Gene Symbol: Egfr
Description: epidermal growth factor receptor
Alias: ERBB1, ErbB-1, Errp, epidermal growth factor receptor, EGFR-related peptide, Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1), avian erythroblastic leukemia viral (v-erbB) oncogene homolog, epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1)
Species: rat
Products:     Egfr

Top Publications

  1. Lynch T, Bell D, Sordella R, Gurubhagavatula S, Okimoto R, Brannigan B, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350:2129-39 pubmed
    ..lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which targets the epidermal growth factor receptor (EGFR). However, about 10 percent of patients have a rapid and often dramatic clinical response...
  2. Karkoulias G, Mastrogianni O, Lymperopoulos A, Paris H, Flordellis C. alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR. Cell Signal. 2006;18:729-39 pubmed
    ..of PLC, AA release, AA metabolism by cytochrome P450-dependent epoxygenase, stimulation of matrix metalloproteinases and subtype-specific transactivation of EGFR through src activation and heparin-binding EGF-like growth factor release.
  3. Xie K, Zhang L, Cao Y, Zhu J, Feng L. Adenosine A(1) receptor-mediated transactivation of the EGF receptor produces a neuroprotective effect on cortical neurons in vitro. Acta Pharmacol Sin. 2009;30:889-98 pubmed publisher
    To understand the mechanism of the transactivation of the epidermal growth factor receptor (EGFR) mediated by the adenosine A(1) receptor (A(1)R)...
  4. Bailly M, Wyckoff J, Bouzahzah B, Hammerman R, Sylvestre V, Cammer M, et al. Epidermal growth factor receptor distribution during chemotactic responses. Mol Biol Cell. 2000;11:3873-83 pubmed
    To determine the distribution of the epidermal growth factor (EGF) receptor (EGFR) on the surface of cells responding to EGF as a chemoattractant, an EGFR-green fluorescent protein chimera was expressed in the MTLn3 mammary carcinoma cell ..
  5. Futamura T, Toyooka K, Iritani S, Niizato K, Nakamura R, Tsuchiya K, et al. Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients. Mol Psychiatry. 2002;7:673-82 pubmed
  6. Choi J, Hong W, Kim M, Kim J, Ryu S, Suh P. Sorting nexin 16 regulates EGF receptor trafficking by phosphatidylinositol-3-phosphate interaction with the Phox domain. J Cell Sci. 2004;117:4209-18 pubmed
    ..implicated in the regulation of membrane trafficking and sorting processes of epithelial growth factor receptor (EGFR). In this study, we investigated whether SNX16 regulates EGF-induced cell signaling by regulating EGFR trafficking...
  7. Ivkovic S, Canoll P, Goldman J. Constitutive EGFR signaling in oligodendrocyte progenitors leads to diffuse hyperplasia in postnatal white matter. J Neurosci. 2008;28:914-22 pubmed publisher
    ..Signaling through the epidermal growth factor receptor (EGFR) has been implicated in regulating these processes in a variety of cell types, including neural ..
  8. Wong H, Lemoine N. Pancreatic cancer: molecular pathogenesis and new therapeutic targets. Nat Rev Gastroenterol Hepatol. 2009;6:412-22 pubmed publisher
    ..Although laboratory results of targeted therapies have been impressive, until now only erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, has demonstrated modest survival benefit in combination with gemcitabine ..
  9. Qu W, Liu J, Li C, Li X, Xie M, Wang W, et al. Rapidly activated epidermal growth factor receptor mediates lipopolysaccharide-triggered migration of microglia. Neurochem Int. 2015;90:85-92 pubmed publisher
    Previous reports have suggested that epidermal growth factor receptor (EGFR) is involved in microglia activation characterized by cell morphology changes, cytokine production and cell migration; and the biochemical regulation of the ..

More Information


  1. Brea M, Díaz R, Escudero D, Caldiz C, Portiansky E, Morgan P, et al. Epidermal Growth Factor Receptor Silencing Blunts the Slow Force Response to Myocardial Stretch. J Am Heart Assoc. 2016;5: pubmed
    ..Based on pharmacological strategies, we proposed that epidermal growth factor (EGF) receptor (EGFR or ErbB1) activation is crucial for SFR development...
  2. Hamilton L, Torres Lozano C, Puddicombe S, Richter A, Kimber I, Dearman R, et al. The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma. Clin Exp Allergy. 2003;33:233-40 pubmed
    The extent of epithelial injury in asthma is reflected by expression of the epidermal growth factor receptor (EGFR), which is increased in proportion to disease severity and is corticosteroid refractory...
  3. Schäfer B, Marg B, Gschwind A, Ullrich A. Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival. J Biol Chem. 2004;279:47929-38 pubmed
    Cross-talk between G protein-coupled receptor (GPCR) and epidermal growth factor receptor (EGFR) signaling systems is widely established in a variety of normal and transformed cell types...
  4. Taylor J, Bernabe K, Guo J, Warner B. Epidermal growth factor receptor-directed enterocyte proliferation does not induce Wnt pathway transcription. J Pediatr Surg. 2007;42:981-6 pubmed
    b>Epidermal growth factor receptor (EGFR) stimulation enhances intestinal adaptation after massive small bowel resection (SBR), measured by taller villi, deeper crypts, and augmented enterocyte proliferation...
  5. Prevot V, Cornea A, Mungenast A, Smiley G, Ojeda S. Activation of erbB-1 signaling in tanycytes of the median eminence stimulates transforming growth factor beta1 release via prostaglandin E2 production and induces cell plasticity. J Neurosci. 2003;23:10622-32 pubmed
  6. Stateva S, Salas V, Benguría A, Cossío I, Anguita E, Martín Nieto J, et al. The activating role of phospho-(Tyr)-calmodulin on the epidermal growth factor receptor. Biochem J. 2015;472:195-204 pubmed publisher
    ..In the present study, the role of tyrosine-phosphorylated CaM [P-(Tyr)-CaM] on the regulation of the epidermal growth factor receptor (EGFR) has been examined using in vitro assay systems...
  7. Amsellem Ouazana D, Bieche I, Tozlu S, Botto H, Debre B, Lidereau R. Gene expression profiling of ERBB receptors and ligands in human transitional cell carcinoma of the bladder. J Urol. 2006;175:1127-32 pubmed
    ..Six genes were over expressed (ERBB2, TGFA, HB-EGF, AREG, EREG and EPGN), 3 were under expressed (ERBB1, ERBB4 and NRG4) and 2 were over or under expressed (ERBB3 and BTC)...
  8. Hegab A, Sakamoto T, Nomura A, Ishii Y, Morishima Y, Iizuka T, et al. Niflumic acid and AG-1478 reduce cigarette smoke-induced mucin synthesis: the role of hCLCA1. Chest. 2007;131:1149-56 pubmed
    ..Sprague-Dawley rats were exposed to cigarette smoke for 4 weeks. The CLCA1, epidermal growth factor receptor (EGFR), and MUC5AC expressions were increased in the trachea and lung tissues...
  9. Kang H, Kim S, Yun M, Kim H, Lim S, Kim M, et al. ER2, a novel human anti-EGFR monoclonal antibody inhibit tumor activity in non-small cell lung cancer models. Lung Cancer. 2016;95:57-64 pubmed publisher
    The epidermal growth factor receptor (EGFR) abnormalities including amplification, mutation, and overexpression are frequent in non-small cell lung cancer (NSCLC)...
  10. Lazarovici P, Dickens G, Kuzuya H, Guroff G. Long-term, heterologous down-regulation of the epidermal growth factor receptor in PC12 cells by nerve growth factor. J Cell Biol. 1987;104:1611-21 pubmed
    ..It is suggested that this heterologous down-regulation is part of the mechanism by which differentiating cells become insensitive to mitogens. ..
  11. Paranjpe S, Bowen W, Tseng G, Luo J, Orr A, Michalopoulos G. RNA interference against hepatic epidermal growth factor receptor has suppressive effects on liver regeneration in rats. Am J Pathol. 2010;176:2669-81 pubmed publisher
    ..Along with hepatocyte growth factor and its receptor MET (HGF-MET), the epidermal growth factor receptor (EGFR) signaling pathway is activated within 60 minutes after PHx...
  12. Yoshida T, Zhang G, Haura E. Targeting epidermal growth factor receptor: central signaling kinase in lung cancer. Biochem Pharmacol. 2010;80:613-23 pubmed publisher
    ..of carcinogenesis have prompted the development of many novel molecular-targeted agents including the epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs)...
  13. Tanimoto T, Lungu A, Berk B. Sphingosine 1-phosphate transactivates the platelet-derived growth factor beta receptor and epidermal growth factor receptor in vascular smooth muscle cells. Circ Res. 2004;94:1050-8 pubmed
    ..several G protein-coupled receptor ligands transactivate receptor tyrosine kinases, such as the epidermal growth factor receptor (EGFR), S1P-stimulated receptor tyrosine kinase transactivation has not been well studied...
  14. Le Cras T, Hardie W, Fagan K, Whitsett J, Korfhagen T. Disrupted pulmonary vascular development and pulmonary hypertension in transgenic mice overexpressing transforming growth factor-alpha. Am J Physiol Lung Cell Mol Physiol. 2003;285:L1046-54 pubmed
    ..infant and adult lung diseases in which increased levels of transforming growth factor (TGF)-alpha and its receptor EGFR have been associated...
  15. Heigener D, Wu Y, van Zandwijk N, Mali P, Horwood K, Reck M. Second-line erlotinib in patients with advanced non-small-cell lung cancer: subgroup analyses from the TRUST study. Lung Cancer. 2011;74:274-9 pubmed publisher
    Erlotinib is a highly potent inhibitor of epidermal growth factor receptor tyrosine-kinase activity that significantly prolongs overall survival in patients with non-small-cell lung cancer (NSCLC), and improves symptom control and quality ..
  16. Sukhotnik I, Mogilner J, Shaoul R, Karry R, Lieber M, Suss Toby E, et al. Responsiveness of intestinal epithelial cell turnover to TGF-alpha after bowel resection in a rat is correlated with EGF receptor expression along the villus-crypt axis. Pediatr Surg Int. 2008;24:21-8 pubmed
    ..In a rat model of SBS, TGF-alpha increased enterocyte proliferation and stimulated intestinal adaptation. The effect of TGF-alpha on enterocyte turnover is correlated with EGF receptor expression along the villus-crypt axis. ..
  17. Chang C, Yang J, Li X, Zhao W, Chen S, Wang G, et al. [SPINK3: A novel growth factor that promotes rat liver regeneration]. Mol Biol (Mosk). 2016;50:457-65 pubmed publisher
    ..factor that has an identical structure to epidermal growth factor (EGF), which could combine with epidermal growth factor receptor (EGFR) to promote cell proliferation...
  18. Benter I, Benboubetra M, Hollins A, Yousif M, Canatan H, Akhtar S. Early inhibition of EGFR signaling prevents diabetes-induced up-regulation of multiple gene pathways in the mesenteric vasculature. Vascul Pharmacol. 2009;51:236-45 pubmed publisher
    ..between the normal and diabetic mesenteric vasculature and to investigate the effect of inhibiting epidermal growth factor receptor (EGFR) signaling on global gene expression in the mesenteric bed of streptozotocin (STZ)-induced ..
  19. Carver R, Stevenson M, Scheving L, Russell W. Diverse expression of ErbB receptor proteins during rat liver development and regeneration. Gastroenterology. 2002;123:2017-27 pubmed
    ..The epidermal growth factor receptor, ErbB2, and ErbB3 were the only ErbB proteins detected in the liver parenchyma on embryonic day 19...
  20. DiCamillo S, Carreras I, Panchenko M, Stone P, Nugent M, Foster J, et al. Elastase-released epidermal growth factor recruits epidermal growth factor receptor and extracellular signal-regulated kinases to down-regulate tropoelastin mRNA in lung fibroblasts. J Biol Chem. 2002;277:18938-46 pubmed the release of soluble 25-26-kDa forms of epidermal growth factor (EGF) and transactivation of EGF receptor (EGFR) in NE-exposed cells...
  21. Sommerfeld A, Reinehr R, Haussinger D. Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis. J Biol Chem. 2009;284:22173-83 pubmed publisher
    Bile acids have been reported to induce epidermal growth factor receptor (EGFR) activation and subsequent proliferation of activated hepatic stellate cells (HSC), but the underlying mechanisms and whether quiescent HSC are also a target ..
  22. Liu X, Lin Z, Zhou T, Zong R, He H, Liu Z, et al. Anti-angiogenic and anti-inflammatory effects of SERPINA3K on corneal injury. PLoS ONE. 2011;6:e16712 pubmed publisher
    ..Meanwhile, SERPINA3K significantly up-regulated the expression of EGFR in the corneal epithelium...
  23. Li Y, Zhang H, Liao W, Song Y, Ma X, Chen C, et al. Transactivated EGFR mediates ??-AR-induced STAT3 activation and cardiac hypertrophy. Am J Physiol Heart Circ Physiol. 2011;301:H1941-51 pubmed publisher determine whether ?(1)-AR induces cardiac hypertrophy through a novel signaling pathway-?(1)-AR/epidermal growth factor receptor (EGFR)/signal transducer and activator of transcription 3 (STAT3)...
  24. Chen S, Bangaru M, Sneade L, Dunckley J, Ben Jonathan N, Kansra S. Epidermal growth factor receptor cross-talks with ligand-occupied estrogen receptor-alpha to modulate both lactotroph proliferation and prolactin gene expression. Am J Physiol Endocrinol Metab. 2009;297:E331-9 pubmed publisher
    ..However, the interactions between ligand-occupied ERalpha and activated ErbB1 and its impact on lactotroph function are unknown...
  25. Kempiak S, Yip S, Backer J, Segall J. Local signaling by the EGF receptor. J Cell Biol. 2003;162:781-7 pubmed
    ..Thus, we find differing spatial scales of signaling from the EGF receptor, supporting models of chemotaxis that integrate short- and long-range signaling. ..
  26. Gui Y, Zheng X. Epidermal growth factor induction of phenotype-dependent cell cycle arrest in vascular smooth muscle cells is through the mitogen-activated protein kinase pathway. J Biol Chem. 2003;278:53017-25 pubmed
  27. Liu B, Chen H, Johns T, Neufeld A. Epidermal growth factor receptor activation: an upstream signal for transition of quiescent astrocytes into reactive astrocytes after neural injury. J Neurosci. 2006;26:7532-40 pubmed
    ..We found that upregulation and activation of the epidermal growth factor receptor (EGFR) occur in astrocytes after different injuries in optic nerves in vivo...
  28. Chen J, Sun W, Zheng Y, Xiong H, Cai Y. Bone morphogenetic protein 4, inhibitor of differentiation 1, and epidermal growth factor receptor regulate the survival of cochlear sensory epithelial cells. J Neurosci Res. 2013;91:515-26 pubmed publisher
    ..survival of cochlear sensory epithelial cells through inhibitor of differentiation 1 (Id1) and the epidermal growth factor receptor (EGFR)...
  29. Tfelt Hansen J, Yano S, John Macleod R, Smajilovic S, Chattopadhyay N, Brown E. High calcium activates the EGF receptor potentially through the calcium-sensing receptor in Leydig cancer cells. Growth Factors. 2005;23:117-23 pubmed
    ..Therefore, we investigated whether stimulation with calcium activates the EGFR in H-500 Leydig cancer cells. We show that treatment of H-500 cells with Ca(2+) results in EGFR phosphorylation...
  30. Methner C, Donat U, Felix S, Krieg T. Cardioprotection of bradykinin at reperfusion involves transactivation of the epidermal growth factor receptor via matrix metalloproteinase-8. Acta Physiol (Oxf). 2009;197:265-71 pubmed publisher
    ..have been shown to couple through a matrix metalloproteinase (MMP)-dependent transactivation of the epidermal growth factor receptor (EGFR). Here we test whether BK protects the rat heart through the EGFR by an MMP-dependent pathway...
  31. Barco R, Hunt L, Frump A, Garcia C, Benesh A, Caldwell R, et al. The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway. Mol Biol Cell. 2007;18:4003-12 pubmed
    ..These results indicate that SYT-SSX2 exerts part of its oncogenic effect by altering cytoskeletal architecture in an Eph-dependent manner and cytoskeletal stability through a concurrent and distinct pathway...
  32. Schmitz Peiffer C, Browne C, Biden T. Characterization of two forms of protein kinase C alpha, with different substrate specificities, from skeletal muscle. Biochem J. 1996;320 ( Pt 1):207-14 pubmed
    ..The results suggest that a modification of PKC alpha in situ limits its substrate specificity, and indicate an additional level of control of the kinase that may be a site for modulation of PKC-mediated signal transduction. ..
  33. Carpe N, Mandeville I, Ribeiro L, Ponton A, Martin J, Kho A, et al. Genetic influences on asthma susceptibility in the developing lung. Am J Respir Cell Mol Biol. 2010;43:720-30 pubmed publisher
    ..represented included growth and development (including the T Box 1 transcription factor [Tbx5], the epidermal growth factor receptor [Egfr], the transforming growth factor beta-1-induced transcript 1 [Tgfbr1i1]), extracellular matrix ..
  34. Gajadhar A, Guha A. A proximity ligation assay using transiently transfected, epitope-tagged proteins: application for in situ detection of dimerized receptor tyrosine kinases. Biotechniques. 2010;48:145-52 pubmed publisher
    ..and antibody inhibitors targeting the interaction of receptor tyrosine kinases (RTKs), such as epidermal growth factor receptor (EGFR), is of high pharmacological and biological interest...
  35. Chen Y, Peng F, Jin J, Chen H, Yu H, Zhang B. Src-mediated ligand release-independent EGFR transactivation involves TGF-?-induced Smad3 activation in mesangial cells. Biochem Biophys Res Commun. 2017;493:914-920 pubmed publisher
    ..TGF-? was shown recently to induce rapid and transient epidermal-like growth factor receptor (EGFR) transactivation and subsequent fibronectin expression via heparin-binding epidermal-like growth factors (HB-EGF) ..
  36. Gajadhar A, Bogdanovic E, Muñoz D, Guha A. In situ analysis of mutant EGFRs prevalent in glioblastoma multiforme reveals aberrant dimerization, activation, and differential response to anti-EGFR targeted therapy. Mol Cancer Res. 2012;10:428-40 pubmed publisher
    Aberrations in epidermal growth factor receptor (EGFR/ErbB1) are the most common oncogenic alterations in glioblastoma multiforme (GBM), the most common primary brain tumor...
  37. Patel B, Hiscott P, Charteris D, Mather J, McLeod D, Boulton M. Retinal and preretinal localisation of epidermal growth factor, transforming growth factor alpha, and their receptor in proliferative diabetic retinopathy. Br J Ophthalmol. 1994;78:714-8 pubmed
    ..These results suggest an autocrine/paracrine role for EGF, TGF-alpha, and EGF-R in PDR. ..
  38. Takaguri A, Kimura K, Hinoki A, Bourne A, Autieri M, Eguchi S. A disintegrin and metalloprotease 17 mediates neointimal hyperplasia in vasculature. Hypertension. 2011;57:841-5 pubmed publisher
    ..Proliferating cell nuclear antigen-positive cells and phospho-epidermal growth factor receptor-positive cells in the neointima were reduced by dominant-negative ADAM17 as well...
  39. Chadwick W, Keselman A, Park S, Zhou Y, Wang L, Brenneman R, et al. Repetitive peroxide exposure reveals pleiotropic mitogen-activated protein kinase signaling mechanisms. J Signal Transduct. 2011;2011:636951 pubmed publisher
    ..Application of hydrogen peroxide to PC12 cells activated multiple tyrosine kinases (c-Src, epidermal growth factor receptor (EGFR), and Pyk2) and the serine-threonine kinase ERK1/2...
  40. Jura N, Endres N, Engel K, Deindl S, Das R, Lamers M, et al. Mechanism for activation of the EGF receptor catalytic domain by the juxtamembrane segment. Cell. 2009;137:1293-307 pubmed publisher
    Signaling by the epidermal growth factor receptor requires an allosteric interaction between the kinase domains of two receptors, whereby one activates the other...
  41. Gardner O, Dewar B, Earp H, Samet J, Graves L. Dependence of peroxisome proliferator-activated receptor ligand-induced mitogen-activated protein kinase signaling on epidermal growth factor receptor transactivation. J Biol Chem. 2003;278:46261-9 pubmed
    ..The selective epidermal growth factor receptor (EGFR) kinase inhibitors, PD153035 and ZD1839 (Iressa), abolished PPARalpha and gamma agonist-..
  42. Ghaderi A, Vasei M, Maleck Hosseini S, Gharesi Fard B, Khodami M, Doroudchi M, et al. The expression of c-erbB-1 and c-erbB-2 in Iranian patients with gastric carcinoma. Pathol Oncol Res. 2002;8:252-6 pubmed
    To assess the significance of epidermal growth factor receptor family members, the overexpression of c-erbB-1 and c-erbB-2 was retrospectively investigated in 146 southern Iranian gastric cancer patients...
  43. Ferrandina G, Lanzone A, Scambia G, Caruso A, Panici P, Mancuso S. Epidermal growth factor receptors in placentae and fetal membranes from hypertension-complicated pregnancies. Hum Reprod. 1995;10:1845-9 pubmed
    b>Epidermal growth factor receptor concentrations (EGFR) in placentae and fetal membranes from 25 normal and 25 hypertension-complicated pregnancies were analysed by a radioreceptor technique...
  44. Ajiro M, Nishidate T, Katagiri T, Nakamura Y. Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis. Int J Oncol. 2010;37:1085-93 pubmed
    ..the biological mechanism of RQCD1 in regulation of the Akt activity as the downstream signal of epidermal growth factor receptor (EGFR)...
  45. Abdallah R, Keum J, El Shewy H, Lee M, Wang B, Gooz M, et al. Plasma kallikrein promotes epidermal growth factor receptor transactivation and signaling in vascular smooth muscle through direct activation of protease-activated receptors. J Biol Chem. 2010;285:35206-15 pubmed publisher
    ..transactivation of epidermal growth factor receptors, and metalloprotease and epidermal growth factor receptor-dependent ERK1/2 activation...
  46. Huang W, Fan X, Tang X. SiRNA targeting EGFR effectively prevents posterior capsular opacification after cataract surgery. Mol Vis. 2011;17:2349-55 pubmed
    We investigated the effect of epidermal growth factor receptor (EGFR) siRNA on human lens epithelium (HLE) cells and the development of posterior capsular opacity (PCO)...
  47. Helle F, Jouzel C, Chadjichristos C, Placier S, Flamant M, Guerrot D, et al. Improvement of renal hemodynamics during hypertension-induced chronic renal disease: role of EGF receptor antagonism. Am J Physiol Renal Physiol. 2009;297:F191-9 pubmed publisher
    ..To achieve full recovery, it is necessary to apply AT(1) receptor antagonism. ..
  48. Del Campo M, Sagredo A, del Campo L, Villalobo A, Ferrer M. Time-dependent effect of orchidectomy on vascular nitric oxide and thromboxane A2 release. Functional implications to control cell proliferation through activation of the epidermal growth factor receptor. PLoS ONE. 2014;9:e102523 pubmed publisher
    ..and their correlation with the proliferation of vascular smooth muscle cells (VSMC) mediated by the epidermal growth factor receptor (EGFR)...
  49. Benter I, Canatan H, Benboubetra M, Yousif M, Akhtar S. Global upregulation of gene expression associated with renal dysfunction in DOCA-salt-induced hypertensive rats occurs via signaling cascades involving epidermal growth factor receptor: a microarray analysis. Vascul Pharmacol. 2009;51:101-9 pubmed publisher
    ..attempt to understand the molecular mechanisms leading to renal dysfunction and in particular that of epidermal growth factor receptor (EGFR) and RasGTPase signaling, we analyzed global gene expression changes in the kidneys of ..
  50. Tamaoka M, Hassan M, McGovern T, Ramos Barbon D, Jo T, Yoshizawa Y, et al. The epidermal growth factor receptor mediates allergic airway remodelling in the rat. Eur Respir J. 2008;32:1213-23 pubmed publisher
    ..Allergen-induced airway epithelial and airway smooth muscle remodelling is mediated by cysteinyl leukotrienes via the cysteinyl leukotriene-1 receptor with downstream effects on the epidermal growth factor receptor axis.
  51. Harada C, Kawaguchi T, Ogata Suetsugu S, Yamada M, Hamada N, Maeyama T, et al. EGFR tyrosine kinase inhibition worsens acute lung injury in mice with repairing airway epithelium. Am J Respir Crit Care Med. 2011;183:743-51 pubmed publisher
    b>Epidermal growth factor receptor (EGFR) and its ligands play important roles in the regeneration of damaged epithelium and proliferation of various epithelial tumors...
  52. Gomez Sandoval Y, Lévesque L, Li Y, Anand Srivastava M. Role of epidermal growth factor receptor transactivation in endothelin-1-induced enhanced expression of Gi protein and proliferation in A10 vascular smooth muscle cells. Can J Physiol Pharmacol. 2013;91:221-7 pubmed publisher
    ..This study was intended to examine the implication of epidermal growth factor receptor (EGFR) activation in ET-1-induced enhanced expression of Gi proteins and proliferation of A10 VSMC, ..
  53. Kim Y, Kim K, Lee H, Han S, Lee Y, Choe J, et al. Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effect. Eur J Pharmacol. 2009;612:131-42 pubmed publisher
    ..Celastrol also showed an inhibitory effect on skin inflammation induced by phorbol myristate acetate (PMA) in Balb/c mice. In summary, celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-inflammatory effect. ..