Gene Symbol: epsilon subunit
Description: cholinergic receptor nicotinic epsilon subunit
Alias: nAChR, acetylcholine receptor subunit epsilon, acetylcholine receptor epsilon, cholinergic receptor, nicotinic epsilon, cholinergic receptor, nicotinic, epsilon (muscle), cholinergic receptor, nicotinic, epsilon polypeptide, epsilon-subunit, gene for acetylcholine receptor epsilon subunit
Witzemann V, Stein E, Barg B, Konno T, Koenen M, Kues W, et al
. Primary structure and functional expression of the alpha-, beta-, gamma-, delta- and epsilon-subunits of the acetylcholine receptor from rat muscle. Eur J Biochem. 1990;194:437-48 pubmed
..Thus in rat skeletal muscle the motor nerve regulates the expression of two functionally different AChR subtypes with different molecular composition by the differential expression of subunit-specific mRNAs. ..
Albuquerque E, Pereira E, Alkondon M, Rogers S. Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev. 2009;89:73-120 pubmed publisher
..nAChRs), and the discovery of alpha-bungarotoxin, a snake toxin that binds pseudo-irreversibly to the muscle nAChR, resulted in the muscle nAChR being the best characterized ligand-gated ion channel hitherto...
Rasoulpour R, Ellis Hutchings R, Terry C, Millar N, Zablotny C, Gibb A, et al
. A novel mode-of-action mediated by the fetal muscle nicotinic acetylcholine receptor resulting in developmental toxicity in rats. Toxicol Sci. 2012;127:522-34 pubmed publisher
..in rats had a single MoA induced by sulfoxaflor agonism on the fetal rat muscle nicotinic acetylcholine receptor (nAChR)...
Yumoto N, Wakatsuki S, Sehara Fujisawa A. The acetylcholine receptor gamma-to-epsilon switch occurs in individual endplates. Biochem Biophys Res Commun. 2005;331:1522-7 pubmed
..This finding will help our understanding of the mechanisms of the gamma-to-epsilon switch during establishment of the neuromuscular junction. ..
Witzemann V, Chevessier F, Pacifici P, Yampolsky P. The neuromuscular junction: selective remodeling of synaptic regulators at the nerve/muscle interface. Mech Dev. 2013;130:402-11 pubmed publisher
..The results show that detailed analysis of mouse models will help to understand the complexity in mechanisms that regulate synaptic remodeling. ..
Criado M, Witzemann V, Koenen M, Sakmann B. Nucleotide sequence of the rat muscle acetylcholine receptor epsilon-subunit. Nucleic Acids Res. 1988;16:10920 pubmed
Witzemann V, Barg B, Nishikawa Y, Sakmann B, Numa S. Differential regulation of muscle acetylcholine receptor gamma- and epsilon-subunit mRNAs. FEBS Lett. 1987;223:104-12 pubmed
..The results support the view that a switch in the relative abundance of the gamma- and epsilon-subunit mRNAs is a major mechanism in regulating the properties of acetylcholine receptor channels in muscle. ..
Gu Y, Franco A, Gardner P, Lansman J, Forsayeth J, Hall Z. Properties of embryonic and adult muscle acetylcholine receptors transiently expressed in COS cells. Neuron. 1990;5:147-57 pubmed
..Thus, some, but not all, of the differences between AChRs at adult endplates and those in the extrasynaptic membrane can be explained by the difference in subunit composition of gamma- and epsilon-AChRs. ..
Walke W, Staple J, Adams L, Gnegy M, Chahine K, Goldman D. Calcium-dependent regulation of rat and chick muscle nicotinic acetylcholine receptor (nAChR) gene expression. J Biol Chem. 1994;269:19447-56 pubmed
Muscle depolarization leads to decreased expression of nicotinic acetylcholine receptor (nAChR) genes in extrajunctional regions of the muscle fiber with little effect on their expression at the neuromuscular junction (NMJ)...