Gene Symbol: Dusp3
Description: dual specificity phosphatase 3
Alias: RGD1560049, dual specificity protein phosphatase 3, dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)-like, vaccinia virus phosphatase VH1-related
Species: rat
Products:     Dusp3

Top Publications

  1. Rahmouni S, Cerignoli F, Alonso A, Tsutji T, Henkens R, Zhu C, et al. Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence. Nat Cell Biol. 2006;8:524-31 pubmed
    ..We conclude that VHR is required for cell-cycle progression as it modulates MAP kinase activation in a cell-cycle phase-dependent manner. ..
  2. Henkens R, Delvenne P, Arafa M, Moutschen M, Zeddou M, Tautz L, et al. Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR. BMC Cancer. 2008;8:147 pubmed publisher
    The 21-kDa Vaccinia virus VH1-related (VHR) dual-specific protein phosphatase (encoded by the DUSP3 gene) plays a critical role in cell cycle progression and is itself regulated during the cell cycle...
  3. Alonso A, Saxena M, Williams S, Mustelin T. Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation. J Biol Chem. 2001;276:4766-71 pubmed
    ..Our results suggest that VHR is a negative regulator of the Erk and Jnk pathways in T cells and, therefore, may play a role in aspects of T lymphocyte physiology that depend on these kinases. ..
  4. Alonso A, Rahmouni S, Williams S, van Stipdonk M, Jaroszewski L, Godzik A, et al. Tyrosine phosphorylation of VHR phosphatase by ZAP-70. Nat Immunol. 2003;4:44-8 pubmed
    ..These results suggest that VHR is a target for ZAP-70 and tempers activation of the Erk2 pathway in a ZAP-70-controlled manner. ..
  5. Kang T, Kim K. VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues. Biochim Biophys Acta. 2008;1783:49-58 pubmed
    ..Our results suggest that in addition to neuronal cells, various other rodent adult tissues and embryos possess a common signaling mechanism which is involved in an indirect regulation of ERK activity by VRK3-mediated VHR activity. ..
  6. Arnoldussen Y, Lorenzo P, Pretorius M, Waehre H, Risberg B, Maelandsmo G, et al. The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer. Cancer Res. 2008;68:9255-64 pubmed publisher
    ..phosphatases during apoptosis of LNCaP cells and found that Vaccinia H1-related protein (VHR/DUSP3) is up-regulated by androgens during inhibition of apoptosis in LNCaP cells, but not in androgen-independent DU145 ..
  7. Jeong D, Wei C, Ku B, Jeon T, Chien P, Kim J, et al. The family-wide structure and function of human dual-specificity protein phosphatases. Acta Crystallogr D Biol Crystallogr. 2014;70:421-35 pubmed publisher
    ..The family-wide structures of DUSPs form a basis for the understanding of phosphorylation-mediated signal transduction and the development of therapeutics. ..
  8. Denu J, Zhou G, Wu L, Zhao R, Yuvaniyama J, Saper M, et al. The purification and characterization of a human dual-specific protein tyrosine phosphatase. J Biol Chem. 1995;270:3796-803 pubmed
    ..Similar results were obtained with F(NLe)(N-Le)pTPpYVVTR, a peptide corresponding to a MAP kinase-like protein (JNK1(180-189)) which is involved in the stress response signaling pathway. ..
  9. Zhou G, Denu J, Wu L, Dixon J. The catalytic role of Cys124 in the dual specificity phosphatase VHR. J Biol Chem. 1994;269:28084-90 pubmed
    ..Our results also demonstrate that the dual specificity phosphatases and the tyrosine-specific PTPases employ similar catalytic mechanisms. ..

More Information


  1. Aoki N, Aoyama K, Nagata M, Matsuda T. A growing family of dual specificity phosphatases with low molecular masses. J Biochem. 2001;130:133-40 pubmed
    ..Taken together, it is conceivable that a distinct class of low molecular mass DSPs is present and plays a role in dephosphorylating unknown molecules other than MAP kinases. ..
  2. Schumacher M, Todd J, Rice A, Tanner K, Denu J. Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase. Biochemistry. 2002;41:3009-17 pubmed
    ..As this structure is the first substrate-enzyme complex reported for the DSP family of enzymes, these results provide the first glimpse into how DSPs bind their protein substrates. ..