E2f1

Summary

Gene Symbol: E2f1
Description: E2F transcription factor 1
Alias: transcription factor E2F1, E2F-1
Species: rat
Products:     E2f1

Top Publications

  1. Yamasaki L, Jacks T, Bronson R, Goillot E, Harlow E, Dyson N. Tumor induction and tissue atrophy in mice lacking E2F-1. Cell. 1996;85:537-48 pubmed
    ..Although overexpression of E2F-1 in tissue culture cells can stimulate cell proliferation and be oncogenic, loss of E2F-1 in mice results in tumorigenesis, demonstrating that E2F-1 also functions as a tumor suppressor. ..
  2. Field S, Tsai F, Kuo F, Zubiaga A, Kaelin W, Livingston D, et al. E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell. 1996;85:549-61 pubmed
    ..These findings suggest that while certain members of the E2F family may positively regulate cell cycle progression, E2F-1 functions to regulate apoptosis and to suppress cell proliferation. ..
  3. Iglesias A, Murga M, Laresgoiti U, Skoudy A, Bernales I, Fullaondo A, et al. Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice. J Clin Invest. 2004;113:1398-407 pubmed
    ..Here we use mutant mouse strains to investigate the function of E2F1 and E2F2 in vivo...
  4. Eymin B, Gazzeri S, Brambilla C, Brambilla E. Distinct pattern of E2F1 expression in human lung tumours: E2F1 is upregulated in small cell lung carcinoma. Oncogene. 2001;20:1678-87 pubmed
    The transcription factor E2F1 is a key component of cell cycle that acts to transactivate genes required for S phase entry. Thus, it plays an important role in cellular proliferation, oncogenesis and differentiation...
  5. Fajas L, Annicotte J, Miard S, Sarruf D, Watanabe M, Auwerx J. Impaired pancreatic growth, beta cell mass, and beta cell function in E2F1 (-/- )mice. J Clin Invest. 2004;113:1288-95 pubmed
    We evaluated the effects of E2F1 on glucose homeostasis using E2F1(-/-) mice. E2F1(-/-) mice show an overall reduction in pancreatic size as the result of impaired postnatal pancreatic growth...
  6. Gorgoulis V, Zacharatos P, Mariatos G, Kotsinas A, Bouda M, Kletsas D, et al. Transcription factor E2F-1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas. J Pathol. 2002;198:142-56 pubmed
  7. Shaw J, Yurkova N, Zhang T, Gang H, Aguilar F, Weidman D, et al. Antagonism of E2F-1 regulated Bnip3 transcription by NF-kappaB is essential for basal cell survival. Proc Natl Acad Sci U S A. 2008;105:20734-9 pubmed publisher
    ..Our data may explain more fundamentally how cells, by selectively inhibiting E2F-1-dependent death gene transcription, avert apoptosis down-stream of the retinoblastoma/E2F-1 cell cycle pathway. ..
  8. Kuhn H, Liebers U, Gessner C, Schumacher A, Witt C, Schauer J, et al. Adenovirus-mediated E2F-1 gene transfer in nonsmall-cell lung cancer induces cell growth arrest and apoptosis. Eur Respir J. 2002;20:703-9 pubmed
    ..Moreover, treatment of implanted tumours in SCID mice with AdE2F inhibited tumour growth. These data suggest that adenovirus-mediated E2F-1 gene therapy may be effective in the treatment of nonsmall-cell lung cancer. ..
  9. Ebelt H, Liu Z, Muller Werdan U, Werdan K, Braun T. Making omelets without breaking eggs: E2F-mediated induction of cardiomyoycte cell proliferation without stimulation of apoptosis. Cell Cycle. 2006;5:2436-9 pubmed
    ..According to a widely accepted model, E2F1, E2F2, and E2F3 are classified as "activating" E2Fs since they induce proliferation of quiescent cells ..

More Information

Publications75

  1. Zaragoza K, Begay V, Schuetz A, Heinemann U, Leutz A. Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. Mol Cell Biol. 2010;30:2293-304 pubmed publisher
    ..Our data suggest a tripartite balance between C/EBPalpha, E2F/DP, and pocket proteins in the control of proliferation, differentiation, and tumorigenesis. ..
  2. Fogal V, Kartasheva N, Trigiante G, Llanos S, Yap D, Vousden K, et al. ASPP1 and ASPP2 are new transcriptional targets of E2F. Cell Death Differ. 2005;12:369-76 pubmed
    ..The identification of ASPP1 and ASPP2 genes as transcriptional targets of E2F provides another mechanism by which E2F cooperates with p53 to induce apoptosis. ..
  3. Leung L, Lam S, Li Y, Ho J. Tumour growth-suppressive effect of arsenic trioxide in squamous cell lung carcinoma. Oncol Lett. 2017;14:3748-3754 pubmed publisher
    ..in the downregulation of X-linked inhibitor of apoptosis, B-cell lymphoma-2 (Bcl-2), E2F transcription factor 1 (E2F1), thymidylate synthase and ribonucleotide reductase M1 in addition to the upregulation of Bcl-2 antagonist/killer ..
  4. Li Q, Dashwood W, Zhong X, Nakagama H, Dashwood R. Bcl-2 overexpression in PhIP-induced colon tumors: cloning of the rat Bcl-2 promoter and characterization of a pathway involving beta-catenin, c-Myc and E2F1. Oncogene. 2007;26:6194-202 pubmed
    ..Protein/DNA arrays identified E2F1, but not beta-catenin/Tcf, as interacting most strongly with the rat Bcl-2 promoter...
  5. Porse B, Pedersen TA -, Xu X, Lindberg B, Wewer U, Friis Hansen L, et al. E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo. Cell. 2001;107:247-58 pubmed
  6. Izumi M, Yokoi M, Nishikawa N, Miyazawa H, Sugino A, Yamagishi M, et al. Transcription of the catalytic 180-kDa subunit gene of mouse DNA polymerase alpha is controlled by E2F, an Ets-related transcription factor, and Sp1. Biochim Biophys Acta. 2000;1492:341-52 pubmed
    ..These data indicate that E2F, GABP and Sp1 regulate the gene expression of this principal replication enzyme. ..
  7. Hosokawa Y, Yang M, Kaneko S, Tanaka M, Nakashima K. Synergistic gene expressions of cyclin E, cdk2, cdk5 and E2F-1 during the prolactin-induced G1/S transition in rat Nb2 pre-T lymphoma cells. Biochem Mol Biol Int. 1995;37:393-9 pubmed
    ..These results suggest that cyclin E, cdk2, cdk5 and E2F-1 play the roles in the G1/S transition being expressed by a common cellular mechanism(s) in the PRL-stimulated pre-T lymphoma cells. ..
  8. Suzuki D, Ariza C, Porcionatto M, Okamoto O. Upregulation of E2F1 in cerebellar neuroprogenitor cells and cell cycle arrest during postnatal brain development. In Vitro Cell Dev Biol Anim. 2011;47:492-9 pubmed publisher
    ..Here, we report that expression of the E2F1 transcription factor in rat GNPs is inversely correlated with cell proliferation rate during postnatal development, ..
  9. Liu L, Xiao L, Liang X, Chen L, Cheng L, Zhang L, et al. TRIM28 knockdown increases sensitivity to etoposide by upregulating E2F1 in non-small cell lung cancer. Oncol Rep. 2017;37:3597-3605 pubmed publisher
    ..that TRIM28 siRNA in combination with etoposide increased apoptosis in vitro and in vivo which was induced by E2F1 activity, since the expression of E2F1 and its target genes was significantly increased in the cotreatment group...
  10. Beijersbergen R, Carlee L, Kerkhoven R, Bernards R. Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. Genes Dev. 1995;9:1340-53 pubmed
    ..A p107-induced cell cycle block can be released by cyclin D1/cdk4 but not by cyclin E/cdk2. These data indicate that the activity of p107 is regulated by phosphorylation through D-type cyclins. ..
  11. Wu J, Kharebava G, Piao C, Stoica B, Dinizo M, Sabirzhanov B, et al. Inhibition of E2F1/CDK1 pathway attenuates neuronal apoptosis in vitro and confers neuroprotection after spinal cord injury in vivo. PLoS ONE. 2012;7:e42129 pubmed publisher
    ..Activation of E2F1-dependent transcription promotes expression of pro-apoptotic factors, including CDK1; this signal transduction ..
  12. Sola S, Ma X, Castro R, Kren B, Steer C, Rodrigues C. Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta1-induced apoptosis of rat hepatocytes. J Biol Chem. 2003;278:48831-8 pubmed
    ..05). In conclusion, these results demonstrate that UDCA inhibits E2F-1 transcriptional activation of hepatocyte apoptosis, thus modulating p53 stabilization, NF-kappaB degradation, and expression of Bcl-2 family members. ..
  13. Grouwels G, Cai Y, Hoebeke I, Leuckx G, Heremans Y, Ziebold U, et al. Ectopic expression of E2F1 stimulates beta-cell proliferation and function. Diabetes. 2010;59:1435-44 pubmed publisher
    ..b>Transcription factor E2F1 controls G(1)- to S-phase transition during the cycling of many cell types and is required for ..
  14. Tanaka H, Terada Y, Okado T, Inoshita S, Kuwahara M, Sasaki S. Role of the E2F1-p19-p53 pathway in ischemic acute renal failure. Nephron Physiol. 2005;101:p27-34 pubmed
    ..The time course of E2F1 induction was observed at 6-24 h, and it was found to precede p19(ARF) expression...
  15. Maiti B, Li J, de Bruin A, Gordon F, Timmers C, Opavsky R, et al. Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem. 2005;280:18211-20 pubmed
    ..evidence in the field, mammalian E2Fs can be functionally categorized into either transcriptional activators (E2F1, E2F2, and E2F3a) or repressors (E2F3b, E2F4, E2F5, E2F6, and E2F7)...
  16. Reed C, Hutcheson J, Mayhew C, Witkiewicz A, Knudsen E. RB tumor suppressive function in response to xenobiotic hepatocarcinogens. Am J Pathol. 2014;184:1853-9 pubmed publisher
    ..These data demonstrate the context specificity of RB and the key role RB plays in the suppression of hepatocellular carcinoma driven by xenobiotic stress. ..
  17. Chen L, Wei T, Si X, Wang Q, Li Y, Leng Y, et al. Lysine acetyltransferase GCN5 potentiates the growth of non-small cell lung cancer via promotion of E2F1, cyclin D1, and cyclin E1 expression. J Biol Chem. 2013;288:14510-21 pubmed publisher
    ..Further study revealed that GCN5 regulates the expression of E2F1, cyclin D1, and cyclin E1...
  18. Kuwako K, Taniura H, Yoshikawa K. Necdin-related MAGE proteins differentially interact with the E2F1 transcription factor and the p75 neurotrophin receptor. J Biol Chem. 2004;279:1703-12 pubmed
    ..Necdin and MAGE-G1 interacted with the transcription factor E2F1 via its transactivation domain, repressed E2F1-dependent transcription, and antagonized E2F1-induced ..
  19. Takeuchi Y, Harada F. Cloning and characterization of rat 4.5S RNAI genes. Nucleic Acids Res. 1986;14:1643-56 pubmed
    ..Four clones (lambda I39, lambda I42, lambda I106 and lambda I154) were found to have 13-18 nucleotide-long direct repeats flanking the 4.5S RNAI sequences. The genomic organization of the genes and their related sequences is discussed. ..
  20. Sung Y, Jin Y, Kang Y, Devkota S, Lee J, Roh J, et al. Ei24, a novel E2F target gene, affects p53-independent cell death upon ultraviolet C irradiation. J Biol Chem. 2013;288:31261-7 pubmed publisher
    ..The Ei24 promoter was activated by E2F1 via multiple E2F-responsive elements, independently of the previously reported p53-responsive element...
  21. Pelegri C, Duran Vilaregut J, del Valle J, Crespo Biel N, Ferrer I, Pallas M, et al. Cell cycle activation in striatal neurons from Huntington's disease patients and rats treated with 3-nitropropionic acid. Int J Dev Neurosci. 2008;26:665-71 pubmed publisher
    ..These results indicate that cell cycle re-entry is activated in Huntington's disease and may contribute to the neurodegenerative process. ..
  22. Yao G, Lee T, Mori S, Nevins J, You L. A bistable Rb-E2F switch underlies the restriction point. Nat Cell Biol. 2008;10:476-82 pubmed publisher
    ..We further show that, at critical concentrations and duration of serum stimulation, bistable E2F activation correlates directly with the ability of a cell to traverse the R-point. ..
  23. Zhang Y, Hamburger A. Heregulin regulates the ability of the ErbB3-binding protein Ebp1 to bind E2F promoter elements and repress E2F-mediated transcription. J Biol Chem. 2004;279:26126-33 pubmed
    ..pombe protein. Whereas GST-Ebp1 alone failed to bind E2F1 promoter elements, Ebp1 contained in nuclear lysates associated with E2F1 consensus sequences in the E2F1 promoter...
  24. Fujita N, Furukawa Y, Itabashi N, Okada K, Saito T, Ishibashi S. Differences in E2F subunit expression in quiescent and proliferating vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2002;283:H204-12 pubmed
    ..In contrast, both FBS and vasoconstrictive hormones drove transcription of the cdc6 gene by downregulating p130 and recruiting free E2F-3 in the latter, which underlies the progression of VSMC into S phase. ..
  25. Bromberg Z, Raj N, Goloubinoff P, Deutschman C, Weiss Y. Enhanced expression of 70-kilodalton heat shock protein limits cell division in a sepsis-induced model of acute respiratory distress syndrome. Crit Care Med. 2008;36:246-55 pubmed
    ..protein ubiquitination and degradation and, thus, stabilized the interaction of retinoblastoma protein with E2F1, a key cell division transcription factor...
  26. Carcagno A, Giono L, Marazita M, Castillo D, Pregi N, Cánepa E. E2F1 induces p19INK4d, a protein involved in the DNA damage response, following UV irradiation. Mol Cell Biochem. 2012;366:123-9 pubmed publisher
    ..Moreover, evidence is presented that demonstrates that E2F1 is involved in the induction of p19INK4d following UV treatment, as it is prevented by E2F1 protein ablation and ..
  27. Benadiba M, Miyake J, Colquhoun A. Gamma-linolenic acid alters Ku80, E2F1, and bax expression and induces micronucleus formation in C6 glioma cells in vitro. IUBMB Life. 2009;61:244-51 pubmed publisher
    ..The aim of this study was to investigate the effects of 150 muM GLA on the expression of E2F1, cyclin D1, bax, bcl2, Ku70, and Ku80 in C6 rat glioma cells...
  28. Jordan Sciutto K, Wang G, Murphey Corb M, Wiley C. Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis. J Neurosci. 2002;22:2185-95 pubmed
    ..that two key regulators of the cell cycle, the retinoblastoma susceptibility gene product (pRb) and transcription factor E2F1, exhibit altered immunostaining patterns in simian immunodeficiency virus encephalitis (SIVE)...
  29. Xie X, Kerrigan J, Minko T, Garbuzenko O, Lee K, Scarborough A, et al. Antitumor and modeling studies of a penetratin-peptide that targets E2F-1 in small cell lung cancer. Cancer Biol Ther. 2013;14:742-51 pubmed publisher
    ..The liposome encapsulated PEP has promise as an antitumor agent, alone or in combination with inhibitors of DNA synthesis. ..
  30. Zhou P, Wang Z, Yuan X, Zhou C, Liu L, Wan X, et al. Mixed lineage leukemia 5 (MLL5) protein regulates cell cycle progression and E2F1-responsive gene expression via association with host cell factor-1 (HCF-1). J Biol Chem. 2013;288:17532-43 pubmed publisher
    ..Moreover, down-regulation of E2F1 target gene expression and decreased H3K4me3 levels at E2F1-responsive promoters were observed in MLL5 knockdown ..
  31. Klappacher G, Lunyak V, Sykes D, Sawka Verhelle D, Sage J, Brard G, et al. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell. 2002;109:169-80 pubmed
  32. Motonaga K, Itoh M, Hirayama A, Hirano S, Becker L, Goto Y, et al. Up-regulation of E2F-1 in Down's syndrome brain exhibiting neuropathological features of Alzheimer-type dementia. Brain Res. 2001;905:250-3 pubmed
    ..Therefore, the implication is that A beta deposition may trigger E2F-1-mediated neuronal apoptosis in DS brains with DAT. ..
  33. Sahin F, Sladek T. E2F-1 has dual roles depending on the cell cycle. Int J Biol Sci. 2010;6:116-28 pubmed
  34. Yuan Z, Yao L, Li M, Liu S, He W, Lu Y. Opposing roles for E2F1 in survival and death of cerebellar granule neurons. Neurosci Lett. 2011;499:164-9 pubmed publisher
    The transcription factor E2F1 is upregulated when cerebellar granular neurons (CGNs) undergo apoptosis under potassium deprivation...
  35. Rubin S, Gall A, Zheng N, Pavletich N. Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Cell. 2005;123:1093-106 pubmed
    ..The crystal structure of an RbC-E2F1-DP1 complex reveals an intertwined heterodimer in which the marked box domains of both E2F1 and DP1 contact RbC...
  36. Ohlson L, Koroxenidou L, Porsch Hällström I. Mitoinhibitory effects of the tumor promoter 2-acetylaminofluorene in rat liver: loss of E2F-1 and E2F-3 expression and cdk 2 kinase activity in late G1. J Hepatol. 2004;40:957-62 pubmed
    ..Examine the mitoinhibitory effect of the liver tumor promoter 2-acetylaminofluorene (2-AAF) in vivo, with focus on the proteins regulating G1- and S progression...
  37. Kramer F, White K, Kubbies M, Swisshelm K, Weber B. Genomic organization of claudin-1 and its assessment in hereditary and sporadic breast cancer. Hum Genet. 2000;107:249-56 pubmed
    ..Other regulatory or epigenetic factors may be involved in the down-regulation of this gene during breast cancer development. ..
  38. Joshi B, Ordonez Ercan D, Dasgupta P, Chellappan S. Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors. Oncogene. 2005;24:2204-17 pubmed
    ..Here, we show that human metallothionein 1G (hMT1G) promoter is upregulated by E2F1 upon VEGF stimulation of human aortic endothelial cells...
  39. Yurkova N, Shaw J, Blackie K, Weidman D, Jayas R, Flynn B, et al. The cell cycle factor E2F-1 activates Bnip3 and the intrinsic death pathway in ventricular myocytes. Circ Res. 2008;102:472-9 pubmed
    ..To our knowledge, the data provide the first direct evidence that activation of the intrinsic mitochondrial death pathway by E2F-1 is mutually dependent on and obligatorily linked to the transcriptional activation of Bnip3. ..
  40. Lang S, McMahon S, Cole M, Hearing P. E2F transcriptional activation requires TRRAP and GCN5 cofactors. J Biol Chem. 2001;276:32627-34 pubmed
    ..These results provide a mechanism for E2F transcription factors to overcome pRb-mediated dominant repression of transcription. ..
  41. Wu H, Meng S, Xu Q, Wang X, Wang J, Gong R, et al. Gene expression profiling of lung adenocarcinoma in Xuanwei, China. Eur J Cancer Prev. 2016;25:508-17 pubmed publisher
    ..selected DEGs (five downregulated genes, PIK3R1, RARB, HGF, MAPK11, and SESN1, and seven upregulated genes, PAK1, E2F1, CCNE1, EGF, CDC25A, PTTG1, and UHRF1) in RTq-PCR was consistent with the expression profiling data...
  42. Lu H, Liang X, Issaenko O, Hallstrom T. Jab1/CSN5 mediates E2F dependent expression of mitotic and apoptotic but not DNA replication targets. Cell Cycle. 2011;10:3317-26 pubmed publisher
    ..We previously showed that the E2F1 binding partner Jab1/CSN5 promotes E2F1-dependent induction of apoptosis but not proliferation...
  43. Magri L, Swiss V, Jablonska B, Lei L, Pedre X, Walsh M, et al. E2F1 coregulates cell cycle genes and chromatin components during the transition of oligodendrocyte progenitors from proliferation to differentiation. J Neurosci. 2014;34:1481-93 pubmed publisher
    ..In this paper we report a lineage-specific decline of nuclear E2F1 during differentiation of rodent OPC into oligodendrocytes (OLs) in developing white matter tracts and in cultured ..
  44. Lee S, Kwon I, Park J, Lee K, Ahn Y, Lee C, et al. Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair. J Biol Chem. 2010;285:29457-68 pubmed publisher
    ..RPS3 induced neuronal apoptosis, up-regulating proapoptotic proteins Dp5/Hrk and Bim by binding to E2F1 and acting synergistically with it...
  45. Angelis E, Zhao P, Zhang R, Goldhaber J, MacLellan W. The role of E2F-1 and downstream target genes in mediating ischemia/reperfusion injury in vivo. J Mol Cell Cardiol. 2011;51:919-26 pubmed publisher
    ..These results suggest that E2F-1 and FoxO-1a belong to a complex transcriptional network that may modulate myocardial cell death during I/R injury. ..
  46. Jordan Sciutto K, Malaiyandi L, Bowser R. Altered distribution of cell cycle transcriptional regulators during Alzheimer disease. J Neuropathol Exp Neurol. 2002;61:358-67 pubmed
    ..Furthermore, in vitro studies have implicated pRb and one of the transcription factors it regulates, E2F1, in Abeta-induced cell death...
  47. Stevens C, Smith L, La Thangue N. Chk2 activates E2F-1 in response to DNA damage. Nat Cell Biol. 2003;5:401-9 pubmed
    ..These results suggest a role for E2F-1 in checkpoint control and provide a plausible explanation for the tumour suppressor activity of E2F-1. ..
  48. Abramova M, Pospelova T, Nikulenkov F, Hollander C, Fornace A, Pospelov V. G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin. J Biol Chem. 2006;281:21040-51 pubmed
    ..Strikingly, E2F1 expression was also down-modulated at the levels of gene transcription, the protein content, and the E2F ..
  49. Wu Y, Ma S, Xia Y, Lu Y, Xiao S, Cao Y, et al. Loss of GCN5 leads to increased neuronal apoptosis by upregulating E2F1- and Egr-1-dependent BH3-only protein Bim. Cell Death Dis. 2017;8:e2570 pubmed publisher
    ..Mechanistically, the BH3-only protein Bim is transcriptionally upregulated by activated Egr-1 and E2F1 and mediates apoptosis following GCN5 inhibition...
  50. Woitach J, Zhang M, Niu C, Thorgeirsson S. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Nat Genet. 1998;19:371-4 pubmed
  51. Meyer G, Cabrera Socorro A, Perez Garcia C, Martinez Millan L, Walker N, Caput D. Developmental roles of p73 in Cajal-Retzius cells and cortical patterning. J Neurosci. 2004;24:9878-87 pubmed
    ..In mice deficient for the transcription factor E2F1, a main activator of the TAp73 (transactivating p73) isoform, we find a defect of the caudal cortical ..
  52. Illenye S, Heintz N. Functional analysis of bacterial artificial chromosomes in mammalian cells: mouse Cdc6 is associated with the mitotic spindle apparatus. Genomics. 2004;83:66-75 pubmed
    ..With RNA interference to assess genetic complementation by BAC alleles, this system will facilitate functional studies on large chromosomal domains at variable copy number in mammalian cell models. ..
  53. Espada L, Udapudi B, Podlesniy P, Fabregat I, Espinet C, Tauler A. Apoptotic action of E2F1 requires glycogen synthase kinase 3-beta activity in PC12 cells. J Neurochem. 2007;102:2020-2028 pubmed publisher
    Both E2F1 and GSK3beta have been described as essential targets in neuronal apoptosis. Previous studies have demonstrated that GSK3beta binds to E2F1 in vivo...
  54. Nowak K, Killmer K, Gessner C, Lutz W. E2F-1 regulates expression of FOXO1 and FOXO3a. Biochim Biophys Acta. 2007;1769:244-52 pubmed
    ..In summary, our data identify E2F-1 as a first transcription factor regulating FOXO expression, providing a link between E2F and FOXO proteins in the control of cell fate. ..
  55. Zhou F, Zhang L, Wang A, Song B, Gong K, Zhang L, et al. The association of GSK3 beta with E2F1 facilitates nerve growth factor-induced neural cell differentiation. J Biol Chem. 2008;283:14506-15 pubmed publisher
    It is widely acknowledged that E2F1 and GSK3beta are both involved in the process of cell differentiation. However, the relationship between E2F1 and GSK3beta in cell differentiation has yet to be discovered...
  56. KINNEY E, Tanida S, Rodrigue A, Johnson J, Tompkins V, Sakamuro D. Adenovirus E1A oncoprotein liberates c-Myc activity to promote cell proliferation through abating Bin1 expression via an Rb/E2F1-dependent mechanism. J Cell Physiol. 2008;216:621-31 pubmed publisher
    ..Furthermore, ectopically expressed E2F1, which is primarily inhibited by Rb under serum-starved condition, represses Bin1 promoter activity in a manner ..
  57. El Darwish K, Parvinen M, Toppari J. Differential expression of members of the E2F family of transcription factors in rodent testes. Reprod Biol Endocrinol. 2006;4:63 pubmed
  58. Paik J, Wang B, Liu K, Lue J, Lin W. Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B. J Biol Chem. 2010;285:6348-63 pubmed publisher
    ..One member of the E2F family, E2F1, also has the paradoxical ability to induce apoptosis; however, the mechanisms underlying this selectivity are not ..
  59. Hughes T, Brady H. E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation. Biochem Biophys Res Commun. 2005;329:1267-74 pubmed
    ..Axin2 is induced by E2F1 and therefore acts as a point of cross-talk between the pRb/E2F and Wnt/beta-catenin pathways: two of the most ..
  60. Wang D, Russell J, Johnson D. E2F4 and E2F1 have similar proliferative properties but different apoptotic and oncogenic properties in vivo. Mol Cell Biol. 2000;20:3417-24 pubmed
    ..of a keratin 5 (K5) promoter were developed, and their phenotypes were compared to those of previously generated K5 E2F1 transgenic mice...
  61. Li Z, Guo Y, Jiang H, Zhang T, Jin C, Young C, et al. Differential regulation of MMPs by E2F1, Sp1 and NF-kappa B controls the small cell lung cancer invasive phenotype. BMC Cancer. 2014;14:276 pubmed publisher
    b>E2F1 transcription factor plays a vital role in the regulation of diverse cellular processes including cell proliferation, apoptosis, invasion and metastasis...
  62. Ofir M, Hacohen D, Ginsberg D. MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin E. Mol Cancer Res. 2011;9:440-7 pubmed publisher
    ..we evidence that the miR-15a, miR-16-1 cluster and related miR-15b, miR-16-2 cluster comprise miRs regulated by E2F1, a pivotal transcription factor that can induce both proliferation and cell death...
  63. Dong H, Xu C. Analysis of the relevance of e2fs and their target genes with rat liver regeneration. Indian J Gastroenterol. 2008;27:31-2 pubmed
  64. de Bruin A, Maiti B, Jakoi L, Timmers C, Buerki R, Leone G. Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation. J Biol Chem. 2003;278:42041-9 pubmed
    ..Like the expression of the known E2F activators, E2F1, E2F2, and E2F3, the expression of E2F7 is growth-regulated, at least in part, through E2F binding elements on its ..
  65. Stanelle J, Tu Rapp H, Pützer B. A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53. Cell Death Differ. 2005;12:347-57 pubmed
    The transcription factor E2F1 does not only induce cell proliferation but also shows the strongest proapoptotic effect of all E2F family members as part of an antitumor safeguard mechanism...
  66. Gizard F, Nomiyama T, Zhao Y, Findeisen H, Heywood E, Jones K, et al. The PPARalpha/p16INK4a pathway inhibits vascular smooth muscle cell proliferation by repressing cell cycle-dependent telomerase activation. Circ Res. 2008;103:1155-63 pubmed publisher
    ..In concert, these results demonstrate that the antiproliferative effects of PPARalpha in VSMCs depend on the suppression of telomerase activity by targeting the p16/RB/E2F transcriptional cascade. ..