Ercc1

Summary

Gene Symbol: Ercc1
Description: ERCC excision repair 1, endonuclease non-catalytic subunit
Alias: DNA excision repair protein ERCC-1, excision repair cross-complementation group 1, excision repair cross-complementing 1, excision repair cross-complementing rodent repair deficiency, complementation group 1
Species: rat
Products:     Ercc1

Top Publications

  1. Prasher J, Lalai A, Heijmans Antonissen C, Ploemacher R, Hoeijmakers J, Touw I, et al. Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice. EMBO J. 2005;24:861-71 pubmed
    The ERCC1-XPF heterodimer is a structure-specific endonuclease involved in both nucleotide excision repair and interstrand crosslink repair...
  2. Viguier J, Boige V, Miquel C, Pocard M, Giraudeau B, Sabourin J, et al. ERCC1 codon 118 polymorphism is a predictive factor for the tumor response to oxaliplatin/5-fluorouracil combination chemotherapy in patients with advanced colorectal cancer. Clin Cancer Res. 2005;11:6212-7 pubmed
    ..excision repair enzyme, excision repair cross-complementing rodent repair deficiency, complementation group 1 (ERCC1), had an effect on the tumor response in patients treated with standard chemotherapy regimens for a metastatic ..
  3. McWhir J, Selfridge J, Harrison D, Squires S, Melton D. Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning. Nat Genet. 1993;5:217-24 pubmed
    ..Elevated p53 levels were detected in liver, brain and kidney, supporting the hypothesised role for p53 as a monitor of DNA damage. ..
  4. Olaussen K, Dunant A, Fouret P, Brambilla E, Andre F, Haddad V, et al. DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N Engl J Med. 2006;355:983-91 pubmed
    ..immunohistochemical analysis to determine the expression of the excision repair cross-complementation group 1 (ERCC1) protein in operative specimens of non-small-cell lung cancer...
  5. Tsodikov O, Enzlin J, SCHARER O, Ellenberger T. Crystal structure and DNA binding functions of ERCC1, a subunit of the DNA structure-specific endonuclease XPF-ERCC1. Proc Natl Acad Sci U S A. 2005;102:11236-41 pubmed
    Human XPF-ERCC1 is a DNA endonuclease that incises a damaged DNA strand on the 5' side of a lesion during nucleotide excision repair and has additional role(s) in homologous recombination and DNA interstrand crosslink repair...
  6. Weeda G, Donker I, de Wit J, Morreau H, Janssens R, Vissers C, et al. Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence. Curr Biol. 1997;7:427-39 pubmed
    The structure-specific ERCC1/XPF endonuclease complex that contains the ERCC1 and XPF subunits is implicated in the repair of two distinct types of lesions in DNA: nucleotide excision repair (NER) for ultraviolet-induced lesions and ..
  7. Zhu X, Niedernhofer L, Kuster B, Mann M, Hoeijmakers J, de Lange T. ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol Cell. 2003;12:1489-98 pubmed
    ..Here we report that ERCC1/XPF-deficient cells retained the telomeric overhang after TRF2 inhibition, identifying this nucleotide excision ..
  8. Hsia K, Millar M, King S, Selfridge J, Redhead N, Melton D, et al. DNA repair gene Ercc1 is essential for normal spermatogenesis and oogenesis and for functional integrity of germ cell DNA in the mouse. Development. 2003;130:369-78 pubmed
    b>Ercc1 is essential for nucleotide excision repair (NER) but, unlike other NER proteins, Ercc1 and Xpf are also involved in recombination repair pathways...
  9. Khrunin A, Moisseev A, Gorbunova V, Limborska S. Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients. Pharmacogenomics J. 2010;10:54-61 pubmed publisher
    ..A higher risk of nephrotoxicity was noted for patients with the heterozygous ERCC1 19007 T/C and 8092 C/A genotypes. No correlations were found between genotypes and complete tumor responses.

More Information

Publications79

  1. Niedernhofer L, Garinis G, Raams A, Lalai A, Robinson A, Appeldoorn E, et al. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature. 2006;444:1038-43 pubmed
    XPF-ERCC1 endonuclease is required for repair of helix-distorting DNA lesions and cytotoxic DNA interstrand crosslinks. Mild mutations in XPF cause the cancer-prone syndrome xeroderma pigmentosum...
  2. Niedernhofer L, Odijk H, Budzowska M, van Drunen E, Maas A, Theil A, et al. The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Mol Cell Biol. 2004;24:5776-87 pubmed
    ..The mechanism of ICL repair in mammalian cells is poorly understood. However, genetic data implicate the Ercc1-Xpf endonuclease and proteins required for homologous recombination-mediated double-strand break (DSB) repair...
  3. Niedernhofer L, Essers J, Weeda G, Beverloo B, de Wit J, Muijtjens M, et al. The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells. EMBO J. 2001;20:6540-9 pubmed
    The Ercc1-Xpf heterodimer, a highly conserved structure-specific endonuclease, functions in multiple DNA repair pathways that are pivotal for maintaining genome stability, including nucleotide excision repair, interstrand crosslink ..
  4. Ji G, Gu A, Xia Y, Lu C, Liang J, Wang S, et al. ERCC1 and ERCC2 polymorphisms and risk of idiopathic azoospermia in a Chinese population. Reprod Biomed Online. 2008;17:36-41 pubmed
    The ERCC1 (excision repair cross complementation group 1) and ERCC2 (excision repair cross complementation group 2) genes are important in repairing DNA damage and genomic instability in germ cells, and are essential for normal ..
  5. Wu Y, Zacal N, Rainbow A, Zhu X. XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening. DNA Repair (Amst). 2007;6:157-66 pubmed
    ..TRF2 is found to be associated with XPF-ERCC1, a structure-specific endonuclease involved in nucleotide excision repair, crosslink repair and DNA recombination...
  6. Deenen M, Meulendijks D, Boot H, Legdeur M, Beijnen J, Schellens J, et al. Phase 1a/1b and pharmacogenetic study of docetaxel, oxaliplatin and capecitabine in patients with advanced cancer of the stomach or the gastroesophageal junction. Cancer Chemother Pharmacol. 2015;76:1285-95 pubmed publisher
    ..5 months (95 % CI 5.4-7.6) and 11.0 months (95 % CI 7.9-14.1), respectively. The polymorphisms ERCC1 354C>T, TYMS 1053C>T and rs2612091 in ENOSF1 were associated with severe toxicity; ERCC1 354C>T and ERCC2 ..
  7. van Duin M, van Den Tol J, Warmerdam P, Odijk H, Meijer D, Westerveld A, et al. Evolution and mutagenesis of the mammalian excision repair gene ERCC-1. Nucleic Acids Res. 1988;16:5305-22 pubmed
    ..Since the ERCC-1 promoter is devoid of all classical promoter elements this region may be responsible for the low constitutive level of expression in all mouse tissues and stages of embryogenesis examined. ..
  8. Vo N, Seo H, Robinson A, Sowa G, Bentley D, Taylor L, et al. Accelerated aging of intervertebral discs in a mouse model of progeria. J Orthop Res. 2010;28:1600-7 pubmed publisher
    ..of disc aging in a murine model of a human progeroid syndrome caused by deficiency of the DNA repair endonuclease, ERCC1-XPF (Ercc1(-/?) mice)...
  9. Kracmarova A, Cermak J, Brdicka R, Bruchova H. High expression of ERCC1, FLT1, NME4 and PCNA associated with poor prognosis and advanced stages in myelodysplastic syndrome. Leuk Lymphoma. 2008;49:1297-305 pubmed publisher
    ..Data analysis identified differently expressed genes in MDS and the cluster of four genes (ERCC1, FLT1, NME4 and PCNA) whose expression was correlated with MDS subtypes...
  10. Hirakawa M, Sato Y, Ohnuma H, Takayama T, Sagawa T, Nobuoka T, et al. A phase II study of neoadjuvant combination chemotherapy with docetaxel, cisplatin, and S-1 for locally advanced resectable gastric cancer: nucleotide excision repair (NER) as potential chemoresistance marker. Cancer Chemother Pharmacol. 2013;71:789-97 pubmed publisher
    ..Expression of damage DNA binding protein complex subunit 2 (DDB2)/excision repair cross-complementing 1 (ERCC1) in the pretreated tumor tissues was examined by immunohistochemistry...
  11. Liu W, Ao L, Cui Z, Zhou Z, Zhou Y, Yuan X, et al. Molecular analysis of DNA repair gene methylation and protein expression during chemical-induced rat lung carcinogenesis. Biochem Biophys Res Commun. 2011;408:595-601 pubmed publisher
    ..rat lung carcinogenesis model to study the evolution of methylation alterations of DNA repair genes BRCA1, ERCC1, XRCC1, and MLH1...
  12. Fareed K, al Attar A, Soomro I, Kaye P, Patel J, Lobo D, et al. Tumour regression and ERCC1 nuclear protein expression predict clinical outcome in patients with gastro-oesophageal cancer treated with neoadjuvant chemotherapy. Br J Cancer. 2010;102:1600-7 pubmed publisher
    ..Expressions of ERCC1, XPF, FANCD2, APE1 and p53 were investigated using immunohistochemistry...
  13. Lei Y, Lu Q, Shao C, He C, Lei Z, Lian Y. Expression profiles of DNA repair-related genes in rat target organs under subchronic cadmium exposure. Genet Mol Res. 2015;14:515-24 pubmed publisher
    ..to different concentrations of CdCl2 for 3 months, and 5 DNA repair-related genes - hMSH2, MLH1, XRCC1, hOGG1, ERCC1 - were cloned in different tissues, including the liver, kidney, heart, and lung...
  14. Ryu J, Hong Y, Han H, Lee J, Kim S, Park Y, et al. Association between polymorphisms of ERCC1 and XPD and survival in non-small-cell lung cancer patients treated with cisplatin combination chemotherapy. Lung Cancer. 2004;44:311-6 pubmed
    b>ERCC1 (excision repair cross-complementation group 1) and XPD (ERCC2, excision repair cross-complementation group 2) as genes have been known to be belonged to the nucleotide excision repair pathway and therefore related to DNA repair...
  15. Bosó V, Herrero M, Santaballa A, Palomar L, Megias J, de la Cueva H, et al. SNPs and taxane toxicity in breast cancer patients. Pharmacogenomics. 2014;15:1845-58 pubmed publisher
    ..Two SNPs associated with docetaxel toxicity were identified: CYP3A4*1B with infusion-related reactions; and ERCC1 Gln504Lys with mucositis (p≤0.01)...
  16. Ying M, Zhao R. Role of single nucleotide polymorphisms of DNA repair genes in susceptibility to pancreatic cancer in Chinese population. Genet Mol Res. 2016;15: pubmed publisher
    We conducted a case-control study to investigate the role of ERCC1-ERCC5 gene polymorphisms in the risk of pancreatic cancer...
  17. Hauck G, Jonigk D, Göhring G, Kreipe H, Hussein K. Myelofibrosis in Philadelphia chromosome-negative myeloproliferative neoplasms is associated with aberrant karyotypes. Cancer Genet. 2013;206:116-23 pubmed publisher
    ..The expression of DNA repair factors ERCC1 and LIG4 were determined in Ph¯ MPN with and without cytogenetic aberrations...
  18. Cortejoso L, Garcia M, García Alfonso P, Gonzalez Haba E, Escolar F, Sanjurjo M, et al. Differential toxicity biomarkers for irinotecan- and oxaliplatin-containing chemotherapy in colorectal cancer. Cancer Chemother Pharmacol. 2013;71:1463-72 pubmed publisher
    ..nine polymorphisms in irinotecan and oxaliplatin metabolism, transport or DNA repair genes (ABCB1, UGT1A1, XRCC1, ERCC1, ERCC2, GSTP1) were genotyped by SNaPshot, polymerase chain reactions' length fragments, or copy number assays...
  19. Schrader C, Vardo J, Linehan E, Twarog M, Niedernhofer L, Hoeijmakers J, et al. Deletion of the nucleotide excision repair gene Ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions. J Exp Med. 2004;200:321-30 pubmed
    The structure-specific endonuclease ERCC1-XPF is an essential component of the nucleotide excision DNA repair pathway. ERCC1-XPF nicks double-stranded DNA immediately adjacent to 3' single-strand regions...
  20. Strom S, Estey E, Outschoorn U, Garcia Manero G. Acute myeloid leukemia outcome: role of nucleotide excision repair polymorphisms in intermediate risk patients. Leuk Lymphoma. 2010;51:598-605 pubmed publisher
    ..We studied the role of six polymorphisms (ERCC1 Gln504Lys, XPD Lys751Gln, XPC Ala499Val, XPC Lys939Gln, XPG Asp1104His, and CCNH Val270Ala) in overall and disease-..
  21. Decordier I, De Bont K, De Bock K, Mateuca R, Roelants M, Ciardelli R, et al. Genetic susceptibility of newborn daughters to oxidative stress. Toxicol Lett. 2007;172:68-84 pubmed
    ..However, these conclusions might not be extrapolable to other types of DNA damage and need confirmation in a study on a larger population. ..
  22. He K, Yang S, Shen D, Zhang L, Lu S, Sun F. Excision repair cross-complementing 1 expression protects against ischemic injury following middle cerebral artery occlusion in the rat brain. Gene Ther. 2009;16:840-8 pubmed publisher
    To study the effects of excision repair cross-complementing 1 (ERCC1) on the pathophysiological process of brain ischemia, we examined the changes in ERCC1 expression, as well as the functional significance of ERCC1 in the rat brain ..
  23. Wang C, George B, Chen S, Feng B, Li X, Chakrabarti S. Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats. Diabetes Metab Res Rev. 2012;28:329-37 pubmed publisher
    Mammalian excision repair cross-complementing 1 (ERCC1) and ERCC4 (a.k.a xeroderma pigmentosum complementation group F) are nucleotide excision repair enzymes, which excise the 5' end of damaged DNA...
  24. Monzo M, Brunet S, Urbano Ispizua A, Navarro A, Perea G, Esteve J, et al. Genomic polymorphisms provide prognostic information in intermediate-risk acute myeloblastic leukemia. Blood. 2006;107:4871-9 pubmed
    ..method to identify polymorphisms in GSTT1, SULT1C2, CDA, SXR (drug metabolic pathways), XPD, XPA, XPG, ERCC1, TOP2A (DNA repair), VEGF (angiogenesis), and MDR1 (multidrug resistance) genes in 110 adult patients with ..
  25. Griffin C, Waard H, Deans B, Thacker J. The involvement of key DNA repair pathways in the formation of chromosome rearrangements in embryonic stem cells. DNA Repair (Amst). 2005;4:1019-27 pubmed
    ..We chose cells deficient in Ku70 (DNA end joining), Xrcc2 (gene conversion), Ercc1 (single-strand annealing) and Csb (transcription-coupled repair) to represent potentially-important DNA repair ..
  26. Nunez F, Chipchase M, Clarke A, Melton D. Nucleotide excision repair gene (ERCC1) deficiency causes G(2) arrest in hepatocytes and a reduction in liver binucleation: the role of p53 and p21. FASEB J. 2000;14:1073-82 pubmed
    ..The ERCC1 protein is essential for NER, but ERCC1 knockout mice are not a model for XP...
  27. Huang J, Zhou Y, Zhang H, Qu T, Mao Y, Zhu H, et al. A phase II study of biweekly paclitaxel and cisplatin chemotherapy for recurrent or metastatic esophageal squamous cell carcinoma: ERCC1 expression predicts response to chemotherapy. Med Oncol. 2013;30:343 pubmed publisher
    ..The excision repair cross-complementation group 1 (ERCC1) expression to predict response is also assessed. Forty-six eligible patients were enrolled...
  28. Hao T, Feng W, Zhang J, Sun Y, Wang G. Association of four ERCC1 and ERCC2 SNPs with survival of bone tumour patients. Asian Pac J Cancer Prev. 2012;13:3821-4 pubmed
    SNPs of ERCC1 and ERCC2 genes have been found to be associated with response to platinum therapy in different clinical settings...
  29. McCutchen Maloney S, Giannecchini C, Hwang M, Thelen M. Domain mapping of the DNA binding, endonuclease, and ERCC1 binding properties of the human DNA repair protein XPF. Biochemistry. 1999;38:9417-25 pubmed
    ..repair, one of the two incisions necessary for removal of a broad spectrum of DNA adducts is made by the human XPF/ERCC1 protein complex...
  30. Kuptsova N, Kopecky K, Godwin J, Anderson J, Hoque A, Willman C, et al. Polymorphisms in DNA repair genes and therapeutic outcomes of AML patients from SWOG clinical trials. Blood. 2007;109:3936-44 pubmed
    ..We evaluated the role of polymorphisms in DNA repair genes APE1, XRCC1, ERCC1, XPD, and XRCC3 in predicting therapeutic outcomes of older adults with acute myeloid leukemia (AML) from 2 ..
  31. Sijbers A, van der Spek P, Odijk H, van Den Berg J, van Duin M, Westerveld A, et al. Mutational analysis of the human nucleotide excision repair gene ERCC1. Nucleic Acids Res. 1996;24:3370-80 pubmed
    The human DNA repair protein ERCC1 resides in a complex together with the ERCC4, ERCC11 and XP-F correcting activities, thought to perform the 5' strand incision during nucleotide excision repair (NER)...
  32. Lindecrona R, Dragsted L, Poulsen M, Vogel U, Autrup H, Mølck A. Effects of sucrose and cornstarch on 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-induced colon and liver carcinogenesis in F344 rats. Cancer Lett. 2004;209:17-24 pubmed
    ..Both IQ and sucrose increased the expression of the DNA-repair enzyme ERCC1 in the liver...
  33. Batar B, Guven M, Baris S, Celkan T, Yildiz I. DNA repair gene XPD and XRCC1 polymorphisms and the risk of childhood acute lymphoblastic leukemia. Leuk Res. 2009;33:759-63 pubmed publisher
  34. Kong J, Mun Y, Kim S, Choi H, Kim Y, Kim H, et al. Polymorphisms of ERCC1 genotype associated with response to imatinib therapy in chronic phase chronic myeloid leukemia. Int J Hematol. 2012;96:327-33 pubmed publisher
    ..association between the single nucleotide polymorphism (SNP) markers involved in the DNA repair enzyme pathway (ERCC1/2/4/5, XRCC1/2/4/5) and the clinical outcomes following an imatinib therapy in chronic phase chronic myeloid ..
  35. de Laat W, Sijbers A, Odijk H, Jaspers N, Hoeijmakers J. Mapping of interaction domains between human repair proteins ERCC1 and XPF. Nucleic Acids Res. 1998;26:4146-52 pubmed
    b>ERCC1-XPF is a heterodimeric protein complexinvolved in nucleotide excision repair and recombinational processes...
  36. Sakaguchi K, Ishibashi T, Uchiyama Y, Iwabata K. The multi-replication protein A (RPA) system--a new perspective. FEBS J. 2009;276:943-63 pubmed publisher
    ..Convergent evolution seems to be ubiquitous in these processes. Using recent findings, we review the composition and biological functions of RPA complexes. ..
  37. Zhou C, Zhao J. Systematic review on the association between ERCC1 rs3212986 and ERCC2 rs13181 polymorphisms and glioma risk. Genet Mol Res. 2015;14:2868-75 pubmed publisher
    Several studies have examined the association between excision repair cross-complementation group 1 (ERCC1) C8092A and ERCC2 Lys751Gln polymorphisms and glioma risk, but the results have been inconclusive...
  38. Cibeira M, de Larrea C, Navarro A, Diaz T, Fuster D, Tovar N, et al. Impact on response and survival of DNA repair single nucleotide polymorphisms in relapsed or refractory multiple myeloma patients treated with thalidomide. Leuk Res. 2011;35:1178-83 pubmed publisher
    ..The response rate was higher in patients with SNPs in ERCC1 (rs735482) (p=0.006), ERCC5 (rs17655) (p=0.04) or XRCC5 (rs1051685) (p=0.013)...
  39. Van Sloun P, Jansen J, Weeda G, Mullenders L, van Zeeland A, Lohman P, et al. The role of nucleotide excision repair in protecting embryonic stem cells from genotoxic effects of UV-induced DNA damage. Nucleic Acids Res. 1999;27:3276-82 pubmed
    ..Cytotoxic and mutagenic effects of photolesions were determined in ES cells differing in NER activity. ERCC1-deficient ES cells were hypermutable (10-fold) compared to wild-type cells, indicating that at physiologically ..
  40. Motycka T, Bessho T, Post S, Sung P, Tomkinson A. Physical and functional interaction between the XPF/ERCC1 endonuclease and hRad52. J Biol Chem. 2004;279:13634-9 pubmed
    The XPF/ERCC1 heterodimer is a DNA structure-specific endonuclease that participates in nucleotide excision repair and homology-dependent recombination reactions, including DNA single strand annealing and gene targeting...
  41. Lee K, Choi J, Kang C, Kang C, Park S, Cho H, et al. Genetic polymorphisms of selected DNA repair genes, estrogen and progesterone receptor status, and breast cancer risk. Clin Cancer Res. 2005;11:4620-6 pubmed
    ..gt; T, XRCC6 1796G > T, LIG4 1977T/C, RAD51 135G > C, 172G > T, RAD52 2259C > T, LIG1 551A > C, ERCC1 8092A > C, 354C > T, hMLH1 -93G > A, and Ile219Val)...
  42. Paul C, Povey J, Lawrence N, Selfridge J, Melton D, Saunders P. Deletion of genes implicated in protecting the integrity of male germ cells has differential effects on the incidence of DNA breaks and germ cell loss. PLoS ONE. 2007;2:e989 pubmed
    ..We have investigated mice with deletions of ERCC1 (excision repair cross-complementing gene 1), MSH2 (MutS homolog 2, involved in mismatch repair pathway), and p53 (..
  43. Matoka D, Yao V, Harya D, Gregg J, Robinson A, Niedernhofer L, et al. Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model. Prostate. 2012;72:1214-22 pubmed publisher
    The excision repair cross complementing (ERCC1) gene product plays a vital role in the nucleotide excision repair (NER) and DNA interstrand crosslink repair pathways, which protect the genome from mutations and chromosomal aberrations, ..
  44. Park C, Bessho T, Matsunaga T, Sancar A. Purification and characterization of the XPF-ERCC1 complex of human DNA repair excision nuclease. J Biol Chem. 1995;270:22657-60 pubmed
    A complex, which consists of ERCC1 (38 kDa) and a 112-kDa protein, was purified from HeLa cells to homogeneity...
  45. Forsberg K, Aalling N, Wörtwein G, Loft S, Møller P, Hau J, et al. Dynamic regulation of cerebral DNA repair genes by psychological stress. Mutat Res Genet Toxicol Environ Mutagen. 2015;778:37-43 pubmed publisher
    ..The mRNA expression of seven genes (Ogg1, Ape1, Ung1, Neil1, Xrcc1, Ercc1, Nudt1) involved in the repair of oxidatively damaged DNA was determined by quantitative real time polymerase ..
  46. Wang S, Zhao H, Zhou B, Chen Y, Zou Y, Zhu X, et al. Polymorphisms in ERCC1 and susceptibility to childhood acute lymphoblastic leukemia in a Chinese population. Leuk Res. 2006;30:1341-5 pubmed
    Excision repair cross-complementation group 1 (ERCC1) is important in repairing DNA damage and genomic instability, and polymorphisms in ERCC1 may play a role in human tumors...
  47. Krivak T, Darcy K, Tian C, Armstrong D, Baysal B, Gallion H, et al. Relationship between ERCC1 polymorphisms, disease progression, and survival in the Gynecologic Oncology Group Phase III Trial of intraperitoneal versus intravenous cisplatin and paclitaxel for stage III epithelial ovarian cancer. J Clin Oncol. 2008;26:3598-606 pubmed publisher
    We hypothesized that common polymorphisms in excision repair cross-complementation group 1 (ERCC1), involved in nucleotide excision repair of platinum-induced damage, would be associated with progression-free survival (PFS) and overall ..
  48. Tse D, Zhai R, Zhou W, Heist R, Asomaning K, Su L, et al. Polymorphisms of the NER pathway genes, ERCC1 and XPD are associated with esophageal adenocarcinoma risk. Cancer Causes Control. 2008;19:1077-83 pubmed publisher
    ..The samples were genotyped for SNPs in NER genes (XPD Lys751Gln, XPD Asp312Asn, ERCC1 8092C/A, and ERCC1 118C/T), and BER genes (XRCC1 Arg399Gln, APE1 Asp148Glu, and hOGG1 Ser326Cys)...
  49. Chen Q, Liu K, Robinson A, Clauson C, Blair H, Robbins P, et al. DNA damage drives accelerated bone aging via an NF-?B-dependent mechanism. J Bone Miner Res. 2013;28:1214-28 pubmed publisher
    ..Excision repair cross complementary group 1-xeroderma pigmentosum group F (ERCC1-XPF) is an evolutionarily conserved structure-specific endonuclease that is required for multiple DNA repair ..
  50. Sorour A, Ayad M, Kassem H. The genotype distribution of the XRCC1, XRCC3, and XPD DNA repair genes and their role for the development of acute myeloblastic leukemia. Genet Test Mol Biomarkers. 2013;17:195-201 pubmed publisher
    ..Combined analysis of the studied DNA repair gene polymorphisms did not show an interaction with the detoxification NQO1 Pro187Ser polymorphism. ..
  51. Dybdahl M, Risom L, Møller P, Autrup H, Wallin H, Vogel U, et al. DNA adduct formation and oxidative stress in colon and liver of Big Blue rats after dietary exposure to diesel particles. Carcinogenesis. 2003;24:1759-66 pubmed
    ..DNA adduct levels measured by 32P-post-labelling were elevated in colon and liver, and the expression of ERCC1 gene was affected in liver, but not in colon...
  52. Ni M, Zhang W, Qiu J, Liu F, Li M, Zhang Y, et al. Association of ERCC1 and ERCC2 polymorphisms with colorectal cancer risk in a Chinese population. Sci Rep. 2014;4:4112 pubmed publisher
    The ERCC1 and ERCC2 genes are important in repairing DNA damage and genomic instability, and are involved in the nucleotide excision repair pathway...
  53. Doig J, Anderson C, Lawrence N, Selfridge J, Brownstein D, Melton D. Mice with skin-specific DNA repair gene (Ercc1) inactivation are hypersensitive to ultraviolet irradiation-induced skin cancer and show more rapid actinic progression. Oncogene. 2006;25:6229-38 pubmed
    b>Ercc1 has an essential role in the nucleotide excision repair (NER) pathway that protects against ultraviolet (UV)-induced DNA damage and is also involved in additional repair pathways...
  54. Park C, Sancar A. Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins. Proc Natl Acad Sci U S A. 1994;91:5017-21 pubmed
    ..We conclude that the XPA damage recognition protein makes a ternary complex with the ERCC1/ERCC4(XPF) heterodimer with a potential nuclease function.
  55. Pérez Oliva A, Lachaud C, Szyniarowski P, Muñoz I, MacArtney T, Hickson I, et al. USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses. EMBO J. 2015;34:326-43 pubmed publisher
    ..Here, we identify the deubiquitylase USP45 as a critical DNA repair regulator. USP45 associates with ERCC1, a subunit of the DNA repair endonuclease XPF-ERCC1, via a short acidic motif outside of the USP45 catalytic ..
  56. Takayama K, Kawakami Y, Lee S, Greco N, Lavasani M, Mifune Y, et al. Involvement of ERCC1 in the pathogenesis of osteoarthritis through the modulation of apoptosis and cellular senescence. J Orthop Res. 2014;32:1326-32 pubmed publisher
    DNA damage is a cause of age related pathologies, including osteoarthritis (OA). Excision repair cross complementation group 1 (ERCC1) is an endonuclease required for DNA damage repair...
  57. Zheng D, Tang G, Chen Y, Zhang T, Qin M. Genetic variability of ERCC1 and ERCC2 genes involved in the nucleotide excision repair pathway influences the treatment outcome of gastric cancer. Genet Mol Res. 2016;15: pubmed publisher
    We conducted a prospective study to investigate whether ERCC1 rs11615 and rs3212986 and ERCC2 rs13181 and rs1799793 gene polymorphisms could serve as potential biomarkers for the prognosis of gastric cancer...
  58. Reardon J, Bessho T, Kung H, Bolton P, Sancar A. In vitro repair of oxidative DNA damage by human nucleotide excision repair system: possible explanation for neurodegeneration in xeroderma pigmentosum patients. Proc Natl Acad Sci U S A. 1997;94:9463-8 pubmed
    ..Our results suggest that XP neurological disease may be caused by defective repair of lesions that are produced in nerve cells by reactive oxygen species generated as by-products of an active oxidative metabolism. ..
  59. Pakakasama S, Sirirat T, Kanchanachumpol S, Udomsubpayakul U, Mahasirimongkol S, Kitpoka P, et al. Genetic polymorphisms and haplotypes of DNA repair genes in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2007;48:16-20 pubmed
    ..The XRCC1 194Trp allele and haplotype B showed a protective effect against development of childhood ALL. In contrast, individuals with the XRCC1 399Gln allele and haplotype C were associated with increased risk for this disease. ..
  60. Lu B, Li J, Gao Q, Yu W, Yang Q, Li X. Laryngeal cancer risk and common single nucleotide polymorphisms in nucleotide excision repair pathway genes ERCC1, ERCC2, ERCC3, ERCC4, ERCC5 and XPA. Gene. 2014;542:64-8 pubmed publisher
    ..Laryngeal cancer cases were more likely to smoke and drink (all P values<0.05). Subjects with the ERCC1 rs11615 CC genotype and C allele had an increased risk of laryngeal cancer...
  61. Karakasilioti I, Kamileri I, Chatzinikolaou G, Kosteas T, Vergadi E, Robinson A, et al. DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria. Cell Metab. 2013;18:403-15 pubmed publisher
    ..However, the underlying mechanisms remain poorly understood. Using mice carrying an ERCC1-XPF DNA repair defect systematically or in adipocytes, we show that DNA damage signaling triggers a chronic ..
  62. van de Ven M, Andressoo J, Holcomb V, von Lindern M, Jong W, De Zeeuw C, et al. Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice. PLoS Genet. 2006;2:e192 pubmed
    ..Specific (but not all) types of genome instability may thus engage a conserved response to stress that evolved to cope with environmental pressures such as food shortage. ..
  63. Tripsianes K, Folkers G, Zheng C, Das D, Grinstead J, Kaptein R, et al. Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization. Nucleic Acids Res. 2007;35:5789-98 pubmed
    Human ERCC1/XPF is a structure-specific endonuclease involved in multiple DNA repair pathways. We present the solution structure of the non-catalytic ERCC1 central domain...
  64. Vannier J, Pavicic Kaltenbrunner V, Petalcorin M, Ding H, Boulton S. RTEL1 dismantles T loops and counteracts telomeric G4-DNA to maintain telomere integrity. Cell. 2012;149:795-806 pubmed publisher
    ..We propose that RTEL1 performs two distinct functions at telomeres: it disassembles T loops and also counteracts telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere. ..
  65. Lambrechts S, Lambrechts D, Despierre E, Van Nieuwenhuysen E, Smeets D, Debruyne P, et al. Genetic variability in drug transport, metabolism or DNA repair affecting toxicity of chemotherapy in ovarian cancer. BMC Pharmacol Toxicol. 2015;16:2 pubmed publisher
    ..002, OR = 2.08, 95% CI = 1.32-3.27) and rs11615 (ERCC1, T > C; p = 0.031, OR = 1.61, 95% CI = 1.04-2...
  66. Middleton M, Friedlander P, Hamid O, Daud A, Plummer R, Falotico N, et al. Randomized phase II study evaluating veliparib (ABT-888) with temozolomide in patients with metastatic melanoma. Ann Oncol. 2015;26:2173-9 pubmed publisher
    ..9 (9.8-14.3) months, respectively; ORR was 10.3%, 8.7%, and 7.0%. Exploratory analyses showed patients with low ERCC1 expression had longer PFS when TMZ was combined with veliparib. Toxicities were as expected for TMZ...
  67. Ganzinelli M, Mariani P, Cattaneo D, Fossati R, Fruscio R, Corso S, et al. Expression of DNA repair genes in ovarian cancer samples: biological and clinical considerations. Eur J Cancer. 2011;47:1086-94 pubmed publisher
    ..The expression of genes involved in DNA repair pathways (PARP1, ERCC1, XPA, XPF, XPG, BRCA1, FANCA, FANCC, FANCD2, FANCF and PolEta), and in DNA damage transduction (Chk1 and Claspin) ..
  68. Matsunaga T, Mu D, Park C, Reardon J, Sancar A. Human DNA repair excision nuclease. Analysis of the roles of the subunits involved in dual incisions by using anti-XPG and anti-ERCC1 antibodies. J Biol Chem. 1995;270:20862-9 pubmed
    ..The activity requires participation of 16-17 polypeptides. Of these, the XPF.ERCC1 complex and XPG were predicted to carry the nuclease active sites based on studies with the recombinant proteins ..
  69. Li J, Zuo X, Lv X, Kong F, Xu W, Yang S. Association of DNA repair gene polymorphisms with response to chemotherapy and prognosis of gastric cancer in a Chinese population. Tumour Biol. 2014;35:7569-74 pubmed publisher
    We conducted a study to investigate the role of excision repair cross-complimentary group 1 gene (ERCC1)-xeroderma pigmentosum complementation group F (XPF) gene polymorphisms in response to chemotherapy and clinical outcome of gastric ..
  70. Kim H, Kim N, Yu L, Tran H, Kim Y, Lee I, et al. Association of GSTT1 polymorphism with acute myeloid leukemia risk is dependent on smoking status. Leuk Lymphoma. 2012;53:681-7 pubmed publisher
    ..We found marginal associations between the risk of AML and CYP1A1 1188, and XRCC1 194, ERCC1 IVS5 + 33 and WRN 787 polymorphisms...