Gene Symbol: Ednrb
Description: endothelin receptor type B
Alias: Ednra, Etb, endothelin receptor type B, endothelin B receptor, ET-B, ET-BR, endothelin receptor non-selective type
Species: rat
Products:     Ednrb

Top Publications

  1. Lee G, Bell D, Kelso E, Argent C, McDermott B. Evidence for altered ETB receptor characteristics during development and progression of ventricular cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol. 2004;287:H425-32 pubmed
  2. Jesmin S, Sakuma I, Togashi H, Yamaguchi T, Ueno K, Yoshioka M, et al. Altered expression of endothelin and its receptors in the brain of SHR-SP at malignant hypertensive stage. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S11-5 pubmed
    ..Downregulation of the endothelin-B receptor may cause suppression of endothelium-derived relaxing factors in the brain of SHR-SP and be an underlying factor in their stroke susceptibility. ..
  3. Lee T, Chen C, Lin M, Chang N. Effect of endothelin receptor antagonists on ventricular susceptibility in postinfarcted rats. Am J Physiol Heart Circ Physiol. 2008;294:H1871-9 pubmed publisher
    ..Independent of their hemodynamic effects, a chronic use of either ET(A) or ET(A)/ET(B) antagonists may modify the arrhythmogenic response to programmed electrical stimulation. ..
  4. Raymond M, Robin P, De Zen F, Vilain G, Tanfin Z. Differential endothelin receptor expression and function in rat myometrial cells and leiomyoma ELT3 cells. Endocrinology. 2009;150:4766-76 pubmed publisher
    ..A major role of ETB receptor in the prosurvival effect was revealed...
  5. Krishnamoorthy R, Rao V, Dauphin R, Prasanna G, Johnson C, Yorio T. Role of the ETB receptor in retinal ganglion cell death in glaucoma. Can J Physiol Pharmacol. 2008;86:380-93 pubmed publisher
    ..Presently we report that ET-1-mediated apoptosis was markedly attenuated in ETB receptor-deficient rats, suggesting a key role for ETB receptors in apoptosis of retinal ganglion cells by ET-1 ..
  6. Ansar S, Vikman P, Nielsen M, Edvinsson L. Cerebrovascular ETB, 5-HT1B, and AT1 receptor upregulation correlates with reduction in regional CBF after subarachnoid hemorrhage. Am J Physiol Heart Circ Physiol. 2007;293:H3750-8 pubmed
    ..These changes occur in parallel with a successive decrease in CBF. Thus there is a temporal correlation between the changes in receptor expression and CBF reduction, suggesting a linkage. ..
  7. Puffenberger E, Hosoda K, Washington S, Nakao K, deWit D, Yanagisawa M, et al. A missense mutation of the endothelin-B receptor gene in multigenic Hirschsprung's disease. Cell. 1994;79:1257-66 pubmed
    ..locus (HSCR2) to human chromosome 13q22, which we now demonstrate to be the endothelin-B receptor gene (EDNRB)...
  8. Granström B, Xu C, Nilsson E, Bengtsson U, Edvinsson L. Up-regulation of endothelin receptor function and mRNA expression in airway smooth muscle cells following Sephadex-induced airway inflammation. Basic Clin Pharmacol Toxicol. 2004;95:43-8 pubmed
    ..9 times P<0.05) of endothelin receptor type B mRNA expression in bronchial smooth muscle cells, but not in tracheal smooth muscle cells...
  9. Nicaud V, Poirier O, Behague I, Herrmann S, Mallet C, Troesch A, et al. Polymorphisms of the endothelin-A and -B receptor genes in relation to blood pressure and myocardial infarction: the Etude Cas-Témoins sur l'Infarctus du Myocarde (ECTIM) Study. Am J Hypertens. 1999;12:304-10 pubmed
    ..This result will have to be confirmed in other studies. ..

More Information


  1. Shin M, Levorse J, Ingram R, Tilghman S. The temporal requirement for endothelin receptor-B signalling during neural crest development. Nature. 1999;402:496-501 pubmed
    Endothelin receptor B (EDNRB) is a G-protein-coupled receptor with seven transmembrane domains which is required for the development of melanocytes and enteric neurons...
  2. Attie T, Till M, Pelet A, Amiel J, Edery P, Boutrand L, et al. Mutation of the endothelin-receptor B gene in Waardenburg-Hirschsprung disease. Hum Mol Genet. 1995;4:2407-9 pubmed
  3. Henriksson M, Stenman E, Edvinsson L. Intracellular pathways involved in upregulation of vascular endothelin type B receptors in cerebral arteries of the rat. Stroke. 2003;34:1479-83 pubmed
    Previous studies have shown that contractile endothelin type B (ETB) receptors are upregulated in cerebral arteries after experimental focal cerebral ischemia...
  4. Gariepy C, Cass D, Yanagisawa M. Null mutation of endothelin receptor type B gene in spotting lethal rats causes aganglionic megacolon and white coat color. Proc Natl Acad Sci U S A. 1996;93:867-72 pubmed
    Mutations in the gene encoding the endothelin receptor type B (EDNRB) produce congenital aganglionic megacolon and pigment abnormalities in mice and humans...
  5. Gariepy C, Williams S, Richardson J, Hammer R, Yanagisawa M. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease. J Clin Invest. 1998;102:1092-101 pubmed
    ..rat, a naturally occurring rodent model of Hirschsprung disease, carries a deletion in the endothelin-B receptor (EDNRB) gene that abrogates expression of functional EDNRB receptors...
  6. Yamamoto S, Matsumoto N, Kanazawa M, Fujita M, Takaoka M, Matsumura Y. Effects of ET(A) and ET(B) receptor blockade on post-ischemic cardiac dysfunction and norepinephrine overflow in isolated rat hearts. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S394-7 pubmed
    We investigated the role of endothelin-A (ETA) and endothelin-B (ETB) receptors in ischemia/reperfusion-induced cardiac dysfunction and norepinephrine overflow using isolated rat hearts...
  7. Luo B, Liu L, Tang L, Zhang J, Stockard C, Grizzle W, et al. Increased pulmonary vascular endothelin B receptor expression and responsiveness to endothelin-1 in cirrhotic and portal hypertensive rats: a potential mechanism in experimental hepatopulmonary syndrome. J Hepatol. 2003;38:556-63 pubmed
    ..in pre-hepatic portal hypertension after portal vein ligation (PVL) initiate vasodilatation through an endothelin B receptor mediated increase in pulmonary endothelial nitric oxide synthase (eNOS)...
  8. Tykocki N, Gariepy C, Watts S. Endothelin ET(B) receptors in arteries and veins: multiple actions in the vein. J Pharmacol Exp Ther. 2009;329:875-81 pubmed publisher
    ..Moreover, the mechanisms of endothelial cell ET(B) receptor-mediated relaxation in RA and RVC are not the same. ..
  9. Laziz I, Larbi A, Grebert D, Sautel M, Congar P, Lacroix M, et al. Endothelin as a neuroprotective factor in the olfactory epithelium. Neuroscience. 2011;172:20-9 pubmed publisher
    ..endothelin is locally matured in the olfactory mucosa and that olfactory sensory neurons preferentially express ETB receptors, while ETA receptors are rather present in non neuronal olfactory mucosa cells...
  10. Loo L, Ng Y, Zhu Y, Lee H, Wong P. Cortical expression of endothelin receptor subtypes A and B following middle cerebral artery occlusion in rats. Neuroscience. 2002;112:993-1000 pubmed
    ..This differential localization of ET(A) and ET(B) receptors suggests that endothelin is involved in some complex neuron-glial interactions in addition to its vascular modulatory activity during ischemia. ..
  11. Filosa J, Naskar K, Perfume G, Iddings J, Biancardi V, Vatta M, et al. Endothelin-mediated calcium responses in supraoptic nucleus astrocytes influence magnocellular neurosecretory firing activity. J Neuroendocrinol. 2012;24:378-92 pubmed publisher
    ..Taken together, our study supports an important role for astrocytes in mediating the actions of ETs on the magnocellular neurosecretory system...
  12. Mazzuca M, Dang Y, Khalil R. Enhanced endothelin receptor type B-mediated vasodilation and underlying [Ca²?]i in mesenteric microvessels of pregnant rats. Br J Pharmacol. 2013;169:1335-51 pubmed publisher
    ..The enhanced ET(B)R-mediated microvascular relaxation may contribute to the decreased vasoconstriction and vascular resistance during pregnancy. ..
  13. Bianciotti L, De Bold A. Natriuretic peptide gene expression in DOCA-salt hypertension after blockade of type B endothelin receptor. Am J Physiol Heart Circ Physiol. 2002;282:H1127-34 pubmed
    ..ET(B) blockade can induce significant ventricular hypertrophy without an increase in ANF or brain NP gene expression. ..
  14. Thai T, Arendshorst W. ADP-ribosyl cyclase and ryanodine receptors mediate endothelin ETA and ETB receptor-induced renal vasoconstriction in vivo. Am J Physiol Renal Physiol. 2008;295:F360-8 pubmed publisher
    ..We hypothesized that this signaling pathway is activated by ETA and ETB receptors in the renal vasculature to mediate vasoconstriction in vivo...
  15. Wu J, Chen J, Rothman T, Gershon M. Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors. Development. 1999;126:1161-73 pubmed
  16. Chichorro J, Zampronio A, Cabrini D, Franco C, Rae G. Mechanisms operated by endothelin ETA and ETB receptors in the trigeminal ganglion contribute to orofacial thermal hyperalgesia induced by infraorbital nerve constriction in rats. Neuropeptides. 2009;43:133-42 pubmed publisher
    ..Endothelin receptors might represent promising therapeutic targets for the control of trigeminal neuropathic pain. ..
  17. Okada Y, Nakata M, Izumoto H, Takasu M, Tazawa N, Takaoka M, et al. Role of endothelin ETB receptor in partial ablation-induced chronic renal failure in rats. Eur J Pharmacol. 2004;494:63-71 pubmed
  18. Skovsted G, Kruse L, Larsen R, Pedersen A, Trautner S, Sheykhzade M, et al. Heart ischaemia-reperfusion induces local up-regulation of vasoconstrictor endothelin ETB receptors in rat coronary arteries downstream of occlusion. Br J Pharmacol. 2014;171:2726-38 pubmed publisher
    Endothelins act via two receptor subtypes, ETA and ETB ...
  19. Zeng C, Wang Z, Asico L, Hopfer U, Eisner G, Felder R, et al. Aberrant ETB receptor regulation of AT receptors in immortalized renal proximal tubule cells of spontaneously hypertensive rats. Kidney Int. 2005;68:623-31 pubmed
    ..Because angiotensin II type 1 (AT(1)) receptor activation increases ETB receptor expression in renal proximal tubule cells from Wistar-Kyoto (WKY) rat, we hypothesize that ETB receptor ..
  20. Johnsson E, Maddahi A, Wackenfors A, Edvinsson L. Enhanced expression of contractile endothelin ET(B) receptors in rat coronary artery after organ culture. Eur J Pharmacol. 2008;582:94-101 pubmed publisher
    ..This is likely not related to endothelial dysfunction with putative loss of its vasodilator components, but rather explained by the up-regulation of contractile endothelin ET(B) receptors on smooth muscle cells. ..
  21. Issa S, Bondurand N, Faubert E, Poisson S, Lecerf L, Nitschke P, et al. EDNRB mutations cause Waardenburg syndrome type II in the heterozygous state. Hum Mutat. 2017;38:581-593 pubmed publisher
    ..We performed exome sequencing in a WS2 index case and identified a heterozygous missense variation in EDNRB. Interestingly, homozygous (and very rare heterozygous) EDNRB mutations are already described in type IV WS (i.e...
  22. Nitescu N, Grimberg E, Herlitz H, Guron G. Role of endothelin ET(A) and ET(B) receptor subtypes in the regulation of intrarenal blood flow and oxygen tension in rats. Clin Exp Pharmacol Physiol. 2008;35:1227-32 pubmed publisher
    ..Finally, BQ-123 increased renal outer medullary perfusion, suggesting a tonic vasoconstrictor effect of ET(A) receptors in the medulla of normotensive rats. ..
  23. Carpenter T, Schomberg S, Steudel W, Ozimek J, Colvin K, Stenmark K, et al. Endothelin B receptor deficiency predisposes to pulmonary edema formation via increased lung vascular endothelial cell growth factor expression. Circ Res. 2003;93:456-63 pubmed
  24. Piechota Polanczyk A, Kleniewska P, Goraca A. The influence of ETA and ETB receptor blockers on LPS-induced oxidative stress and NF-?B signaling pathway in heart. Gen Physiol Biophys. 2012;31:271-8 pubmed publisher
    The aim of this study was to assess whether an endothelin-A receptor (ETA-R) blocker, BQ123, or an endothelin-B (ETB-R) receptor blocker, BQ788, influences nuclear factor kappa beta (NF-?B) pathway, free radical generation, tumor ..
  25. Friese R, Schmid Schonbein G, O Connor D. Systematic polymorphism discovery after genome-wide identification of potential susceptibility loci in a hereditary rodent model of human hypertension. Blood Press. 2011;20:222-31 pubmed publisher
    ..A [Chga], dopamine beta-hydroxylase [Dbh], electron transferring flavoprotein dehydrogenase [Etfdh], endothelin receptor type B [Ednrb], neuropeptide Y [Npy] and phenylethanolamine-N-methyltransferase [Pnmt]), and then discovered ..
  26. Paxian M, Keller S, Baveja R, Korneszczuk K, Huynh T, Clemens M. Functional link between ETB receptors and eNOS maintain tissue oxygenation in the normal liver. Microcirculation. 2004;11:435-49 pubmed
    ..Coupling between ET(B) receptor stimulation and eNOS activation decreases sinusoidal constriction and plays a functionally important role in maintaining microcirculation and tissue oxygenation in the normal liver. ..
  27. Lee C, Kim S, Lee S. Effect of pyrrolidine dithiocarbamate on hepatic vascular stress gene expression during ischemia and reperfusion. Eur J Pharmacol. 2008;595:100-7 pubmed publisher
    ..In a rat model of hepatic ischemia and reperfusion, our results suggest that the hepatoprotective actions of pyrrolidine dithiocarbamate may be mediated in part through the modulation of imbalanced expression of vascular stress genes. ..
  28. Dingemann J, Doi T, Ruttenstock E, Puri P. Upregulation of endothelin receptors A and B in the nitrofen induced hypoplastic lung occurs early in gestation. Pediatr Surg Int. 2010;26:65-9 pubmed publisher
    ..Up-regulation of pulmonary Endothelin Receptors A and B (EDNRA, EDNRB) has been reported in human CDH and animal models, but the onset of those alterations during lung ..
  29. Sauter G, Wolf S, Risler T, Brehm B. Influence of endothelin receptor antagonism on smooth muscle cell proliferation after chronic renal failure. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S165-7 pubmed
    ..This indicates a regulatory influence of these drugs on gene transcription and supports the importance of early treatment to inhibit coronary artery disease in uremic patients. ..
  30. Li J, Cao Y, Liu Y, Xu C. Minimally modified LDL upregulates endothelin type B receptors in rat basilar artery. Microvasc Res. 2012;83:178-84 pubmed publisher
    ..In conclusion, mmLDL upregulates ET(B) receptors of cerebral basilar artery via the PKC, MAPK and NF-?B signal pathways...
  31. Du Q, Han L, Jiang J, Li P, Wang X, Jia X. Increased endothelin receptor B and G protein coupled kinase-2 in the mesentery of portal hypertensive rats. World J Gastroenterol. 2013;19:2065-72 pubmed publisher
    ..circulation was determined by radioimmunoassay, and the expression of the endothelin A receptor (ETAR) and endothelin B receptor (ETBR) was assessed by immunofluorescence and Western blot...
  32. Sun L, Zhang W, Wang X, Song J, Li M. Inhibition of protein kinase C signal reduces ET receptor expression and basilar vasospasm after subarachnoid hemorrhage in rats. J Integr Neurosci. 2012;11:439-51 pubmed publisher
    ..Application of RO-31-7549 reduced the expression of ET receptors and reduced cerebral vasospasm, suggesting that inhibition of PKC signaling pathway could effectively reduce DCVS after SAH. ..
  33. Van Raamsdonk C, Fitch K, Fuchs H, de Angelis M, Barsh G. Effects of G-protein mutations on skin color. Nat Genet. 2004;36:961-8 pubmed
    ..and Gna11, which encode widely expressed Galphaq subunits, act in an additive and quantitative manner, and require Ednrb. Interactions between Gq and Kit receptor tyrosine kinase signaling can mediate coordinate or independent control ..
  34. Maddahi A, Edvinsson L. Enhanced expressions of microvascular smooth muscle receptors after focal cerebral ischemia occur via the MAPK MEK/ERK pathway. BMC Neurosci. 2008;9:85 pubmed publisher
    ..The expression of phosphorylated ERK1/2 and Elk-1, and of endothelin ETA and ETB, angiotensin AT1, and 5-hydroxytryptamine 5-HT1B receptors were analyzed with immunohistochemistry using confocal ..
  35. Sanchez A, Martinez P, Munoz M, Benedito S, Garcia Sacristan A, Hernandez M, et al. Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: role of ET(A) and ET(B) receptors. Br J Pharmacol. 2014;171:5682-95 pubmed publisher
    ..Selective ETA (BQ123) or ETB receptor (BQ788) antagonists reduced both basal and ET-1-stimulated superoxide generation and reversed ET-1-induced ..
  36. Huang J, Dang R, Torigoe D, Li A, Lei C, Sasaki N, et al. Genetic variation in the GDNF promoter affects its expression and modifies the severity of Hirschsprung's disease (HSCR) in rats carrying Ednrb(sl) mutations. Gene. 2016;575:144-8 pubmed publisher
    ..In a previous study, a modifier locus on chromosome 2 in rats carrying Ednrb(sl) mutations was identified, and several mutations in the putative regulatory region of the Gdnf gene in AGH-..
  37. Mathison Y, del Garrido M, Israel A. Multiple signaling pathways involved in the effect of endothelin type B receptor in rat median eminence. Acta Biol Hung. 2007;58:139-50 pubmed
    ..rich plexus of nitric oxide synthase (NOS)-containing neurons and fibers, together with densely arranged endothelin ETB-receptors-like immunoreactive fibres...
  38. Lindstedt I, Xu C, Zhang Y, Edvinsson L. Increased perfusion pressure enhances the expression of endothelin (ETB) and angiotensin II (AT1, AT2) receptors in rat mesenteric artery smooth muscle cells. Blood Press. 2009;18:78-85 pubmed publisher
    ..that changes in perfusion pressure result in altered expression of mRNA and protein encoding for the ETA-, ETB-, AT1- and AT2-receptors in rat mesenteric vessels...
  39. Deng A, Dene H, Pravenec M, Rapp J. Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes. J Clin Invest. 1994;93:2701-9 pubmed
    ..We conclude that, in the rat, one new blood pressure QTL is located on chromosome 5 marked by the ET2 locus and another new QTL is located on chromosome 17 near the HITH locus. ..
  40. Leonard M, Prazad P, Puppala B, Gulati A. Selective Endothelin-B Receptor Stimulation Increases Vascular Endothelial Growth Factor in the Rat Brain during Postnatal Development. Drug Res (Stuttg). 2015;65:607-13 pubmed publisher
    ..Results indicate that ET(B) receptors appear to play a role in the development of the CNS and selective stimulation of ET(B) receptors enhances VEGF but not NGF in the postnatal rat brain. ..
  41. Kassuya C, Rogerio A, Calixto J. The role of ET(A) and ET(B) receptor antagonists in acute and allergic inflammation in mice. Peptides. 2008;29:1329-37 pubmed publisher
    ..However, both ET(A) and ET(B) receptor antagonists were found to be effective in inhibiting the allergic response in a murine model of asthma. ..
  42. Ohkita M, Wang Y, Nguyen N, Tsai Y, Williams S, Wiseman R, et al. Extrarenal ETB plays a significant role in controlling cardiovascular responses to high dietary sodium in rats. Hypertension. 2005;45:940-6 pubmed
    ..Expression of ET1 and ET(A) are regulated by dietary Na. ET(B) receptors outside of the kidney, likely by functioning as a clearance receptor for ET1, limit salt-sensitivity in rats...
  43. Bailey M, Haton C, Orea V, Sassard J, Bailly C, Unwin R, et al. ETA receptor-mediated Ca2+ signaling in thin descending limbs of Henle's loop: impairment in genetic hypertension. Kidney Int. 2003;63:1276-84 pubmed
    Endothelins (ET) have diuretic and natriuretic actions via ETB receptors that are found in most renal tubular segments, although the thin limbs have not been studied...
  44. Nishida M, Eshiro K, Okada Y, Takaoka M, Matsumura Y. Roles of endothelin ETA and ETB receptors in the pathogenesis of monocrotaline-induced pulmonary hypertension. J Cardiovasc Pharmacol. 2004;44:187-91 pubmed
    The functional roles of endothelin ETA and ETB receptors in the development of monocrotaline (MCT)-induced pulmonary hypertension were investigated using MCT-treated rats in the absence or presence of a daily administration of A-192621, ..
  45. Al Lafi S, Artinian S, Boutary S, Zwainy N, Bitar K, Bikhazi A. Aliskiren, exendin-4, and insulin: their impact on endothelin receptor subtype(s) regulation/binding in type 1 diabetic rat hearts. Can J Physiol Pharmacol. 2013;91:830-8 pubmed publisher
    ..Our data indicate that aliskiren alleviates diabetes-associated hypertrophy in type 1 diabetes mellitus. ..
  46. Liu B, Wu D. The first inner loop of endothelin receptor type B is necessary for specific coupling to Galpha 13. J Biol Chem. 2003;278:2384-7 pubmed
    Endothelin (EDN) receptor type B (EDNRB) activates serum response factor (SRF) via G(q/11) and G(12/13) G proteins. In this study, we investigated the involvement of intracellular loop sequences of EDNRB in coupling to these G proteins...
  47. Hayzer D, Cicila G, Cockerham C, Griendling K, Delafontaine P, Ng S, et al. Endothelin A and B receptors are down-regulated in the hearts of hypertensive rats. Am J Med Sci. 1994;307:222-7 pubmed
    ..Conversely, in the brain of spontaneously hypertensive rats, mRNAs for both ET-R(A) and ET-R(B) mRNA were present.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  48. Jie L, Yong Xiao C, Zu Yi Y, Cang Bao X. Minimally modified LDL upregulates endothelin type B receptors in rat coronary artery via ERK1/2 MAPK and NF-?B pathways. Biochim Biophys Acta. 2012;1821:582-9 pubmed publisher
    ..In conclusion, mmLDL upregulates the ET(B) receptors in rat coronary arterial smooth muscle cells, mainly via activation of the ERK1/2 MAPK and the downstream transcriptional factor NF-?B. ..
  49. Xie D, Croaker G, Li J, Song Z. Reduced cell proliferation and increased apoptosis in the hippocampal formation in a rat model of Hirschsprung's disease. Brain Res. 2016;1642:79-86 pubmed publisher
    ..known as spotting lethal (sl/sl) rat, which carries a spontaneous deletion in the gene of endothelin receptor B (EDNRB) and a similar phenotype as humans with HSCR...
  50. Sullivan J, Goodchild T, Cai Z, Pollock D, Pollock J. Endothelin(A) (ET(A)) and ET(B) receptor-mediated regulation of nitric oxide synthase 1 (NOS1) and NOS3 isoforms in the renal inner medulla. Acta Physiol (Oxf). 2007;191:329-36 pubmed
    ..These results provide evidence that both ET(A) and ET(B) receptors regulate NOS isoform activity in the renal inner medulla and specifically support the hypothesis that ET(A) receptor activation increases NOS1 expression. ..
  51. Konrad D, Haney M, Johansson G, Wanecek M, Weitzberg E, Oldner A. Cardiac effects of endothelin receptor antagonism in endotoxemic pigs. Am J Physiol Heart Circ Physiol. 2007;293:H988-96 pubmed
    ..Positive hemodynamic effects from ET receptor antagonism in acute endotoxemia may be due to changes in cardiac load and enhanced diastolic function rather than improved contractile function. ..
  52. Nakano D, Pollock J, Pollock D. Renal medullary ETB receptors produce diuresis and natriuresis via NOS1. Am J Physiol Renal Physiol. 2008;294:F1205-11 pubmed publisher
    ..These results demonstrate that renal medullary ET(B) receptor activation induces diuretic and natriuretic responses through a NOS1, cGMP, and PKG pathway...
  53. Chi X, Anselmi K, Watkins S, Gandhi C. Prevention of cultured rat stellate cell transformation and endothelin-B receptor upregulation by retinoic acid. Br J Pharmacol. 2003;139:765-74 pubmed
    ..5 micro M retinoic acid without or with 50 nM ET-1 (ETA+ETB agonist) or sarafotoxin S6c (ETB agonist)...
  54. Hori S, Komatsu Y, Shigemoto R, Mizuno N, Nakanishi S. Distinct tissue distribution and cellular localization of two messenger ribonucleic acids encoding different subtypes of rat endothelin receptors. Endocrinology. 1992;130:1885-95 pubmed
    ..tissue distribution and cellular localization of rat mRNAs encoding two different subtypes of ET receptors (ETA and ETB). We isolated 46 cDNA clones from a rat lung cDNA library by hybridization with the bovine ETA cDNA...
  55. Yoon S, Gariepy C, Yanagisawa M, Zuccarello M, Rapoport R. Functional ET(A)-ET(B) Receptor Cross-talk in Basilar Artery In Situ From ET(B) Receptor Deficient Rats. J Cardiovasc Pharmacol. 2016;67:212-7 pubmed publisher
    ..These findings confirm the presence of ET(A)-ET(B) receptor cross-talk in the basilar artery. We speculate that mutant ET(B) receptor expression produced by alternative splicing may be sufficient to allow cross-talk. ..
  56. Fabricio A, Rae G, Zampronio A, D Orléans Juste P, Souza G. Central endothelin ET(B) receptors mediate IL-1-dependent fever induced by preformed pyrogenic factor and corticotropin-releasing factor in the rat. Am J Physiol Regul Integr Comp Physiol. 2006;290:R164-71 pubmed
    ..8 pmol) reduced fever to TNF-alpha (14.7 pmol) but not to ET-1. The results of the present study suggest that PFPF and CRF recruit the brain ET system to cause ET(B) receptor-mediated IL-1-dependent fever. ..
  57. McGuane J, Danielson L, Debrah J, Rubin J, Novak J, Conrad K. Angiogenic growth factors are new and essential players in the sustained relaxin vasodilatory pathway in rodents and humans. Hypertension. 2011;57:1151-60 pubmed publisher
    ..for 3 hours in vitro attenuated myogenic constriction, which was blocked by inhibitors of gelatinases, the endothelin B receptor, and NO synthase...
  58. Peters C, Rogers S, Pomonis J, Egnaczyk G, Keyser C, Schmidt J, et al. Endothelin receptor expression in the normal and injured spinal cord: potential involvement in injury-induced ischemia and gliosis. Exp Neurol. 2003;180:1-13 pubmed
    ..that exert their biological effects via two distinct receptors, the endothelin A receptor (ET(A)R) and the endothelin B receptor (ET(B)R)...
  59. Lau Y, Galligan J, Kreulen D, Fink G. Activation of ETB receptors increases superoxide levels in sympathetic ganglia in vivo. Am J Physiol Regul Integr Comp Physiol. 2006;290:R90-5 pubmed
    ..We conclude that ET(B) receptor activation in vivo significantly enhances O2- levels in sympathetic ganglia, due to both pressor effects and direct stimulation of ET(B) receptors in ganglion cells. ..
  60. Ceccherini I, Zhang A, Matera I, Yang G, Devoto M, Romeo G, et al. Interstitial deletion of the endothelin-B receptor gene in the spotting lethal (sl) rat. Hum Mol Genet. 1995;4:2089-96 pubmed
    ..05 at theta = 0) was found between the Endothelin-B Receptor (EDNRB) gene and the sl phenotype...
  61. Kuwaki T, Ling G, Onodera M, Ishii T, Nakamura A, Ju K, et al. Endothelin in the central control of cardiovascular and respiratory functions. Clin Exp Pharmacol Physiol. 1999;26:989-94 pubmed
    ..To address this question, we examined ABP and ventilation in mutant mice deficient in ET-1, ETA and ETB receptors and endothelin-converting enzyme-1, which were made by gene targeting. 2...
  62. Harris A, Elgebaly M, Li W, Sachidanandam K, Ergul A. Effect of chronic endothelin receptor antagonism on cerebrovascular function in type 2 diabetes. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1213-9 pubmed publisher
    ..Goto-Kakizaki (GK) model of Type 2 diabetes, and 2) pharmacological antagonism of ETA receptors ameliorates, while ETB receptor blockade augments vascular dysfunction...
  63. Francis B, Abassi Z, Heyman S, Winaver J, Hoffman A. Differential regulation of ET(A) and ET(B) in the renal tissue of rats with compensated and decompensated heart failure. J Cardiovasc Pharmacol. 2004;44 Suppl 1:S362-5 pubmed
    ..ET-1) exerts its biological actions through two receptor subtypes: endothelin-A (ETA) receptor and endothelin-B (ETB) receptor...
  64. Dschietzig T, Alexiou K, Richter C, Bobzin M, Baumann G, Stangl K, et al. Endotoxin causes pulmonary hypertension by upregulating smooth muscle endothelin type-B receptors: role of aldose reductase. Shock. 2008;30:189-96 pubmed
    ..We conclude that endotoxin-induced pulmonary hypertension in the rat results from a loss of endothelial and concomitant gain of vascular smooth muscle ET(B) receptors. These changes are at least partly mediated by aldose reductase. ..
  65. Kim J, Ko A, Hyun H, Kang T. ETB receptor-mediated MMP-9 activation induces vasogenic edema via ZO-1 protein degradation following status epilepticus. Neuroscience. 2015;304:355-67 pubmed publisher
    ..Among TJ proteins, the alteration in ZO-1 expression was relevant to endothelin B (ETB) receptor-mediated endothelial nitric oxide synthase (eNOS) activation, which increased matrix metalloproteinase-9 (..
  66. Nangaku M, Yamada K, Gariepy C, Miyata T, Inagi R, Kurokawa K, et al. ET(B) receptor protects the tubulointerstitium in experimental thrombotic microangiopathy. Kidney Int. 2002;62:922-8 pubmed
    ..These findings suggest that the ET(B) receptor may protect peritubular capillaries under the ischemic insult, and serve a defensive role in the tubulointerstitium induced by renal microvascular injury. ..
  67. Reid K, Turnley A, Maxwell G, Kurihara Y, Kurihara H, Bartlett P, et al. Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation. Development. 1996;122:3911-9 pubmed
    ..These findings indicate two key roles for endothelin in melanocyte development: regulation of expansion of the progenitor pool and differentiation of progenitors into mature melanocytes. ..
  68. Chichorro J, Fiuza C, Bressan E, Claudino R, Leite D, Rae G. Endothelins as pronociceptive mediators of the rat trigeminal system: role of ETA and ETB receptors. Brain Res. 2010;1345:73-83 pubmed publisher
    ..Taken together, these findings suggest that endothelins, acting through ET(A) and/or ET(B) receptors, may play an important role in mediating pain resulting from activation of most trigeminal nerve branches. ..
  69. Plusczyk T, Witzel B, Menger M, Schilling M. ETA and ETB receptor function in pancreatitis-associated microcirculatory failure, inflammation, and parenchymal injury. Am J Physiol Gastrointest Liver Physiol. 2003;285:G145-53 pubmed
    The role of endothelin (ET)A and ETB receptor function in experimental pancreatitis is still not fully understood...
  70. Nishida M, Ieshima M, Konishi F, Yamashita J, Takaoka M, Matsumura Y. Role of endothelin B receptor in the pathogenesis of ischemic acute renal failure. J Cardiovasc Pharmacol. 2002;40:586-93 pubmed
    ..Thus, ET receptor-mediated actions do not play an important role in the development of ischemic ARF but may be involved in the recovery process from ischemia/reperfusion-induced renal injury. ..
  71. Sakurai T, Yanagisawa M, Takuwa Y, Miyazaki H, Kimura S, Goto K, et al. Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor. Nature. 1990;348:732-5 pubmed
    ..These results indicate that this cDNA encodes a 'nonselective' subtype of the receptor which is different from the vascular smooth muscle receptor. ..
  72. CONTRERAS C, Sanchez A, Martinez P, Climent B, Benedito S, García Sacristán A, et al. Impaired endothelin calcium signaling coupled to endothelin type B receptors in penile arteries from insulin-resistant obese Zucker rats. J Sex Med. 2013;10:2141-53 pubmed publisher
    ..Erectile dysfunction is considered as an early sign of subclinical vascular disease and endothelial dysfunction and a highly prevalent condition in diabetic patients...
  73. Oktar B, Gülpinar M, Bozkurt A, Ghandour S, Cetinel S, Moini H, et al. Endothelin receptor blockers reduce I/R-induced intestinal mucosal injury: role of blood flow. Am J Physiol Gastrointest Liver Physiol. 2002;282:G647-55 pubmed
    ..Furthermore, ET is involved in the pathogenesis of post-reperfusion-induced damage and beneficial effects of ET receptor antagonism are related to an improvement of disturbed blood flow during the reperfusion period...
  74. Yamamoto T, Ono K, Hitomi S, Harano N, Sago T, Yoshida M, et al. Endothelin receptor-mediated responses in trigeminal ganglion neurons. J Dent Res. 2013;92:335-9 pubmed publisher
    ..In the present study, we investigated the expression of the endothelin receptors ETA and ETB and endothelin-induced responses in rat TRG neurons...
  75. Stones R, Calaghan S, Billeter R, Harrison S, White E. Transmural variations in gene expression of stretch-modulated proteins in the rat left ventricle. Pflugers Arch. 2007;454:545-9 pubmed
  76. Oh P, Horner T, Witkiewicz H, Schnitzer J. Endothelin induces rapid, dynamin-mediated budding of endothelial caveolae rich in ET-B. J Biol Chem. 2012;287:17353-62 pubmed publisher
    ..Caveolae trafficking may occur more rapidly than previously documented when it is stimulated by a specific ligand to signaling receptors already located in caveolae before ligand engagement. ..
  77. Koyama Y, Tanaka K. Decreases in rat brain aquaporin-4 expression following intracerebroventricular administration of an endothelin ET B receptor agonist. Neurosci Lett. 2010;469:343-7 pubmed publisher
    ..These findings indicate that activation of brain ET(B) receptors causes a decrease in AQP4 expression, suggesting that ET down-regulates brain AQP4 via ET(B) receptors. ..
  78. Boesen E, Pollock D. Cooperative role of ETA and ETB receptors in mediating the diuretic response to intramedullary hyperosmotic NaCl infusion. Am J Physiol Renal Physiol. 2010;299:F1424-32 pubmed publisher
    ..Moreover, these data suggest ET(A) and ET(B) receptors are both required for the full diuretic and natriuretic actions of endothelin. ..
  79. Berti Mattera L, Gariepy C, Burke R, Hall A. Reduced expression of endothelin B receptors and mechanical hyperalgesia in experimental chronic diabetes. Exp Neurol. 2006;201:399-406 pubmed
    ..These results suggest that changes in the expression of ETBR in peripheral nerve may contribute to the development of mechanical hyperalgesia and tactile allodynia in chronic diabetes. ..
  80. Jaureguiberry M, di Nunzio A, Dattilo M, Bianciotti L, Vatta M. Endothelin 1 and 3 enhance neuronal nitric oxide synthase activity through ETB receptors involving multiple signaling pathways in the rat anterior hypothalamus. Peptides. 2004;25:1133-8 pubmed
    We have previously reported that endothelin 1 and 3 (ET-1, ET-3) through the ETB receptor decrease norepinephrine release in the anterior hypothalamus and activate the nitric oxide (NO) pathway...
  81. Perry M, Molero M, Giulumian A, Katakam P, Pollock J, Pollock D, et al. ET(B) receptor-deficient rats exhibit reduced contraction to ET-1 despite an increase in ET(A) receptors. Am J Physiol Heart Circ Physiol. 2001;281:H2680-6 pubmed
    ..Reduced contraction may be related to elevated plasma ET-1 and occurs in the presence of increased ET(A) receptor protein expression, suggesting an uncoupling of ET(A) receptor expression from functional activity...
  82. Skovsted G, Kilic S, Edvinsson L. Endothelin-1 and Endothelin-3 Regulate Endothelin Receptor Expression in Rat Coronary Arteries. Basic Clin Pharmacol Toxicol. 2015;117:297-305 pubmed publisher
    ..We previously reported that ETB receptors are up-regulated in the smooth muscle layer of coronary arteries after myocardial ischaemia-reperfusion ..
  83. Maron B, Zhang Y, White K, Chan S, Handy D, Mahoney C, et al. Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension. Circulation. 2012;126:963-74 pubmed publisher
    ..Our findings demonstrate that aldosterone modulates an ET(B) cysteinyl thiol redox switch to decrease pulmonary endothelium-derived NO(·) and promote PAH. ..
  84. Moller S, Uddman E, Welsh N, Edvinsson L, Adner M. Analysis of the time course for organ culture-induced endothelin ET B receptor upregulation in rat mesenteric arteries. Eur J Pharmacol. 2002;454:209-15 pubmed
    ..These results demonstrate a rapid induction of transcription within less than 7 h followed by an increase in the response to receptor stimulation. ..
  85. Briyal S, Nguyen C, Leonard M, Gulati A. Stimulation of endothelin B receptors by IRL-1620 decreases the progression of Alzheimer's disease. Neuroscience. 2015;301:1-11 pubmed publisher
    ..Recent studies in our lab have shown that stimulation of ETB receptors provide significant neuroprotection following Aβ1-40 administration...
  86. Povlsen G, Waldsee R, Ahnstedt H, Kristiansen K, Johansen F, Edvinsson L. In vivo experimental stroke and in vitro organ culture induce similar changes in vasoconstrictor receptors and intracellular calcium handling in rat cerebral arteries. Exp Brain Res. 2012;219:507-20 pubmed publisher
  87. Yoon S, Zuccarello M, Rapoport R. EndothelinA-endothelinB receptor cross-talk in rat basilar artery in situ. Naunyn Schmiedebergs Arch Pharmacol. 2012;385:437-41 pubmed publisher
    ..These findings suggest that the inability of ET(A) receptor antagonist to completely relax the ET-1 plateau contraction in rat basilar artery is due to ET(A)-ET(B) receptor cross-talk. ..
  88. Yono M, Latifpour J, Takahashi W, Pouresmail M, Afiatpour P, Weiss R. Age-related changes in the properties of the endothelin receptor system at protein and mRNA levels in the rat vas deferens. J Recept Signal Transduct Res. 2004;24:53-66 pubmed
    ..These results demonstrate the presence of age-related changes in the properties of the ET receptor system at both protein and mRNA levels in the rat vas deferens. ..