Shigeru Nishida
    Department of Biochemistry, Nihon University School of Medicine, Itabashi, Tokyo, Japan, Department of the Third Internal Medicine, Nihon University School of Medicine, Itabashi, Tokyo, Japan
    J Pineal Res 32:26-33. 2002
    ..Thus, subcutaneous implantation of a melatonin-releasing pellet thus resulted in improved lipid metabolism in diabetic rats, probably through restored insulin resistance...
  11. ncbi Desaturase activities are depleted before and after weaning in liver microsomes of spontaneously hypertensive rats
    J L Savelli
    Université de Corse, BP 52, Corte, France
    Prostaglandins Leukot Essent Fatty Acids 66:541-7. 2002
    ..Such a loss of desaturase activities may be under the control of hormones involved in the regulation of SHR blood pressure...
  12. ncbi Desaturase activities in rat model of insulin resistance induced by a sucrose-rich diet
    Rodolfo R Brenner
    Instituto de Investigaciones Bioquimicas de La Plata, CONICET UNLP, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, 1900 La Plata, Argentina
    Lipids 38:733-42. 2003
    ..It appears that neither blood insulin levels nor insulin resistance is a factor affecting the delta9, delta6, and delta5 desaturase changes in mRNA and activity found with the sucrose-rich diet...
  13. ncbi Effects of fenofibrate and insulin on the biosynthesis of unsaturated fatty acids in streptozotocin diabetic rats
    Mauro A Montanaro
    Facultad de Ciencias Medicas, Instituto de Investigaciones Bioquímicas de La Plata INIBIOLP, CONICET UNLP, calles 60 y 120, Argentina
    Prostaglandins Leukot Essent Fatty Acids 73:369-78. 2005
    ..The 20:4/18:2 ratio was maintained. Fenofibrate increased palmitic acid, but decreased stearic acid percentage in liver lipids...
  14. ncbi A newly discovered member of the fatty acid desaturase gene family: a non-coding, antisense RNA gene to delta5-desaturase
    Thomas D Dreesen
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Prostaglandins Leukot Essent Fatty Acids 75:97-106. 2006
    ..These findings support a significant role for reverse Delta5-desaturase as a natural antisense regulator of Delta5-desaturase...