Erbb2

Summary

Gene Symbol: Erbb2
Description: erb-b2 receptor tyrosine kinase 2
Alias: receptor tyrosine-protein kinase erbB-2, Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog), C-erbB-2, NEU proto-oncogene, epidermal growth factor receptor-related protein, p185erbB2, p185neu, proto-oncogene NEU, proto-oncogene c-ErbB-2, v-erb-b2 avian erythroblastic leukemia viral oncogene 2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Species: rat
Products:     Erbb2

Top Publications

  1. Audisio C, Nicolino S, Scevola A, Tos P, Geuna S, Battiston B, et al. ErbB receptors modulation in different types of peripheral nerve regeneration. Neuroreport. 2008;19:1605-9 pubmed publisher
    ..No significant changes in ErbB2 mRNA were detected...
  2. Doggen K, Ray L, Mathieu M, Mc Entee K, Lemmens K, De Keulenaer G. Ventricular ErbB2/ErbB4 activation and downstream signaling in pacing-induced heart failure. J Mol Cell Cardiol. 2009;46:33-8 pubmed publisher
    ..In parallel, levels of activated ErbB2 and ErbB4, phosphorylated at tyrosine residues 877/1248 and 1284 respectively, became progressively higher...
  3. Guertin A, Zhang D, Mak K, Alberta J, Kim H. Microanatomy of axon/glial signaling during Wallerian degeneration. J Neurosci. 2005;25:3478-87 pubmed
    ..We show a hitherto undetected rapid, but transient, activation of the receptor tyrosine kinase erbB2 in myelinating Schwann cells after sciatic nerve axotomy...
  4. Carroll S, Miller M, Frohnert P, Kim S, Corbett J. Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration. J Neurosci. 1997;17:1642-59 pubmed
    ..Of the four known erbB kinases, Schwann cells express both erbB2 and erbB3 receptors over the entire interval studied...
  5. Erickson S, O Shea K, Ghaboosi N, Loverro L, Frantz G, Bauer M, et al. ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice. Development. 1997;124:4999-5011 pubmed
    ..to ErbB3 and ErbB4 receptors, leading to multiple dimerization possibilities including heterodimerization with the ErbB2 receptor...
  6. Gui C, Zhu L, Hu M, Lei L, Long Q. Neuregulin-1/ErbB signaling is impaired in the rat model of diabetic cardiomyopathy. Cardiovasc Pathol. 2012;21:414-20 pubmed publisher
    ..The left ventricle fibrosis was evaluated using Masson's trichrome staining. The mRNA expression profiles of ErbB2 and ErbB4 receptors were evaluated using real-time polymerase chain reaction...
  7. Garratt A, Voiculescu O, Topilko P, Charnay P, Birchmeier C. A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool. J Cell Biol. 2000;148:1035-46 pubmed
    ..axonally derived signal for the survival and growth of developing Schwann cells, which is transmitted by the ErbB2/ErbB3 receptor tyrosine kinases...
  8. Cho H, Mason K, Ramyar K, Stanley A, Gabelli S, Denney D, et al. Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab. Nature. 2003;421:756-60 pubmed
    HER2 (also known as Neu, ErbB2) is a member of the epidermal growth factor receptor (EGFR; also known as ErbB) family of receptor tyrosine kinases, which in humans includes HER1 (EGFR, ERBB1), HER2, HER3 (ERBB3) and HER4 (ERBB4)...
  9. Junttila T, Laato M, Vahlberg T, Söderström K, Visakorpi T, Isola J, et al. Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients. Clin Cancer Res. 2003;9:5346-57 pubmed
    ..Determination of cutoff expression levels indicated tumor-specific overexpression of ErbB2, ErbB3, and specific ErbB4 isoforms in a subset of TCC patients...

More Information

Publications62

  1. Li Ping Z, Da Lei Z, Jian H, Liang Quan X, Ai Xia X, Xiao Yu D, et al. Proto-oncogene c-erbB2 initiates rat primordial follicle growth via PKC and MAPK pathways. Reprod Biol Endocrinol. 2010;8:66 pubmed publisher
    c-erbB2, a proto-oncogene coding epidermal growth factor receptor-like receptor, also as a chemosensitivity/prognosis marker for gynecologic cancer, may be involved in initiation of growth of rat primordial follicles...
  2. Lemmens K, Segers V, Demolder M, De Keulenaer G. Role of neuregulin-1/ErbB2 signaling in endothelium-cardiomyocyte cross-talk. J Biol Chem. 2006;281:19469-77 pubmed
    ..In the present study, we have investigated to what extent ErbB2, the favored co-factor of ErbB4 for heterodimerization, participates in the cardiac effects of endothelium-derived ..
  3. Barnes N, Khavari S, Boland G, Cramer A, Knox W, Bundred N. Absence of HER4 expression predicts recurrence of ductal carcinoma in situ of the breast. Clin Cancer Res. 2005;11:2163-8 pubmed
    The type 1 tyrosine kinase receptor HER2 (c-erbB2/neu) is associated with resistance to hormone therapy and poor survival in invasive breast cancer, whereas HER4 expression is associated with endocrine responsiveness...
  4. Rohrbach S, Niemann B, Silber R, Holtz J. Neuregulin receptors erbB2 and erbB4 in failing human myocardium -- depressed expression and attenuated activation. Basic Res Cardiol. 2005;100:240-9 pubmed
    ..In cultured cardiomyocytes, erbB2 and erbB4 receptors regulate apoptosis by controlling bcl-x splicing, and conditional elimination of erbB2 induces ..
  5. Peng X, Guo X, Borkan S, Bharti A, Kuramochi Y, Calderwood S, et al. Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes. J Biol Chem. 2005;280:13148-52 pubmed
    ..chaperone that stabilizes expression of multiple signaling kinases involved in growth regulation, including ErbB2, Raf-1, and Akt...
  6. Ozcelik C, Erdmann B, Pilz B, Wettschureck N, Britsch S, Hubner N, et al. Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci U S A. 2002;99:8880-5 pubmed
    The ErbB2 (Her2) proto-oncogene encodes a receptor tyrosine kinase, which is frequently amplified and overexpressed in human tumors...
  7. Guy C, Webster M, Schaller M, Parsons T, Cardiff R, Muller W. Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease. Proc Natl Acad Sci U S A. 1992;89:10578-82 pubmed
    Overexpression and amplification of the neu (c-erbB2, ERBB2) protooncogene have been implicated in the development of aggressive human breast cancer...
  8. Wallasch C, Weiss F, Niederfellner G, Jallal B, Issing W, Ullrich A. Heregulin-dependent regulation of HER2/neu oncogenic signaling by heterodimerization with HER3. EMBO J. 1995;14:4267-75 pubmed
  9. Rohrbach S, Yan X, Weinberg E, Hasan F, Bartunek J, Marchionni M, et al. Neuregulin in cardiac hypertrophy in rats with aortic stenosis. Differential expression of erbB2 and erbB4 receptors. Circulation. 1999;100:407-12 pubmed
    ..We used ribonuclease protection assays to quantify mRNA levels of neuregulin, erbB2, and erbB4 in left ventricular (LV) tissue and myocytes of normal rats and rats with aortic stenosis with pressure-..
  10. Odiete O, Konik E, Sawyer D, Hill M. Type 1 diabetes mellitus abrogates compensatory augmentation of myocardial neuregulin-1?/ErbB in response to myocardial infarction resulting in worsening heart failure. Cardiovasc Diabetol. 2013;12:52 pubmed publisher
    ..Myocardial protein expression of NRG-1?, ErbB2 and ErbB4 receptors, and MDM2 (a downstream signaling pathway induced by NRG-1 that has been implicated in cell ..
  11. Crone S, Negro A, Trumpp A, Giovannini M, Lee K. Colonic epithelial expression of ErbB2 is required for postnatal maintenance of the enteric nervous system. Neuron. 2003;37:29-40 pubmed
    We utilized the Cre-LoxP system to establish erbB2 conditional mutant mice in order to investigate the role of erbB2 in postnatal development of the enteric nervous system...
  12. Wang B, Kennan W, Yasukawa Barnes J, Lindstrom M, Gould M. Frequent induction of mammary carcinomas following neu oncogene transfer into in situ mammary epithelial cells of susceptible and resistant rat strains. Cancer Res. 1991;51:5649-54 pubmed
  13. Negishi Koga T, Shinohara M, Komatsu N, Bito H, Kodama T, Friedel R, et al. Suppression of bone formation by osteoclastic expression of semaphorin 4D. Nat Med. 2011;17:1473-80 pubmed publisher
    ..Notably, Sema4D-specific antibody treatment markedly prevented bone loss in a model of postmenopausal osteoporosis. Thus, Sema4D has emerged as a new therapeutic target for the discovery and development of bone-increasing drugs. ..
  14. Kim S, Chao T, Xiang R, Lo J, Campbell M, Fearns C, et al. Tid1, the human homologue of a Drosophila tumor suppressor, reduces the malignant activity of ErbB-2 in carcinoma cells. Cancer Res. 2004;64:7732-9 pubmed
    ..Moreover, the cochaperonic and regulatory functions of Tid1 on HSP70 most likely play an essential role in this antitumor function of Tid1 in carcinoma cells. ..
  15. Louzada S, Adega F, Chaves R. Defining the sister rat mammary tumor cell lines HH-16 cl.2/1 and HH-16.cl.4 as an in vitro cell model for Erbb2. PLoS ONE. 2012;7:e29923 pubmed publisher
    ..This comprehensive cytogenetic analysis revealed an increase in the number of copies of the Mycn and Erbb2 genes in the investigated cell lines...
  16. Houliston R, Hodges R, Sharom F, Davis J. Characterization of the proto-oncogenic and mutant forms of the transmembrane region of Neu in micelles. J Biol Chem. 2004;279:24073-80 pubmed
  17. Chang H, Shyu M, Tseng G, Liu C, Chang H, Lan C, et al. Neuregulin facilitates nerve regeneration by speeding Schwann cell migration via ErbB2/3-dependent FAK pathway. PLoS ONE. 2013;8:e53444 pubmed publisher
    ..Cultured RSC96 cells treated with neuregulin were processed for erbB2/3 immunofluorescence and FAK immunoblotings...
  18. Lai C, Lemke G. An extended family of protein-tyrosine kinase genes differentially expressed in the vertebrate nervous system. Neuron. 1991;6:691-704 pubmed
    ..Together with recent studies in invertebrates, these data are consistent with the hypothesis that protein-tyrosine kinases play a central role in neural development. ..
  19. Hawthorne V, Huang W, Neal C, Tseng L, Hung M, Yu D. ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells. Mol Cancer Res. 2009;7:592-600 pubmed publisher
    Overexpression of the ErbB2 receptor tyrosine kinase is prevalent in approximately 30% of human breast cancers and confers Taxol resistance...
  20. Tuefferd M, Couturier J, Penault Llorca F, Vincent Salomon A, Broet P, Guastalla J, et al. HER2 status in ovarian carcinomas: a multicenter GINECO study of 320 patients. PLoS ONE. 2007;2:e1138 pubmed
    ..This raises the question of whether HER2 status and paclitaxel sensitively are linked. ..
  21. Levchenko V, Zheleznova N, Pavlov T, Vandewalle A, Wilson P, Staruschenko A. EGF and its related growth factors mediate sodium transport in mpkCCDc14 cells via ErbB2 (neu/HER-2) receptor. J Cell Physiol. 2010;223:252-9 pubmed publisher
    ..Inhibition of PI3-kinase with LY294002 abolished acute effect of EGF. As assessed by Western blotting, ErbB2 is the most predominant member of the ErbB family detected in mpkCCD(c14) cells...
  22. Beevers A, Damianoglou A, Oates J, Rodger A, Dixon A. Sequence-dependent oligomerization of the Neu transmembrane domain suggests inhibition of "conformational switching" by an oncogenic mutant. Biochemistry. 2010;49:2811-20 pubmed publisher
    Membrane-spanning epidermal growth factor receptor ErbB2 is of key importance in cell division, in which a dimeric complex of the protein is responsible for tyrosine kinase activation following ligand binding...
  23. Bargmann C, Hung M, Weinberg R. The neu oncogene encodes an epidermal growth factor receptor-related protein. Nature. 1986;319:226-30 pubmed
    ..Our results suggest strongly that the neu gene encodes the receptor for an as yet unidentified growth factor. ..
  24. Brown N, Deb K, Paria B, Das S, Reese J. Embryo-uterine interactions via the neuregulin family of growth factors during implantation in the mouse. Biol Reprod. 2004;71:2003-11 pubmed
    ..We also observed upregulation of the erbB2 and erbB3 receptors at the blastocyst stage of embryo development...
  25. Sidera K, Gaitanou M, Stellas D, Matsas R, Patsavoudi E. A critical role for HSP90 in cancer cell invasion involves interaction with the extracellular domain of HER-2. J Biol Chem. 2008;283:2031-41 pubmed
    ..Our data suggest that surface HSP90 is involved in heregulin-induced HER-2 activation and signaling, leading to cytoskeletal rearrangement, essential for cell invasion. ..
  26. Zaoui K, Benseddik K, Daou P, Salaün D, Badache A. ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Proc Natl Acad Sci U S A. 2010;107:18517-22 pubmed publisher
    ..It was previously demonstrated that the ErbB2 receptor tyrosine kinase regulated MT outgrowth to the cell cortex via a complex including Memo, the GTPase RhoA, ..
  27. Chang X, Gao J, Jiang Q, Wen J, Seifers N, Su L, et al. The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis. J Exp Med. 2005;202:1141-51 pubmed
    ..FoxP3 mutation also results in overexpression of ErbB2 in the thymic stroma, which may be involved in defective thymopoiesis...
  28. Huang Q, Zhang J, Liang L, Lan Z, Huo T, Li S. The Significance of Neuregulin-1/ErbB Expression in Autogenous Vein Grafts in a Diabetic Rat Model. J Cardiovasc Pharmacol. 2015;66:300-6 pubmed publisher
    ..NRG-1, ErbB2, and ErbB4 expression significantly decreased in vein grafts over time...
  29. Lofts F, Hurst H, Sternberg M, Gullick W. Specific short transmembrane sequences can inhibit transformation by the mutant neu growth factor receptor in vitro and in vivo. Oncogene. 1993;8:2813-20 pubmed
    ..As predicted by molecular modelling, the magnitude of inhibition depended on the nature of the packing surface, suggesting that the neu transmembrane domain is directly involved in neu protein dimerization. ..
  30. Sysa Shah P, Sørensen L, Abraham M, Gabrielson K. Electrocardiographic Characterization of Cardiac Hypertrophy in Mice that Overexpress the ErbB2 Receptor Tyrosine Kinase. Comp Med. 2015;65:295-307 pubmed
    ..We hypothesized that the recently developed transgenic mouse model of cardiac hypertrophy (ErbB2(tg)) will display distinct ECG features, enabling WT (wild type) mice to be distinguished from transgenic mice ..
  31. Koike T, Wakabayashi T, Mori T, Hirahara Y, Yamada H. Sox2 promotes survival of satellite glial cells in vitro. Biochem Biophys Res Commun. 2015;464:269-74 pubmed publisher
    ..Using this culture system, Sox2 was downregulated by siRNA against Sox2. The knockdown of Sox2 downregulated ErbB2 and ErbB3 mRNA at 2 and 4 days after siRNA treatment...
  32. Gabrielli F, Salvi R, Garulli C, Kalogris C, Arima S, Tardella L, et al. Identification of relevant conformational epitopes on the HER2 oncoprotein by using Large Fragment Phage Display (LFPD). PLoS ONE. 2013;8:e58358 pubmed publisher
  33. Wang X, Chao L, Chen L, Tian B, Ma G, Zang Y, et al. Correlation of mammographic calcifications with Her-2/neu overexpression in primary breast carcinomas. J Digit Imaging. 2008;21:170-6 pubmed publisher
    ..Calcifications detected during screening mammography are not only of diagnostic value but of use in determining therapeutic options and prognosis. ..
  34. Papadopoulou E, Tripsianis G, Anagnostopoulos K, Tentes I, Kakolyris S, Galazios G, et al. The influence of serum HER-2 levels and HER-2 codon 655 polymorphism on breast cancer outcome. Neoplasma. 2008;55:113-21 pubmed
    ..Furthermore, they provide clinical evidence that HER-2 Ile655Val SNP does affect serum HER-2 levels and it can be regarded as a predictive biomarker for breast cancer patients with poor prognosis. ..
  35. Fernandes A, Hamburger A, Gerwin B. Dominance of ErbB-1 heterodimers in lung epithelial cells overexpressing ErbB-2. Both ErbB-1 and ErbB-2 contribute significantly to tumorigenicity. Am J Respir Cell Mol Biol. 1999;21:701-9 pubmed
    ..This work further suggests that ErbB-3 and -4 species may also contribute to tumorigenic conversion and that their expression levels may be increased by signaling initiated by TGF-alpha. ..
  36. Carver R, Stevenson M, Scheving L, Russell W. Diverse expression of ErbB receptor proteins during rat liver development and regeneration. Gastroenterology. 2002;123:2017-27 pubmed
    ..The epidermal growth factor receptor, ErbB2, and ErbB3 were the only ErbB proteins detected in the liver parenchyma on embryonic day 19...
  37. Frohnert P, Stonecypher M, Carroll S. Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line. Glia. 2003;43:104-18 pubmed
    ..Relative to nontransformed Schwann cells, JS1 cells overexpress the NRG-1 receptor erbB3 and its erbB2 coreceptor; JS1 erbB2 transcripts show no evidence of the activating mutation commonly found in N-ethyl-N-..
  38. Belmonte F, Das S, Sysa Shah P, Sivakumaran V, Stanley B, Guo X, et al. ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity. Am J Physiol Heart Circ Physiol. 2015;309:H1271-80 pubmed publisher
    Levels of the HER2/ErbB2 protein in the heart are upregulated in some women during breast cancer therapy, and these women are at high risk for developing heart dysfunction after sequential treatment with anti-ErbB2/trastuzumab or ..
  39. Hao J, Galindo C, Tran T, Sawyer D. Neuregulin-1? induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors. Biochem J. 2014;458:335-41 pubmed publisher
    ..multiple functions during embryonic heart development by signalling through ErbB family receptor tyrosine kinases (ErbB2, ErbB3 and ErbB4)...
  40. Mocanu M, Váradi T, Szollosi J, Nagy P. Comparative analysis of fluorescence resonance energy transfer (FRET) and proximity ligation assay (PLA). Proteomics. 2011;11:2063-70 pubmed publisher
    ..Our data imply that PLA is a semiquantitative measure of protein colocalizations due to non-linear effects in the reaction and that caution should be exercised when interpreting PLA data in a quantitative way. ..
  41. Peoples G, Holmes J, Hueman M, Mittendorf E, Amin A, Khoo S, et al. Combined clinical trial results of a HER2/neu (E75) vaccine for the prevention of recurrence in high-risk breast cancer patients: U.S. Military Cancer Institute Clinical Trials Group Study I-01 and I-02. Clin Cancer Res. 2008;14:797-803 pubmed publisher
    ..These findings warrant a prospective, randomized phase III trial of the E75 vaccine with periodic booster to prevent breast cancer recurrences. ..
  42. Thomasson M, Hedman H, Junttila T, Elenius K, Ljungberg B, Henriksson R. ErbB4 is downregulated in renal cell carcinoma--a quantitative RT-PCR and immunohistochemical analysis of the epidermal growth factor receptor family. Acta Oncol. 2004;43:453-9 pubmed
    In the present study the authors evaluated the expression of the EGFR family members ErbB2-4 in renal cell carcinoma (RCC). Thirty-one RCCs were examined for gene expression of ErbB2-4 mRNA by quantitative real-time RT-PCR...
  43. Pao W, Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol. 2011;12:175-80 pubmed publisher
    ..reviewed elsewhere, here, we discuss subsets defined by so-called driver mutations in ALK, HER2 (also known as ERBB2), BRAF, PIK3CA, AKT1, MAP2K1, and MET...
  44. Radovic S, Babic M, Doric M, Secic S, Beslić S, Balta E, et al. Immunohistochemical evaluation of the HER-2 protein in the infiltrative lobular breast cancer. Med Arh. 2006;60:213-6 pubmed
  45. Menezes M, Cestari A, Almeida O, Alvarenga M, Pinto G, Gurgel M, et al. Protein expression of c-erbB-2 and p53 in normal ducts, ductal carcinoma in situ and invasive carcinoma of the same breast. Sao Paulo Med J. 2006;124:121-4 pubmed
    ..The general features of an occurrence of breast carcinoma are formulated at the outset of carcinogenesis, and the Her-2/neu and TP53 genes are involved. ..
  46. Hansen M, Roehm P, Chatterjee P, Green S. Constitutive neuregulin-1/ErbB signaling contributes to human vestibular schwannoma proliferation. Glia. 2006;53:593-600 pubmed
    ..We have previously shown that VSs produce the glial growth factor, neuregulin-1 (NRG1), and its receptors, ErbB2 and ErbB3...
  47. Suen T, Hung M. Multiple cis- and trans-acting elements involved in regulation of the neu gene. Mol Cell Biol. 1990;10:6306-15 pubmed
    ..Sp1-binding site was found, in addition to various sequence motifs common to the promoters of the human neu gene (erbB2), the epidermal growth factor receptor gene, and the simian virus 40 enhancer. A 2...
  48. Howard P, Chia M, Del Rizzo S, Liu F, Pawson T. Redirecting tyrosine kinase signaling to an apoptotic caspase pathway through chimeric adaptor proteins. Proc Natl Acad Sci U S A. 2003;100:11267-72 pubmed
    ..These hybrid adaptors can be used to selectively kill oncogenic cells in which RTK activity is deregulated. ..
  49. Zhang Q, Park E, Kani K, Landgraf R. Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling. Proc Natl Acad Sci U S A. 2012;109:13237-42 pubmed publisher
    ..Heterodimers of the ligand-binding-deficient ERBB2 (HER2) receptor and the kinase impaired ERBB3 (HER3) create a potent mitogenic signal, but the phosphorylation of ..
  50. Carraway K, Carvajal M, Li P, Carraway C. ErbB2 and its ligand Muc4 (sialomucin complex) in rat lacrimal gland. Adv Exp Med Biol. 2002;506:289-95 pubmed
    ..The secreted, soluble form is likely produced for the soluble phase of the ocular tear film. Analyses of ErbB2 and the Muc4/SMC-ErbB2 complex in the lacrimal gland suggest a second function for Muc4/SMC, a role in cell ..
  51. Dankort D, Wang Z, Blackmore V, Moran M, Muller W. Distinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformation. Mol Cell Biol. 1997;17:5410-25 pubmed
    ..These data argue that the transforming potential of activated neu is mediated both by positive and negative regulatory tyrosine phosphorylation sites. ..
  52. Vairaktaris E, Goutzanis L, Vassiliou S, Spyridonidou S, Nkenke E, Papageorgiou G, et al. Enhancement of erbB2 and erbB3 expression during oral oncogenesis in diabetic rats. J Cancer Res Clin Oncol. 2008;134:337-44 pubmed
    The expression of erbB2 and erbB3 receptors was investigated in an experimental model of chemically induced oral carcinogenesis in normal and diabetic (type I) Sprague-Dawley rats...
  53. Young P, Nie J, Wang X, McGlade C, Rich M, Feng G. LNX1 is a perisynaptic Schwann cell specific E3 ubiquitin ligase that interacts with ErbB2. Mol Cell Neurosci. 2005;30:238-48 pubmed
    ..Schwann cells at synapses and that this control may be achieved by the developmental downregulation of the ErbB2 receptor...