Eif5a

Summary

Gene Symbol: Eif5a
Description: eukaryotic translation initiation factor 5A
Alias: eukaryotic translation initiation factor 5A-1, eIF-4D, eIF-5A, eIF-5A-1, eIF-5A1, eukaryotic initiation factor 5A
Species: rat
Products:     Eif5a

Top Publications

  1. Gulappa T, Menon B, Menon K. Hypusination of eukaryotic initiation factor 5A via cAMP-PKA-ERK1/2 pathway is required for ligand-induced downregulation of LH receptor mRNA expression in the ovary. Mol Cell Endocrinol. 2015;413:90-5 pubmed publisher
    ..b>Eukaryotic initiation factor 5A (EIF5A), identified as an LRBP-interacting protein plays a crucial role in LHR mRNA expression...
  2. Hyvonen M, Keinänen T, Cerrada Gimenez M, Sinervirta R, Grigorenko N, Khomutov A, et al. Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis. J Biol Chem. 2007;282:34700-6 pubmed
    ..Taken together, the results show that growth inhibition in response to polyamine depletion involves two phases, an acute and a late hypusine-dependent phase. ..
  3. Tome M, Fiser S, Payne C, Gerner E. Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis. Biochem J. 1997;328 ( Pt 3):847-54 pubmed
    ..reaction that proceeds by the transfer of the butylamine moiety of spermidine to a lysine residue in eukaryotic initiation factor 5A (eIF-5A)...
  4. Li A, Li H, Jin B, Ye Q, Zhou T, Yu X, et al. A novel eIF5A complex functions as a regulator of p53 and p53-dependent apoptosis. J Biol Chem. 2004;279:49251-8 pubmed
    Although eukaryotic translation initiation factor 5A (eIF5A) was originally designated as an "initiation factor," recent data have shown it to be also involved in apoptosis...
  5. Tan X, Wang D, Lu X, Wei H, Zhu R, Zhu S, et al. Doxorubicin induces apoptosis in H9c2 cardiomyocytes: role of overexpressed eukaryotic translation initiation factor 5A. Biol Pharm Bull. 2010;33:1666-72 pubmed
    ..Eukaryotic translation initiation factor 5A (eIF5A) is a ubiquitously expressed multifunctional protein that interacts with a range of ligands and is implicated in ..
  6. Liu W, Shang F, Xu Y, Belegu V, Xia L, Zhao W, et al. eIF5A1/RhoGDIα pathway: a novel therapeutic target for treatment of spinal cord injury identified by a proteomics approach. Sci Rep. 2015;5:16911 pubmed publisher
    ..Therefore, we have identified eIF5A1/RhoGDIα pathway as a new therapeutic target for treatment of spinal cord injured patients. ..
  7. Shang F, Zhao W, Zhao Q, Liu J, Li D, Zhang H, et al. Upregulation of eIF-5A1 in the paralyzed muscle after spinal cord transection associates with spontaneous hindlimb locomotor recovery in rats by upregulation of the ErbB, MAPK and neurotrophin signal pathways. J Proteomics. 2013;91:188-99 pubmed publisher
  8. Huang Y, Higginson D, Hester L, Park M, Snyder S. Neuronal growth and survival mediated by eIF5A, a polyamine-modified translation initiation factor. Proc Natl Acad Sci U S A. 2007;104:4194-9 pubmed
    Eukaryotic translation initiation factor 5A (eIF5A), the only known protein containing the polyamine-derived amino acid hypusine, modulates protein synthesis...
  9. Yao T, Fujimura T, Murayama K, Seko Y. Plasma levels of oxidative stress-responsive apoptosis inducing protein (ORAIP) in rats subjected to physicochemical oxidative stresses. Biosci Rep. 2016;36: pubmed publisher
    ..We named this novel post-translationally modified secreted form of eukaryotic translation initiation factor 5A (eIF5A) as oxidative stress-responsive apoptosis inducing protein (ORAIP)...

More Information

Publications25

  1. Goulart Silva F, Teixeira S, Luchessi A, Dos Santos L, Rebelato E, Carpinelli A, et al. Potential contribution of translational factors to triiodo-L-thyronine-induced insulin synthesis by pancreatic beta cells. Thyroid. 2012;22:637-42 pubmed publisher
    ..and the cells were processed for Western blot detection of insulin, eukaryotic initiation factor 2 (eIF2), p-eIF2, eIF5A, EF1A, eIF4E binding protein (4E-BP), p-4E-BP, p70S6K, and p-p70S6K...
  2. Clement P, Henderson C, Jenkins Z, Smit McBride Z, Wolff E, Hershey J, et al. Identification and characterization of eukaryotic initiation factor 5A-2. Eur J Biochem. 2003;270:4254-63 pubmed
    The phylogenetically conserved eukaryotic translation initiation factor 5A (eIF5A) is the only known cellular protein to contain the post-translationally derived amino acid hypusine [Nepsilon-(4-amino-2-hydroxybutyl)lysine]...
  3. Xu A, Jao D, Chen K. Identification of mRNA that binds to eukaryotic initiation factor 5A by affinity co-purification and differential display. Biochem J. 2004;384:585-90 pubmed
    b>Eukaryotic initiation factor 5A (eIF-5A) is the only protein in nature that contains hypusine, an unusual amino acid formed post-translationally by deoxyhypusine synthase and deoxyhypusine hydroxylase...
  4. Wang L, Gulappa T, Menon K. Identification and characterization of proteins that selectively interact with the LHR mRNA binding protein (LRBP) in rat ovaries. Biochim Biophys Acta. 2010;1803:591-7 pubmed publisher
  5. Luchessi A, Cambiaghi T, Hirabara S, Lambertucci R, Silveira L, Baptista I, et al. Involvement of eukaryotic translation initiation factor 5A (eIF5A) in skeletal muscle stem cell differentiation. J Cell Physiol. 2009;218:480-9 pubmed publisher
    The eukaryotic translation initiation factor 5A (eIF5A) contains a special amino acid residue named hypusine that is required for its activity, being produced by a post-translational modification using spermidine as substrate...
  6. Liu Y, Nemeroff M, Yan Y, Chen K. Interaction of eukaryotic initiation factor 5A with the human immunodeficiency virus type 1 Rev response element RNA and U6 snRNA requires deoxyhypusine or hypusine modification. Biol Signals. 1997;6:166-74 pubmed
    Hypusine formation on the eukaryotic initiation factor 5A (eIF-5A) precursor represents a unique posttranslational modification that is ubiquitously present in eukaryotic cells and archaebacteria...
  7. Bevec D, Jaksche H, Oft M, Wohl T, Himmelspach M, Pacher A, et al. Inhibition of HIV-1 replication in lymphocytes by mutants of the Rev cofactor eIF-5A. Science. 1996;271:1858-60 pubmed
    b>Eukaryotic initiation factor 5A(eIF-5A) is a cellular cofactor require d for the function of the human immunodeficiency virus type-1 (HIV-1) Rev trans-activator protein...
  8. Jin B, He K, Wang H, Wang J, Zhou T, Lan Y, et al. Proteomic analysis of ubiquitin-proteasome effects: insight into the function of eukaryotic initiation factor 5A. Oncogene. 2003;22:4819-30 pubmed
    ..b>Eukaryotic initiation factor 5A (eIF-5A) was identified in two spots; however, the peptide mass-fingerprinting for the accumulated ..
  9. Jao D, Yu Chen K. Subcellular localization of the hypusine-containing eukaryotic initiation factor 5A by immunofluorescent staining and green fluorescent protein tagging. J Cell Biochem. 2002;86:590-600 pubmed
    b>Eukaryotic initiation factor 5A (eIF-5A) is the only protein in nature that contains hypusine, an unusual amino acid residue formed posttranslationally by deoxyhypusine synthase and deoxyhypusine hydroxylase...
  10. Schatz O, Oft M, Dascher C, Schebesta M, Rosorius O, Jaksche H, et al. Interaction of the HIV-1 rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5. Proc Natl Acad Sci U S A. 1998;95:1607-12 pubmed
    It has previously been shown that interaction of eukaryotic initiation factor 5A (eIF-5A) with the Rev trans-activator protein of HIV-1 mediates the transport of unspliced or incompletely spliced viral mRNAs across the nuclear envelope...
  11. Luchessi A, Cambiaghi T, Alves A, Parreiras E Silva L, Britto L, Costa Neto C, et al. Insights on eukaryotic translation initiation factor 5A (eIF5A) in the brain and aging. Brain Res. 2008;1228:6-13 pubmed publisher
    ..Western blotting analysis revealed a high content of eukaryotic translation initiation factor 5A (eIF5A) in the brain of neonatal rats, a period of intense neurogenesis rate, differentiation and synaptic establishment, ..
  12. Taylor C, Sun Z, Cliche D, Ming H, Eshaque B, Jin S, et al. Eukaryotic translation initiation factor 5A induces apoptosis in colon cancer cells and associates with the nucleus in response to tumour necrosis factor alpha signalling. Exp Cell Res. 2007;313:437-49 pubmed
    Eukaryotic translation initiation factor 5A (eIF5A) is thought to function as a nucleocytoplasmic shuttle protein...
  13. Rosorius O, Reichart B, Kratzer F, Heger P, Dabauvalle M, Hauber J. Nuclear pore localization and nucleocytoplasmic transport of eIF-5A: evidence for direct interaction with the export receptor CRM1. J Cell Sci. 1999;112 ( Pt 14):2369-80 pubmed
    b>Eukaryotic initiation factor 5A (eIF-5A) is the only cellular protein known to contain the unusual amino acid hypusine. The exact in vivo function of eIF-5A, however, is to date unknown...
  14. Shang F, Xia Q, Liu W, Xia L, Qian B, You L, et al. miR-434-3p and DNA hypomethylation co-regulate eIF5A1 to increase AChRs and to improve plasticity in SCT rat skeletal muscle. Sci Rep. 2016;6:22884 pubmed publisher
    ..Finally, HRM and MeDIP-PCR analyses revealed that DNA demethylation also up-regulated eIF5A1 after SCT. Consequently, miR-434-3p/eIF5A1 in muscle is a promising potential biotherapy for SCI repair. ..
  15. Gulappa T, Menon B, Menon K. LHCGR Expression During Follicle Stimulating Hormone-Induced Follicle Growth Is Negatively Regulated by Eukaryotic Initiation Factor 5A. Endocrinology. 2017;158:2672-2679 pubmed publisher
    ..b>Eukaryotic initiation factor 5A (eIF5A), an LRBP-interacting protein, participates in this process...
  16. Parreiras E Silva L, Gomes M, Oliveira E, Costa Neto C. The N-terminal region of eukaryotic translation initiation factor 5A signals to nuclear localization of the protein. Biochem Biophys Res Commun. 2007;362:393-8 pubmed
    The eukaryotic translation initiation factor 5A (eIF5A) is a ubiquitous protein of eukaryotic and archaeal organisms which undergoes hypusination, a unique post-translational modification...