Gene Symbol: Exoc4
Description: exocyst complex component 4
Alias: ALR, Sec8, Sec8l1, exocyst complex component 4, SEC8-like 1, augmenter of liver regeneration (ALR) pseudogene, exocyst complex component Sec8, rSec8, secretory protein SEC8
Species: rat
Products:     Exoc4

Top Publications

  1. Zuo X, Zhang J, Zhang Y, Hsu S, Zhou D, Guo W. Exo70 interacts with the Arp2/3 complex and regulates cell migration. Nat Cell Biol. 2006;8:1383-8 pubmed
    ..We propose that Exo70, in addition to functioning in exocytosis, also regulates actin at the leading edges of migrating cells, therefore coordinating cytoskeleton and membrane traffic during cell migration. ..
  2. Seixas C, Choi S, Polgar N, Umberger N, East M, Zuo X, et al. Arl13b and the exocyst interact synergistically in ciliogenesis. Mol Biol Cell. 2016;27:308-20 pubmed publisher
    ..Nevertheless, the precise role of Arl13b remains elusive. Here we report that the exocyst subunits Sec8, Exo70, and Sec5 bind preferentially to the GTP-bound form of Arl13b, consistent with the exocyst being an effector ..
  3. Lalli G. RalA and the exocyst complex influence neuronal polarity through PAR-3 and aPKC. J Cell Sci. 2009;122:1499-506 pubmed publisher
    ..Furthermore, depletion of the Sec6, Sec8 or Exo84 subunits of the exocyst complex also leads to unpolarized neurons...
  4. Gerges N, Backos D, Rupasinghe C, Spaller M, Esteban J. Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. EMBO J. 2006;25:1623-34 pubmed
    ..We have found that two components of the exocyst complex, Sec8 and Exo70, separately control synaptic targeting and insertion of AMPA-type glutamate receptors...
  5. Sans N, Prybylowski K, Petralia R, Chang K, Wang Y, Racca C, et al. NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Nat Cell Biol. 2003;5:520-30 pubmed
    ..Here, we find that synapse-associated protein 102 (SAP102) interacts with the PDZ-binding domain of Sec8, a member of the exocyst complex...
  6. Riefler G, Balasingam G, Lucas K, Wang S, Hsu S, Firestein B. Exocyst complex subunit sec8 binds to postsynaptic density protein-95 (PSD-95): a novel interaction regulated by cypin (cytosolic PSD-95 interactor). Biochem J. 2003;373:49-55 pubmed
    ..We observed that one of the subunits in the sec6/8 or exocyst complex, sec8, contains a C-terminal consensus sequence for PDZ binding...
  7. Goehring A, Pedroja B, Hinke S, Langeberg L, Scott J. MyRIP anchors protein kinase A to the exocyst complex. J Biol Chem. 2007;282:33155-67 pubmed
    ..Similar approaches show that MyRIP interacts with the Sec6 and Sec8 components of the exocyst complex, an evolutionarily conserved protein unit that controls protein trafficking and ..
  8. Friedrich G, Hildebrand J, Soriano P. The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse. Dev Biol. 1997;192:364-74 pubmed
    ..An open reading frame in the cDNA encodes a 971-amino-acid leucine-rich protein, similar to rat rSec8. A description of the mutant phenotype and the cloning of the gene is presented here and the results are ..
  9. Bolis A, Coviello S, Visigalli I, Taveggia C, Bachi A, Chishti A, et al. Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination. J Neurosci. 2009;29:8858-70 pubmed publisher
    ..We here report that, in Schwann cells, Dlg1 also interacts with kinesin 13B (kif13B) and Sec8, which are involved in vesicle transport and membrane tethering in polarized cells, respectively...

More Information


  1. Anitei M, Ifrim M, Ewart M, Cowan A, Carson J, Bansal R, et al. A role for Sec8 in oligodendrocyte morphological differentiation. J Cell Sci. 2006;119:807-18 pubmed
    ..for the targeting of transport vesicles to areas of rapid membrane growth, including the exocyst components Sec8 and Sec6 and the multidomain scaffolding proteins CASK and Mint1...
  2. Rosse C, Formstecher E, Boeckeler K, Zhao Y, Kremerskothen J, White M, et al. An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation. PLoS Biol. 2009;7:e1000235 pubmed publisher
  3. Brymora A, Valova V, Larsen M, Roufogalis B, Robinson P. The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene. J Biol Chem. 2001;276:29792-7 pubmed
    ..Western blots confirmed that two rat exocyst proteins, rSec6 and rSec8, bound active RalA in nerve terminals, as did RalBP1...
  4. Shin D, Zhao X, Zeng W, Mozhayeva M, Muallem S. The mammalian Sec6/8 complex interacts with Ca(2+) signaling complexes and regulates their activity. J Cell Biol. 2000;150:1101-12 pubmed
    ..Accordingly, immunoprecipitation (IP) of Sec8 did not coimmunoprecipitate betaCOP, Golgi 58K protein, or mannosidase II, all Golgi-resident proteins...
  5. Saito T, Shibasaki T, Seino S. Involvement of Exoc3l, a protein structurally related to the exocyst subunit Sec6, in insulin secretion. Biomed Res. 2008;29:85-91 pubmed
    ..In co-immunoprecipitation experiments, Exoc3l was found to interact with Sec5, Sec8, and Sec10, all of which are binding partners of Sec6 in the exocyst complex...
  6. Chernyshova Y, Leshchyns ka I, Hsu S, Schachner M, Sytnyk V. The neural cell adhesion molecule promotes FGFR-dependent phosphorylation and membrane targeting of the exocyst complex to induce exocytosis in growth cones. J Neurosci. 2011;31:3522-35 pubmed publisher
    ..NCAM promotes FGF receptor-mediated phosphorylation of two tyrosine residues in the sec8 subunit of the exocyst complex and is required for efficient recruitment of the exocyst complex to growth cones...
  7. Ting A, Hazuka C, Hsu S, Kirk M, Bean A, Scheller R. rSec6 and rSec8, mammalian homologs of yeast proteins essential for secretion. Proc Natl Acad Sci U S A. 1995;92:9613-7 pubmed
    ..5S particle that interacts with the GTP-binding protein Sec4p. Here we report the sequences of rSec6 and rSec8, rat homologs of Sec6p and Sec8p...
  8. Parrini M, Sadou Dubourgnoux A, Aoki K, Kunida K, Biondini M, Hatzoglou A, et al. SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility. Mol Cell. 2011;42:650-61 pubmed publisher
    ..Our finding that SH3BP1 downregulates Rac1 at the motile-cell front indicates that Rac1 inactivation in this location, as well as its activation by GEF proteins, is a fundamental requirement for cell motility. ..