Gene Symbol: Dusp4
Description: dual specificity phosphatase 4
Alias: Mkp-2, Mkp2, dual specificity protein phosphatase 4, MAP kinase phosphatase 2, mitogen-activated protein kinase phosphatase 2
Guan K, Butch E. Isolation and characterization of a novel dual specific phosphatase, HVH2, which selectively dephosphorylates the mitogen-activated protein kinase. J Biol Chem. 1995;270:7197-203 pubmed
..HVH2 mRNA showed an expression pattern distinct from CL100 (human homologue of mouse MKP1) and PAC1, two previously identified MAP kinase phosphatases. Our data suggest a possible role of HVH2 in MAP kinase regulation. ..
Berasi S, Huard C, Li D, Shih H, Sun Y, Zhong W, et al
. Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase. J Biol Chem. 2006;281:27167-77 pubmed
..We report that a dual specificity phosphatase, Dusp4, is induced by AMPK in AML12, H4IIE, and Fao cells at both mRNA and protein levels...
Höfken T, Keller N, Fleischer F, Goke B, Wagner A. Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis. Biochem Biophys Res Commun. 2000;276:680-5 pubmed
..Interestingly, inhibition of MKP-1 expression by Ro-31-8220 maximally induced activation of JNK but not of p38 and ERK in acutely isolated acini. These effects indicate that JNK may indeed be a preferred MKP-1 substrate in vivo. ..
Edwards L, Ernsberger P. The I(1)-imidazoline receptor in PC12 pheochromocytoma cells reverses NGF-induced ERK activation and induces MKP-2 phosphatase. Brain Res. 2003;980:71-9 pubmed
..Thus, I(1)-receptors can abrogate the primary signaling cascade activated by NGF, most likely by increasing levels of a specific phosphatase to return dually phosphorylated ERK to its unphosphorylated state. ..
Barajas Espinosa A, Basye A, Jesse E, Yan H, QUAN D, Chen C. Redox activation of DUSP4 by N-acetylcysteine protects endothelial cells from CdÂ²âº-induced apoptosis. Free Radic Biol Med. 2014;74:188-199 pubmed publisher
..Immunoblotting of endothelial NO synthase (eNOS) and DUSP4, a dual-specificity phosphatase with a cysteine as its active residue, revealed that both enzymes are upregulated ..
Misra Press A, Rim C, Yao H, Roberson M, Stork P. A novel mitogen-activated protein kinase phosphatase. Structure, expression, and regulation. J Biol Chem. 1995;270:14587-96 pubmed
..MKP-2 differed from MKP-1 in its tissue distribution and in its extent of induction by growth factors and agents that induce cellular stress, suggesting that these MKPs may have distinct physiological functions. ..
Zhen X, Torres C, Cai G, Friedman E. Inhibition of protein tyrosine/mitogen-activated protein kinase phosphatase activity is associated with D2 dopamine receptor supersensitivity in a rat model of Parkinson's disease. Mol Pharmacol. 2002;62:1356-63 pubmed
..The results indicate that attenuation of the PTP/MKP pathway may be responsible for the development of D(2)DR supersensitivity. ..
Jeong D, Wei C, Ku B, Jeon T, Chien P, Kim J, et al
. The family-wide structure and function of human dual-specificity protein phosphatases. Acta Crystallogr D Biol Crystallogr. 2014;70:421-35 pubmed publisher
..The family-wide structures of DUSPs form a basis for the understanding of phosphorylation-mediated signal transduction and the development of therapeutics. ..