E cadherin


Gene Symbol: E cadherin
Description: cadherin 1
Alias: cadherin-1, E-cadherin, epithelial cadherin, uvomorulin
Species: rat
Products:     E cadherin

Top Publications

  1. Haegel H, Larue L, Ohsugi M, Fedorov L, Herrenknecht K, Kemler R. Lack of beta-catenin affects mouse development at gastrulation. Development. 1995;121:3529-37 pubmed
    ..Our results demonstrate that, although beta-catenin is expressed rather ubiquitously, it is specifically required in the ectodermal cell layer. ..
  2. Sivasankar S, Zhang Y, Nelson W, Chu S. Characterizing the initial encounter complex in cadherin adhesion. Structure. 2009;17:1075-81 pubmed publisher
  3. Harrison O, Bahna F, Katsamba P, Jin X, Brasch J, Vendome J, et al. Two-step adhesive binding by classical cadherins. Nat Struct Mol Biol. 2010;17:348-57 pubmed publisher
    ..These results reconcile apparently disparate results from prior structural studies and suggest that X dimers are binding intermediates that facilitate the formation of strand-swapped dimers. ..
  4. Ciatto C, Bahna F, Zampieri N, VanSteenhouse H, Katsamba P, Ahlsen G, et al. T-cadherin structures reveal a novel adhesive binding mechanism. Nat Struct Mol Biol. 2010;17:339-47 pubmed publisher
    ..The adhesive binding mode used by T-cadherin may also be used by other nonclassical cadherins. ..
  5. Zhang Y, Sivasankar S, Nelson W, Chu S. Resolving cadherin interactions and binding cooperativity at the single-molecule level. Proc Natl Acad Sci U S A. 2009;106:109-14 pubmed publisher
    ..We could not detect the formation of cadherin cis dimers, but found that increasing the density of cadherin monomers cooperatively increased the probability of trans adhesive binding. ..
  6. Bharti S, Handrow Metzmacher H, Zickenheiner S, Zeitvogel A, Baumann R, Starzinski Powitz A. Novel membrane protein shrew-1 targets to cadherin-mediated junctions in polarized epithelial cells. Mol Biol Cell. 2004;15:397-406 pubmed
    ..In summary, we introduce shrew-1 as a novel component of adherens junctions, interacting with E-cadherin-beta-catenin complexes in polarized epithelial cells. ..
  7. Izumi G, Sakisaka T, Baba T, Tanaka S, Morimoto K, Takai Y. Endocytosis of E-cadherin regulated by Rac and Cdc42 small G proteins through IQGAP1 and actin filaments. J Cell Biol. 2004;166:237-48 pubmed
    ..These results indicate the important role of the Rac/Cdc42-IQGAP1 system in the dynamic organization and maintenance of the E-cadherin-based AJs. ..
  8. Kikuchi M, Yatabe M, Kouki T, Fujiwara K, Takigami S, Sakamoto A, et al. Changes in E- and N-cadherin expression in developing rat adenohypophysis. Anat Rec (Hoboken). 2007;290:486-90 pubmed
    ..These results may suggest that undetermined adenohypophyseal cells express both E- and N-cadherin, but come to express either E- or N-cadherin during cytogenesis. ..
  9. Tang Y, Liu Z, Zhao L, Clemens T, Cao X. Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion. J Biol Chem. 2008;283:23956-63 pubmed publisher
    ..Thereby, rather than being translocated to the nucleus for regulating the target gene transcription, Smad7-stabilized-beta-catenin is shunted to the E-cadherin complex to modulate cell-cell adhesion. ..

More Information

Publications102 found, 100 shown here

  1. Basak S, Desai D, Rho E, Ramos R, Maurel P, Kim H. E-cadherin enhances neuregulin signaling and promotes Schwann cell myelination. Glia. 2015;63:1522-36 pubmed publisher
    ..Altogether, our data suggest a regulatory function of E-cadherin that modulates Nrg1 signaling and promotes Schwann cell myelin formation. ..
  2. Meng Q, Qi M, Chen D, Yuan R, Goldberg I, Rosen E, et al. Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. J Mol Med (Berl). 2000;78:155-65 pubmed
    ..Thus, clinical application of I3C may contribute to the potential benefit for suppression of breast cancer invasion and metastasis. ..
  3. Li Q, Wang J, Armant D, Bagchi M, Bagchi I. Calcitonin down-regulates E-cadherin expression in rodent uterine epithelium during implantation. J Biol Chem. 2002;277:46447-55 pubmed
  4. Chae T, Kim S, Marz K, Hanson P, Walsh C. The hyh mutation uncovers roles for alpha Snap in apical protein localization and control of neural cell fate. Nat Genet. 2004;36:264-70 pubmed
    ..Apical localization of the SNARE Vamp7 is also disrupted. Thus, alpha Snap is essential for apical protein localization and cell fate determination in neuroepithelial cells. ..
  5. Schmidt C, Gi Y, Patel T, Coffey R, Beauchamp R, Pearson A. E-cadherin is regulated by the transcriptional repressor SLUG during Ras-mediated transformation of intestinal epithelial cells. Surgery. 2005;138:306-12 pubmed
    ..These data suggest a mechanism whereby Ras signaling causes an upregulation of transcriptional repressors and subsequent downregulation of E-cadherin as a malignant phenotype is propagated. ..
  6. Kim K, Kugler M, Wolters P, Robillard L, Galvez M, Brumwell A, et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A. 2006;103:13180-5 pubmed
    ..These data reveal alveolar epithelial cells as progenitors for fibroblasts in vivo and implicate the provisional extracellular matrix as a key regulator of epithelial transdifferentiation during fibrogenesis. ..
  7. Ueberham E, Aigner T, Ueberham U, Gebhardt R. E-cadherin as a reliable cell surface marker for the identification of liver specific stem cells. J Mol Histol. 2007;38:359-68 pubmed
    ..In human cirrhotic liver samples E-cadherin expression was found as a common feature of both, typical and atypical reactions, and, thus, can also serve as an indication of the progenitor cell compartment activation. ..
  8. Dürer U, Hartig R, Bang S, Thim L, Hoffmann W. TFF3 and EGF induce different migration patterns of intestinal epithelial cells in vitro and trigger increased internalization of E-cadherin. Cell Physiol Biochem. 2007;20:329-46 pubmed
    ..TFF3, in contrast to EGF, enhanced a collective cell migration ensuring a precise coverage of the re-populated area avoiding gaps. ..
  9. Zhang K, Haversat J, Mager J. CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Dev Biol. 2013;383:15-27 pubmed publisher
    ..These findings show that the PAF1 complex is required for mammalian development, likely through regulation of H3K36me3, and indicate functional conservation of the PAF1 complex from yeast to mammals in vivo. ..
  10. Jesse S, Koenig A, Ellenrieder V, Menke A. Lef-1 isoforms regulate different target genes and reduce cellular adhesion. Int J Cancer. 2010;126:1109-20 pubmed publisher
    ..Our findings indicate that expression of alternatively spliced Lef-1 isoforms is involved in the determination of proliferative or migratory characteristics of pancreatic carcinoma cells. ..
  11. Wang J, Ruan K. miR-200c affects the mRNA expression of E-cadherin by regulating the mRNA level of TCF8 during post-natal epididymal development in juvenile rats. Acta Biochim Biophys Sin (Shanghai). 2010;42:628-34 pubmed publisher
  12. Itoh Y, Moriyama Y, Hasegawa T, Endo T, Toyoda T, Gotoh Y. Scratch regulates neuronal migration onset via an epithelial-mesenchymal transition-like mechanism. Nat Neurosci. 2013;16:416-25 pubmed publisher
  13. Cantù C, Valenta T, Hausmann G, Vilain N, Aguet M, Basler K. The Pygo2-H3K4me2/3 interaction is dispensable for mouse development and Wnt signaling-dependent transcription. Development. 2013;140:2377-86 pubmed publisher
  14. Fasen K, Beck H, Elger C, Lie A. Differential regulation of cadherins and catenins during axonal reorganization in the adult rat CNS. J Neuropathol Exp Neurol. 2002;61:903-13 pubmed
    ..Our results imply that members of the cadherin/catenin families undergo specific spatiotemporal patterns of regulation, which may be important in axon target recognition and synapse formation during lesion-induced sprouting. ..
  15. Simonneau L, Gallego M, Pujol R. Comparative expression patterns of T-, N-, E-cadherins, beta-catenin, and polysialic acid neural cell adhesion molecule in rat cochlea during development: implications for the nature of Kölliker's organ. J Comp Neurol. 2003;459:113-26 pubmed
    ..neural cadherin (N-cad) and polysialic acid neural CAM (PSA-NCAM) as two different neural CAM paradigms; epithelial cadherin (E-cad), which was restricted to the epitheloid phenotype; and the cytoplasmic domain-free truncated-..
  16. Mustonen H, Lepistö A, Lehtonen S, Lehtonen E, Puolakkainen P, Kivilaakso E. CD2AP contributes to cell migration and adhesion in cultured gastric epithelium. Biochem Biophys Res Commun. 2005;332:426-32 pubmed
    ..It is concluded that CD2AP interacts with E-cadherin and co-localizes with F-actin in the leading edge of migrating cells, and significantly contributes to cell migration in restituting gastric epithelium. ..
  17. Zheng G, Lyons J, Tan T, Wang Y, Hsu T, Min D, et al. Disruption of E-cadherin by matrix metalloproteinase directly mediates epithelial-mesenchymal transition downstream of transforming growth factor-beta1 in renal tubular epithelial cells. Am J Pathol. 2009;175:580-91 pubmed publisher
    ..Specific inhibition rather than activation of matrix metalloproteinases may offer a novel approach for treatment of fibrotic disease. ..
  18. Xu C, Zhou Q, Liu L, Liu P, Pei G, Zeng R, et al. Cdc42-Interacting Protein 4 Represses E-Cadherin Expression by Promoting β-Catenin Translocation to the Nucleus in Murine Renal Tubular Epithelial Cells. Int J Mol Sci. 2015;16:19170-83 pubmed publisher
    ..In conclusion, these results suggest that CIP4 overexpression represses E-cadherin expression by promoting β-catenin translocation to the nucleus. ..
  19. Batchuluun K, Azuma M, Yashiro T, Kikuchi M. Notch signaling-mediated cell-to-cell interaction is dependent on E-cadherin adhesion in adult rat anterior pituitary. Cell Tissue Res. 2017;368:125-133 pubmed publisher
    ..The present results suggest that E-cadherin-mediated cell attachment is necessary for the activation of Notch signaling in the anterior pituitary gland but not for the expression of the Notch2 molecule. ..
  20. Sørensen C, Lukas C, Kramer E, Peters J, Bartek J, Lukas J. A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression. Mol Cell Biol. 2001;21:3692-703 pubmed
    ..Collectively, these data provide a mechanistic explanation for the mutual functional interplay between cyclin A-Cdk2 and APC-Cdh1 and the first evidence that Cdh1 may activate the APC by binding specific substrates. ..
  21. Karube H, Masuda H, Ishii Y, Takayama T. E-cadherin expression is inversely proportional to tumor size in experimental liver metastases. J Surg Res. 2002;106:173-8 pubmed
    ..36%, while it was 82.33 +/- 16.35% in group B (P = 0.0003). In liver metastasis, E-cadherin's function is preserved when the tumor is small and E-cadherin's expression is reduced in large tumors in which neovascularization is increased. ..
  22. Haussinger D, Ahrens T, Sass H, Pertz O, Engel J, Grzesiek S. Calcium-dependent homoassociation of E-cadherin by NMR spectroscopy: changes in mobility, conformation and mapping of contact regions. J Mol Biol. 2002;324:823-39 pubmed
    ..The calcium-induced oligomerization of the N-terminal two domains of epithelial cadherin (ECAD12) was followed by NMR spectroscopy in solution over a large range of protein (10 microM-5 mM) and ..
  23. Lau A, Mruk D. Rab8B GTPase and junction dynamics in the testis. Endocrinology. 2003;144:1549-63 pubmed
    ..Taken collectively, these studies suggest that Rab8B participates in adherens junction dynamics in the testis. ..
  24. Den Z, Cheng X, Merched Sauvage M, Koch P. Desmocollin 3 is required for pre-implantation development of the mouse embryo. J Cell Sci. 2006;119:482-9 pubmed
    ..Unexpectedly, homozygous mutants show a pre-implantation lethal phenotype. In fact, most mutants die even before mature desmosomes are formed in the embryo, suggesting a new and unexpected role of Dsc3 during early development. ..
  25. Desai R, Gao L, Raghavan S, Liu W, Chen C. Cell polarity triggered by cell-cell adhesion via E-cadherin. J Cell Sci. 2009;122:905-11 pubmed publisher
    ..Together, these findings demonstrate a novel role for cell-cell adhesion in polarization, and have implications for wound healing and developmental patterning. ..
  26. Maeda A, Moriguchi T, Hamada M, Kusakabe M, Fujioka Y, Nakano T, et al. Transcription factor GATA-3 is essential for lens development. Dev Dyn. 2009;238:2280-91 pubmed publisher
    ..Thus, these observations suggest that GATA-3 is essential for lens cells differentiation and proper cell cycle control. ..
  27. Yamato M, Ito T, Iwatani H, Yamato M, Imai E, Rakugi H. E-cadherin and claudin-4 expression has circadian rhythm in adult rat kidney. J Nephrol. 2010;23:102-10 pubmed
    ..Expression of E-cadherin and claudin-4 has a circadian rhythm. The dynamic change in protein levels of E-cadherin and claudin-4 seems to coincide with that in the level of sodium excretion. ..
  28. Greene S, Gunaratne P, Hammond S, Rosen J. A putative role for microRNA-205 in mammary epithelial cell progenitors. J Cell Sci. 2010;123:606-18 pubmed publisher
    ..Additionally, in normal mouse MECs, high expression of miR-205 was observed in stem-cell-enriched cell populations isolated by FACS using established cell-surface markers. ..
  29. Saarikangas J, Mattila P, Varjosalo M, Bovellan M, Hakanen J, Calzada Wack J, et al. Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J Cell Sci. 2011;124:1245-55 pubmed publisher
    ..Collectively, these data demonstrate that MIM modulates interplay between the actin cytoskeleton and plasma membrane to promote the maintenance of intercellular contacts in kidney epithelia...
  30. Edwards J, Kolman K, Lamar P, Chandar N, Fay M, Prozialeck W. Effects of cadmium on the sub-cellular localization of ?-catenin and ?-catenin-regulated gene expression in NRK-52E cells. Biometals. 2013;26:33-42 pubmed publisher
    ..Overall, these results indicate that Cd disrupts the cadherin/?-catenin complex in NRK-52E cells, but this effect leads to only partial activation of ?-catenin-mediated gene transcription. ..
  31. Smythe W, Williams J, Wheelock M, Johnson K, Kaiser L, Albelda S. Cadherin and catenin expression in normal human bronchial epithelium and non-small cell lung cancer. Lung Cancer. 1999;24:157-68 pubmed
  32. Pecina Slaus N, Gall Troselj K, Slaus M, Radic K, Nikuseva Martic T, Pavelic K. Genetic changes of the E-cadherin and APC tumour suppressor genes in clear cell renal cell carcinoma. Pathology. 2004;36:145-51 pubmed
    ..Microsatellite genetic instability of the E-cadherin gene indicates that another cellular mechanism, mismatch repair, may also be targeted in this malignancy. ..
  33. Strumpf D, Mao C, Yamanaka Y, Ralston A, Chawengsaksophak K, Beck F, et al. Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development. 2005;132:2093-102 pubmed
    ..Thus, Cdx2 is essential for segregation of the ICM and TE lineages at the blastocyst stage by ensuring repression of Oct4 and Nanog in the TE. ..
  34. Murakami A, Nakagawa T, Fukushima C, Torii M, Sueoka K, Nawata S, et al. Relationship between decreased expression of squamous cell carcinoma antigen 2 and E-cadherin in primary cervical cancer lesions and lymph node metastasis. Oncol Rep. 2008;19:99-104 pubmed
    ..These findings suggest that SCCA2 may be involved in cancer behavior such as metastasis, and as such can be a useful marker in predicting lymph node metastasis. ..
  35. Tanoue T, Takeichi M. Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact. J Cell Biol. 2004;165:517-28 pubmed
    ..These results suggest that Fat1 regulates actin cytoskeletal organization at cell peripheries, thereby modulating cell contacts and polarity. ..
  36. Ramos C, Becerril C, Montaño M, García de Alba C, Ramirez R, Checa M, et al. FGF-1 reverts epithelial-mesenchymal transition induced by TGF-{beta}1 through MAPK/ERK kinase pathway. Am J Physiol Lung Cell Mol Physiol. 2010;299:L222-31 pubmed publisher
    ..These findings indicate that TGF-beta1-induced EMT is reversed by FGF-1 and suggest therapeutic approaches to target this process in IPF. ..
  37. Rinehart J, Kahle K, de los Heros P, Vazquez N, Meade P, Wilson F, et al. WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis. Proc Natl Acad Sci U S A. 2005;102:16777-82 pubmed
    ..The effects of WNK3 on these transporters and their coexpression in renal epithelia implicate WNK3 in NaCl, water, and blood pressure homeostasis, perhaps via signaling downstream of vasopressin. ..
  38. Erden O, Imir A, Guvenal T, Muslehiddinoglu A, Arici S, Cetin M, et al. Investigation of the effects of heparin and low molecular weight heparin on E-cadherin and laminin expression in rat pregnancy by immunohistochemistry. Hum Reprod. 2006;21:3014-8 pubmed
    ..They might modulate trophoblast invasion. We suggest that this is the possible underlying mechanism involving in improvement of trophoblast invasion by the use of heparin and LMWH in patients with the history of miscarriage. ..
  39. Masciari S, Larsson N, Senz J, Boyd N, Kaurah P, Kandel M, et al. Germline E-cadherin mutations in familial lobular breast cancer. J Med Genet. 2007;44:726-31 pubmed
    ..The finding, if confirmed, may have implications for management of individuals at risk for this breast cancer subtype. Clarification of the cancer risks in the syndrome is essential. ..
  40. Kadri C, Pereira J, da Silva C, Nonose R, Nascimento E, Jacomo A, et al. E-cadherin expression in colonic mucosa with and without fecal stream. J Invest Surg. 2013;26:72-9 pubmed publisher
    ..The content of E-cadherin was maintained over the entire time of the intestinal exclusion. Diversion of the fecal stream decreases the expression of E-cadherin of the colon epithelium. ..
  41. Kan N, Stemmler M, Junghans D, Kanzler B, de Vries W, Dominis M, et al. Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development. 2007;134:31-41 pubmed
    ..Thus, N-cadherin can maintain epithelia in differentiating ES cells, but not during the formation of the trophectoderm. Our results point to a specific and unique function for E-cadherin during mouse preimplantation development. ..
  42. Etournay R, Zwaenepoel I, Perfettini I, Legrain P, Petit C, El Amraoui A. Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions. J Cell Sci. 2007;120:2838-50 pubmed
  43. Li Y, Liang J, Kang S, Dong Z, Wang N, Xing H, et al. E-cadherin gene polymorphisms and haplotype associated with the occurrence of epithelial ovarian cancer in Chinese. Gynecol Oncol. 2008;108:409-14 pubmed
  44. Peng X, Cuff L, Lawton C, DeMali K. Vinculin regulates cell-surface E-cadherin expression by binding to beta-catenin. J Cell Sci. 2010;123:567-77 pubmed publisher
    ..Thus, our study identifies vinculin as a novel regulator of E-cadherin function and provides important new insight into the dynamic regulation of adherens junctions. ..
  45. Yao R, Natsume Y, Noda T. MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap. Oncogene. 2004;23:6023-30 pubmed
    ..These results indicate that MAGI-3 functions as a scaffold protein for frizzled-4 and Ltap and regulates the JNK signaling cascade. ..
  46. Shivapurkar N, Sherman M, Stastny V, Echebiri C, Rader J, Nayar R, et al. Evaluation of candidate methylation markers to detect cervical neoplasia. Gynecol Oncol. 2007;107:549-53 pubmed
    ..None of the five genes showed detectable methylation in normal cervical tissues. Our data support further evaluation of HS3ST2 and CDH1 methylation as potential markers of cervical cancer and its precursor lesions. ..
  47. Gervais M, Henry P, Saravanan A, Burry T, Gallie B, Jewett M, et al. Nuclear E-cadherin and VHL immunoreactivity are prognostic indicators of clear-cell renal cell carcinoma. Lab Invest. 2007;87:1252-64 pubmed
    ..These findings provide the first evidence of aberrant nuclear localization of E-cadherin in CC-RCC harboring VHL mutations, and suggest potential prognostic value of VHL and E-cadherin in CC-RCC. ..
  48. Gravdal K, Halvorsen O, Haukaas S, Akslen L. A switch from E-cadherin to N-cadherin expression indicates epithelial to mesenchymal transition and is of strong and independent importance for the progress of prostate cancer. Clin Cancer Res. 2007;13:7003-11 pubmed
  49. Frasa M, Maximiano F, Smolarczyk K, Francis R, Betson M, Lozano E, et al. Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation. Curr Biol. 2010;20:198-208 pubmed publisher
    ..Thus, the integration of Rac1 and Rab7 activities by Armus provides an important regulatory node for E-cadherin turnover and stability of cell-cell contacts. ..
  50. Pyrgaki C, Liu A, Niswander L. Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Dev Biol. 2011;353:38-49 pubmed publisher
    ..Taken together, our studies point to a complex regulation of neural tube fusion and highlight the importance of comparisons between these two models to understand more fully the molecular pathways of embryonic tissue closure. ..
  51. Ghoumid J, Stichelbout M, Jourdain A, Frénois F, Lejeune Dumoulin S, Alex Cordier M, et al. Blepharocheilodontic syndrome is a CDH1 pathway-related disorder due to mutations in CDH1 and CTNND1. Genet Med. 2017;19:1013-1021 pubmed publisher
    ..Our data assert BCD syndrome as a CDH1 pathway-related disorder due to mutations in CDH1 and CTNND1 and widen the phenotypic spectrum of E-cadherin anomalies.Genet Med advance online publication 09 March 2017. ..
  52. Lim Y, Lee H, Lee H. Switch of cadherin expression from E- to N-type during the activation of rat hepatic stellate cells. Histochem Cell Biol. 2007;127:149-60 pubmed
    ..These results suggest that HSC activation represents transdifferentiation from an epithelial to a mesenchymal phenotype. ..
  53. Barthelemy J, Adeeko A, Robaire B, Cyr D. In utero exposure to tributyltin alters the expression of E-cadherin and localization of claudin-1 in intercellular junctions of the rat ventral prostate. Mol Reprod Dev. 2007;74:455-67 pubmed
    ..These data indicate that in utero TBT exposure results in permanent alterations in ventral prostate and that these are associated with alterations in the expression and distribution of cell adhesion and tight junctional proteins. ..
  54. Ierodiakonou D, Postma D, Koppelman G, Boezen H, Gerritsen J, ten Hacken N, et al. E-cadherin gene polymorphisms in asthma patients using inhaled corticosteroids. Eur Respir J. 2011;38:1044-52 pubmed publisher
    ..These effects are modified by the use of inhaled corticosteroids. ..
  55. Murchie R, Guo C, Persaud A, Muise A, Rotin D. Protein tyrosine phosphatase ? targets apical junction complex proteins in the intestine and regulates epithelial permeability. Proc Natl Acad Sci U S A. 2014;111:693-8 pubmed publisher
  56. Santolim L, Amaral M, Fachi J, Mendes M, Oliveira C. Vitamin E and caloric restriction promote hepatic homeostasis through expression of connexin 26, N-cad, E-cad and cholesterol metabolism genes. J Nutr Biochem. 2017;39:86-92 pubmed publisher
    ..Finally, vitamin E, with or without CR, increased Cx26, probably modulated by expression of the Hmgcr and LDLr genes. This suggests important relationship of Cxs and cholesterol metabolism genes. ..
  57. Hülsken J, Birchmeier W, Behrens J. E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J Cell Biol. 1994;127:2061-9 pubmed
  58. Wendeler M, Praus M, Jung R, Hecking M, Metzig C, Gessner R. Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin. Exp Cell Res. 2004;294:345-55 pubmed
    ..In conclusion, both cadherins are thus not only structurally but also functionally related and may share other functions within their respective epithelia. ..
  59. Asayesh A, Alanentalo T, Khoo N, Ahlgren U. Developmental expression of metalloproteases ADAM 9, 10, and 17 becomes restricted to divergent pancreatic compartments. Dev Dyn. 2005;232:1105-14 pubmed
    ..Altogether, the dynamic expression profile of the ADAM proteases described here may reflect a functional divergence of these as mediators of pancreas biology. ..
  60. Hosking C, Ulloa F, Hogan C, Ferber E, Figueroa A, Gevaert K, et al. The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol Biol Cell. 2007;18:1918-27 pubmed
    ..These data indicate that p120 has additional novel functions in the nucleus together with Glis2. ..
  61. Wang H, Tekpetey F, Kidder G. Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. Mol Hum Reprod. 2009;15:11-7 pubmed publisher
    ..The results suggest that WNT2 could act through its receptor FZD9 to regulate the beta-CATENIN pathway in cumulus cells, recruiting beta-CATENIN into plasma membranes and promoting the formation of adherens junctions involving CDH1. ..
  62. Rakshit S, Zhang Y, Manibog K, Shafraz O, Sivasankar S. Ideal, catch, and slip bonds in cadherin adhesion. Proc Natl Acad Sci U S A. 2012;109:18815-20 pubmed publisher
    ..Our data suggests that ideal bonds are formed as X-dimers convert to strand-swap binding. Catch, slip, and ideal bonds allow cadherins to withstand tensile force and tune the mechanical properties of adhesive junctions. ..
  63. Qi Y, Yao W, Zhang C, Guo Y. Effect of lentivirus-mediated RNA interference of APC-Cdh1 expression on spinal cord injury in rats. Genet Mol Res. 2014;13:1366-72 pubmed publisher
    ..These results suggest that the anaphase-promoting complex-Cdh1 may play an important role in inhibiting axonal growth. ..
  64. Shimamoto T, Ohyashiki J, Ohyashiki K. Methylation of p15(INK4b) and E-cadherin genes is independently correlated with poor prognosis in acute myeloid leukemia. Leuk Res. 2005;29:653-9 pubmed
  65. Peignon G, Thenet S, Schreider C, Fouquet S, Ribeiro A, Dussaulx E, et al. E-cadherin-dependent transcriptional control of apolipoprotein A-IV gene expression in intestinal epithelial cells: a role for the hepatic nuclear factor 4. J Biol Chem. 2006;281:3560-8 pubmed
    ..Altogether, our results suggest that E-cadherin controls enterocyte-specific expression of genes, such as the apoA-IV gene, through the control of hepatic nuclear factor 4alpha nuclear abundance. ..
  66. Green A, Krivinskas S, Young P, Rakha E, Paish E, Powe D, et al. Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast. Breast Cancer Res Treat. 2009;113:59-66 pubmed publisher
    ..In addition to CDH1, loss of CTCF and DPEP1 gene expression suggest they are possible TSG in breast cancer and may, similar to CDH1, be potentially utilised as markers of predisposition of women diagnosed with LCIS. ..
  67. Saha B, Chaiwun B, Imam S, Tsao Wei D, Groshen S, Naritoku W, et al. Overexpression of E-cadherin protein in metastatic breast cancer cells in bone. Anticancer Res. 2007;27:3903-8 pubmed
    ..001). This is the first demonstration of membranous overexpression of E-cadherin on metastatic breast cancer cells in bone; the high frequency of its expression may have a role in the intercellular adhesion of metastatic cells in bone. ..
  68. Wang H, Ding T, Brown N, Yamamoto Y, Prince L, Reese J, et al. Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev Biol. 2008;318:112-25 pubmed publisher
    ..These results provide the first evidence that ZO-1 is involved in blastocyst formation from the morula by regulating accumulation of fluid and differentiation of nonpolar blastomeres to polar trophoblast cells...
  69. Reardon S, King M, Maclean J, Mann J, DeMayo F, Lydon J, et al. CDH1 is essential for endometrial differentiation, gland development, and adult function in the mouse uterus. Biol Reprod. 2012;86:141, 1-10 pubmed publisher
    ..CDH1 has a capacity to control cell fate by altering directional cell proliferation and apoptosis. ..
  70. Carothers A, Javid S, Moran A, Hunt D, Redston M, Bertagnolli M. Deficient E-cadherin adhesion in C57BL/6J-Min/+ mice is associated with increased tyrosine kinase activity and RhoA-dependent actomyosin contractility. Exp Cell Res. 2006;312:387-400 pubmed
    ..Thus, the positive regulation of E-cadherin adhesion provided by Apc+ in vivo allows proper negative regulation of Egfr, Src, Pyk2, and MAPK, as well as RhoA activities. ..
  71. Tsujiuchi T, Shimizu K, Itsuzaki Y, Onishi M, Sugata E, Fujii H, et al. CpG site hypermethylation of E-cadherin and Connexin26 genes in hepatocellular carcinomas induced by a choline-deficient L-Amino Acid-defined diet in rats. Mol Carcinog. 2007;46:269-74 pubmed
    ..These results suggested that hypermethylation of E-cadherin and Cx26 genes may be involved in the development of HCCs induced by a CDAA diet in rats. ..
  72. Suzuki S, Furue H, Koga K, Jiang N, Nohmi M, Shimazaki Y, et al. Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation. J Neurosci. 2007;27:3466-76 pubmed
    ..The cad8-/- mice also showed a reduced sensitivity to cold temperature. These results demonstrate that cad8 is essential for establishing the physiological coupling between cold-sensitive sensory neurons and their target DH neurons. ..
  73. Lee H, Lee D, Park S, Cho K, Bae H, Park J. Nuclear factor I-C (NFIC) regulates dentin sialophosphoprotein (DSPP) and E-cadherin via control of Krüppel-like factor 4 (KLF4) during dentinogenesis. J Biol Chem. 2014;289:28225-36 pubmed publisher
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