Edc3

Summary

Gene Symbol: Edc3
Description: enhancer of mRNA decapping 3
Alias: Lsm16, RGD1306898, enhancer of mRNA-decapping protein 3, LSM16 homolog (EDC3, S. cerevisiae), enhancer of mRNA decapping 3 homolog
Species: rat
Products:     Edc3

Top Publications

  1. Ling S, Decker C, Walsh M, She M, Parker R, Song H. Crystal structure of human Edc3 and its functional implications. Mol Cell Biol. 2008;28:5965-76 pubmed publisher
    b>Edc3 is an enhancer of decapping and serves as a scaffold that aggregates mRNA ribonucleoproteins together for P-body formation...
  2. Jonas S, Izaurralde E. The role of disordered protein regions in the assembly of decapping complexes and RNP granules. Genes Dev. 2013;27:2628-41 pubmed publisher
    ..These factors include enhancer of decapping 3 (EDC3), EDC4, like Sm14A (LSm14A), Pat, the LSm1-7 complex, and the RNA helicase DDX6...
  3. Ahmed I, Buchert R, Zhou M, Jiao X, Mittal K, Sheikh T, et al. Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment. Hum Mol Genet. 2015;24:3172-80 pubmed publisher
    ..In another family, we identified a homozygous mutation (c.161T>C; p.Phe54Ser) in EDC3 in two affected children...