Gene Symbol: Eloc
Description: elongin C
Alias: Tceb1, elongin-C, transcription elongation factor B polypeptide 1, RNA polymerase II transcription factor SIII subunit C, SIII p15, elongation factor SIII p15 subunit, elongin 15 kDa subunit, stromal membrane-associated protein SMAP1B homolog, transcription elongation factor B (SIII), polypeptide 1, transcription elongation factor B subunit 1
Species: rat
Products:     Eloc

Top Publications

  1. Brower C, Shilatifard A, Mather T, Kamura T, Takagi Y, Haque D, et al. The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C. J Biol Chem. 1999;274:13629-36 pubmed
    ..this report, we show that the Elongin B ubiquitin-like domain is necessary and sufficient for interaction with Elongin C and for positive regulation of Elongin A transcriptional activity...
  2. Kamura T, Burian D, Yan Q, Schmidt S, Lane W, Querido E, et al. Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. J Biol Chem. 2001;276:29748-53 pubmed
    ..Taken together, our findings identify MUF1 as a new member of the BC-box family of proteins, and they predict the existence of a larger family of Elongin BC-based E3 ubiquitin ligases. ..
  3. Woo J, Imm J, Min C, Kim K, Cha S, Oh B. Structural and functional insights into the B30.2/SPRY domain. EMBO J. 2006;25:1353-63 pubmed
    ..2/SPRY domains, suggesting that these domains are protein-interacting modules, which recognize a specific individual partner protein rather than a consensus sequence motif. ..
  4. Semenza G. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda). 2009;24:97-106 pubmed publisher
    ..HIF-1 also mediates maladaptive responses to chronic continuous and intermittent hypoxia, which underlie the development of pulmonary and systemic hypertension, respectively. ..
  5. Garrett K, Tan S, Bradsher J, Lane W, Conaway J, Conaway R. Molecular cloning of an essential subunit of RNA polymerase II elongation factor SIII. Proc Natl Acad Sci U S A. 1994;91:5237-41 pubmed
    ..A homology search revealed that the amino-terminal half of the SIII p15 subunit shares significant sequence similarity with a portion of the RNA-binding domain of Escherichia coli ..
  6. Bradsher J, Jackson K, Conaway R, Conaway J. RNA polymerase II transcription factor SIII. I. Identification, purification, and properties. J Biol Chem. 1993;268:25587-93 pubmed
    ..All three polypeptides are required to reconstitute SIII transcriptional activity. SIII appears distinct from previously identified mammalian transcription factors. ..
  7. Takagi Y, Pause A, Conaway R, Conaway J. Identification of elongin C sequences required for interaction with the von Hippel-Lindau tumor suppressor protein. J Biol Chem. 1997;272:27444-9 pubmed
    b>Elongin C is a 112-amino acid protein that is found in mammalian cells as a positive regulatory subunit of heterotrimeric RNA polymerase II elongation factor Elongin (SIII) and as a component of a multiprotein complex containing the von ..
  8. Yasukawa T, Kamura T, Kitajima S, Conaway R, Conaway J, Aso T. Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1. EMBO J. 2008;27:3256-66 pubmed publisher
    ..Taken together, our results suggest that mammalian Elongin A is directly involved in ubiquitylation and degradation of Rpb1 following DNA damage. ..
  9. Kamura T, Koepp D, Conrad M, Skowyra D, Moreland R, Iliopoulos O, et al. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science. 1999;284:657-61 pubmed
    ..The VHL protein is part of a complex that includes Elongin B, Elongin C, and Cullin-2, proteins associated with transcriptional elongation and ubiquitination...