Etv4

Summary

Gene Symbol: Etv4
Description: ets variant 4
Alias: Pea3, ETS translocation variant 4, ets variant gene 4 (E1A enhancer binding protein, E1AF), polyomavirus enhancer activator-3
Species: rat
Products:     Etv4

Top Publications

  1. Hedvat C, Yao J, Sokolic R, Nimer S. Myeloid ELF1-like factor is a potent activator of interleukin-8 expression in hematopoietic cells. J Biol Chem. 2004;279:6395-400 pubmed
    ..MEF, but not the closely related ETS factors PEA3, ETS1, ETS2, ELF1, or PU.1, strongly activates the IL-8 promoter...
  2. Park S, Do H, Ha W, Han M, Park K, Song H, et al. Transcriptional activation of OCT4 by the ETS transcription factor PEA3 in NCCIT human embryonic carcinoma cells. FEBS Lett. 2014;588:3129-36 pubmed publisher
    We examined the molecular mechanism of OCT4 gene regulation by polyomavirus enhancer activator 3 (PEA3) in NCCIT cells. Endogenous PEA3 and OCT4 were significantly elevated in undifferentiated cells and reduced upon differentiation...
  3. Livet J, Sigrist M, Stroebel S, de Paola V, Price S, Henderson C, et al. ETS gene Pea3 controls the central position and terminal arborization of specific motor neuron pools. Neuron. 2002;35:877-92 pubmed
    ..of specific motor neuron pools is associated with the expression of ETS class transcription factors, notably PEA3 and ER81...
  4. Shou Z, Yamada K, Inazu T, Kawata H, Hirano S, Mizutani T, et al. Genomic structure and analysis of transcriptional regulation of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene. Gene. 2003;302:83-94 pubmed
    ..Electrophoretic mobility shift assays with specific competitors and antibodies show that PEA3 and Yin and Yang 1 (YY1) bind to Box A and Box B, respectively...
  5. Chotteau Lelievre A, Montesano R, Soriano J, Soulie P, Desbiens X, De Launoit Y. PEA3 transcription factors are expressed in tissues undergoing branching morphogenesis and promote formation of duct-like structures by mammary epithelial cells in vitro. Dev Biol. 2003;259:241-57 pubmed
    ..Erm, Er81 and Pea3 are three highly related transcription factors belonging to the Ets family, within which they form the PEA3 group...
  6. Kurpios N, MacNeil L, Shepherd T, Gludish D, Giacomelli A, Hassell J. The Pea3 Ets transcription factor regulates differentiation of multipotent progenitor cells during mammary gland development. Dev Biol. 2009;325:106-21 pubmed publisher
    The Pea3 Ets transcription factor is overexpressed in breast tumors suggesting that it plays a role in mammary oncogenesis. However, the normal biological function of Pea3 in the mammary gland is not known...
  7. Fontanet P, Irala D, Alsina F, Paratcha G, Ledda F. Pea3 transcription factor family members Etv4 and Etv5 mediate retrograde signaling and axonal growth of DRG sensory neurons in response to NGF. J Neurosci. 2013;33:15940-51 pubmed publisher
    ..Here, we show that the Pea3 transcription factor family members Etv4 and Etv5 are expressed by developing TrkA-positive dorsal root ganglion (DRG) neurons during the period of target ..
  8. Xu B, Washington A, Hinton B. PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility. Proc Natl Acad Sci U S A. 2014;111:18643-8 pubmed publisher
  9. Yang L, Fox S, Kirby J, Troan B, Hinton B. Putative regulation of expression of members of the Ets variant 4 transcription factor family and their downstream targets in the rat epididymis. Biol Reprod. 2006;74:714-20 pubmed
    ..Promoter analyses indicated that these genes contain several ETS DNA-binding sites. Members of the polyomavirus enhancer activator 3 (ETV4) family bind to ETS sites on the promoter of target genes to regulate transcription...

More Information

Publications14

  1. Lee Y, Fryer J, Kang H, Crespo Barreto J, Bowman A, Gao Y, et al. ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization. Dev Cell. 2011;21:746-57 pubmed publisher
    ..Consistent with this, Cic deficiency causes lung alveolarization defect. Loss of either ATXN1L or CIC derepresses Etv4, an activator for Mmp genes, thereby mediating MMP9 overexpression...
  2. Perez A, Barco R, Fernandez I, Price Schiavi S, Carraway K. PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells. J Biol Chem. 2003;278:36942-52 pubmed
    ..in the 13762 sublines of the rat mammary adenocarcinoma correlates with the overexpression of transcription factor PEA3 and the receptor tyrosine kinase ErbB2...
  3. Firlej V, Bocquet B, Desbiens X, De Launoit Y, Chotteau Lelievre A. Pea3 transcription factor cooperates with USF-1 in regulation of the murine bax transcription without binding to an Ets-binding site. J Biol Chem. 2005;280:887-98 pubmed
    The Pea3 transcription factor (which belongs to the PEA3 group) from the Ets family has been shown to be involved in mammary embryogenesis and oncogenesis. However, except for proteinases, only few of its target genes have been reported...
  4. Chen Q, Xu S, Huang S, Zhang A, Feng Q, Guo X, et al. Suppression subtractive hybridization analysis of gene expression during late kidney development identifies the developmentally regulated gene rPEA3. Nephron Exp Nephrol. 2009;111:e103-15 pubmed publisher
    ..Several differentially expressed genes were identified, including rPEA3, a member of the PEA3 subfamily of Ets domain transcription factors...
  5. Brent A, Tabin C. FGF acts directly on the somitic tendon progenitors through the Ets transcription factors Pea3 and Erm to regulate scleraxis expression. Development. 2004;131:3885-96 pubmed
    ..Of particular interest were the Ets transcription factors Pea3 and Erm, which function as transcriptional effectors of FGF signaling...