Gene Symbol: E2f5
Description: E2F transcription factor 5
Alias: E2f-5, transcription factor E2F5
Species: rat
Products:     E2f5

Top Publications

  1. Lindeman G, Dagnino L, Gaubatz S, Xu Y, Bronson R, Warren H, et al. A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting. Genes Dev. 1998;12:1092-8 pubmed
    ..Cell cycle kinetics were not perturbed in homozygous knockout embryo fibroblasts. Thus, E2F-5 is not essential for cell proliferation. Rather, it affects the secretory behavior of a differentiated neural tissue. ..
  2. Gill R, Hamel P. Subcellular compartmentalization of E2F family members is required for maintenance of the postmitotic state in terminally differentiated muscle. J Cell Biol. 2000;148:1187-201 pubmed
    ..These data demonstrate that regulation of the subcellular compartmentalization of E2F-family members is required to maintain nuclei in a quiescent state in terminally differentiated cells. ..
  3. Morris L, Allen K, La Thangue N. Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators. Nat Cell Biol. 2000;2:232-9 pubmed
    ..These results indicate that E2F activity may be directly regulated by cyclin E-Cdk2, and imply an autoregulatory mechanism for cell-cycle-dependent transcription through the CDK-stimulated interaction of E2F with p300/CBP co-activators. ..
  4. Vara D, Bicknell K, Coxon C, Brooks G. Inhibition of E2F abrogates the development of cardiac myocyte hypertrophy. J Biol Chem. 2003;278:21388-94 pubmed
    ..Thus, we have shown that the inhibition of E2F function prevents the development of hypertrophy. Targeting E2F function might be a useful approach for treating diseases that cause pathophysiological hypertrophic growth. ..
  5. Rubin S, Gall A, Zheng N, Pavletich N. Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell. 2005;123:1093-106 pubmed
    ..Our findings explain the requirement of RbC for high-affinity E2F binding and growth suppression and establish a mechanism for the regulation of Rb-E2F association by phosphorylation. ..
  6. Dong H, Xu C. Analysis of the relevance of e2fs and their target genes with rat liver regeneration. Indian J Gastroenterol. 2008;27:31-2 pubmed
  7. Gaubatz S, Lindeman G, Ishida S, Jakoi L, Nevins J, Livingston D, et al. E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. Mol Cell. 2000;6:729-35 pubmed
    ..E2F4 and E2F5 constitute a defined subset of the family...
  8. Fujita N, Furukawa Y, Itabashi N, Okada K, Saito T, Ishibashi S. Differences in E2F subunit expression in quiescent and proliferating vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2002;283:H204-12 pubmed
    ..In contrast, both FBS and vasoconstrictive hormones drove transcription of the cdc6 gene by downregulating p130 and recruiting free E2F-3 in the latter, which underlies the progression of VSMC into S phase. ..
  9. Swetloff A, Ferretti P. Changes in E2F5 intracellular localization in mouse and human choroid plexus epithelium with development. Int J Dev Biol. 2005;49:859-65 pubmed
    ..It has been recently shown that mice lacking functional transcription factors, E2F5, foxJ1 or p73, develop non-obstructive hydrocephalus likely due to CPe dysfunction...

More Information


  1. Hayashi R, Goto Y, Haga A, Kobayashi D, Ikeda R, Yoshida K. Comparative genomics on MCM8 orthologous genes reveals the transcriptional regulation by transcription factor E2F. Gene. 2006;367:126-34 pubmed
    ..We also showed that the transcription of human MCM8 is activated by transcription factors E2F1-4, but not by factors E2F5-8.
  2. Ebelt H, Liu Z, Muller Werdan U, Werdan K, Braun T. Making omelets without breaking eggs: E2F-mediated induction of cardiomyoycte cell proliferation without stimulation of apoptosis. Cell Cycle. 2006;5:2436-9 pubmed
    ..are classified as "activating" E2Fs since they induce proliferation of quiescent cells whereas E2F4 and E2F5 do not have the power to incite cell cycle progression but are related to differentiation processes and were ..
  3. Itoh A, Levinson S, Morita T, Kourembanas S, Brody J, Mitsialis S. Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors. Cell Mol Biol Res. 1995;41:147-54 pubmed
    ..The structural divergence between the two branches of the E2F family may thus reflect participation in different regulatory networks. ..
  4. Nili E, Cojocaru G, Kalma Y, Ginsberg D, Copeland N, Gilbert D, et al. Nuclear membrane protein LAP2beta mediates transcriptional repression alone and together with its binding partner GCL (germ-cell-less). J Cell Sci. 2001;114:3297-307 pubmed
    ..Co-expression of both LAP2beta and mGCL with the E2F-DP complex resulted in a reduced transcriptional activity equal to that exerted by the pRb protein. ..