Elob

Summary

Gene Symbol: Elob
Description: elongin B
Alias: Tceb2, elongin-B, transcription elongation factor B polypeptide 2, RNA polymerase II transcription factor SIII subunit B, SIII p18, elongin 18 kDa subunit, transcription elongation factor B (SIII) polypeptide 2 (18kD, elongin B), transcription elongation factor B (SIII), polypeptide 2, transcription elongation factor B subunit 2
Species: rat
Products:     Elob

Top Publications

  1. Kamura T, Koepp D, Conrad M, Skowyra D, Moreland R, Iliopoulos O, et al. Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science. 1999;284:657-61 pubmed
    ..The VHL protein is part of a complex that includes Elongin B, Elongin C, and Cullin-2, proteins associated with transcriptional elongation and ubiquitination...
  2. Semenza G. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology (Bethesda). 2009;24:97-106 pubmed publisher
    ..HIF-1 also mediates maladaptive responses to chronic continuous and intermittent hypoxia, which underlie the development of pulmonary and systemic hypertension, respectively. ..
  3. Garrett K, Aso T, Bradsher J, Foundling S, Lane W, Conaway R, et al. Positive regulation of general transcription factor SIII by a tailed ubiquitin homolog. Proc Natl Acad Sci U S A. 1995;92:7172-6 pubmed
    ..Here we report molecular cloning and biochemical characterization of the SIII p18 subunit, which is found to be a member of the ubiquitin homology (UbH) gene family and functions as a positive ..
  4. Takagi Y, Pause A, Conaway R, Conaway J. Identification of elongin C sequences required for interaction with the von Hippel-Lindau tumor suppressor protein. J Biol Chem. 1997;272:27444-9 pubmed
    ..A subunit and potently induces its elongation activity; in addition, Elongin C interacts with the ubiquitin-like Elongin B subunit, which regulates the interaction of Elongin C with Elongin A...
  5. Brower C, Shilatifard A, Mather T, Kamura T, Takagi Y, Haque D, et al. The elongin B ubiquitin homology domain. Identification of Elongin B sequences important for interaction with Elongin C. J Biol Chem. 1999;274:13629-36 pubmed
    Mammalian Elongin B is a 118-amino acid protein composed of an 84-amino acid amino-terminal ubiquitin-like domain and a 34-amino acid carboxyl-terminal tail...
  6. Ferguson J, Wu Y, Smith K, Charles P, Powers K, Wang H, et al. ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism. Mol Cell Biol. 2007;27:6407-19 pubmed
    ..Like other SOCS box-containing proteins, ASB4 is the substrate recognition molecule of an elongin B/elongin C/cullin/Roc ubiquitin ligase complex that mediates the ubiquitination and degradation of substrate ..
  7. Kamura T, Burian D, Yan Q, Schmidt S, Lane W, Querido E, et al. Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. J Biol Chem. 2001;276:29748-53 pubmed
    ..Taken together, our findings identify MUF1 as a new member of the BC-box family of proteins, and they predict the existence of a larger family of Elongin BC-based E3 ubiquitin ligases. ..
  8. Brower C, Sato S, Tomomori Sato C, Kamura T, Pause A, Stearman R, et al. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc Natl Acad Sci U S A. 2002;99:10353-8 pubmed
    ..Taken together, our findings are consistent with the model that MED8 could function to recruit ubiquitin ligase activity directly to the RNA polymerase II transcriptional machinery. ..
  9. Bradsher J, Jackson K, Conaway R, Conaway J. RNA polymerase II transcription factor SIII. I. Identification, purification, and properties. J Biol Chem. 1993;268:25587-93 pubmed
    ..All three polypeptides are required to reconstitute SIII transcriptional activity. SIII appears distinct from previously identified mammalian transcription factors. ..

More Information

Publications11

  1. Woo J, Imm J, Min C, Kim K, Cha S, Oh B. Structural and functional insights into the B30.2/SPRY domain. EMBO J. 2006;25:1353-63 pubmed
    ..2/SPRY domains, suggesting that these domains are protein-interacting modules, which recognize a specific individual partner protein rather than a consensus sequence motif. ..
  2. Yasukawa T, Kamura T, Kitajima S, Conaway R, Conaway J, Aso T. Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1. EMBO J. 2008;27:3256-66 pubmed publisher
    ..Taken together, our results suggest that mammalian Elongin A is directly involved in ubiquitylation and degradation of Rpb1 following DNA damage. ..