Gene Symbol: Dusp3
Description: dual specificity phosphatase 3
Alias: RGD1560049, dual specificity protein phosphatase 3, dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)-like, vaccinia virus phosphatase VH1-related
Rahmouni S, Cerignoli F, Alonso A, Tsutji T, Henkens R, Zhu C, et al
. Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence. Nat Cell Biol. 2006;8:524-31 pubmed
..We conclude that VHR is required for cell-cycle progression as it modulates MAP kinase activation in a cell-cycle phase-dependent manner. ..
Henkens R, Delvenne P, Arafa M, Moutschen M, Zeddou M, Tautz L, et al
. Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR. BMC Cancer. 2008;8:147 pubmed publisher
The 21-kDa Vaccinia virus VH1-related (VHR) dual-specific protein phosphatase (encoded by the DUSP3 gene) plays a critical role in cell cycle progression and is itself regulated during the cell cycle...
Alonso A, Saxena M, Williams S, Mustelin T. Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation. J Biol Chem. 2001;276:4766-71 pubmed
..Our results suggest that VHR is a negative regulator of the Erk and Jnk pathways in T cells and, therefore, may play a role in aspects of T lymphocyte physiology that depend on these kinases. ..
Alonso A, Rahmouni S, Williams S, van Stipdonk M, Jaroszewski L, Godzik A, et al
. Tyrosine phosphorylation of VHR phosphatase by ZAP-70. Nat Immunol. 2003;4:44-8 pubmed
..These results suggest that VHR is a target for ZAP-70 and tempers activation of the Erk2 pathway in a ZAP-70-controlled manner. ..
Kang T, Kim K. VRK3-mediated inactivation of ERK signaling in adult and embryonic rodent tissues. Biochim Biophys Acta. 2008;1783:49-58 pubmed
..Our results suggest that in addition to neuronal cells, various other rodent adult tissues and embryos possess a common signaling mechanism which is involved in an indirect regulation of ERK activity by VRK3-mediated VHR activity. ..
Arnoldussen Y, Lorenzo P, Pretorius M, Waehre H, Risberg B, Maelandsmo G, et al
. The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer. Cancer Res. 2008;68:9255-64 pubmed publisher
..phosphatases during apoptosis of LNCaP cells and found that Vaccinia H1-related protein (VHR/DUSP3) is up-regulated by androgens during inhibition of apoptosis in LNCaP cells, but not in androgen-independent DU145 ..
Jeong D, Wei C, Ku B, Jeon T, Chien P, Kim J, et al
. The family-wide structure and function of human dual-specificity protein phosphatases. Acta Crystallogr D Biol Crystallogr. 2014;70:421-35 pubmed publisher
..The family-wide structures of DUSPs form a basis for the understanding of phosphorylation-mediated signal transduction and the development of therapeutics. ..
Denu J, Zhou G, Wu L, Zhao R, Yuvaniyama J, Saper M, et al
. The purification and characterization of a human dual-specific protein tyrosine phosphatase. J Biol Chem. 1995;270:3796-803 pubmed
..Similar results were obtained with F(NLe)(N-Le)pTPpYVVTR, a peptide corresponding to a MAP kinase-like protein (JNK1(180-189)) which is involved in the stress response signaling pathway. ..
Zhou G, Denu J, Wu L, Dixon J. The catalytic role of Cys124 in the dual specificity phosphatase VHR. J Biol Chem. 1994;269:28084-90 pubmed
..Our results also demonstrate that the dual specificity phosphatases and the tyrosine-specific PTPases employ similar catalytic mechanisms. ..