Gene Symbol: Eri1
Description: exoribonuclease 1
Alias: RGD1308378, Thex1, 3'-5' exoribonuclease 1, 3 ' exoribonuclease, 3' exoribonuclease, histone mRNA 3'-exonuclease 1, three prime histone mRNA exonuclease 1
Species: rat
Products:     Eri1

Top Publications

  1. Ansel K, Pastor W, Rath N, Lapan A, Glasmacher E, Wolf C, et al. Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing. Nat Struct Mol Biol. 2008;15:523-30 pubmed publisher
    b>Eri1 is a 3'-to-5' exoribonuclease conserved from fission yeast to humans. Here we show that Eri1 associates with ribosomes and ribosomal RNA (rRNA). Ribosomes from Eri1-deficient mice contain 5...
  2. Yang X, Purdy M, Marzluff W, Dominski Z. Characterization of 3'hExo, a 3' exonuclease specifically interacting with the 3' end of histone mRNA. J Biol Chem. 2006;281:30447-54 pubmed
    ..3'hExo removes 3' overhangs of small interfering RNAs, whereas the double-stranded region is resistant to the enzymatic activity. ..
  3. Dominski Z, Yang X, Kaygun H, Dadlez M, Marzluff W. A 3' exonuclease that specifically interacts with the 3' end of histone mRNA. Mol Cell. 2003;12:295-305 pubmed
    ..These features make 3'hExo a primary candidate for the exonuclease that initiates rapid decay of histone mRNA upon completion and/or inhibition of DNA replication. ..
  4. Yang X, Torres M, Marzluff W, Dominski Z. Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA. Mol Cell Biol. 2009;29:4045-56 pubmed publisher
    ..These proteins likely rigidify the substrate and function as the molecular ruler in determining the site of cleavage. ..
  5. Henras A, Plisson Chastang C, O Donohue M, Chakraborty A, Gleizes P. An overview of pre-ribosomal RNA processing in eukaryotes. Wiley Interdiscip Rev RNA. 2015;6:225-42 pubmed publisher
    ..A consensus scheme of pre-ribosomal RNA maturation is emerging from studies in various kinds of eukaryotic organisms. However, major differences between mammalian and yeast pre-ribosomal RNA processing have recently come to light. ..