endoglin

Summary

Gene Symbol: endoglin
Description: endoglin
Alias: endoglin
Species: rat
Products:     endoglin

Top Publications

  1. McAllister K, Grogg K, Johnson D, Gallione C, Baldwin M, Jackson C, et al. Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet. 1994;8:345-51 pubmed
    ..Linkage for some families has been established to chromosome 9q33-q34. In the present study, endoglin, a transforming growth factor beta (TGF-beta) binding protein, was analysed as a candidate gene for the disorder ..
  2. Nachtigal P, Pospisilova N, Jamborova G, Pospechova K, Solichova D, Andrys C, et al. Endothelial expression of endoglin in normocholesterolemic and hypercholesterolemic C57BL/6J mice before and after atorvastatin treatment. Can J Physiol Pharmacol. 2007;85:767-73 pubmed
    b>Endoglin (CD105) is a homodimeric transmembrane glycoprotein strongly related to transforming growth factor (TGF)-beta signaling and many pathological states...
  3. Chen K, Mehta J, Li D, Joseph L, Joseph J. Transforming growth factor beta receptor endoglin is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II. Circ Res. 2004;95:1167-73 pubmed
    ..that Ang II alters transforming growth factor beta (TGF-beta) receptor expression, specifically that of endoglin, and thereby modulates cardiac fibroblast (CF) collagen metabolism...
  4. Shyu K, Wang B, Wu G, Lin C, Chang H. Mechanical stretch via transforming growth factor-?1 activates microRNA208a to regulate endoglin expression in cultured rat cardiac myoblasts. Eur J Heart Fail. 2013;15:36-45 pubmed publisher
    ..Mechanical stretch significantly increased endoglin and collagen I expression for 6-24 h...
  5. David L, Mallet C, Mazerbourg S, Feige J, Bailly S. Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood. 2007;109:1953-61 pubmed
    ..Overexpression of endoglin increases the BMP9 response, whereas silencing of both BMPRII and ActRIIA expressions completely abolishes it...
  6. Meurer S, Tihaa L, Borkham Kamphorst E, Weiskirchen R. Expression and functional analysis of endoglin in isolated liver cells and its involvement in fibrogenic Smad signalling. Cell Signal. 2011;23:683-99 pubmed publisher
    b>Endoglin is an accessory component of the TGF-?-binding receptor complex that differentially modulates TGF-? and BMP responses...
  7. Bourdeau A, Dumont D, Letarte M. A murine model of hereditary hemorrhagic telangiectasia. J Clin Invest. 1999;104:1343-51 pubmed
    b>Endoglin (CD105), an accessory protein of the TGF-beta receptor superfamily, is highly expressed on endothelial cells...
  8. Arthur H, Ure J, Smith A, Renforth G, Wilson D, Torsney E, et al. Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. Dev Biol. 2000;217:42-53 pubmed
    b>Endoglin (CD105) is expressed on the surface of endothelial and haematopoietic cells in mammals and binds TGFbeta isoforms 1 and 3 in combination with the signaling complex of TGFbeta receptors types I and II...
  9. Shyu K, Wang B, Chen W, Kuan P, Hung C. Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-beta1 in cultured cardiac fibroblasts. Eur J Heart Fail. 2010;12:219-26 pubmed publisher
    Transforming growth factor-beta1 (TGF-beta1) and endoglin play a causal role in promoting cardiac fibrosis. Atorvastatin has been shown to have an inhibitory effect on cardiac fibroblasts in vitro...

More Information

Publications76

  1. Guerrero Esteo M, Sanchez Elsner T, Letamendia A, Bernabeu C. Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II. J Biol Chem. 2002;277:29197-209 pubmed
    b>Endoglin is an auxiliary component of the transforming growth factor-beta (TGF-beta) receptor system, able to associate with the signaling receptor types I (TbetaRI) and II (TbetaRII) in the presence of ligand and to modulate the cellular ..
  2. Docherty N, Lopez Novoa J, Arevalo M, Düwel A, Rodriguez Peña A, Perez Barriocanal F, et al. Endoglin regulates renal ischaemia-reperfusion injury. Nephrol Dial Transplant. 2006;21:2106-19 pubmed
    Renal ischaemia-reperfusion (I-R) can cause acute tubular necrosis and chronic renal deterioration. Endoglin, an accessory receptor for Transforming Growth Factor-beta1 (TGF-beta1), is expressed on activated endothelium during macrophage ..
  3. Scherner O, Meurer S, Tihaa L, Gressner A, Weiskirchen R. Endoglin differentially modulates antagonistic transforming growth factor-beta1 and BMP-7 signaling. J Biol Chem. 2007;282:13934-43 pubmed
    ..protein-7; OP-1) play central, antagonistic roles in kidney fibrosis, a setting in which the expression of endoglin (CD105), an accessory TGF-beta type III receptor, is increased...
  4. Blanco F, Santibanez J, Guerrero Esteo M, Langa C, Vary C, Bernabeu C. Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex. J Cell Physiol. 2005;204:574-84 pubmed
    ..b>Endoglin and ALK-1 are components of the TGF-beta receptor complex, predominantly expressed in endothelial cells, and ..
  5. Li D, Sorensen L, Brooke B, Urness L, Davis E, Taylor D, et al. Defective angiogenesis in mice lacking endoglin. Science. 1999;284:1534-7 pubmed
    b>Endoglin is a transforming growth factor-beta (TGF-beta) binding protein expressed on the surface of endothelial cells...
  6. Tomlinson R, McKenzie J, Schmieder A, Wohl G, Lanza G, Silva M. Angiogenesis is required for stress fracture healing in rats. Bone. 2013;52:212-9 pubmed publisher
    ..These results indicate that angiogenesis is required for stress fracture healing, and may have implications for inducing rapid repair of stress fractures. ..
  7. Bellon T, Corbi A, Lastres P, Calés C, Cebrian M, Vera S, et al. Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Eur J Immunol. 1993;23:2340-5 pubmed
    b>Endoglin is an homodimeric membrane antigen with capacity to bind transforming growth factor-beta (TGF-beta) and whose expression is up-regulated on myeloid cells upon differentiation to macrophages...
  8. Dubinski W, Gabril M, Iakovlev V, Scorilas A, Youssef Y, Faragalla H, et al. Assessment of the prognostic significance of endoglin (CD105) in clear cell renal cell carcinoma using automated image analysis. Hum Pathol. 2012;43:1037-43 pubmed publisher
    ..Angiogenesis has proven to be a useful prognostic indicator in different malignancies. Endoglin (CD105) is a new marker of angiogenesis found to have prognostic utility in various tumors...
  9. Toporsian M, Jerkic M, Zhou Y, Kabir M, Yu L, McIntyre B, et al. Spontaneous adult-onset pulmonary arterial hypertension attributable to increased endothelial oxidative stress in a murine model of hereditary hemorrhagic telangiectasia. Arterioscler Thromb Vasc Biol. 2010;30:509-17 pubmed publisher
    ..How these abnormalities lead to seemingly disparate pulmonary pathologies remains unknown. Endoglin (Eng), a transforming growth factor-beta coreceptor, is mutated in hereditary hemorrhagic telangiectasia and ..
  10. Romero D, Terzic A, Conley B, Craft C, Jovanovic B, Bergan R, et al. Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration. Carcinogenesis. 2010;31:359-66 pubmed publisher
    b>Endoglin, a transmembrane glycoprotein that acts as a transforming growth factor-beta (TGF-beta) coreceptor, is downregulated in PC3-M metastatic prostate cancer cells...
  11. Oxmann D, Held Feindt J, Stark A, Hattermann K, Yoneda T, Mentlein R. Endoglin expression in metastatic breast cancer cells enhances their invasive phenotype. Oncogene. 2008;27:3567-75 pubmed publisher
    b>Endoglin is a cell-surface adhesion protein as well as a coreceptor for transforming growth factor-beta (TGF-beta). It is located on endothelial and few other cells, but also found on certain tumor cells...
  12. Wang B, Wu G, Cheng W, Shyu K. MicroRNA-208a increases myocardial fibrosis via endoglin in volume overloading heart. PLoS ONE. 2014;9:e84188 pubmed publisher
    MicroRNA-208a (mir-208a) is essential for cardiac hypertrophy and fibrosis. Endoglin, a co-receptor of transforming growth factor-? is also essential for cardiac fibrosis...
  13. Wang J, Xu X, Jia J, Wu C, Ge R. Expressions of SE-1, CD31 and CD105 in the vascular endothelial cells and serum of rat with hepatocellular carcinoma. Chin Med J (Engl). 2010;123:730-3 pubmed
    ..4983, P = 0.0011). SE-1, CD31 and CD105 are closely related with liver tumor angiogenesis, which is similar to their performances in terms of their expressions in the serum. ..
  14. Zimmer J, Takahashi T, Hofmann A, Puri P. Decreased Endoglin expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia rat model. Pediatr Surg Int. 2017;33:263-268 pubmed publisher
    ..b>Endoglin (Eng), an auxiliary receptor component of the transforming growth factor ? (TGF?) signalling pathway, is ..
  15. Sorensen L, Brooke B, Li D, Urness L. Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor. Dev Biol. 2003;261:235-50 pubmed
    ..The genes implicated in this disease, ALK1 and endoglin, may be involved in defining the fundamental boundaries between arteries and veins...
  16. Korish A. Magnesium sulfate therapy of preeclampsia: an old tool with new mechanism of action and prospect in management and prophylaxis. Hypertens Res. 2012;35:1005-11 pubmed publisher
    ..placental growth factor (PlGF), nitric oxide (NO) metabolites, soluble fm-like tyrosine kinase-1 (sFlt-1) and endoglin levels in PE rats and the effect of this treatment on the feto-maternal outcome...
  17. Bossler A, Richards J, George C, Godmilow L, Ganguly A. Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype. Hum Mutat. 2006;27:667-75 pubmed
    ..However, when diagnosed early, the complications can usually be prevented. Mutations in two genes, Endoglin (ENG) and activin receptor-like kinase 1 (ACVRL1 or ALK1) have been associated with HHT...
  18. Takahashi N, Haba A, Matsuno F, Seon B. Antiangiogenic therapy of established tumors in human skin/severe combined immunodeficiency mouse chimeras by anti-endoglin (CD105) monoclonal antibodies, and synergy between anti-endoglin antibody and cyclophosphamide. Cancer Res. 2001;61:7846-54 pubmed
    b>Endoglin (EDG; CD105) is a proliferation-associated cell membrane antigen of endothelial cells and is strongly expressed on the tumor-associated angiogenic vascular endothelium...
  19. Scharpfenecker M, Floot B, Russell N, Stewart F. The TGF-? co-receptor endoglin regulates macrophage infiltration and cytokine production in the irradiated mouse kidney. Radiother Oncol. 2012;105:313-20 pubmed publisher
    We previously showed that mice with reduced levels of the transforming growth factor-beta (TGF-?) co-receptor endoglin (Eng(+/-) mice) develop less fibrosis and vascular damage after kidney irradiation than their wild type (Eng(+/+) mice) ..
  20. Fowler C, Josefsson A, Thors L, Chung S, Hammarsten P, Wikstrom P, et al. Tumour epithelial expression levels of endocannabinoid markers modulate the value of endoglin-positive vascular density as a prognostic marker in prostate cancer. Biochim Biophys Acta. 2013;1831:1579-87 pubmed publisher
    ..Scores for the angiogenesis markers endoglin and von Willebrand factor (vWf), the endocannabinoid markers fatty acid amide hydrolase (FAAH) and cannabinoid ..
  21. Wood L, Pan Z, Guirnalda P, Tsai P, Seavey M, Paterson Y. Targeting tumor vasculature with novel Listeria-based vaccines directed against CD105. Cancer Immunol Immunother. 2011;60:931-42 pubmed publisher
    ..One promising target present specifically on tumor vasculature is endoglin (CD105), a member of the TGF-? receptor complex expressed on vascular endothelium and believed to play a role in ..
  22. Letarte M, McDonald M, Li C, Kathirkamathamby K, Vera S, Pece Barbara N, et al. Reduced endothelial secretion and plasma levels of transforming growth factor-beta1 in patients with hereditary hemorrhagic telangiectasia type 1. Cardiovasc Res. 2005;68:155-64 pubmed
    ..TGF-beta1 in plasma, or secreted by HUVEC, and plasma endoglin levels were measured by ELISA...
  23. Cheifetz S, Bellon T, Calés C, Vera S, Bernabeu C, Massague J, et al. Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. J Biol Chem. 1992;267:19027-30 pubmed
    b>Endoglin, a dimeric membrane glycoprotein expressed at high levels on human vascular endothelial cells, shares regions of sequence identity with betaglycan, a major binding protein for transforming growth factor-beta (TGF-beta) that co-..
  24. Shovlin C, Hughes J, Scott J, Seidman C, Seidman J. Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia. Am J Hum Genet. 1997;61:68-79 pubmed
    ..Linkage studies in four of eight families indicated an endoglin (ENG) gene mutation...
  25. Prieto M, Rodríguez Peña A, Duwel A, Rivas J, Docherty N, Perez Barriocanal F, et al. Temporal changes in renal endoglin and TGF-beta1 expression following ureteral obstruction in rats. J Physiol Biochem. 2005;61:457-67 pubmed
    ..b>Endoglin is a membrane glycoprotein of the TGF-beta1 receptor system...
  26. Ramesar S, Drewes S, Gathiram P, Moodley J, Mackraj I. The effect of Kraussianone-2 (Kr2), a natural pyrano-isoflavone from Eriosema kraussianum, in an L-NAME- induced pre-eclamptic rat model. Phytother Res. 2012;26:1375-80 pubmed publisher
    ..the plasma concentrations of two antiangiogenic factors, soluble fms-like tyrosine kinase1 (sFlt-1) and soluble endoglin (sEng)...
  27. Sanz Rodriguez F, Fernandez L A, Zarrabeitia R, Perez Molino A, Ramirez J, Coto E, et al. Mutation analysis in Spanish patients with hereditary hemorrhagic telangiectasia: deficient endoglin up-regulation in activated monocytes. Clin Chem. 2004;50:2003-11 pubmed
    Mutations in the endoglin (ENG) or ALK1 genes are responsible for hereditary hemorrhagic telangiectasia types 1 and 2 (HHT1 and HHT2), respectively, a dominant vascular dysplasia caused by haploinsufficiency...
  28. Catchpoole D, Lail A, Guo D, Chen Q, Khan J. Gene expression profiles that segregate patients with childhood acute lymphoblastic leukaemia: an independent validation study identifies that endoglin associates with patient outcome. Leuk Res. 2007;31:1741-7 pubmed
    ..An artificial neural network identified endoglin, which was reported in the initial study as a potential lineage marker, was actually better at identifying ALL ..
  29. Sandlund J, Hedberg Y, Bergh A, Grankvist K, Ljungberg B, Rasmuson T. Endoglin (CD105) expression in human renal cell carcinoma. BJU Int. 2006;97:706-10 pubmed
    To evaluate the prognostic potential of endoglin (CD105) expression in human renal cell carcinoma (RCC), as endoglin is a cell membrane glycoprotein expressed in tumour-associated vascular endothelium and a marker of angiogenesis; ..
  30. Yu Y, Jenkins A, Nankervis A, Hanssen K, Scholz H, Henriksen T, et al. Anti-angiogenic factors and pre-eclampsia in type 1 diabetic women. Diabetologia. 2009;52:160-8 pubmed publisher
    ..as soluble fms-like tyrosine kinase 1 (sFlt1), a soluble form of vascular endothelial growth factor receptor, and endoglin, a co-receptor for TGFbeta1, confer high risk of pre-eclampsia in healthy pregnant women...
  31. Ikemoto T, Hojo Y, Kondo H, Takahashi N, Hirose M, Nishimura Y, et al. Plasma endoglin as a marker to predict cardiovascular events in patients with chronic coronary artery diseases. Heart Vessels. 2012;27:344-51 pubmed publisher
    Recent clinical studies have revealed that the expression of endoglin, an accessory protein for the TGF-? receptor, is increased in patients with atherosclerotic diseases...
  32. Alvarez Muñoz P, Mauer M, Kim Y, Rich S, Miller M, Russell G, et al. Cellular basis of diabetic nephropathy: V. Endoglin expression levels and diabetic nephropathy risk in patients with Type 1 diabetes. J Diabetes Complications. 2010;24:242-9 pubmed publisher
    b>Endoglin is an accessory receptor molecule that, in association with transforming growth factor beta (TGF-beta) family receptors Types I and II, binds TGF-beta1, TGF-beta3, activin A, bone morphogenetic protein (BMP)-2 and BMP-7, ..
  33. Yinon Y, Nevo O, Xu J, Many A, Rolfo A, Todros T, et al. Severe intrauterine growth restriction pregnancies have increased placental endoglin levels: hypoxic regulation via transforming growth factor-beta 3. Am J Pathol. 2008;172:77-85 pubmed
    b>Endoglin, a co-receptor for transforming growth factor (TGF)-beta 1 and -beta 3 is expressed in the human placenta and plays an important role in the pathogenesis of preeclampsia...
  34. Shen F, Degos V, Chu P, Han Z, Westbroek E, Choi E, et al. Endoglin deficiency impairs stroke recovery. Stroke. 2014;45:2101-6 pubmed publisher
    b>Endoglin deficiency causes hereditary hemorrhagic telangiectasia-1 and impairs myocardial repair...
  35. Martins P, Schmitt F, Almeida H, Frazao J. Evaluation of parathyroid gland angiogenesis in chronic kidney disease associated with secondary hyperparathyroidism. Nephrol Dial Transplant. 2008;23:2889-94 pubmed publisher
    ..Angiogenesis was evaluated by immunohistochemistry staining with anti-endoglin (CD105) antibody in 21 SPH and 5 NPG by stereological analysis...
  36. Gilbert J, Gilbert S, Arany M, Granger J. Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expression. Hypertension. 2009;53:399-403 pubmed publisher
    Recent clinical studies indicate that an excess of angiostatic factors, such as soluble endoglin (sEng), is related to the occurrence of preeclampsia...
  37. Lesca G, Plauchu H, Coulet F, Lefebvre S, Plessis G, Odent S, et al. Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France. Hum Mutat. 2004;23:289-99 pubmed
    ..1231C>T (p.Arg411Trp), c.1232G>C (p.Arg411Pro), and c.1232G>A (p.Arg411Gln) were found in seven, two, and one patients, respectively. Haplotype analysis was in favor of both a founder effect and a mutation hot-spot. ..
  38. Doridot L, Passet B, Mehats C, Rigourd V, Barbaux S, Ducat A, et al. Preeclampsia-like symptoms induced in mice by fetoplacental expression of STOX1 are reversed by aspirin treatment. Hypertension. 2013;61:662-8 pubmed publisher
    ..hypertension, proteinuria, and elevated plasma levels of soluble fms-like tyrosine kinase 1 and soluble endoglin. Placental and kidney histology were altered. Symptoms were prevented or alleviated by aspirin treatment...
  39. Li W, Febbraio M, Reddy S, Yu D, Yamamoto M, Silverstein R. CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest. 2010;120:3996-4006 pubmed publisher
    ..These data suggest that CD36-mediated downregulation of antioxidant systems in VSMCs may contribute to its prothrombotic, proinflammatory, and atherogenic effects. ..
  40. Shyu K, Wang B, Cheng W, Lo H. MicroRNA-208a Increases Myocardial Endoglin Expression and Myocardial Fibrosis in Acute Myocardial Infarction. Can J Cardiol. 2015;31:679-90 pubmed publisher
    ..MiR-208a activates endoglin expression and may result in cardiac fibrosis. The role of miR-208a and endoglin in AMI is not known...
  41. Lastres P, Bellon T, Cabanas C, Sanchez Madrid F, Acevedo A, Gougos A, et al. Regulated expression on human macrophages of endoglin, an Arg-Gly-Asp-containing surface antigen. Eur J Immunol. 1992;22:393-7 pubmed
    b>Endoglin is an endothelial homodimeric membrane antigen containing the tripeptide arginine-glycine-aspartic acid (RGD), which is a recognition motif for adhesion receptors of the integrin family...
  42. Barbara N, Wrana J, Letarte M. Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. J Biol Chem. 1999;274:584-94 pubmed
    b>Endoglin (CD105) is a transmembrane glycoprotein that binds transforming growth factor (TGF)-beta1 and -beta3, and coprecipitates with the Ser/Thr kinase signaling receptor complex by affinity labeling of endothelial and leukemic cells...
  43. Wallace G, Shovlin C. A hereditary haemorrhagic telangiectasia family with pulmonary involvement is unlinked to the known HHT genes, endoglin and ALK-1. Thorax. 2000;55:685-90 pubmed
    ..Mutations in two genes, endoglin and ALK-1, are known to cause HHT...
  44. Ozbey O, Sahin Z, Ozenci A, Acar N, Ustunel I. The effect of systemic corticosteroid treatment on the immunolocalisation of Notch-1, Delta, CD105 and CD166 in rat articular cartilage. Acta Histochem. 2010;112:424-31 pubmed publisher
  45. Choi E, Chen W, Jun K, Arthur H, Young W, Su H. Novel brain arteriovenous malformation mouse models for type 1 hereditary hemorrhagic telangiectasia. PLoS ONE. 2014;9:e88511 pubmed publisher
    b>Endoglin (ENG) is a causative gene of type 1 hereditary hemorrhagic telangiectasia (HHT1). HHT1 patients have a higher prevalence of brain arteriovenous malformation (AVM) than the general population and patients with other HHT subtypes...
  46. Fujita K, Ewing C, Chan D, Mangold L, Partin A, Isaacs W, et al. Endoglin (CD105) as a urinary and serum marker of prostate cancer. Int J Cancer. 2009;124:664-9 pubmed publisher
    We have previously shown that endoglin (CD105) is upregulated in prostatic fluid of men with large volume prostate cancer...
  47. Prieto M, Rodriguez Peña A, Arevalo M, Rivas J, Düwel A, Eleno N, et al. Effect of the long-term treatment with trandolapril on endoglin expression in rats with experimental renal fibrosis induced by renal mass reduction. Kidney Blood Press Res. 2005;28:32-40 pubmed
    b>Endoglin is a membrane glycoprotein that regulates TGF-beta1 signaling...
  48. Gu J, Young E, Pan Z, Tucker K, Shparago M, Huang M, et al. Long-term high salt diet causes hypertension and alters renal cytokine gene expression profiles in Sprague-Dawley rats. Beijing Da Xue Xue Bao Yi Xue Ban. 2009;41:505-15 pubmed
    ..upward arrowIL-17, CCL28; downward arrow NFkappabib); (2) endothelial dysfunction ( downward arrowVEGF-A, VEGF-B, endoglin); (3) pro-matrix formation ( upward arrowosteopontin, IGFBP-5; downward arrow IFN-gamma); and (4) attenuated cell ..
  49. Mancini M, Verdi J, Conley B, Nicola T, Spicer D, Oxburgh L, et al. Endoglin is required for myogenic differentiation potential of neural crest stem cells. Dev Biol. 2007;308:520-33 pubmed
    ..Here we demonstrate that the TGFbeta auxiliary coreceptor endoglin (eng, CD105) is expressed in a subset of neural crest stem cells (NCSCs) in vivo and is required for their ..
  50. Ozbey O, Sahin Z, Acar N, Ustunel I. Distribution of CD105 and CD166 positive cells in the proximal epiphysis of developing rat humerus. Histol Histopathol. 2010;25:1437-45 pubmed publisher
  51. Blanco F, Grande M, Langa C, Oujo B, Velasco S, Rodriguez Barbero A, et al. S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology. Circ Res. 2008;103:1383-92 pubmed publisher
    ..Here, we have analyzed the expression, during EC senescence, of 2 different isoforms (L, long; S, short) of endoglin, an auxiliary transforming growth factor (TGF)-beta receptor involved in vascular remodeling and angiogenesis...
  52. Somashekar S, Sammour I, Huang J, Dominguez Bendala J, Pastori R, Alvarez Cubela S, et al. Intra-Amniotic Soluble Endoglin Impairs Lung Development in Neonatal Rats. Am J Respir Cell Mol Biol. 2017;57:468-476 pubmed publisher
    Soluble endoglin (sENG) is increased in the amniotic fluid of women with preeclampsia and chorioamnionitis. Preterm infants born to women with these disorders have an increased risk of aberrant lung development...
  53. Saito T, Bokhove M, Croci R, Zamora Caballero S, Han L, Letarte M, et al. Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1. Cell Rep. 2017;19:1917-1928 pubmed publisher
    b>Endoglin (ENG)/CD105 is an essential endothelial cell co-receptor of the transforming growth factor β (TGF-β) superfamily, mutated in hereditary hemorrhagic telangiectasia type 1 (HHT1) and involved in tumor angiogenesis and ..
  54. Pappa C, Alexandrakis M, Boula A, Psarakis F, Kolovou A, Bantouna V, et al. Emerging roles of endoglin/CD105 and angiogenic cytokines for disease development and progression in multiple myeloma patients. Hematol Oncol. 2013;31:201-5 pubmed publisher
    ..b>Endoglin (CD105) is a transforming growth factor-? co-receptor, being mainly expressed in angiogenic endothelial cells and ..
  55. St Jacques S, Cymerman U, Pece N, Letarte M. Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells. Endocrinology. 1994;134:2645-57 pubmed
    b>Endoglin is an integral membrane glycoprotein predominantly expressed on human endothelial cells and recently shown to bind transforming growth factor-beta 1 (TGF beta 1) with high affinity...
  56. Meurer S, Tihaa L, Lahme B, Gressner A, Weiskirchen R. Identification of endoglin in rat hepatic stellate cells: new insights into transforming growth factor beta receptor signaling. J Biol Chem. 2005;280:3078-87 pubmed
    ..signaling is mediated by the cell surface TGF-beta type I (ALK5), type II, and the accessory type III receptors endoglin and betaglycan...
  57. Nomura Kitabayashi A, Anderson G, Sleep G, Mena J, Karabegovic A, Karamath S, et al. Endoglin is dispensable for angiogenesis, but required for endocardial cushion formation in the midgestation mouse embryo. Dev Biol. 2009;335:66-77 pubmed publisher
    ..b>Endoglin is a transmembrane receptor for members of the TGF-beta superfamily that is expressed on endothelial cells from ..
  58. Ilhan N, Gungor H, Gül H, Eroksuz H. Expression of Endoglin and Vascular Endothelial Growth Factor as Prognostic Markers in Experimental Colorectal Cancer. Anticancer Res. 2016;36:3953-9 pubmed
    b>Endoglin (CD105) is a receptor for the transforming growth factor-beta 1 (TGF?1) with crucial role in vascular development and angiogenesis...
  59. Vrbacky F, Nekvindova J, Rezácová V, Simkovic M, Motyckova M, Belada D, et al. Prognostic relevance of angiopoietin-2, fibroblast growth factor-2 and endoglin mRNA expressions in chronic lymphocytic leukemia. Neoplasma. 2014;61:585-92 pubmed publisher
    ..pilot results, we measured mRNA expressions of angiopoietin-2 (Ang-2), fibroblast growth factor-2 (FGF-2) and endoglin (CD105) by reverse transcription quantitative PCR in purified CD19+ cells from 70 untreated CLL patients (median ..
  60. Hlushchuk R, Styp Rekowska B, Dzambazi J, Wnuk M, Huynh Do U, Makanya A, et al. Endoglin inhibition leads to intussusceptive angiogenesis via activation of factors related to COUP-TFII signaling pathway. PLoS ONE. 2017;12:e0182813 pubmed publisher
    ..In the current study two molecules involved in vascular growth and differentiation, namely endoglin (ENG/CD105) and chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) were examined to unravel ..
  61. Qiu J, Li J, He T. Endothelial cell damage induces a blood-alveolus barrier breakdown in the development of radiation-induced lung injury. Asia Pac J Clin Oncol. 2011;7:392-8 pubmed publisher
  62. Berg J, Guttmacher A, Marchuk D, Porteous M. Clinical heterogeneity in hereditary haemorrhagic telangiectasia: are pulmonary arteriovenous malformations more common in families linked to endoglin?. J Med Genet. 1996;33:256-7 pubmed
    ..At least two different loci have been shown for HHT. Mutations in endoglin have been found in some families and the locus designated ORW1. In other families this locus has been excluded...
  63. Wang X, Abraham S, McKenzie J, Jeffs N, Swire M, Tripathi V, et al. LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling. Nature. 2013;499:306-11 pubmed publisher
    ..LRG1 binds directly to the TGF-β accessory receptor endoglin, which, in the presence of TGF-β1, results in promotion of the pro-angiogenic Smad1/5/8 signalling pathway...
  64. Malik R, Li C, Aziz W, Olson J, Vohra A, McHardy K, et al. Elevated plasma CD105 and vitreous VEGF levels in diabetic retinopathy. J Cell Mol Med. 2005;9:692-7 pubmed
    ..Further studies are required to determine whether circulating CD105 levels could serve as a surrogate marker for early stage retinopathy and for monitoring disease progression. ..
  65. Irani R, Zhang Y, Zhou C, Blackwell S, Hicks M, Ramin S, et al. Autoantibody-mediated angiotensin receptor activation contributes to preeclampsia through tumor necrosis factor-alpha signaling. Hypertension. 2010;55:1246-53 pubmed publisher
    ..Injection of AT(1)-AA increased the serum levels of circulating soluble fms-like tyrosine kinase 1 and soluble endoglin (34.1+/-5.1, 2.4+/-0...
  66. Sadlier D, Connolly S, Kieran N, Roxburgh S, Brazil D, Kairaitis L, et al. Sequential extracellular matrix-focused and baited-global cluster analysis of serial transcriptomic profiles identifies candidate modulators of renal tubulointerstitial fibrosis in murine adriamycin-induced nephropathy. J Biol Chem. 2004;279:29670-80 pubmed
    ..Among the genes clustering with ECM proteins in the latter analysis were endoglin, clusterin, and gelsolin. In several notable cases (e.g...
  67. Leaños Miranda A, Campos Galicia I, Ramírez Valenzuela K, Chinolla Arellano Z, Isordia Salas I. Circulating angiogenic factors and urinary prolactin as predictors of adverse outcomes in women with preeclampsia. Hypertension. 2013;61:1118-25 pubmed publisher
    ..Serum concentrations of soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF), and soluble endoglin (sEng), as well as urinary PRL levels, were measured by enzymed-linked immunosorbent assay...