Gene Symbol: Eno1
Description: enolase 1
Alias: Nne, alpha-enolase, 2-phospho-D-glycerate hydro-lyase, enolase 1, (alpha), enolase 1, alpha non-neuron, non-neural enolase
Species: rat
Products:     Eno1

Top Publications

  1. Kang H, Jung S, Kim S, Chung S. Structure of human alpha-enolase (hENO1), a multifunctional glycolytic enzyme. Acta Crystallogr D Biol Crystallogr. 2008;64:651-7 pubmed publisher
    Aside from its enzymatic function in the glycolytic pathway, alpha-enolase (ENO1) has been implicated in numerous diseases, including metastatic cancer, autoimmune disorders, ischaemia and bacterial infection...
  2. Keller A, Rouzeau J, Farhadian F, Wisnewsky C, Marotte F, Lamande N, et al. Differential expression of alpha- and beta-enolase genes during rat heart development and hypertrophy. Am J Physiol. 1995;269:H1843-51 pubmed
    ..This study indicates that the decrease in beta-enolase gene expression may be linked to beneficial energetic changes in contractile properties occurring during cardiac hypertrophy...
  3. Nakamura N, Dai Q, Williams J, Goulding E, Willis W, Brown P, et al. Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility. Biol Reprod. 2013;88:90 pubmed publisher
    ..The Gm5506 gene encodes a protein identical to ENO1 and also is transcribed at a low level in testis...
  4. Uys G, Ramburan A, Loos B, Kinnear C, Korkie L, Mouton J, et al. Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C. BMC Cell Biol. 2011;12:18 pubmed publisher
    ..Other PKA targets, viz. CARP, COMMD4, ENO1, ENO3 and cTNI were identified as putative interactors, with cTNI being the most frequent interactor...
  5. Ueta H, Nagasawa H, Oyabu Manabe Y, Toida K, Ishimura K, Hori H. Localization of enolase in synaptic plasma membrane as an alphagamma heterodimer in rat brain. Neurosci Res. 2004;48:379-86 pubmed
    ..These findings indicate that all forms (alphaalpha, alphagamma, and gammagamma) of enolase translocate to the plasma membrane and associate with some components in the SPM. ..
  6. Sakimura K, Kushiya E, Obinata M, Takahashi Y. Molecular cloning and the nucleotide sequence of cDNA to mRNA for non-neuronal enolase (alpha alpha enolase) of rat brain and liver. Nucleic Acids Res. 1985;13:4365-78 pubmed
    The nucleotide sequence for alpha alpha enolase (non-neuronal enolase: NNE) of rat brain and liver was determined from recombinant cDNA clones...
  7. Das R, Burke T, Plow E. Histone H2B as a functionally important plasminogen receptor on macrophages. Blood. 2007;110:3763-72 pubmed
    ..Taken together, these data suggest that multiple Plg-Rs do contribute to Plg binding to macrophages, and among these, H2B plays a very prominent and functionally important role. ..
  8. Rapicavoli N, Poth E, Zhu H, Blackshaw S. The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity. Neural Dev. 2011;6:32 pubmed publisher
  9. Subramanian A, Miller D. Structural analysis of alpha-enolase. Mapping the functional domains involved in down-regulation of the c-myc protooncogene. J Biol Chem. 2000;275:5958-65 pubmed
    ..Our data suggest that alpha-enolase plays an important role in regulation of c-myc promoter activity in the form of an alternative translation product MBP-1, which is distinct from its role as a glycolytic enzyme. ..

More Information


  1. Hernández Pérez L, Depardon F, Fernández Ramírez F, Sánchez Trujillo A, Bermúdez Cruz R, Dangott L, et al. ?-Enolase binds to RNA. Biochimie. 2011;93:1520-8 pubmed publisher
    ..Enolase may play other roles in addition to its well described function in glycolysis. ..
  2. Zhu L, Fang N, Gao P, Jin X, Wang H. Differential expression of alpha-enolase in the normal and pathological cardiac growth. Exp Mol Pathol. 2009;87:27-31 pubmed publisher
    ..This phenomenon provides the potential clues to understanding pathophysiological mechanisms in cardiac hypertrophy of SHR. ..
  3. Jin X, Wang L, Xia L, Zheng Y, Meng C, Yu Y, et al. Hyper-phosphorylation of alpha-enolase in hypertrophied left ventricle of spontaneously hypertensive rat. Biochem Biophys Res Commun. 2008;371:804-9 pubmed publisher
    ..The further investigation based on these results would provide new clues to understand the pathological process of cardiac hypertrophy in SHR. ..
  4. Jin X, Xia L, Wang L, Shi J, Zheng Y, Chen W, et al. Differential protein expression in hypertrophic heart with and without hypertension in spontaneously hypertensive rats. Proteomics. 2006;6:1948-56 pubmed
    ..Our results also provide evidence to support the hypothesis that oxidative stress plays an important role in the development of hypertensive cardiac hypertrophy. ..
  5. Lopez Alemany R, Longstaff C, Hawley S, Mirshahi M, Fábregas P, Jardi M, et al. Inhibition of cell surface mediated plasminogen activation by a monoclonal antibody against alpha-Enolase. Am J Hematol. 2003;72:234-42 pubmed
    ..These data suggest that, although leukocytic cells display several molecules that bind plasminogen, alpha-enolase is responsible for the majority of the promotion of plasminogen activation on the surfaces of leukocytic cells. ..
  6. Nakajima K, Hamanoue M, Takemoto N, Hattori T, Kato K, Kohsaka S. Plasminogen binds specifically to alpha-enolase on rat neuronal plasma membrane. J Neurochem. 1994;63:2048-57 pubmed
    ..These results suggest that alpha-enolase may function as a PGn-binding molecule on the neuronal cell surface. ..
  7. Jørgensen O, Centervall G. Alpha gamma-enolase in the rat: ontogeny and tissue distribution. J Neurochem. 1982;39:537-42 pubmed
  8. Giallongo A, Feo S, Moore R, Croce C, Showe L. Molecular cloning and nucleotide sequence of a full-length cDNA for human alpha enolase. Proc Natl Acad Sci U S A. 1986;83:6741-5 pubmed
    ..The transcriptional regulation of enolase expression in response to mitogenic stimulation of peripheral blood lymphocytes and in response to heat shock is also discussed. ..
  9. Gao S, Li H, Feng X, Li M, Liu Z, Cai Y, et al. α-Enolase plays a catalytically independent role in doxorubicin-induced cardiomyocyte apoptosis and mitochondrial dysfunction. J Mol Cell Cardiol. 2015;79:92-103 pubmed publisher
  10. Mizukami Y, Iwamatsu A, Aki T, Kimura M, Nakamura K, Nao T, et al. ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation. J Biol Chem. 2004;279:50120-31 pubmed
    ..Our results reveal that ERK1/2 plays a role in the contractility of cardiomyocytes and cell survival through alpha-enolase expression during ischemic hypoxia and reoxygenation. ..
  11. Obermajer N, Doljak B, Jamnik P, Fonović U, Kos J. Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells. Int J Biochem Cell Biol. 2009;41:1685-96 pubmed publisher
    ..On the other hand, the proliferation of cells is decreased, indicating induction of differentiation. Our study reveals enolase isozymes as crucial neurotrophic factors that are regulated by the proteolytic activity of cathepsin X. ..
  12. Ghosh A, Steele R, Ray R. Functional domains of c-myc promoter binding protein 1 involved in transcriptional repression and cell growth regulation. Mol Cell Biol. 1999;19:2880-6 pubmed
    ..Taken together, our results indicate that MBP-1 is a complex cellular factor containing multiple transcriptional regulatory domains that play an important role in cell growth regulation. ..
  13. Berry M, Gregory R, Grivell A, Henly D, Phillips J, Wallace P, et al. Evidence that stimulation of gluconeogenesis by fatty acid is mediated through thermodynamic mechanisms. FEBS Lett. 1988;231:19-24 pubmed
    ..e. mitochondrial membrane and redox potentials and cellular phosphorylation potential). These findings suggest that the fatty acid stimulation of glucose synthesis is in part mediated through thermodynamic mechanisms. ..
  14. Ledesma M, Da Silva J, Schevchenko A, Wilm M, Dotti C. Proteomic characterisation of neuronal sphingolipid-cholesterol microdomains: role in plasminogen activation. Brain Res. 2003;987:107-16 pubmed
    ..These observations suggest that neuronal rafts may play, in addition to intracellular signaling, a role in extracellular/membrane protein proteolysis. ..
  15. Luo Q, Jiang L, Chen G, Feng Y, Lv Q, Zhang C, et al. Constitutive heat shock protein 70 interacts with ?-enolase and protects cardiomyocytes against oxidative stress. Free Radic Res. 2011;45:1355-65 pubmed publisher
    ..Our research suggests that the protective effect of Hsc70 on the cardiomyocytes against oxidative stress is partly associated with its interaction with ?-enolase. ..
  16. Couldrey C, Carlton M, Ferrier J, Colledge W, Evans M. Disruption of murine alpha-enolase by a retroviral gene trap results in early embryonic lethality. Dev Dyn. 1998;212:284-92 pubmed
    ..Mutations of this gene in humans are reported to be associated with rare autosomal-dominant, non-spherocytic haemolytic anaemia. This phenotype is not reproduced in mice heterozygous for this mutation. ..
  17. Forster F, Paster W, Supper V, Schatzlmaier P, Sunzenauer S, Ostler N, et al. Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton. J Immunol. 2014;192:771-81 pubmed publisher
    ..We conclude that GBP-1 is a downstream processor of IFN-? via which T cells regulate cytoskeleton-dependent cell functions. ..
  18. Ray R, Miller D. Cloning and characterization of a human c-myc promoter-binding protein. Mol Cell Biol. 1991;11:2154-61 pubmed
    ..Coexpression of the MBP-1 protein repress transcription from the human c-myc promoter, suggesting that MBP-1 may act as a negative regulatory factor for the human c-myc gene. ..