Gene Symbol: Fadd
Description: Fas associated via death domain
Alias: Mort1, FAS-associated death domain protein, Fas (TNFRSF6)-associated via death domain, protein FADD
Species: rat
Products:     Fadd

Top Publications

  1. Strasser A, Jost P, Nagata S. The many roles of FAS receptor signaling in the immune system. Immunity. 2009;30:180-92 pubmed publisher
    ..Fas thereby functions as a guardian against autoimmunity and tumor development. FAS triggers apoptosis through FADD-mediated recruitment and activation of caspase-8...
  2. Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol. 2000;1:489-95 pubmed
    ..caspase-independent death is absent in T cells that are deficient in either Fas-associated death domain (FADD) or receptor-interacting protein (RIP)...
  3. Zheng L, Bidere N, Staudt D, Cubre A, Orenstein J, Chan F, et al. Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. Mol Cell Biol. 2006;26:3505-13 pubmed
    ..These single transducers determine cell fate by triggering NF-kappaB activation, apoptosis, and nonapoptotic death signals through separate and competing signaling pathways. ..
  4. Song X, Tian H, Zhang Z. Differential activation of CD95-mediated apoptosis related proteins in proximal and distal tubules during rat renal development. Tissue Cell. 2016;48:417-24 pubmed publisher
    ..Western blotting demonstrated that expression of CD95, FasL and FADD was very weak during embryonic development, but rapidly increased at P14...
  5. Wang J, Zhang X, Li Q, Wang K, Wang Y, Jiao J, et al. MicroRNA-103/107 Regulate Programmed Necrosis and Myocardial Ischemia/Reperfusion Injury Through Targeting FADD. Circ Res. 2015;117:352-63 pubmed publisher
    ..kinase (RIPK) 1 and 3 which may be negatively regulated by Fas-associated protein with death domain (FADD)...
  6. García Fuster M, Clinton S, Watson S, Akil H. Effect of cocaine on Fas-associated protein with death domain in the rat brain: individual differences in a model of differential vulnerability to drug abuse. Neuropsychopharmacology. 2009;34:1123-34 pubmed publisher
    This study was designed to (1) assess the effects of cocaine on Fas-associated protein with death domain (FADD) system and its role in the activation of apoptotic vs nonapoptotic events and (2) ascertain whether animals selectively bred ..
  7. Howard P, Chia M, Del Rizzo S, Liu F, Pawson T. Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins. Proc Natl Acad Sci U S A. 2003;100:11267-72 pubmed
    ..that activate signaling pathways involved in growth and survival, whereas death receptors bind adaptors, such as Fadd, that promote apoptosis...
  8. Boldin M, Goncharov T, Goltsev Y, Wallach D. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell. 1996;85:803-15 pubmed
    ..Upon activation of these receptors, Fas/APO-1 binds a protein called MORT1 (or FADD) and p55-R binds a protein called TRADD. MORT1 and TRADD can also bind to each other...
  9. Yang C, Ting W, Shen C, Hsu H, Lin Y, Kuo C, et al. Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl4 -induced hepatotoxicity in rats. Environ Toxicol. 2016;31:663-70 pubmed publisher
    ..As the results, the FAS-FADD expressions leaded apoptosis in CCl4 intraperitoneal (IP) injection induced acute liver injury in rats...

More Information


  1. Cheng S, Cheng Y, Wu L, Kuo C, Lee Y, Wu M, et al. Activated apoptotic and anti-survival effects on rat hearts with fructose induced metabolic syndrome. Cell Biochem Funct. 2014;32:133-41 pubmed publisher
    ..The TNF-?, TNF receptor 1, Fas ligand, Fas receptor, FADD, and activated caspase-3 and 8 protein levels (Fas pathway) and the Bax, Bak, Bax/Bcl-2, Bak/Bcl-xL, cytosolic ..
  2. Kim S, Eum H, Billiar T, Lee S. Role of heme oxygenase 1 in TNF/TNF receptor-mediated apoptosis after hepatic ischemia/reperfusion in rats. Shock. 2013;39:380-8 pubmed publisher
    ..Ischemia/reperfusion increased the quantity of DISC components, including TRADD (TNFR1-associated death domain), FADD (Fas-associated death domain), and caspase-8, as well as the assembly of DISCs within the liver...
  3. Rébé C, Cathelin S, Launay S, Filomenko R, Prevotat L, L Ollivier C, et al. Caspase-8 prevents sustained activation of NF-kappaB in monocytes undergoing macrophagic differentiation. Blood. 2007;109:1442-50 pubmed
    ..factor (M-CSF) exposure, caspase-8 associates with the adaptor protein Fas-associated death domain (FADD), the serine/threonine kinase receptor-interacting protein 1 (RIP1) and the long isoform of FLICE-inhibitory ..
  4. Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol. 2005;6:981-8 pubmed
    ..Knockdown' of IPS-1 by small interfering RNA blocked interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses. ..
  5. Chengke L, Weiwei L, Xiyang W, Ping W, Xiaoyang P, Zhengquan X, et al. Effect of infliximab combined with methylprednisolone on expressions of NF-?B, TRADD, and FADD in rat acute spinal cord injury. Spine (Phila Pa 1976). 2013;38:E861-9 pubmed publisher
    ..expressions of NF-?B (nuclear factor Kappa B), TRADD (tumor necrosis factor receptor associated death domain), and FADD (fas associated death domain) in a rat model of acute spinal cord injury (ASCI), and to confirm the therapeutic ..
  6. Cudrici C, Niculescu F, Jensen T, Zafranskaia E, Fosbrink M, Rus V, et al. C5b-9 terminal complex protects oligodendrocytes from apoptotic cell death by inhibiting caspase-8 processing and up-regulating FLIP. J Immunol. 2006;176:3173-80 pubmed
    ..C5b-9 also down-regulated the expression of FasL and the Fas-induced apoptosis. These data suggest that C5b-9 through PI3K signaling can rescue OLG from Fas-mediated apoptosis by regulating caspase-8 processing. ..
  7. Fu K, Ren H, Wang Y, Fei E, Wang H, Wang G. DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD. Oncogene. 2012;31:1311-22 pubmed publisher
    ..Here we show that DJ-1 inhibits TRAIL-induced apoptosis by blocking Fas-associated protein death domain (FADD)-mediated pro-caspase-8 activation...
  8. Roy D, Mandal S, Sen G, Mukhopadhyay S, Biswas T. 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. Br J Pharmacol. 2010;160:1823-43 pubmed publisher
    ..This can be used as a strategy against cytokine-mediated hepatocyte apoptosis in liver dysfunctions. ..
  9. Wang Y, Kim P, Peng X, Loughran P, Vodovotz Y, Zhang B, et al. Cyclic AMP and cyclic GMP suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation via a protein kinase A-dependent pathway. Apoptosis. 2006;11:441-51 pubmed
    ..Recently we have also shown that FADD levels increase 10 folds in response to TNFalpha/ActD...
  10. Estelles A, Charlton C, Blau H. The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis. Dev Biol. 1999;216:16-28 pubmed
    ..These results show that PEA-15 provides a potential mechanism during development for distinguishing between diverse extracellular death-inducing signals that culminate either in apoptosis or in survival. ..
  11. Wajant H, Pfizenmaier K, Scheurich P. Tumor necrosis factor signaling. Cell Death Differ. 2003;10:45-65 pubmed
    ..In particular, the multiple facets of crosstalk between the various signalling pathways engaged by TNF will be addressed. ..
  12. Ikner A, Ashkenazi A. TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated death domain (FADD), and caspase-8. J Biol Chem. 2011;286:21546-54 pubmed publisher
    ..TNF receptor 1-dependent assembly of a death-signaling complex containing receptor-interacting protein 1 (RIP1), FADD, and caspase-8...
  13. Dzietko M, Boos V, Sifringer M, Polley O, Gerstner B, Genz K, et al. A critical role for Fas/CD-95 dependent signaling pathways in the pathogenesis of hyperoxia-induced brain injury. Ann Neurol. 2008;64:664-73 pubmed publisher
    ..hyperoxia resulted in induction of downstream signaling events of Fas, such as Fas-associated death domain (FADD), the long and short form of FADD-like interleukin-1beta-converting enzyme (FLICE) inhibitory protein (FLIP-L, FLIP-..
  14. Lee S, Kuo W, Bau D, Ko F, Wu F, Kuo C, et al. The coexistence of nocturnal sustained hypoxia and obesity additively increases cardiac apoptosis. J Appl Physiol (1985). 2008;104:1144-53 pubmed publisher
    ..the evidence for which is based on decreases in an anti-apoptotic protein Bcl2 level and Bid and increases in Fas, FADD, pro-apoptotic Bad, BNIP3, cytosolic cytochrome c, activated caspase-8, activated caspase-9, and activated caspase-..
  15. Bi F, Xiao B, Hu Y, Tian F, Wu Z, Ding L, et al. Expression and localization of Fas-associated proteins following focal cerebral ischemia in rats. Brain Res. 2008;1191:30-8 pubmed
    ..The expression of Fas-associated death domain protein (FADD), Fas-associated phosphatase-1 (FAP-1) caspase-8 and death-associated protein (Daxx), the pro-apoptotic genes, were ..
  16. Ramos Miguel A, Miralles A, Garcia Sevilla J. Correlation of rat cortical Fas-associated death domain (FADD) protein phosphorylation with the severity of spontaneous morphine abstinence syndrome: role of ?(2)-adrenoceptors and extracellular signal-regulated kinases. J Psychopharmacol. 2011;25:1691-702 pubmed publisher
    Fas-associated death domain (FADD) phosphorylation was recently implicated in opiate-induced neuroplasticity...
  17. Hafez M, Al Harbi N, Al Hoshani A, Al hosaini K, Al Shrari S, Al Rejaie S, et al. Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats. Biol Res. 2015;48:30 pubmed publisher
    ..real-time PCR: interleukin-6 (IL-6), dual-specificity protein kinase 5 (MEK5), Fas-associated death domain protein (FADD), epidermal growth factor (EGF), signal transducer and activator of transcription 3 (STAT3), Janus kinase (JAK), B-..
  18. Vanlangenakker N, Bertrand M, Bogaert P, Vandenabeele P, Vanden Berghe T. TNF-induced necroptosis in L929 cells is tightly regulated by multiple TNFR1 complex I and II members. Cell Death Dis. 2011;2:e230 pubmed publisher
    ..Finally, we also report RIP1-independent but RIP3-mediated necroptosis in the context of TNF signaling in particular conditions. ..
  19. Tao R, Berkova Z, Wise J, Rezaeian A, Daniluk U, Ao X, et al. PMLRAR? binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo. Blood. 2011;118:3107-18 pubmed publisher
    ..The presence of PML-Fas complexes across different tissues implicates that PML functions in apoptosis regulation and tumor suppression are mediated by direct interaction with Fas. ..
  20. Lu J, Weist B, van Raam B, Marro B, Nguyen L, Srinivas P, et al. Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proc Natl Acad Sci U S A. 2011;108:15312-7 pubmed publisher
    ..Indeed, following mitogenic stimulation, T cells lacking casp8 or its adaptor protein FADD (Fas-associated death domain protein) develop a hyperautophagic morphology, and die a programmed necrosis-like ..
  21. Pennarun B, Meijer A, de Vries E, Kleibeuker J, Kruyt F, de Jong S. Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. Biochim Biophys Acta. 2010;1805:123-40 pubmed publisher
    ..Primary components of the DISC are trimerized TRAIL-R1/-R2, FADD, caspase 8 and caspase 10...
  22. Tourneur L, Delluc S, Levy V, Valensi F, Radford Weiss I, Legrand O, et al. Absence or low expression of fas-associated protein with death domain in acute myeloid leukemia cells predicts resistance to chemotherapy and poor outcome. Cancer Res. 2004;64:8101-8 pubmed
    ..Because Fas-associated protein with death domain (FADD) is the main adaptor for transmitting the Fas, TNF-related apoptosis-inducing ligand receptors, and TNF receptor 1 ..
  23. Liang X, Li H, Yang X, Zhou W, Niu J, Chen B. Effect of Danshen aqueous extract on serum hs-CRP, IL-8, IL-10, TNF-? levels, and IL-10 mRNA, TNF-? mRNA expression levels, cerebral TGF-?1 positive expression level and its neuroprotective mechanisms in CIR rats. Mol Biol Rep. 2013;40:3419-27 pubmed publisher
    ..and cerebral neuron specific enolase (NSE) levels, and decrease in fas-associated protein with death domain (FADD) and death-associated protein (Daxx) positive expression levels in the CIR group...
  24. García Fuster M, Miralles A, Garcia Sevilla J. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway. Neuropsychopharmacology. 2007;32:399-411 pubmed
    ..designed to assess the effects of opiate treatment on the expression of Fas-associated protein with death domain (FADD) in the rat brain...
  25. Razmara M, Srinivasula S, Wang L, Poyet J, Geddes B, DiStefano P, et al. CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis. J Biol Chem. 2002;277:13952-8 pubmed
    ..Overexpression of CARD-8 can also induce apoptosis in transfected cells. The results suggest that CARD-8 represents a new signaling molecule involved in the regulation of caspase-1 and NF-kappaB activation. ..
  26. Bolze A, Byun M, McDonald D, Morgan N, Abhyankar A, Premkumar L, et al. Whole-exome-sequencing-based discovery of human FADD deficiency. Am J Hum Genet. 2010;87:873-81 pubmed publisher
    ..By a combination of genome-wide linkage and whole-exome sequencing, we identified a homozygous missense mutation in FADD, encoding the Fas-associated death domain protein (FADD), in the patients...
  27. Falschlehner C, Emmerich C, Gerlach B, Walczak H. TRAIL signalling: decisions between life and death. Int J Biochem Cell Biol. 2007;39:1462-75 pubmed
    ..In this review we intend to summarise the most important findings on the TRAIL signalling network and the interplay in the decisions between life and death of a tumor cell. ..
  28. Han S, Koo H, Lan Q, Lee K, Park A, Park S, et al. Common variation in genes related to immune response and risk of childhood leukemia. Hum Immunol. 2012;73:316-9 pubmed publisher
    ..The AT or TT genotype of rs7939734 in Fas-associated protein with death domain (FADD) was associated with increased risk of childhood leukemia compared with the AA genotype (odds ratio [OR] = 2...
  29. Alvaro Bartolomé M, La Harpe R, Callado L, Meana J, García Sevilla J. Molecular adaptations of apoptotic pathways and signaling partners in the cerebral cortex of human cocaine addicts and cocaine-treated rats. Neuroscience. 2011;196:1-15 pubmed publisher
    ..of cocaine abusers, FS7-associated cell surface antigen (Fas) receptor aggregates and Fas-associated death domain (FADD) adaptor were reduced (-26% and -66%, respectively) as well as the content of mitochondrial cytochrome c (-61%)...
  30. Wang L, Yang J, Kabaleeswaran V, Rice A, Cruz A, Park A, et al. The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat Struct Mol Biol. 2010;17:1324-9 pubmed publisher
    The death-inducing signaling complex (DISC) formed by the death receptor Fas, the adaptor protein FADD and caspase-8 mediates the extrinsic apoptotic program...
  31. Davis A, Lotocki G, Marcillo A, Dietrich W, Keane R. FasL, Fas, and death-inducing signaling complex (DISC) proteins are recruited to membrane rafts after spinal cord injury. J Neurotrauma. 2007;24:823-34 pubmed
    ..into membrane raft microdomains where Fas associates with the adaptor proteins Fas-associated death domain (FADD), caspase-8, cellular FLIP long form (cFLIPL ), and caspase-3, forming a death-inducing signaling complex (DISC)...
  32. Shu H, Halpin D, Goeddel D. Casper is a FADD- and caspase-related inducer of apoptosis. Immunity. 1997;6:751-63 pubmed
    ..TNF-R1) through interaction of its prodomain with the death effector domain (DED) of the receptor-associating FADD. Here we describe a novel 55 kDa protein, Casper, that has sequence similarity to caspase-8 throughout its length...
  33. Berube C, Boucher L, Ma W, Wakeham A, Salmena L, Hakem R, et al. Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD. Proc Natl Acad Sci U S A. 2005;102:14314-20 pubmed
    ..Our findings suggest that caspase-2 contributes to PIDD-mediated cell death, but that it is not the sole effector of this pathway. ..
  34. Xu D, Gao C, Niu W, Li Y, Wang Y, Gao C, et al. Sodium hydrosulfide alleviates lung inflammation and cell apoptosis following resuscitated hemorrhagic shock in rats. Acta Pharmacol Sin. 2013;34:1515-25 pubmed publisher
    ..and Fas-ligand and the number apoptotic cells in lung tissue, as well as the expression of pro-apoptotic proteins FADD, active-caspase 3, active-caspase 8, Bax, and decreased the expression of Bcl-2...
  35. Boldin M, Varfolomeev E, Pancer Z, Mett I, Camonis J, Wallach D. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J Biol Chem. 1995;270:7795-8 pubmed
    ..Induced expression of the protein results in ligand-independent triggering of cytotoxicity, suggesting that it is involved in cell death induction by Fas/APO1. ..
  36. Feoktistova M, Geserick P, Kellert B, Dimitrova D, Langlais C, Hupe M, et al. cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell. 2011;43:449-63 pubmed publisher
    ..It contains RIP1, FADD, caspase-8, caspase-10, and caspase inhibitor cFLIP isoforms...
  37. Ugolini G, Raoul C, Ferri A, Haenggeli C, Yamamoto Y, Salaün D, et al. Fas/tumor necrosis factor receptor death signaling is required for axotomy-induced death of motoneurons in vivo. J Neurosci. 2003;23:8526-31 pubmed
    ..and pathological situations, we used several mutant mice deficient for Fas signaling and made a novel transgenic FADD-DN (FAS-associated death domain-dominant-negative) strain...
  38. Garcia Fuster M, Flagel S, Mahmood S, Mayo L, Thompson R, Watson S, et al. Decreased proliferation of adult hippocampal stem cells during cocaine withdrawal: possible role of the cell fate regulator FADD. Neuropsychopharmacology. 2011;36:2303-17 pubmed publisher
    ..Moreover, the results point to Fas-Associated protein with Death Domain (FADD), a molecular marker previously associated with the propensity to substance abuse and cocaine sensitization, as a ..
  39. Kim P, Wang Y, Gambotto A, Kim Y, Weller R, Zuckerbraun B, et al. Hepatocyte Fas-associating death domain protein/mediator of receptor-induced toxicity (FADD/MORT1) levels increase in response to pro-apoptotic stimuli. J Biol Chem. 2002;277:38855-62 pubmed
    ..FADD/mediator of receptor-induced toxicity (MORT1) is required for activation of several signaling pathways of cell death...
  40. Yang C, Ting W, Pai P, Chang S, Ho T, Lin J, et al. Anti-apoptosis effects on hearts of SHSST cyclodextrin complex in a carbon tetrachloride-induced cirrhotic cardiomyopathy rat model. Chin J Physiol. 2015;58:38-45 pubmed publisher
    ..protection effects were determined through activation of the IGF1R cell survival pathway and inhibition of Fas-FADD death domain induced-apoptosis...
  41. Dillon C, Oberst A, Weinlich R, Janke L, Kang T, Ben Moshe T, et al. Survival function of the FADD-CASPASE-8-cFLIP(L) complex. Cell Rep. 2012;1:401-7 pubmed
    Caspase-8, the initiator caspase of the death receptor pathway of apoptosis, its adapter molecule, FADD, required for caspase-8 activation, and cFLIPL, a caspase-8-like protein that lacks a catalytic site and blocks caspase-8-mediated ..
  42. Koncz G, Hancz A, Chakrabandhu K, Gogolak P, Kerekes K, Rajnavolgyi E, et al. Vesicles released by activated T cells induce both Fas-mediated RIP-dependent apoptotic and Fas-independent nonapoptotic cell deaths. J Immunol. 2012;189:2815-23 pubmed publisher
    ..We propose that besides cell-to-cell interaction-mediated Fas triggering, stimuli induced by secreted vesicles can mediate important additional cell death signals regulating activation-induced cell death under physiological conditions. ..
  43. Jang C, Kim H, Kim J. Ribosomal protein S3 interacts with TRADD to induce apoptosis through caspase dependent JNK activation. Biochem Biophys Res Commun. 2012;421:474-8 pubmed publisher
    ..Based on the findings of this study, we concluded that rpS3 is recruited to the DISC and plays a critical role in both genotoxic stress and cytokine induced apoptosis. ..
  44. Wang J, Chun H, Wong W, Spencer D, Lenardo M. Caspase-10 is an initiator caspase in death receptor signaling. Proc Natl Acad Sci U S A. 2001;98:13884-8 pubmed
    ..indicates that the death-effector domains of caspase-8 and -10 both interact with the death-effector domain of FADD. Nonetheless, we find that caspase-8 and -10 may have different apoptosis substrates and therefore potentially ..
  45. Jia J, Guan D, Zhu W, Alkayed N, Wang M, Hua Z, et al. Estrogen inhibits Fas-mediated apoptosis in experimental stroke. Exp Neurol. 2009;215:48-52 pubmed publisher
    ..Expression of Fas and Fas-associated death domain (FADD) were measured at 3, 6 and 12 h of reperfusion by RT-PCR and Western blot, respectively...
  46. Wang G, Bertin J, Wang Y, Martin D, Wang J, Tomaselli K, et al. Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses. J Virol. 1997;71:8928-32 pubmed
    Fas- and tumor necrosis factor receptor 1 (TNFR1)-induced apoptosis is mediated by the interaction of FADD with caspase-8...
  47. Ketteler R, Sun Z, Kovacs K, He W, Seed B. A pathway sensor for genome-wide screens of intracellular proteolytic cleavage. Genome Biol. 2008;9:R64 pubmed publisher
    ..By including protease cleavage sites between GLUC and beta-actin, proteolytic cleavage can be detected. Using this assay, we have identified regulators of autophagy, apoptosis and beta-actin cleavage. ..
  48. Tan W, Wang J, Lin Z, Li Y, Lin Y, Li P. Novel cardiac apoptotic pathway: the dephosphorylation of apoptosis repressor with caspase recruitment domain by calcineurin. Circulation. 2008;118:2268-76 pubmed publisher
    ..Our study identifies a novel cardiac apoptotic pathway in which ARC is dephosphorylated by calcineurin. This pathway could be a component in the cardiac apoptotic machinery. ..
  49. Deng J, Lee S, Kuo W, Fan M, Lin Y, Hu W, et al. Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts. Chem Biol Interact. 2014;209:77-84 pubmed publisher
    ..Protein levels of Fas ligand, Fas death receptor, Fas-associated death domain (FADD), Bid, t-Bid, Bax, cytochrome c, activated caspase-8, activated caspase 9 and activated caspase-3 were decreased in ..
  50. Vouyouka A, Lin L, Basson M. Pressure and endothelial coculture upregulate myocytic Fas-FasL pathway and induce apoptosis by way of direct and paracrine mechanisms. Am J Surg. 2005;190:780-6 pubmed
    ..65-fold and 1.7-fold for FasL [P < or = .05]). Coculture had synergistic effect on Fas expression and no effect on FasL expression. Pressure plays significant role in EC-SMC interaction, SMC apoptosis, and vascular remodeling. ..
  51. Lotocki G, Alonso O, Dietrich W, Keane R. Tumor necrosis factor receptor 1 and its signaling intermediates are recruited to lipid rafts in the traumatized brain. J Neurosci. 2004;24:11010-6 pubmed
    ..Thus, redistribution of TNFR1 in lipid rafts and nonraft regions of the plasma membrane may regulate the diversity of signaling responses initiated by these receptors in the normal brain and after TBI. ..