Gene Symbol: Ets2
Description: ETS proto-oncogene 2, transcription factor
Alias: protein C-ets-2, E26 avian leukemia oncogene 2, 3' domain, avian erythroblastosis virus E26 (v-ets) oncogene homolog 2, v-ets avian erythroblastosis virus E26 oncogene homolog 2
Species: rat
Products:     Ets2

Top Publications

  1. Kidder B, Palmer S. Examination of transcriptional networks reveals an important role for TCFAP2C, SMARCA4, and EOMES in trophoblast stem cell maintenance. Genome Res. 2010;20:458-72 pubmed publisher
    ..with DNA microarray hybridization (ChIP-chip) analysis to investigate targets of the TFs-TCFAP2C, EOMES, ETS2, and GATA3-and a chromatin remodeling factor, SMARCA4...
  2. Sheydina A, Volkova M, Jiang L, Juhasz O, Zhang J, Tae H, et al. Linkage of cardiac gene expression profiles and ETS2 with lifespan variability in rats. Aging Cell. 2012;11:350-9 pubmed publisher
    ..Specifically, four transcription factors (Max, Ets2, Erg, and Msx2) present in heart displayed longevity-dependent, strain-independent changes in abundance, but only ..
  3. Hagman J, Grosschedl R. An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene. Proc Natl Acad Sci U S A. 1992;89:8889-93 pubmed
    ..Together, these data suggest that one or more ETS family factors are involved in the regulation of mb-1 gene expression. ..
  4. Baker K, Wei G, Schaffner A, Ostrowski M. Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter. J Biol Chem. 2003;278:17876-84 pubmed
    ..These results support a role for ets-2 as a repressor and indicate that components of the mammalian SNF/SWI complex are required as co-repressors. ..
  5. Polychronopoulos S, Verykokakis M, Yazicioglu M, Sakarellos Daitsiotis M, Cobb M, Mavrothalassitis G. The transcriptional ETS2 repressor factor associates with active and inactive Erks through distinct FXF motifs. J Biol Chem. 2006;281:25601-11 pubmed
    The transcriptional ETS2 repressor factor (ERF) is phosphorylated by Erks both in vivo and in vitro. This phosphorylation determines the subcellular localization and biological function of ERF...
  6. Le Manac h Y, Pats B. [Preoperative disclosing of factor XI deficiency]. Ann Fr Anesth Reanim. 1992;11:725 pubmed
  7. Mullick J, Anandatheerthavarada H, Amuthan G, Bhagwat S, Biswas G, Camasamudram V, et al. Physical interaction and functional synergy between glucocorticoid receptor and Ets2 proteins for transcription activation of the rat cytochrome P-450c27 promoter. J Biol Chem. 2001;276:18007-17 pubmed
    ..P-450c27 promoter involves a physical interaction and functional synergy between glucocorticoid receptor (GR) and Ets2 factor...
  8. Lin C, Hare B, Wagner G, Harrison S, Maniatis T, Fraenkel E. A small domain of CBP/p300 binds diverse proteins: solution structure and functional studies. Mol Cell. 2001;8:581-90 pubmed
    ..We demonstrate the significance both in vitro and in vivo of interactions between IBiD and a number of diverse partners. Thus, IBiD is an important contributor to signal integration by CBP and p300. ..
  9. Wasylyk C, Schlumberger S, Criqui Filipe P, Wasylyk B. Sp100 interacts with ETS-1 and stimulates its transcriptional activity. Mol Cell Biol. 2002;22:2687-702 pubmed
    ..Sp100 acts as a novel coactivator that potentiates the activator function of ETS-1. Our results provide an important new connection between nuclear structures and an important regulator of gene expression. ..

More Information


  1. Yu J, Chen J, Lin C, Zhang G, Lam P, Wenger K, et al. Tensile strain-induced Ets-2 phosphorylation by CaMKII and the homeostasis of cranial sutures. Plast Reconstr Surg. 2009;123:83S-93S pubmed publisher
    ..Of note, Ets-2 is at the intersection of three key pathways important in craniosynostosis: fibroblast growth factor-2, transforming growth factor-beta, and mechanotransduction. ..
  2. Polydorou C, Georgiades P. Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation. Nat Commun. 2013;4:1658 pubmed publisher
    ..Here, using Ets2-/- mice, we show that trophoblast signalling is also required in vivo for primitive streak elongation, completion ..
  3. Donnison M, Broadhurst R, Pfeffer P. Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner. Dev Biol. 2015;397:77-88 pubmed publisher
    The ETS superfamily transcription factors Elf5 and Ets2 have both been implicated in the maintenance of the extraembryonic ectoderm (ExE) of the mouse embryo...