Gene Symbol: Eda
Description: ectodysplasin-A
Alias: RGD1563178, Tnlg7c, ectodysplasin-A, tumor necrosis factor ligand 7c
Species: rat
Products:     Eda

Top Publications

  1. Mikkola M, Pispa J, Pekkanen M, Paulin L, Nieminen P, Kere J, et al. Ectodysplasin, a protein required for epithelial morphogenesis, is a novel TNF homologue and promotes cell-matrix adhesion. Mech Dev. 1999;88:133-46 pubmed
    In the mouse Tabby (Ta) mutant and human X-linked anhidrotic ectodermal dysplasia (EDA) syndrome development of several ectodermal organs such as hair, teeth, and sweat glands is impaired...
  2. Crocker M, Cattanach B. The genetics of Sleek: a possible regulatory mutation of the tabby-crinkled-downless syndrome. Genet Res. 1979;34:231-8 pubmed
  3. Cattanach B, Wolfe H, Lyon M. A comparative study of the coats of chimaeric mice and those of heterozygotes for X-linked genes. Genet Res. 1972;19:213-28 pubmed
  4. GRUNEBERG H. Genes and genotypes affecting the teeth of the mouse. J Embryol Exp Morphol. 1965;14:137-59 pubmed
  5. Kere J, Srivastava A, Montonen O, Zonana J, Thomas N, Ferguson B, et al. X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Nat Genet. 1996;13:409-16 pubmed
    Ectodermal dysplasias comprise over 150 syndromes of unknown pathogenesis. X-linked anhidrotic ectodermal dysplasia (EDA) is characterized by abnormal hair, teeth and sweat glands...
  6. Cui C, Kunisada M, Esibizione D, Grivennikov S, Piao Y, Nedospasov S, et al. Lymphotoxin-beta regulates periderm differentiation during embryonic skin development. Hum Mol Genet. 2007;16:2583-90 pubmed
    ..As expected, Tabby mice, which lack the EDA gene, the putative upstream regulator of LTbeta in skin, showed similar though milder periderm histopathology and ..
  7. Fliniaux I, Mikkola M, Lefebvre S, Thesleff I. Identification of dkk4 as a target of Eda-A1/Edar pathway reveals an unexpected role of ectodysplasin as inhibitor of Wnt signalling in ectodermal placodes. Dev Biol. 2008;320:60-71 pubmed publisher
    ..Ectodysplasin-A1 (Eda-A1) and Wnts are high in hierarchy of placode activators...
  8. Zhang Y, Tomann P, Andl T, Gallant N, Huelsken J, Jerchow B, et al. Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell. 2009;17:49-61 pubmed publisher
    ..Wnt/beta-catenin signaling is initially activated independently of EDA/EDAR/NF-kappaB activity in primary hair follicle primordia...
  9. Shen W, Wang Y, Liu Y, Liu H, Zhao H, Zhang G, et al. Functional Study of Ectodysplasin-A Mutations Causing Non-Syndromic Tooth Agenesis. PLoS ONE. 2016;11:e0154884 pubmed publisher
    Recent studies have demonstrated that ectodysplasin-A (EDA) mutations are associated with non-syndromic tooth agenesis...

More Information


  1. Miard S, Peterkova R, Vonesch J, Peterka M, Ruch J, Lesot H. Alterations in the incisor development in the Tabby mouse. Int J Dev Biol. 1999;43:517-29 pubmed
    ..Our observations suggest independent development of the labial and lingual parts of the cervical loop. Furthermore, it appeared that the consequences of Ta mutation could not be interpreted only as a delay in tooth development. ..
  2. Yan M, Wang L, Hymowitz S, Schilbach S, Lee J, Goddard A, et al. Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors. Science. 2000;290:523-7 pubmed
    Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth...
  3. Pispa J, Pummila M, Barker P, Thesleff I, Mikkola M. Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development. Hum Mol Genet. 2008;17:3380-91 pubmed publisher
    The development of ectodermal organs requires signalling by ectodysplasin (Eda), a tumor necrosis factor (TNF) family member, its receptor Edar and downstream activation of the nuclear factor kappaB (NF-kappaB) transcription factor...
  4. Jaskoll T, Zhou Y, Trump G, Melnick M. Ectodysplasin receptor-mediated signaling is essential for embryonic submandibular salivary gland development. Anat Rec A Discov Mol Cell Evol Biol. 2003;271:322-31 pubmed
    ..Mutations in the EDA (ectodysplasin-A) and EDAR (ectodysplasin-A receptor) genes are responsible for X-linked and autosomal HED, ..
  5. Rawlins E, Hogan B. Intercellular growth factor signaling and the development of mouse tracheal submucosal glands. Dev Dyn. 2005;233:1378-85 pubmed
    ..Glands are completely absent in mice lacking Ectodysplasin (Eda) and Edaradd (Eda receptor adaptor protein), members of the tumor necrosis (TNF) superfamily of signaling factors...