Edn1

Summary

Gene Symbol: Edn1
Description: endothelin 1
Alias: Et1, endothelin-1, ET-1, PPET1, preproendothelin-1
Species: rat

Top Publications

  1. ncbi Association between the endothelin-1 gene Lys198Asn polymorphism blood pressure and plasma endothelin-1 levels in normal and pre-eclamptic pregnancy
    A E Barden
    University of Western Australia, Department of Medicine, Royal Perth Hospital, Perth, Australia
    J Hypertens 19:1775-82. 2001
  2. ncbi Role of endothelin in intermittent hypoxia-induced hypertension
    N L Kanagy
    Vascular Physiology Group, Department of Cell Biology and Physiology, Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    Hypertension 37:511-5. 2001
  3. ncbi Involvement of endothelin-1 and its receptors in PGF2alpha-induced luteolysis in the rat
    Eliezer Girsh
    Department of Biological Regulation, Weizmann Institute, Rehovot, Israel
    Mol Reprod Dev 63:71-8. 2002
  4. ncbi Chronic endothelin-1 treatment leads to insulin resistance in vivo
    Jason J Wilkes
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California, USA
    Diabetes 52:1904-9. 2003
  5. ncbi Chronic endothelin exposure inhibits connexin43 expression in cultured cortical astroglia
    Joanna Rozyczka
    Institute of Anatomy, University of Leipzig, Medical Faculty, Leipzig, Germany
    J Neurosci Res 79:303-9. 2005
  6. ncbi Augmented endothelin vasoconstriction in intermittent hypoxia-induced hypertension
    Kyan J Allahdadi
    Vascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico, Health Sciences Center, Albuquerque, NM 87131, USA
    Hypertension 45:705-9. 2005
  7. ncbi Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells
    Fengtian He
    Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, School of Pharmacy, Pittsburgh, PA 15261, USA
    Circ Res 98:192-9. 2006
  8. ncbi Adrenomedullin in the rat testis. I: Its production, actions on testosterone secretion, regulation by human chorionic gonadotropin, and its interaction with endothelin 1 in the leydig cell
    Yuen Fan Chan
    Department of Anatomy, the Centre of Heart, Brain, Hormone, and Healthy Aging, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Biol Reprod 78:773-9. 2008
  9. ncbi Adrenomedullin in the rat testis. II: Its production, actions on inhibin secretion, regulation by follicle-stimulating hormone, and its interaction with endothelin 1 in the Sertoli cell
    Yuen Fan Chan
    Department of Anatomy, the Centre of Heart, Brain, Hormone, and Healthy Aging, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Biol Reprod 78:780-5. 2008
  10. doi Endothelin-1 induces the expression of C-reactive protein in rat vascular smooth muscle cells
    Chenjing Wang
    Department of Pharmacology, Xi an Jiaotong University School of Medicine, Xi an, PR China
    Biochem Biophys Res Commun 389:537-42. 2009

Detail Information

Publications151 found, 100 shown here

  1. ncbi Association between the endothelin-1 gene Lys198Asn polymorphism blood pressure and plasma endothelin-1 levels in normal and pre-eclamptic pregnancy
    A E Barden
    University of Western Australia, Department of Medicine, Royal Perth Hospital, Perth, Australia
    J Hypertens 19:1775-82. 2001
    ..This study examined the frequency of the Lys198Asn polymorphism in the endothelin-1 (ET-1) gene in women with pre-eclampsia and normal pregnancy; and its contribution to levels of plasma ET-1 and blood pressure...
  2. ncbi Role of endothelin in intermittent hypoxia-induced hypertension
    N L Kanagy
    Vascular Physiology Group, Department of Cell Biology and Physiology, Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    Hypertension 37:511-5. 2001
    ..There was no significant change in plasma ET-1 over time in air-air rats. We conclude that IH exposure increases both MAP and plasma ET-1 and that the increased ET-1 may contribute to the hypertension...
  3. ncbi Involvement of endothelin-1 and its receptors in PGF2alpha-induced luteolysis in the rat
    Eliezer Girsh
    Department of Biological Regulation, Weizmann Institute, Rehovot, Israel
    Mol Reprod Dev 63:71-8. 2002
    ....
  4. ncbi Chronic endothelin-1 treatment leads to insulin resistance in vivo
    Jason J Wilkes
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California, USA
    Diabetes 52:1904-9. 2003
    ....
  5. ncbi Chronic endothelin exposure inhibits connexin43 expression in cultured cortical astroglia
    Joanna Rozyczka
    Institute of Anatomy, University of Leipzig, Medical Faculty, Leipzig, Germany
    J Neurosci Res 79:303-9. 2005
    ..We suggest that the observed ET-dependent inhibition of Cx43 expression and the resulting decline of GJIC might represent a major pathway by which ETs regulate astrocytic gene expression in the injured brain...
  6. ncbi Augmented endothelin vasoconstriction in intermittent hypoxia-induced hypertension
    Kyan J Allahdadi
    Vascular Physiology Group, Department of Cell Biology and Physiology, University of New Mexico, Health Sciences Center, Albuquerque, NM 87131, USA
    Hypertension 45:705-9. 2005
    ..Future studies will determine the specific changes in vascular smooth muscle signaling in IH hypertension causing this augmented contractile phenotype...
  7. ncbi Downregulation of endothelin-1 by farnesoid X receptor in vascular endothelial cells
    Fengtian He
    Center for Pharmacogenetics, Department of Pharmaceutical Sciences, University of Pittsburgh, School of Pharmacy, Pittsburgh, PA 15261, USA
    Circ Res 98:192-9. 2006
    ..These studies suggest that FXR may play a role in endothelial homeostasis and may serve as a novel molecular target for manipulating ET-1 expression in vascular EC...
  8. ncbi Adrenomedullin in the rat testis. I: Its production, actions on testosterone secretion, regulation by human chorionic gonadotropin, and its interaction with endothelin 1 in the leydig cell
    Yuen Fan Chan
    Department of Anatomy, the Centre of Heart, Brain, Hormone, and Healthy Aging, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Biol Reprod 78:773-9. 2008
    ..The regulation of ADM by hCG and its interaction with endothelin 1 (EDN1) in the rat Leydig cells are also observed...
  9. ncbi Adrenomedullin in the rat testis. II: Its production, actions on inhibin secretion, regulation by follicle-stimulating hormone, and its interaction with endothelin 1 in the Sertoli cell
    Yuen Fan Chan
    Department of Anatomy, the Centre of Heart, Brain, Hormone, and Healthy Aging, Faculty of Medicine, The University of Hong Kong, Hong Kong, China
    Biol Reprod 78:780-5. 2008
    ..The regulation of ADM by FSH and its interaction with endothelin 1 (EDN1) in the rat Sertoli cells have also been established...
  10. doi Endothelin-1 induces the expression of C-reactive protein in rat vascular smooth muscle cells
    Chenjing Wang
    Department of Pharmacology, Xi an Jiaotong University School of Medicine, Xi an, PR China
    Biochem Biophys Res Commun 389:537-42. 2009
    ....
  11. ncbi Endothelins stimulate deoxyribonucleic acid synthesis and cell proliferation in rat adrenal zona glomerulosa, acting through an endothelin A receptor coupled with protein kinase C- and tyrosine kinase-dependent signaling pathways
    G Mazzocchi
    Department of Anatomy, University of Padua, Italy
    Endocrinology 138:2333-7. 1997
    ....
  12. ncbi Transcriptional regulation of pre-pro-endothelin-1 gene by glucocorticoids in vascular smooth muscle cells
    C Morin
    Department of Medicine, Faculty of Medicine, Sherbrooke University, Quebec, Canada
    Biochem Biophys Res Commun 244:583-7. 1998
    ..Our results suggest a role for glucocorticoids in the regulation of biosynthesis and action of this important vasoactive peptide in vascular smooth muscle cells...
  13. ncbi Glucocorticoids increase preproendothelin-1 expression in rat aorta
    P H Provencher
    Department of Medicine, University of Sherbrooke, QC, Canada
    Endocr Res 24:737-41. 1998
    ..Together, our results strongly suggest that the increase in preproendothelin-1 expression by glucocorticoids contributes to the regulatory action of these corticosteroids on blood pressure in health and disease...
  14. ncbi Exaggerated vascular and renal pathology in endothelin-B receptor-deficient rats with deoxycorticosterone acetate-salt hypertension
    Y Matsumura
    Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Nasahara, Takatsuki, Osaka, Japan
    Circulation 102:2765-73. 2000
    ....
  15. ncbi Extraocular blood flow and endothelin-1 plasma levels in patients with multiple sclerosis
    Mona Pache
    University Eye Clinic Basel, University Hospital Basel, Basel, Switzerland
    Eur Neurol 49:164-8. 2003
    ..0 +/- 0.4 pg/ml, range 1.1-2.8 vs. 1.5 +/- 0.2 pg/ml, range 0.9-2.0; p < 0.001). Moreover, the patients exhibited significant alterations of extraocular blood flow. The role of ET-1 in the inflammatory process remains to be clarified...
  16. ncbi An autocrine role for endothelin-1 in the regulation of proximal tubule NHE3
    Christoph Licht
    Department of Internal Medicine and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Kidney Int 65:1320-6. 2004
    ..Chronic metabolic acidosis increases preproET-1 mRNA abundance in kidney cortex, but the cell responsible has not been identified...
  17. ncbi Activation of peroxisome proliferator-activated receptor-alpha decreases endothelin-1-induced p38 mitogen-activated protein kinase activation in cardiomyocytes
    Yoko Irukayama-Tomobe
    Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    J Cardiovasc Pharmacol 44:S358-61. 2004
    ..These results suggest that the negative effect of the PPAR-alpha activator, fenofibrate, on ET-1-induced cardiac hypertrophy may be partly due to inhibition of the p38 signaling pathway...
  18. ncbi Endothelin-induced, long lasting, and Ca2+ influx-independent blockade of intrinsic secretion in pituitary cells by Gz subunits
    Silvana A Andric
    Section on Cellular Signaling, Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    J Biol Chem 280:26896-903. 2005
    ....
  19. ncbi Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes
    E Miles Whitman
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Am J Physiol Lung Cell Mol Physiol 294:L309-18. 2008
    ..These results suggest that the inhibition of K(v) channel expression and rise in [Ca(2+)](i) during chronic hypoxia may be the result of HIF-1-dependent induction of ET-1...
  20. doi Oxidative stress-induced, poly(ADP-ribose) polymerase-dependent upregulation of ET-1 expression in chronic diabetic complications
    Jane Chiu
    Department of Pathology, 4033 Dental Sciences Building, University of Western Ontario, 1151 Richmond Street North, London, ON N6A5C1, Canada
    Can J Physiol Pharmacol 86:365-72. 2008
    ..Hence, blockade of such pathways may constitute potential adjuvant treatment modalities in chronic diabetic complications...
  21. doi Regulation of the neuronal norepinephrine transporter by endothelin-1 and -3 in the rat anterior and posterior hypothalamus
    Sandra I Hope
    Cátedra de Fisiología e Instituto de Química y Metabolismo del Fármaco, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Neurochem Int 53:207-13. 2008
    ..Present results permit us to conclude that both endothelins play an important role in the regulation of norepinephrine neurotransmission at the presynaptic nerve endings in the hypothalamus...
  22. doi Downregulated FKBP12.6 expression and upregulated endothelin signaling contribute to elevated diastolic calcium and arrhythmogenesis in rat cardiomyopathy produced by l-thyroxin
    Yuan Zhang
    Research Division of Pharmacology, China Pharmaceutical University, Nanjing, 210009, China
    Int J Cardiol 130:463-71. 2008
    ..6 and upregulation of endothelin (ET-1) signaling pathway...
  23. pmc Endothelin-1 inhibits thick ascending limb transport via Akt-stimulated nitric oxide production
    Marcela Herrera
    Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Michigan 48202, USA
    J Biol Chem 284:1454-60. 2009
    ..We conclude that endothelin-1 stimulates THAL NO production by activating PI3K, stimulating Akt activity, and phosphorylating NOS3 at Ser1177. This enhances NO production and inhibits sodium transport...
  24. doi Endothelin-1 gene polymorphism and hearing impairment in elderly Japanese
    Yasue Uchida
    Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Obu, Japan
    Laryngoscope 119:938-43. 2009
    To investigate the association between the Lys198Asn (G/T) polymorphism (rs5370) in the endothelin-1 gene (EDN1) and hearing impairment in middle-aged and elderly Japanese.
  25. ncbi Spinal cord injury blunted effects of endothelin-1 on Ca(2+) transients and calcium current in isolated rat cardiomyocytes
    Y F Guo
    Department of Orthopaedics, Changzheng Hospital, Second Military Medical University, Shanghai, China
    Physiol Res 59:195-201. 2010
    ..in myocytes from SCI rats. These results suggest that the positive inotropic effects of ET-1 on control myocardial contraction may be altered in pathological states such as SCI...
  26. doi Effects of rhynchophylline and isorhynchophylline on nitric oxide and endothelin-1 secretion from RIMECs induced by Listeriolysin O in vitro
    Xi Chen
    College of Veterinary Medicine, China Agricultural University, Beijing 100094, PR China
    Vet Microbiol 143:262-9. 2010
    ..By preventing the morphological changes, decreasing cell death, and preventing disordered NO and ET-1 production in RIMECs induced by LLO, rhynchophylline and isorhynchophylline may help improve therapy for listeriosis...
  27. doi Increased ET-1 and reduced ET(B) receptor expression in uremic hypertensive rats
    Martin D'Amours
    CHUQ Research Center and Division of Nephrology and Hypertension, L Hôtel Dieu de Québec Hospital and Department of Medicine, Laval University, Quebec, Canada
    Clin Exp Hypertens 32:61-9. 2010
    ..This study reveals that ET-1 levels are augmented in the vascular endothelium of uremic rats, whereas the ET(B) receptor expression is reduced which may play a major role in hypertension and renal failure progression...
  28. doi Inhibitory effects of PPAR-gamma on endothelin-1-induced inflammatory pathways in vascular smooth muscle cells from normotensive and hypertensive rats
    Augusto C Montezano
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    J Am Soc Hypertens 1:150-60. 2007
    ..These effects may be abrogated by the PPAR-gamma activator rosiglitazone. PPAR-gamma activators may thus prevent deleterious ET-1-dependent proinflammatory vascular effects in VSMC in hypertension...
  29. doi Endothelin signaling via guanine exchange factor C3G in renal glomerular mesangial cells
    Victoriya A Rufanova
    Department of Medicine, Division of Nephrology and Kidney Disease Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Can J Physiol Pharmacol 88:808-16. 2010
    ....
  30. doi Telmisartan prevents the progression of renal injury in daunorubicin rats with the alteration of angiotensin II and endothelin-1 receptor expression associated with its PPAR-γ agonist actions
    Wawaimuli Arozal
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265 1 Higashijima Akiha ku, Niigata City 956 8603, Japan
    Toxicology 279:91-9. 2011
    ....
  31. pmc Inhibition of endothelin-1-mediated contraction of hepatic stellate cells by FXR ligand
    Jiang Li
    Department of Pharmaceutical Sciences, School of Pharmacy, Center for Pharmacogenetics, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 5:e13955. 2010
    ..To elucidate the potential mechanism we showed that GW4064 inhibited ET-1-mediated activation of Rho/ROCK pathway in activated HSCs. Our studies unveiled a new mechanism that might contribute to the anti-cirrhotic effects of FXR ligands...
  32. doi Novel regulation of endothelin-1 promoter activity by protein kinase C
    Peter K Stricklett
    Division of Nephrology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA
    Cell Biochem Biophys 61:643-50. 2011
    ..In summary, PKC stimulates collecting duct ET-1 synthesis via transcriptional activation of the ET-1 promoter. Such transcriptional activation occurs at a heretofore undescribed PKC-regulated region of the ET-1 promoter...
  33. doi Hepatic endothelin-1 and endocannabinoids-dependent effects of hyperleptinemia in nonalcoholic steatohepatitis-cirrhotic rats
    Ying Ying Yang
    Division of General Medicine, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Hepatology 55:1540-50. 2012
    ..Interestingly, acute incubation of leptin directly increases the expression of ET(A) R, OBRb and activator protein-1 in HSCs...
  34. pmc Feedback regulation by Atf3 in the endothelin-1-responsive transcriptome of cardiomyocytes: Egr1 is a principal Atf3 target
    Alejandro Giraldo
    Institute of Cardiovascular and Metabolic Research, School of Biological Sciences, University of Reading, Whiteknights, UK
    Biochem J 444:343-55. 2012
    ..The results of the present study therefore identify Atf3 as a nexus in cardiomyocyte hypertrophy required to facilitate the full and proper growth response...
  35. doi Oestradiol ameliorates monocrotaline pulmonary hypertension via NO, prostacyclin and endothelin-1 pathways
    Ping Yuan
    Dept of Cardio Pulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China
    Eur Respir J 41:1116-25. 2013
    ..Oestrogen deficiency may aggravate development of pulmonary hypertension. 17β-oestradiol improved pulmonary hypertension via activation of the PI3K/Akt pathway to regulate NO, PGI2 and ET-1 expression...
  36. ncbi Increased cardiac endothelin-1 and nitric oxide in adriamycin-induced acute cardiotoxicity: protective effect of Ginkgo biloba extract
    Noha Ahmed El-Boghdady
    Biochemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
    Indian J Biochem Biophys 50:202-9. 2013
    ..Thus, EGb761 may find use as promising adjuvant therapy to ameliorate cardiotoxicity of ADR...
  37. doi Involvement of peptidyl-prolyl isomerase Pin1 in the inhibitory effect of fluvastatin on endothelin-1-induced cardiomyocyte hypertrophy
    Satoshi Sakai
    Division of Cardiovascular Medicine, Department of Clinical Medicine, Faculty of Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan Electronic address
    Life Sci 102:98-104. 2014
    ..There is no report whether the Pin1 activation contributes to ET-1-induced cardiomyocyte hypertrophy and whether the Pin1 inactivation contributes to the inhibitory effect of statins. The aim of this study was to reveal these questions...
  38. doi Endothelin-1 exacerbates development of hypertension and atherosclerosis in modest insulin resistant syndrome
    Yan Jie Lin
    Institute of Physiology, National Yang Ming University, Taipei, Taiwan Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan
    Biochem Biophys Res Commun 460:497-503. 2015
    ....
  39. pmc Two-photon imaging of endothelin-1-mediated intracellular Ca(2+) handling in smooth muscle cells of rat renal resistance arteries
    Oleg Palygin
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Life Sci 159:140-3. 2016
    ..The aim of this study was to evaluate ET-1-mediated elevation of intracellular Ca(2+) in smooth muscle cells (SMC) of renal resistance arteries...
  40. ncbi Plasma endothelin-1 levels in Behçet's disease
    T Uslu
    Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
    Clin Rheumatol 16:59-61. 1997
    ....
  41. pmc Endogenous plasma endothelin concentrations and coronary circulation in patients with mild dilated cardiomyopathy
    M Mundhenke
    Division of Cardiology, Pneumology and Angiology, School of Medicine, Heinrich Heine University, Moorenstrabetae 5, 40225 Dusseldorf, Germany
    Heart 81:278-84. 1999
    ..To determine whether increased plasma concentrations of endothelin-1 (ET-1) and big endothelin (BET) play a role in the regulation of coronary circulation in patients with idiopathic dilated cardiomyopathy (IDCM)...
  42. ncbi Vascular endothelin-1 gene expression and synthesis and effect on renal type I collagen synthesis and nephroangiosclerosis during nitric oxide synthase inhibition in rats
    P L Tharaux
    INSERM U 489, Paris, France
    Circulation 99:2185-91. 1999
    ..The purpose of the present study was to investigate whether endothelin-1 (ET-1) is involved in this pathophysiological process...
  43. ncbi Ex vivo blockade of endothelin-1 inhibits graft coronary artery disease in a rodent cardiac allograft model
    Atsushi Yamaguchi
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California, USA
    J Heart Lung Transplant 21:417-24. 2002
    ..In this study, we hypothesized that antisense (AS) oligodeoxynucleotides (ODN) for preproendothelin-1 (ppET-1) delivered to rat cardiac allografts by means of hyperbaric pressure would reduce the incidence of GCAD...
  44. pmc Effects of endothelin-1 on hepatic stellate cell proliferation, collagen synthesis and secretion, intracellular free calcium concentration
    Chuan Yong Guo
    Department of Gastroenterology, Shanghai Tenth People Hospital of Tongji University, Shanghai 200072, China
    World J Gastroenterol 10:2697-700. 2004
    ....
  45. ncbi Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile response
    Margaret V Westfall
    Department of Surgery, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 280:41324-31. 2005
    ....
  46. ncbi Strontium fructose 1,6-diphosphate rescues adenine-induced male hypogonadism and upregulates the testicular endothelin-1 system
    Yu Feng
    Research Division of Pharmacology, China Pharmaceutical University, Nanjing, China
    Clin Exp Pharmacol Physiol 34:1131-7. 2007
    ..These abnormalities were significantly restored by FDP-Sr in a dose-dependent manner. These data indicate the possibility of using FDP-Sr to treat male hypogonadism...
  47. doi Normoalbuminuric type 1 diabetic patients with retinopathy have an impaired tubular response to desmopressin: its relationship with plasma endothelin-1
    Cristina Hernandez
    Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas, Diabetes Research Unit, Institut de Recerca Hospital Universitari Vall d Hebron, Universitat Autonoma de Barcelona, Barcelona 08035, Spain
    J Clin Endocrinol Metab 94:2060-5. 2009
    ....
  48. doi Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats
    Emerson Marcelo Motta
    Department of Pharmacology, Universidade Federal de Santa Catarina, Center of Biological Sciences, Block D, Florianopolis, 88049 490, SC, Brazil
    Neurosci Lett 457:146-50. 2009
    ..Importantly, although ET-1 augments capsaicin-induced overt nociception and thermal hyperalgesia, potentiation of the former relies solely on ET(A) receptor-mediated signaling mechanisms, whereas both receptors contribute to the latter...
  49. doi Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction
    Takayuki Matsumoto
    Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Peptides 31:346-53. 2010
    ....
  50. pmc Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections
    Philipp Schuetz
    Department of Internal Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland
    Crit Care 14:R106. 2010
    ..Measurement of prohormones representing different pathophysiological pathways could enhance risk stratification in patients with community-acquired pneumonia (CAP) and other lower respiratory tract infections (LRTI)...
  51. ncbi Despite similar reduction of blood pressure and renal ANG II and ET-1 levels aliskiren but not losartan normalizes albuminuria in hypertensive Ren-2 rats
    Z Vanourková
    Department of Experimental Hypertension, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Physiol Res 59:339-45. 2010
    ..Despite similar reductions of MAP and renal ET-1 and ANG II levels aliskiren appears to be more effective than losartan, at the doses used, in reducing albuminuria in heterozygous hypertensive Ren-2 rats...
  52. doi Mechanisms involved in the long-term modulation of tyrosine hydroxylase by endothelins in the olfactory bulb of normotensive rats
    Sabrina L Nabhen
    Instituto de Química y Metabolismo del Fármaco Consejo Nacional de Investigaciones Científicas y Tecnológicas IQUIMEFA CONICET, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Neurochem Int 58:196-205. 2011
    ....
  53. pmc Endothelin 1 activation of endothelin A receptor/NADPH oxidase pathway and diminished antioxidants critically contribute to endothelial progenitor cell reduction and dysfunction in salt-sensitive hypertension
    Dan Dan Chen
    Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Hypertension 59:1037-43. 2012
    ....
  54. doi Endothelin receptors in augmented vasoconstrictor responses to endothelin-1 in chronic intermittent hypoxia
    Qiu Hong Guo
    Department of Pharmacology, Hebei Medical University, Shijiazhuang, China
    Clin Exp Pharmacol Physiol 40:449-57. 2013
    ..It appears that the ETB receptor-induced buffering of ET-1 responsiveness is mediated via a nitric oxide-dependent mechanism. ..
  55. ncbi [The vasoactive material and pulmonary vascular structural remodeling in rats]
    Qiu Hong Chen
    Qinghai High Altitude Medical Sciences Institute, Xining 810012, China
    Zhongguo Ying Yong Sheng Li Xue Za Zhi 22:71-4. 2006
    ..To investigate the role of vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) on pulmonary vascular structural remodeling in rats and pika...
  56. doi Effect of chronic central endothelin-1 on hemodynamics and plasma vasopressin in conscious rats
    Noreen F Rossi
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurol Res 33:169-75. 2011
    ..These studies were designed to test whether chronic central administration of endothelin-1 induces changes in systemic hemodynamics and plasma vasopressin similar to those observed with acute microinjections of endothelin-1...
  57. ncbi Elevated plasma endothelin in patients with diabetes mellitus
    K Takahashi
    Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Diabetologia 33:306-10. 1990
    ..The elevation of endothelin in diabetic patients may be a marker of, and further exacerbate, their vascular disease...
  58. ncbi Increased tissue endothelin immunoreactivity in atherosclerotic lesions associated with acute coronary syndromes
    A M Zeiher
    Department of Internal Medicine III, University of Freiburg, Germany
    Lancet 344:1405-6. 1994
    ..Tissue endothelin-1-like immunoreactivity might contribute to the exaggerated coronary vasoconstriction...
  59. ncbi Effect of a specific endothelin receptor A antagonist and an angiotensin-converting enzyme inhibitor on glomerular mRNA levels for extracellular matrix components, metalloproteinases (MMP) and a tissue inhibitor of MMP in aminonucleoside nephrosis
    I Ebihara
    Department of Medicine, Koto Hospital, Tokyo, Japan
    Nephrol Dial Transplant 12:1001-6. 1997
    ....
  60. ncbi Sputum endothelin-1 is increased in cystic fibrosis and chronic obstructive pulmonary disease
    G W Chalmers
    Dept of Respiratory Medicine, West Glasgow Hospitals University NHS Trust, UK
    Eur Respir J 13:1288-92. 1999
    ..The role of endothelin-1 in contributing to airflow obstruction through bronchoconstriction and mitogenesis in cystic fibrosis needs now to be explored...
  61. ncbi Chronic hypoxia enhances endothelin-1-induced intracellular calcium elevation in rat carotid body chemoreceptors and up-regulates ETA receptor expression
    Yueping Chen
    Department of Physiology, Faculty of Medicine, University of Hong Kong, 5 Sassoon Road, Pokfulam, Hong Kong
    Pflugers Arch 443:565-73. 2002
    ..The enhancement of the paracrine/autocrine effect of ET-1 on the chemoreceptors is consistent with an excitatory and mitogenic role of the ET-1 and ETA receptor in the CB during chronic hypoxia...
  62. ncbi Mechanism of inhibition of endothelin-1-stimulated proteoglycan and collagen synthesis in rat articular chondrocytes
    A M Khatib
    INSERM Unit 349, Lariboisiere Hospital, 75475 Paris, Cedex 10, France
    Cytokine 17:254-61. 2002
    ..In conclusion, NO, produced by rat AC in response to ET-1, counteracts the stimulation and finally induces inhibition of PG-collagen synthesis by ET-1 in these cells but NO-induced cGMP is only partially responsible for this inhibition...
  63. ncbi Levels of endothelin-1 in embryos from control and neonatal streptozotocin-induced diabetic rats, and their relationship with nitric oxide generation
    Debora Sinner
    Centro de Estudios Farmacologicos y Botanicos, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Reprod Fertil Dev 14:23-8. 2002
    ..Endothelin-1 has been shown to be a negative modulator of embryonic NO levels, a mechanism likely to be important during development. Endothelin-1 may prevent damage induced by NO overproduction in embryos from n-stz diabetic rats...
  64. ncbi Endothelin-1 and -3 diminish neuronal NE release through an NO mechanism in rat anterior hypothalamus
    Andrea S di Nunzio
    Catedras de Fisiologia y Fisiopatologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires Consejo Nacional de Investigaciones Científicas y Técnicas CONICET, 1113 Buenos Aires, Argentina
    Am J Physiol Regul Integr Comp Physiol 283:R615-22. 2002
    ..ET-1 and ET-3 may thus diminish available NE in the synaptic gap leading to decreased noradrenergic activity...
  65. ncbi Contributions of endothelin-1 and sodium hydrogen exchanger-1 in the diabetic myocardium
    Denise Hileeto
    Department of Pathology, The University of Western Ontario, London, Ontario, Canada
    Diabetes Metab Res Rev 18:386-94. 2002
    ..Accordingly, the aim of this study was to investigate the interactive roles of ET-1 and NHE-1 in the pathogenesis of diabetic cardiomyopathy, a significant cause of morbidity in diabetic patients...
  66. ncbi Endothelin-1 stimulated capacitative Ca2+ entry through ET(A) receptors of a rat brain-derived type-1 astrocyte cell line, IA-1g1
    You Jing Ju
    Institute of Neuroscience, College of Life Science, National Yang Ming University, 155, Section 2, Li Non Street, Shi Pai, Taipei, Taiwan, ROC
    Cell Signal 15:197-207. 2003
    ..Thus, protein kinase C (PKC) negatively regulated and cAMP-dependent protein kinase (PKA) positively regulated the ET-1-mediated CCE in these cells...
  67. ncbi Co-localisation of nitric oxide synthase and endothelin in the rat supraoptic nucleus
    Andrew B Mukherjee
    Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, Gower Street, London WCIE 6BT, UK
    Histochem J 34:181-7. 2002
    ..The findings are discussed in terms of the possible role and significance of nitric oxide and endothlin-1 in the hypothalamo-neurohypophysial system...
  68. ncbi Expression and cellular localisation of renal endothelin-1 and endothelin receptor subtypes in autosomal-dominant polycystic kidney disease
    Albert C M Ong
    Sheffield Kidney Institute, Section of Human Metabolism, Division of Clinical Sciences NGH, University of Sheffield, London, UK
    Nephron Exp Nephrol 93:e80. 2003
    ..As a first step in investigating the potential role of endothelin-1 (ET1) and its receptors (ETA and ETB) in the pathophysiology of progression in ADPKD, we have studied their expression ..
  69. ncbi Increased pulmonary vascular endothelin B receptor expression and responsiveness to endothelin-1 in cirrhotic and portal hypertensive rats: a potential mechanism in experimental hepatopulmonary syndrome
    Bao Luo
    Department of Internal Medicine, Liver Center, University of Alabama at Birmingham, 290 MCLM, 1918 University Boulevard, Birmingham, AL 35294 0005, USA
    J Hepatol 38:556-63. 2003
    ..We evaluated if pulmonary ET receptor expression changes in experimental cirrhosis and portal hypertension and confers susceptibility to HPS...
  70. pmc Cardiac myofibroblasts isolated from the site of myocardial infarction express endothelin de novo
    Laxmansa C Katwa
    Department of Physiology, Rm 6N 98 Brody Building, Brody School of Medicine at East Carolina University, 600 Moye Blvd, Greenville, NC 27858, USA
    Am J Physiol Heart Circ Physiol 285:H1132-9. 2003
    ..In cultured cells, we found: 1) expression of mRNA for ET precursor gene (ppET1), ECE-1, and ETA and ETB receptors by semiquantitative RT-PCR; 2) phosphoramidon-sensitive ECE-1 activity, which ..
  71. ncbi Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation
    Alexander G Minchenko
    Department of Anesthesiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    FASEB J 17:1514-6. 2003
    ..PARP inhibitors could provide a novel therapeutic approach for diabetic complications including nephropathy, and other diseases that involve the endothelin system...
  72. ncbi Cholesterol dependence of vascular ERK1/2 activation and growth in response to stretch: role of endothelin-1
    Asad Zeidan
    Division of Molecular and Cellular Physiology, Department of Physiological Sciences, Lund University, Biomedical Centre, Lund, Sweden
    Arterioscler Thromb Vasc Biol 23:1528-34. 2003
    ..This study tested the role of rafts/caveolae in stretch-induced vascular growth by manipulation of membrane cholesterol contents...
  73. ncbi Detection of prepro-ET-1 mRNA in normal rat kidney by in situ RT-PCR
    Kazuaki Moridaira
    Department of Hygiene and Preventive Medicine, Faculty of Medicine, Saitama Medical School, Tokyo University of Science, Saitama, Japan
    Nephron Exp Nephrol 95:e55-61. 2003
    ..In this study, in situ RT-PCR was utilized to detect tubular expression of prepro-ET-1 mRNA in normal rat kidney...
  74. ncbi Amlodipine at high dose increases preproendothelin-1 expression in the ventricles and aorta of normotensive rats
    Peter Krenek
    Laboratoire de Pharmacologie, Universite Catholique de Louvain, Avenue Hippocrate 54, B 1200 Brussels, Belgium
    J Hypertens 22:827-35. 2004
    ..Both noradrenaline and angiotensin II stimulate preproendothelin-1 gene expression, yet the effects of high doses of dihydropyridines on preproendothelin-1 expression in vivo remain unknown...
  75. ncbi Intracellular coexpression of endothelin-1 and inducible nitric oxide synthase underlies hypoperfusion after traumatic brain injury in the rat
    D Rafols
    Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neurosci Lett 362:154-7. 2004
    ..The results further indicate that interaction between ET-1 and iNOS occurs at the cytosol and possibly the nuclear membranes, implicating mediation via endothelin receptors...
  76. ncbi The roles of free oxygen radicals, nitric oxide, and endothelin in caustic injury of rat esophagus
    S Kerem Ozel
    Department of Pediatric Surgery, Marmara University School of Medicine, Istanbul, Turkey
    J Pediatr Surg 39:1381-5. 2004
    ..The authors aimed to find out the roles of free oxygen radicals, nitric oxide (NO), and endothelin (ET) in caustic injury of rat esophagus...
  77. ncbi Interaction between endothelial heme oxygenase-2 and endothelin-1 in altered aortic reactivity after hypoxia in rats
    Vasanthi Govindaraju
    Meakins Christie Laboratories, McGill University, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 288:H962-70. 2005
    ..HO-2 is expressed by aortic endothelial cells early during hypoxic exposure and impairs ET-1-mediated potentiation of contraction to alpha-adrenoceptor stimulation...
  78. ncbi Cardiac myocytes control release of endothelin-1 in coronary vasculature
    Daphne Merkus
    Experimental Cardiology, Thoraxcenter, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 288:H2088-92. 2005
    ....
  79. ncbi Effects of endothelin-1 on the membrane potential and slow waves in circular smooth muscle of rat gastric antrum
    Kenro Imaeda
    Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya 467 8601, Japan
    J Smooth Muscle Res 40:199-210. 2004
    ..ET-1 also appears to increase the frequency of slow waves via ETB receptors, however this mechanism would seem to be independent of membrane depolarization...
  80. ncbi Differential circadian expression of endothelin-1 mRNA in the rat suprachiasmatic nucleus and peripheral tissues
    Shuji Hanai
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    Neurosci Lett 377:65-8. 2005
    ..The results are the first description of the circadian expression of ET-1 mRNA. The diversity of rhythmic expressions among the SCN, whole brain, lungs and heart suggests that ET-1 has different functions in these tissues...
  81. ncbi Expression of endothelin-1 in the brain and lung of rats exposed to permanent hypobaric hypoxia
    Fumiko Kanazawa
    Biochemical Section, 2nd Division, Aeromedical Laboratory, Japan Air Self Defense Force, Tachikawa 190 0003, Japan
    Brain Res 1036:145-54. 2005
    ....
  82. ncbi Effects of medium-chain triglyceride (MCT) application to SHR on cardiac function, hypertrophy and expression of endothelin-1 mRNA and other genes
    Nobutake Shimojo
    Cardiovascular Division, Department of Internal Medicine, University of Tsukuba, Tsukuba, Japan
    J Cardiovasc Pharmacol 44:S181-5. 2004
    ..Because mechanical stress to the heart is similar between SHR-LCT and SHR-MCT, this may be a reason for the lack of difference in expression of molecular markers...
  83. ncbi Establishment of hypoxia inducible factor-1alpha overexpressing cells that produce endothelin-1
    Masakatsu Takanashi
    Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Japan
    J Cardiovasc Pharmacol 44:S268-73. 2004
    ..The endothelin-1 mRNA was significantly altered in HIF-1alpha-overexpressing cells. These results indicate that we have established the cells overexpressing-HIF-1alpha, and that these cells produce endothelin-1 mRNA...
  84. ncbi Endothelin-1-dependent leptin induction in gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide
    Bronislaw L Slomiany
    Research Center, University of Medicine and Dentistry of New Jersey, Newark, 07103 2400, USA
    Biochem Biophys Res Commun 336:1106-11. 2005
    ..pylori infection. We also show that the effect of ET-1 on leptin production is a consequence of ET(A) receptor activation...
  85. ncbi Involvement of endothelium and endothelin-1 in lead-induced smooth muscle cell dysfunction in rats
    L Molero
    Cardiovascular Research Unit, Hospital Clinico San Carlos, Madrid, Spain, and Department of Medicine, University of California, Irvine, USA
    Kidney Int 69:685-90. 2006
    ..As conclusion, the endothelium through the activation of ETA-type receptors mediates the downregulation of sGC expression by lead in the vascular wall...
  86. ncbi Inhibition of endothelin-1-mediated up-regulation of iNOS by bosentan ameliorates endotoxin-induced liver injury in cirrhosis
    Steve Keller
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    Shock 25:306-13. 2006
    ..Thus, due to significant increases in ET-1 levels during cirrhosis, ET-1 receptor blockade may prove to be of great therapeutic value in the treatment of cirrhotic patients exposed to secondary injuries such as endotoxemia...
  87. ncbi Hypoxia-inducible factor (HIF)-1alpha and endothelin-1 expression in the rat carotid body during intermittent hypoxia
    Siu Yin Lam
    Department of Physiology, The University of Hong Kong, Faculty of Medicine Building, 21 Sassoon Road, Pokfulam, Hong Kong, China
    Adv Exp Med Biol 580:21-7; discussion 351-9. 2006
  88. ncbi A novel endothelin receptor antagonist CPU0213 improves diabetic cardiac insufficiency attributed to up-regulation of the expression of FKBP12.6, SERCA2a, and PLB in rats
    Min You Qi
    Research Division of Pharmacology, China Pharmaceutical University, Nanjing, China
    J Cardiovasc Pharmacol 47:729-35. 2006
    ..After 4-week treatment, CPU0213 was capable to attenuate completely the down-regulated FKBP12.6 and SERCA2a, and up-regulated ET system in association with a recovery of the cardiac insufficiency of diabetic cardiomyopathy...
  89. ncbi Effect of YM598, a selective endothelin ETA receptor antagonist, on endothelin-1-induced bone formation
    Akiyoshi Someya
    Pharmacology Laboratories, Institute for Drug Discovery Research, Astellas Pharma, Inc 21, Miyukigaoka, Tsukuba shi, Ibaraki 305 8585, Japan
    Eur J Pharmacol 543:14-20. 2006
    ..These results suggest that endothelin-1 may induce bone formation via endothelin ET(A) receptors in vitro and in vivo...
  90. ncbi Endothelin-mediated oncofetal fibronectin expression in chronic allograft nephropathy
    Iram Siddiqui
    Department of Pathology, University of Western Ontario, London, Canada
    Transplantation 82:406-14. 2006
    ..In the present study, we investigated ED-B FN expression in chronic allograft nephropathy and its relationship with endothelins (ET)...
  91. ncbi Role of Rho kinase in endothelin-1-induced phosphorylation of CPI-17 in rat bronchial smooth muscle
    Hiroyasu Sakai
    Department of Pharmacology, School of Pharmacy, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Pulm Pharmacol Ther 20:734-9. 2007
    ..Thus, RhoA/ROCK/CPI-17 pathway is considered to play an important role in the ET-1-induced Ca(2+) sensitisation of bronchial smooth muscle contraction...
  92. ncbi 17beta-Estradiol modulates vasoconstriction induced by endothelin-1 following trauma-hemorrhage
    Zheng F Ba
    Center for Surgical Research and Dept of Surgery, Univ of Alabama at Birmingham, 1670 University Blvd, Volker Hall, Rm G094, Birmingham, AL 35294 0019, USA
    Am J Physiol Heart Circ Physiol 292:H245-50. 2007
    ..Thus, E(2) administration attenuates ET-1-induced vasoconstriction following trauma-hemorrhage via an ER-beta-mediated pathway that is dependent on endothelium-derived NO synthesis...
  93. ncbi Differential Signaling and Hypertrophic Responses in Cyclically Stretched vs Endothelin-1 Stimulated Neonatal Rat Cardiomyocytes
    Henriëtte W de Jonge
    Department of Biochemistry, Cardiovascular Research School COEUR, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Cell Biochem Biophys 47:21-32. 2007
    ....
  94. ncbi Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use
    Muammer Kendirci
    Department of Urology, Tulane University School of Medicine, New Orleans, LA 70112, USA
    Eur Urol 52:555-63. 2007
    ..To evaluate the peripheral mechanisms of erectile dysfunction (ED) in a rat model of triple-binge cocaine administration...
  95. ncbi C-terminal pro-endothelin-1 offers additional prognostic information in patients after acute myocardial infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) Study
    Sohail Q Khan
    Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK
    Am Heart J 154:736-42. 2007
    ..We investigated the cardiovascular prognostic value post-AMI of CT-proET-1 and compared it to N-terminal pro-B-type natriuretic peptide (NTproBNP), a marker of death and HF...
  96. doi Heat shock proteins, endothelin, and peripheral neuronal injury
    Markus G Klass
    Emory University Department of Anesthesiology, Atlanta, GA, United States
    Neurosci Lett 433:188-93. 2008
    ..Regulation of heat shock proteins after nerve injury is not likely due to endothelin signaling...
  97. ncbi The role of endothelin-1 and nitric oxide in the pathogenesis of hypertension in diabetic patients
    Monika Tomic
    Department of Nephrology and Hemodialysis, Mostar University Hospital, Mostar, Bosnia and Herzegovina
    Coll Antropol 32:93-8. 2008
    ..In addition, the increase in plasma NO was accompanied by a statistically significant decline of both systolic and diastolic blood pressure in diabetic patients receiving ACEI...
  98. doi Role of endothelin ET(A) and ET(B) receptor subtypes in the regulation of intrarenal blood flow and oxygen tension in rats
    Nicoletta Nitescu
    Department of Anaesthesiology and Intensive Care, Institute of Clinical Sciences, Institute of Mdicine, The Sahlgrenska Academy at Göteborg, Sweden
    Clin Exp Pharmacol Physiol 35:1227-32. 2008
    ..Finally, BQ-123 increased renal outer medullary perfusion, suggesting a tonic vasoconstrictor effect of ET(A) receptors in the medulla of normotensive rats...
  99. pmc Regulation of the epithelial Na+ channel by endothelin-1 in rat collecting duct
    Vladislav Bugaj
    Department of Physiology 7756, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Am J Physiol Renal Physiol 295:F1063-70. 2008
    ..These findings may provide a potential mechanism for the natriuresis observed in vivo in response to ET-1, as well as a potential cause for the salt-sensitive hypertension found in animals with impaired endothelin signaling...
  100. doi Endothelin-1 induces organ-specific histamine liberation and neutrophil granulocyte accumulation in the rat
    J Kaszaki
    Institute of Surgical Research, University of Szeged, Pécsi u 4, 6701, Szeged, Hungary
    Inflamm Res 57:396-402. 2008
    ..We compared local consequences of transient increases in circulating ET-1 in three separate circulatory beds in pentobarbital-anesthetized Wistar rats...

Research Grants8

  1. Neural Control of Sodium Balance in Hypertension: Exercise
    Noreen Rossi; Fiscal Year: 2009
    ..These studies will provide data to direct strategic pharmacologic and nonpharmacologic interventions for cardiovascular health that may be readily translated into clinical practice. ..
  2. ENDOTHELIN AND INTRAUTERINE GROWTH RESTRICTION
    LARRY THAETE; Fiscal Year: 2002
    ..Cellular localization of ET, ET receptors, and NOS isoforms will be performed with immunocytochemistry. ..
  3. VASCULAR ALPHA2 ADRENOCEPTORS IN NITRIC OXIDE SYNTHASE I
    Nancy Kanagy; Fiscal Year: 2002
    ..End of Abstract) ..
  4. IMPACT OF ENDOTHELIN IN INTRAUTERINE GROWTH RESTRICTION
    LARRY THAETE; Fiscal Year: 2005
    ....
  5. Mechanisms of Pregnancy Induced Hypertension
    Babbette LaMarca; Fiscal Year: 2007
    ....
  6. ET and PAF Synergism in intrauterine growth restriction
    LARRY THAETE; Fiscal Year: 2008
    ..Our goal is to assess the specific role of ET-1, as well as its interaction with PAF, in the pathophysiology of I/R-induced IUGR. ..
  7. Influence of Troponin I Phosphrylation by PKC on Contractile Function
    Margaret V Westfall; Fiscal Year: 2010
    ..The ability to restore relaxation by gene transfer of Asp-substituted cTnl will be examined in failing myocytes. These studies could aid in the development of therapies to improve relaxation during heart failure. ..
  8. Endothelin vasoconstriction in a rat model of sleep apnea-induced hypertension.
    Nancy L Kanagy; Fiscal Year: 2010
    ....