Gene Symbol: Fa2h
Description: fatty acid 2-hydroxylase
Alias: RGD1310347, Wdr59, fatty acid 2-hydroxylase, WD repeat domain 59, fatty acid alpha-hydroxylase
Eckhardt M, Yaghootfam A, Fewou S, Zöller I, Gieselmann V. A mammalian fatty acid hydroxylase responsible for the formation of alpha-hydroxylated galactosylceramide in myelin. Biochem J. 2005;388:245-54 pubmed
..the basis of sequence similarity to a yeast C26 fatty acid hydroxylase, we have identified a murine cDNA encoding FA2H (fatty acid 2-hydroxylase)...
Alderson N, Maldonado E, Kern M, Bhat N, Hama H. FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain. J Lipid Res. 2006;47:2772-80 pubmed
..To fill this gap, we have identified a human fatty acid 2-hydroxylase gene (FA2H) that is highly expressed in brain...
Zöller I, Meixner M, Hartmann D, Bussow H, Meyer R, Gieselmann V, et al
. Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration. J Neurosci. 2008;28:9741-54 pubmed publisher
..To prove this hypothesis, we generated mice lacking a functional fatty acid 2-hydroxylase (FA2H) gene. FA2H-deficient (FA2H(-/-)) mice lacked 2-hydroxylated sphingolipids in the brain and in peripheral nerves...
Potter K, Kern M, Fullbright G, Bielawski J, Scherer S, Yum S, et al
. Central nervous system dysfunction in a mouse model of FA2H deficiency. Glia. 2011;59:1009-21 pubmed publisher
Fatty acid 2-hydroxylase (FA2H) is responsible for the synthesis of myelin galactolipids containing hydroxy fatty acid (hFA) as the N-acyl chain...
Maier H, Meixner M, Hartmann D, Sandhoff R, Wang Eckhardt L, Zöller I, et al
. Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands. J Biol Chem. 2011;286:25922-34 pubmed publisher
..Fatty acid 2-hydroxylase (FA2H), required for the synthesis of 2-hydroxylated sphingolipids in various organs, is highly expressed in skin, and ..
Maldonado E, Alderson N, Monje P, Wood P, Hama H. FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin. J Lipid Res. 2008;49:153-61 pubmed
..We recently reported that fatty acid 2-hydroxylase (FA2H), encoded by the FA2H gene, is the major fatty acid 2-hydroxylase in the mouse brain...