Esr2

Summary

Gene Symbol: Esr2
Description: estrogen receptor 2
Alias: ER-beta, ERbeta, Erb2, estrogen receptor beta, estrogen receptor 2 (ER beta), estrogen receptor 2 beta, nuclear receptor subfamily 3 group A member 2
Species: rat
Products:     Esr2

Top Publications

  1. Petersen D, Tkalcevic G, Koza Taylor P, Turi T, Brown T. Identification of estrogen receptor beta2, a functional variant of estrogen receptor beta expressed in normal rat tissues. Endocrinology. 1998;139:1082-92 pubmed
    The effects of estrogen and estrogen agonists can be mediated by estrogen receptor alpha (ER alpha) and estrogen receptor beta (ER beta)...
  2. Kuiper G, Carlsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, et al. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology. 1997;138:863-70 pubmed
    The rat estrogen receptor (ER) exists as two subtypes, ER alpha and ER beta, which differ in the C-terminal ligand binding domain and in the N-terminal transactivation domain...
  3. Lund T, Rovis T, Chung W, Handa R. Novel actions of estrogen receptor-beta on anxiety-related behaviors. Endocrinology. 2005;146:797-807 pubmed
    ..response to estrogens may be mediated by the existence of two distinct estrogen receptor (ER) systems, ERalpha and ERbeta. In brain, ERalpha plays a critical role in regulating reproductive neuroendocrine function, whereas ERbeta may be ..
  4. Zhu Y, Bian Z, Lu P, Karas R, Bao L, Cox D, et al. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science. 2002;295:505-8 pubmed
    ..We show that vascular smooth muscle cells and blood vessels from estrogen receptor beta (ERbeta)-deficient mice exhibit multiple functional abnormalities...
  5. Gold B, Kalush F, Bergeron J, Scott K, Mitra N, Wilson K, et al. Estrogen receptor genotypes and haplotypes associated with breast cancer risk. Cancer Res. 2004;64:8891-900 pubmed
    ..receptor gene (PGR), 17 SNPs in estrogen receptor 1 gene (ESR1), and 8 SNPs in the estrogen receptor 2 gene (ESR2)...
  6. Rissman E, Heck A, Leonard J, Shupnik M, Gustafsson J. Disruption of estrogen receptor beta gene impairs spatial learning in female mice. Proc Natl Acad Sci U S A. 2002;99:3996-4001 pubmed
    ..evidence, to our knowledge, that estradiol (E(2)) affects learning and memory via the newly discovered estrogen receptor beta (ERbeta)...
  7. Maruyama K, Endoh H, Sasaki Iwaoka H, Kanou H, Shimaya E, Hashimoto S, et al. A novel isoform of rat estrogen receptor beta with 18 amino acid insertion in the ligand binding domain as a putative dominant negative regular of estrogen action. Biochem Biophys Res Commun. 1998;246:142-7 pubmed
    A novel isoform of rat estrogen receptor (ER) beta, ER beta 2, which is a putative alternative splicing product of the reported ER beta (ER beta 1) has been identified...
  8. Imamov O, Yakimchuk K, Morani A, Schwend T, Wada Hiraike O, Razumov S, et al. Estrogen receptor beta-deficient female mice develop a bladder phenotype resembling human interstitial cystitis. Proc Natl Acad Sci U S A. 2007;104:9806-9 pubmed
    ..has been implicated in the etiology of this disease, but the role of the two estrogen receptors (ER), ERalpha and ERbeta, has not been investigated...
  9. Liu J, Hu P, Qi X, Meng F, Kalsbeek A, Zhou J. Acute restraint stress increases intrahypothalamic oestradiol concentrations in conjunction with increased hypothalamic oestrogen receptor ? and aromatase mRNA expression in female rats. J Neuroendocrinol. 2011;23:435-43 pubmed publisher
    ..The rising hypothalamic oestradiol concentration together with increased ER? gene expression indicates a positive feedback of hypothalamic oestradiol signalling during acute stress in rats. ..

More Information

Publications62

  1. Maguire P, Margolin S, Skoglund J, Sun X, Gustafsson J, Børresen Dale A, et al. Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer. Breast Cancer Res Treat. 2005;94:145-52 pubmed
    ..through binding to the estrogen receptors, estrogen receptor alpha (ESR1) and the more recently discovered estrogen receptor beta (ESR2)...
  2. Jankowski M, Rachelska G, Donghao W, McCann S, Gutkowska J. Estrogen receptors activate atrial natriuretic peptide in the rat heart. Proc Natl Acad Sci U S A. 2001;98:11765-70 pubmed
    ..study, semiquantitative reverse transcription-PCR analysis showed that estrogen receptor alpha (ERalpha) and beta (ERbeta) mRNAs are developmentally regulated in the rat heart...
  3. Kuiper G, Enmark E, Pelto Huikko M, Nilsson S, Gustafsson J. Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci U S A. 1996;93:5925-30 pubmed
    ..We conclude that clone 29 cDNA encodes a novel rat ER, which we suggest be named rat ERbeta to distinguish it from the previously cloned ER (ERalpha) from rat uterus.
  4. Lalmansingh A, Uht R. Estradiol regulates corticotropin-releasing hormone gene (crh) expression in a rapid and phasic manner that parallels estrogen receptor-alpha and -beta recruitment to a 3',5'-cyclic adenosine 5'-monophosphate regulatory region of the proximal crh pro. Endocrinology. 2008;149:346-57 pubmed
    ..b>ERbeta associated with CBP and increased acetylated histone 4...
  5. Yang S, Liu R, Perez E, Wen Y, Stevens S, Valencia T, et al. Mitochondrial localization of estrogen receptor beta. Proc Natl Acad Sci U S A. 2004;101:4130-5 pubmed
    ..To date, two ERs have been identified: ERalpha and ERbeta. ERalpha plays major role in the estrogen-mediated genomic actions in both reproductive and nonreproductive tissue,..
  6. Patisaul H, Bateman H. Neonatal exposure to endocrine active compounds or an ERbeta agonist increases adult anxiety and aggression in gonadally intact male rats. Horm Behav. 2008;53:580-8 pubmed publisher
    ..Recent evidence suggests that these effects may be mediated through the beta form of the estrogen receptor (ERbeta)...
  7. Saijo K, Collier J, Li A, Katzenellenbogen J, Glass C. An ADIOL-ER?-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Cell. 2011;145:584-95 pubmed publisher
    ..These findings provide evidence for an ADIOL/ER?/CtBP-transrepression pathway that regulates inflammatory responses in microglia and can be targeted by selective ER? modulators. ..
  8. Waters E, Yildirim M, Janssen W, Lou W, McEwen B, Morrison J, et al. Estrogen and aging affect the synaptic distribution of estrogen receptor ?-immunoreactivity in the CA1 region of female rat hippocampus. Brain Res. 2011;1379:86-97 pubmed publisher
    ..This suggests that synaptic ER? may be a more responsive target to E, particularly in aged females. ..
  9. Treeck O, Elemenler E, Kriener C, Horn F, Springwald A, Hartmann A, et al. Polymorphisms in the promoter region of ESR2 gene and breast cancer susceptibility. J Steroid Biochem Mol Biol. 2009;114:207-11 pubmed publisher
    ..Our data suggest that a SNP in the promoter region of ESR2 gene might be able to affect breast cancer risk. These results further support the emerging hypothesis that ERbeta is an important factor in breast cancer development.
  10. Powell E, Xu W. Intermolecular interactions identify ligand-selective activity of estrogen receptor alpha/beta dimers. Proc Natl Acad Sci U S A. 2008;105:19012-7 pubmed publisher
    ..Because the two forms of ER, ERalpha and ERbeta, exhibit opposing functions in cell proliferation, the ability of ligands to induce ERalpha/beta heterodimers vs...
  11. Miller W, Suzuki S, Miller L, Handa R, Uht R. Estrogen receptor (ER)beta isoforms rather than ERalpha regulate corticotropin-releasing hormone promoter activity through an alternate pathway. J Neurosci. 2004;24:10628-35 pubmed
    ..of the corticotropin-releasing hormone (CRH) promoter via either of its receptors: estrogen receptor (ER)alpha or ERbeta. Immunocytochemistry revealed that a subset (12%) of medial parvocellular CRH neurons in the rat hypothalamus ..
  12. Liu F, Day M, Muniz L, Bitran D, Arias R, Revilla Sanchez R, et al. Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. Nat Neurosci. 2008;11:334-43 pubmed publisher
    ..molecular mechanisms underlying these effects and the roles of the estrogen receptors alpha (ERalpha) and beta (ERbeta) remain unclear...
  13. Tena Sempere M, Navarro V, Mayen A, Bellido C, Sanchez Criado J. Regulation of estrogen receptor (ER) isoform messenger RNA expression by different ER ligands in female rat pituitary. Biol Reprod. 2004;70:671-8 pubmed
    ..agonistic or antagonistic properties at the ER, to modulate the expression of the transcripts encoding ERalpha and ERbeta isoforms, as well as those for the truncated ERalpha product (TERP), and the variant ERbeta2, in pituitaries from ..
  14. Ogawa S, Inoue S, Watanabe T, Orimo A, Hosoi T, Ouchi Y, et al. Molecular cloning and characterization of human estrogen receptor betacx: a potential inhibitor ofestrogen action in human. Nucleic Acids Res. 1998;26:3505-12 pubmed
    ..Biochemical analysis reveals that the average dissociation constants ( K d) of ERalpha and ERbeta for 17beta-estradiol (E2) are 0.2 and 0.6 nM respectively, but ERbetacx has no ligand binding ability...
  15. Fytili P, Giannatou E, Papanikolaou V, Stripeli F, Karachalios T, Malizos K, et al. Association of repeat polymorphisms in the estrogen receptors alpha, beta, and androgen receptor genes with knee osteoarthritis. Clin Genet. 2005;68:268-77 pubmed
    ..002 and 0.001). An association between c.1092+3607(CA)(13-27) and c.172(CAG)(8-34) repeat polymorphisms of the ER-beta and AR genes and knee OA was found in individuals of Greek descent. ..
  16. Selva D, Tirado O, Toran N, Suárez Quian C, Reventos J, Munell F. Estrogen receptor beta expression and apoptosis of spermatocytes of mice overexpressing a rat androgen-binding protein transgene. Biol Reprod. 2004;71:1461-8 pubmed
    ..In view of the recent localization of estrogen receptor beta (ERbeta) in primary spermatocytes and data suggesting the ability of ERbeta to repress cellular ..
  17. Zheng S, Zheng W, Chang B, Shu X, Cai Q, Yu H, et al. Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women. Cancer Res. 2003;63:7624-9 pubmed
    ..DNA samples from the Shanghai Breast Cancer Study, we tested the hypothesis that sequence variants of the estrogen receptor beta gene (ESR2) may be associated with increased risk for breast cancer, particularly among women who have a ..
  18. Edinger K, Frye C. Androgens' effects to enhance learning may be mediated in part through actions at estrogen receptor-beta in the hippocampus. Neurobiol Learn Mem. 2007;87:78-85 pubmed
    ..We found that intrahippocampal administration of AS-ODNs for ERbeta, but not ERalpha, significantly decreased learning and memory of 3alpha-diol replaced rats...
  19. Tsezou A, Tzetis M, Gennatas C, Giannatou E, Pampanos A, Malamis G, et al. Association of repeat polymorphisms in the estrogen receptors alpha, beta (ESR1, ESR2) and androgen receptor (AR) genes with the occurrence of breast cancer. Breast. 2008;17:159-66 pubmed
    ..To determine the possible contribution of genetic variation in the ESR1 (ER-alpha), ESR2 (ER-beta) and AR genes in breast cancer risk the -1174(TA)(7-27), c. 1092+3607(CA)(10-26) and c...
  20. Chen Y, Kraft P, Bretsky P, Ketkar S, Hunter D, Albanes D, et al. Sequence variants of estrogen receptor beta and risk of prostate cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. Cancer Epidemiol Biomarkers Prev. 2007;16:1973-81 pubmed
    b>Estrogen receptor beta (ESR2) may play a role in modulating prostate carcinogenesis through the regulation of genes related to cell proliferation and apoptosis...
  21. Weihua Z, Lathe R, Warner M, Gustafsson J. An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc Natl Acad Sci U S A. 2002;99:13589-94 pubmed
    ..We have used ERbeta(-/-) and CYP7B1(-/-) mice to investigate the role of ERbeta and one of its ligands, 5alpha-androstane-3beta,17beta-..
  22. Sárvári M, Hrabovszky E, Kallo I, Galamb O, Solymosi N, Liko I, et al. Gene expression profiling identifies key estradiol targets in the frontal cortex of the rat. Endocrinology. 2010;151:1161-76 pubmed publisher
    ..Identification of estradiol-regulated genes in the frontal cortex helps to understand the pathomechanism of neurological and psychiatric disorders associated with altered levels of estrogens. ..
  23. Jazbutyte V, Arias Loza P, Hu K, Widder J, Govindaraj V, von Poser Klein C, et al. Ligand-dependent activation of ER{beta} lowers blood pressure and attenuates cardiac hypertrophy in ovariectomized spontaneously hypertensive rats. Cardiovasc Res. 2008;77:774-81 pubmed
    The biological effects of oestrogens are mediated by two different oestrogen receptor (ER) subtypes, ERalpha and ERbeta, which might play different, redundant, or opposing roles in cardiovascular disease...
  24. Sonestedt E, Ivarsson M, Harlid S, Ericson U, Gullberg B, Carlson J, et al. The protective association of high plasma enterolactone with breast cancer is reasonably robust in women with polymorphisms in the estrogen receptor alpha and beta genes. J Nutr. 2009;139:993-1001 pubmed publisher
    It is plausible that polymorphisms in the estrogen receptor alpha and beta genes (ESR1 and ESR2) may modulate the association between enterolactone and breast cancer...
  25. Zuloaga D, Yahn S, Pang Y, Quihuis A, Oyola M, Reyna A, et al. Distribution and estrogen regulation of membrane progesterone receptor-? in the female rat brain. Endocrinology. 2012;153:4432-43 pubmed publisher
    ..Furthermore, E(2) regulation of mPR? indicates a mechanism through which estrogens can regulate P(4) function within discrete brain regions to potentially impact behavior. ..
  26. Orikasa C, Sakuma Y. Sex and region-specific regulation of oestrogen receptor beta in the rat hypothalamus. J Neuroendocrinol. 2004;16:964-9 pubmed
    ..in gonadectomized adult rats, that the amount of oestrogen caused a significant reduction in the number of ERbeta messages and protein in the ventromedial nucleus in both sexes, but no such effects were detected in the preoptic ..
  27. Jakimiuk A, Bogusiewicz M, Tarkowski R, Dziduch P, Adamiak A, Wrobel A, et al. Estrogen receptor alpha and beta expression in uterine leiomyomas from premenopausal women. Fertil Steril. 2004;82 Suppl 3:1244-9 pubmed
    ..None. Quantitative RT-PCR was used for evaluation of ERalpha and ERbeta expression. Results were normalized to total cellular DNA...
  28. Taylor A, Guzail M, Al Azzawi F. Differential expression of oestrogen receptor isoforms and androgen receptor in the normal vulva and vagina compared with vulval lichen sclerosus and chronic vaginitis. Br J Dermatol. 2008;158:319-28 pubmed
    ..androgen receptor (AR) has been examined in vulval lichen sclerosus (VLS), the distribution pattern of ERalpha, ERbeta and AR has not been described in chronic atrophic vaginitis nor correlated with markers of proliferation (Ki-67) ..
  29. Pérez P, Petiti J, Picech F, Guido C, dV Sosa L, Grondona E, et al. Estrogen receptor ? regulates the tumoral suppressor PTEN to modulate pituitary cell growth. J Cell Physiol. 2018;233:1402-1413 pubmed publisher
  30. Sá S, Fonseca B, Teixeira N, Madeira M. Estrogen receptors α and β have different roles in the induction and trafficking of progesterone receptors in hypothalamic ventromedial neurons. FEBS J. 2015;282:1126-36 pubmed publisher
    ..Our findings reveal that individual and simultaneous activation of ERα and ERβ have different effects on the levels and subcellular location of PRs in VMNvl neurons. ..
  31. Koyama S, Wada Hiraike O, Nakagawa S, Tanikawa M, Hiraike H, Miyamoto Y, et al. Repression of estrogen receptor beta function by putative tumor suppressor DBC1. Biochem Biophys Res Commun. 2010;392:357-62 pubmed publisher
    ..Estrogen receptor (ER) alpha appears to promote the proliferation of cancer tissues, while ERbeta can protect against the mitogenic effect of estrogen in breast tissue...
  32. Dumasia K, Kumar A, Kadam L, Balasinor N. Effect of estrogen receptor-subtype-specific ligands on fertility in adult male rats. J Endocrinol. 2015;225:169-80 pubmed publisher
  33. Kudwa A, McGivern R, Handa R. Estrogen receptor β and oxytocin interact to modulate anxiety-like behavior and neuroendocrine stress reactivity in adult male and female rats. Physiol Behav. 2014;129:287-96 pubmed publisher
    ..These data indicate that ERβ and OT interact to modulate the HPA reactivity and the display of anxiety-like behaviors. ..
  34. Grassi S, Scarduzio M, Panichi R, Dall Aglio C, Boiti C, Pettorossi V. Opposite long-term synaptic effects of 17?-estradiol and 5?-dihydrotestosterone and localization of their receptors in the medial vestibular nucleus of rats. Brain Res Bull. 2013;97:1-7 pubmed publisher
  35. Gonzalez M, Reyes R, Damas C, Alonso R, Bello A. Oestrogen receptor alpha and beta in female rat pituitary cells: an immunochemical study. Gen Comp Endocrinol. 2008;155:857-68 pubmed
    ..Previous reports have demonstrated the presence of oestrogen receptor alpha (ERalpha) and beta (ERbeta) in specific anterior pituitary cells from ovariectomized rats, as well as in the whole anterior pituitary at ..
  36. Bois C, Delalande C, Nurmio M, Parvinen M, Zanatta L, Toppari J, et al. Age- and cell-related gene expression of aromatase and estrogen receptors in the rat testis. J Mol Endocrinol. 2010;45:147-59 pubmed publisher
    ..seems to also be controlled by estrogens which exert their effects via nuclear estrogen receptors (ESRs) ESR1 and ESR2. Estrogens are synthesized by aromatase which is biologically expressed in the rat testis...
  37. Mitrovic N, Zaric M, Drakulic D, Martinovic J, Stanojlovic M, Sevigny J, et al. 17?-Estradiol upregulates ecto-5'-nucleotidase (CD73) in hippocampal synaptosomes of female rats through action mediated by estrogen receptor-? and -?. Neuroscience. 2016;324:286-96 pubmed publisher
    ..Together these results imply that E2-induced effects on connectivity and functional properties of the hippocampal synapses may be in part mediated through observed effect on eN. ..
  38. Zhai G, Grubbs C, Stockard C, Umphrey H, Beasley T, Kim H. Diffusion weighted imaging evaluated the early therapy effect of tamoxifen in an MNU-induced mammary cancer rat model. PLoS ONE. 2013;8:e64445 pubmed publisher
    ..The significant correlation between ADC7D and ER?-positive cell density suggests that ER? may play an important role as a therapeutic indicator of tamoxifen. ..
  39. Cao J, Patisaul H. Sexually dimorphic expression of hypothalamic estrogen receptors ? and ? and Kiss1 in neonatal male and female rats. J Comp Neurol. 2011;519:2954-77 pubmed publisher
    ..These detailed profiles of neonatal Kiss1 and ERs mRNA levels will help elucidate the relative roles each plays in the sex-specific, estrogen-dependent organization of gonadotropin signaling pathways. ..
  40. Stamatakis A, Kalpachidou T, Raftogianni A, Zografou E, Tzanou A, Pondiki S, et al. Rat dams exposed repeatedly to a daily brief separation from the pups exhibit increased maternal behavior, decreased anxiety and altered levels of receptors for estrogens (ERα, ERβ), oxytocin and serotonin (5-HT1A) in their brain. Psychoneuroendocrinology. 2015;52:212-28 pubmed publisher
  41. Marzioni M, Torrice A, Saccomanno S, Rychlicki C, Agostinelli L, Pierantonelli I, et al. An oestrogen receptor ?-selective agonist exerts anti-neoplastic effects in experimental intrahepatic cholangiocarcinoma. Dig Liver Dis. 2012;44:134-42 pubmed publisher
    ..Cholangiocarcinoma cells over-express oestrogen receptor-?, which displays anti-proliferative and pro-apoptotic effects...
  42. Westberry J, Trout A, Wilson M. Epigenetic regulation of estrogen receptor beta expression in the rat cortex during aging. Neuroreport. 2011;22:428-32 pubmed publisher
    ..One mechanism by which ER? mRNA could be regulated is by epigenetic modification of ER? promoter. Here, we show an increase in methylation of ER? promoter corresponding to decrease in ER? mRNA in the cortex of an aging female. ..
  43. Qi C, Chang J, Zhu Y, Yeldandi A, Rao S, Zhu Y. Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. J Biol Chem. 2002;277:28624-30 pubmed
    ..PRMT2 also binds to ERbeta, PR, TRbeta, RARalpha, PPARgamma, and RXRalpha in a ligand-independent manner...
  44. Hong Goka B, Chang F. Estrogen receptors alpha and beta in choroid plexus epithelial cells in Alzheimer's disease. Neurosci Lett. 2004;360:113-6 pubmed
    ..ER alpha and ER beta were present in CP epithelial cells in both cytosolic and nuclear compartments...
  45. Alvarez Delgado C, Mendoza Rodriguez C, Picazo O, Cerbón M. Different expression of alpha and beta mitochondrial estrogen receptors in the aging rat brain: interaction with respiratory complex V. Exp Gerontol. 2010;45:580-5 pubmed publisher
    ..The overall results demonstrate that there is a differential expression of mtERalpha and mtERbeta variants in different brain areas, indicating that they may participate in different functions in the brain during aging. ..
  46. Maharjan S, Serova L, Sabban E. Transcriptional regulation of tyrosine hydroxylase by estrogen: opposite effects with estrogen receptors alpha and beta and interactions with cyclic AMP. J Neurochem. 2005;93:1502-14 pubmed
    ..PC12 cells, transiently co-transfected with expression vector for ERalpha or ERbeta, and luciferase gene under control of the TH promoter, were treated with 17 beta-estradiol (E2)...
  47. Follettie M, Pinard M, Keith J, Wang L, Chelsky D, Hayward C, et al. Organ messenger ribonucleic acid and plasma proteome changes in the adjuvant-induced arthritis model: responses to disease induction and therapy with the estrogen receptor-beta selective agonist ERB-041. Endocrinology. 2006;147:714-23 pubmed
    Two receptors [estrogen receptor (ER)alpha and ERbeta] mediate the manifold effects of estrogens throughout the body...
  48. Guo C, Savage L, Sarge K, Park Sarge O. Gonadotropins decrease estrogen receptor-beta messenger ribonucleic acid stability in rat granulosa cells. Endocrinology. 2001;142:2230-7 pubmed
    We have previously shown that the preovulatory LH surge down-regulates estrogen receptor-beta (ERbeta) messenger RNA (mRNA) levels selectively in the granulosa cells of preovulatory follicles...
  49. Atawia R, Tadros M, Khalifa A, Mosli H, Abdel Naim A. Role of the phytoestrogenic, pro-apoptotic and anti-oxidative properties of silymarin in inhibiting experimental benign prostatic hyperplasia in rats. Toxicol Lett. 2013;219:160-9 pubmed publisher
    ..Collectively these findings elucidate the effectiveness of SIL in preventing testosterone-induced BPH in rats. This could be attributed, at least partly, to its phytoestrogenic, pro-apoptotic and anti-oxidative properties. ..
  50. Donner N, Handa R. Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat dorsal raphe nuclei. Neuroscience. 2009;163:705-18 pubmed publisher
    ..Therefore, we tested the hypothesis that ER beta may contribute to the regulation of gene expression in 5-HT neurons of the dorsal raphe nuclei (DRN) by examining ..
  51. Yaffe K, Lindquist K, Sen S, Cauley J, Ferrell R, Penninx B, et al. Estrogen receptor genotype and risk of cognitive impairment in elders: findings from the Health ABC study. Neurobiol Aging. 2009;30:607-14 pubmed
    To determine whether variants in the estrogen receptors 1 (alpha) and 2 (beta) (ESR1 and ESR2) genes are associated with cognitive impairment in non-demented elderly men and women...
  52. Cho J, Allanson M, Domanski D, Arun S, Reeve V. Estrogen receptor-beta signaling protects epidermal cytokine expression and immune function from UVB-induced impairment in mice. Photochem Photobiol Sci. 2008;7:120-5 pubmed publisher
  53. Ashworth J, Smyth J, Pendleton N, Horan M, Payton A, Worthington J, et al. Polymorphisms spanning the 0N exon and promoter of the estrogen receptor-beta (ERbeta) gene ESR2 are associated with venous ulceration. Clin Genet. 2008;73:55-61 pubmed
    ..The estrogen receptor (ER) proteins, ER-alpha (ERalpha) and ER-beta (ERbeta) mediate the actions of estrogen during wound repair through the activation or repression of target gene ..