espin

Summary

Gene Symbol: espin
Description: espin
Alias: espin, Jerker, deafness locus, actin cytoskeletal regulatory protein, ectoplasmic specialization protein
Species: rat
Products:     espin

Top Publications

  1. Salles F, Merritt R, Manor U, Dougherty G, Sousa A, Moore J, et al. Myosin IIIa boosts elongation of stereocilia by transporting espin 1 to the plus ends of actin filaments. Nat Cell Biol. 2009;11:443-50 pubmed publisher
    Two proteins implicated in inherited deafness, myosin IIIa, a plus-end-directed motor, and espin, an actin-bundling protein containing the actin-monomer-binding motif WH2, have been shown to influence the length of mechanosensory ..
  2. Chen B, Li A, Wang D, Wang M, Zheng L, Bartles J. Espin contains an additional actin-binding site in its N terminus and is a major actin-bundling protein of the Sertoli cell-spermatid ectoplasmic specialization junctional plaque. Mol Biol Cell. 1999;10:4327-39 pubmed
    The espins are actin-binding and -bundling proteins localized to parallel actin bundles. The 837-amino-acid "espin" of Sertoli cell-spermatid junctions (ectoplasmic specializations) and the 253-amino-acid "small espin"..
  3. Zheng L, Sekerkova G, Vranich K, Tilney L, Mugnaini E, Bartles J. The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins. Cell. 2000;102:377-85 pubmed
    ..have determined that espins are also present in hair cell stereocilia and have uncovered a connection between the espin gene and jerker, a recessive mutation that causes hair cell degeneration, deafness, and vestibular dysfunction...
  4. Bartles J, Zheng L, Li A, Wierda A, Chen B. Small espin: a third actin-bundling protein and potential forked protein ortholog in brush border microvilli. J Cell Biol. 1998;143:107-19 pubmed
    An approximately 30-kD isoform of the actin-binding/ bundling protein espin has been discovered in the brush borders of absorptive epithelial cells in rat intestine and kidney...
  5. Bartles J, Wierda A, Zheng L. Identification and characterization of espin, an actin-binding protein localized to the F-actin-rich junctional plaques of Sertoli cell ectoplasmic specializations. J Cell Sci. 1996;109 ( Pt 6):1229-39 pubmed
    ..Using a monoclonal antibody, we have identified 'espin,' a novel actin-binding protein localized to ectoplasmic specializations...
  6. Sekerkova G, Zheng L, Loomis P, Changyaleket B, Whitlon D, Mugnaini E, et al. Espins are multifunctional actin cytoskeletal regulatory proteins in the microvilli of chemosensory and mechanosensory cells. J Neurosci. 2004;24:5445-56 pubmed
    ..Moreover, we show that hair cells and these other sensory cells contain novel espin isoforms that arise from a different transcriptional start site and differ significantly from other espin isoforms ..
  7. Gillespie P, Muller U. Mechanotransduction by hair cells: models, molecules, and mechanisms. Cell. 2009;139:33-44 pubmed publisher
  8. Lelli A, Michel V, Boutet de Monvel J, Cortese M, Bosch Grau M, Aghaie A, et al. Class III myosins shape the auditory hair bundles by limiting microvilli and stereocilia growth. J Cell Biol. 2016;212:231-44 pubmed publisher
    ..Myosin IIIa, defective in the late-onset deafness form DFNB30, has been proposed to transport espin-1 to the tips of stereocilia, thereby promoting their elongation...
  9. Merritt R, Manor U, Salles F, Grati M, Dose A, Unrath W, et al. Myosin IIIB uses an actin-binding motif in its espin-1 cargo to reach the tips of actin protrusions. Curr Biol. 2012;22:320-5 pubmed publisher
    ..Strikingly, when MYO3B is coexpressed with espin-1 (ESPN1), a MYO3A cargo protein endogenously expressed in stereocilia [2], MYO3B targets and carries ESPN1 to ..

More Information

Publications17

  1. Sekerkova G, Zheng L, Mugnaini E, Bartles J. Espin actin-cytoskeletal proteins are in rat type I spiral ganglion neurons and include splice-isoforms with a functional nuclear localization signal. J Comp Neurol. 2008;509:661-76 pubmed publisher
    ..b>Espin antibody labeled approximately 83% of type I SGNs, and the labeling intensity increased dramatically during early ..
  2. Primiani N, Gregory M, Dufresne J, Smith C, Liu Y, Bartles J, et al. Microvillar size and espin expression in principal cells of the adult rat epididymis are regulated by androgens. J Androl. 2007;28:659-69 pubmed
    ..The objectives of this study were to assess the regulation of espin in epididymal principal cells both in vitro and in vivo...
  3. Calderon A, Derr A, Stagner B, Johnson K, Martin G, Noben Trauth K. Cochlear developmental defect and background-dependent hearing thresholds in the Jackson circler (jc) mutant mouse. Hear Res. 2006;221:44-58 pubmed
    ..Genome-wide linkage scans of backcross, intercross, and congenic progeny revealed a complex pattern of genetic and stochastic effects. ..
  4. Kitajiri S, Sakamoto T, Belyantseva I, Goodyear R, Stepanyan R, Fujiwara I, et al. Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Cell. 2010;141:786-98 pubmed publisher
    ..organizes actin filaments into uniquely dense bundles reminiscent of rootlets but distinct from bundles formed by espin, an actin crosslinker in stereocilia...
  5. Show M, Anway M, Zirkin B. An ex vivo analysis of Sertoli cell actin dynamics following gonadotropic hormone withdrawal. J Androl. 2004;25:1013-21 pubmed
    ..Cofilin and profilin I gene expression was unaffected by hypophysectomy, whereas the expression of profilin II and espin both decreased significantly (47% and 42%, respectively)...
  6. Sekerkova G, Zheng L, Mugnaini E, Bartles J. Differential expression of espin isoforms during epithelial morphogenesis, stereociliogenesis and postnatal maturation in the developing inner ear. Dev Biol. 2006;291:83-95 pubmed
    ..Here, we demonstrate that the different espin isoforms are expressed in complex spatiotemporal patterns during inner ear development...
  7. Schwander M, Kachar B, Muller U. Review series: The cell biology of hearing. J Cell Biol. 2010;190:9-20 pubmed publisher
    ..The study of genes that are linked to deafness has provided insights into the cell biological mechanisms that control hair cell development and their function as mechanosensors. ..
  8. Sekerkova G, Loomis P, Changyaleket B, Zheng L, Eytan R, Chen B, et al. Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53. J Neurosci. 2003;23:1310-9 pubmed
    ..These proteins are novel isoforms of the actin-bundling protein espin that arise through the use of a unique site for transcriptional initiation and differential splicing...