Gene Symbol: Dusp10
Description: dual specificity phosphatase 10
Alias: Mkp-5, Mkp5, dual specificity protein phosphatase 10
Species: rat
Products:     Dusp10

Top Publications

  1. Tanoue T, Moriguchi T, Nishida E. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5. J Biol Chem. 1999;274:19949-56 pubmed
    ..These results suggest that MKP-5 is a novel type of dual specificity phosphatase specific for p38 and SAPK/JNK. ..
  2. Zhang Y, Blattman J, Kennedy N, Duong J, Nguyen T, Wang Y, et al. Regulation of innate and adaptive immune responses by MAP kinase phosphatase 5. Nature. 2004;430:793-7 pubmed
    ..JNK activity was selectively increased in Mkp5 (also known as Dusp10)-deficient mouse cells...
  3. Qian F, Deng J, Cheng N, Welch E, Zhang Y, Malik A, et al. A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury. EMBO J. 2009;28:2896-907 pubmed publisher
    ..Using a modified mouse model of local Shwartzman reaction, we found that deletion of the MKP5 gene, but not the MKP1 gene, led to robust and accelerated vascular inflammatory responses to a single dose of LPS ..
  4. Chang C, Zhang Q, Liu Z, Clynes R, Suciu Foca N, Vlad G. Downregulation of inflammatory microRNAs by Ig-like transcript 3 is essential for the differentiation of human CD8(+) T suppressor cells. J Immunol. 2012;188:3042-52 pubmed publisher
    ..In conclusion, ILT3Fc inhibits T cell activation and induces the generation of Ts targeting multiple inflammatory miRNA pathways. ..
  5. Png C, Weerasooriya M, Guo J, James S, Poh H, Osato M, et al. DUSP10 regulates intestinal epithelial cell growth and colorectal tumorigenesis. Oncogene. 2016;35:206-17 pubmed publisher
    Dual specificity phosphatase 10 (DUSP10), also known as MAP kinase phosphatase 5 (MKP5), negatively regulates the activation of MAP kinases...
  6. Höfken T, Keller N, Fleischer F, Goke B, Wagner A. Map kinase phosphatases (MKP's) are early responsive genes during induction of cerulein hyperstimulation pancreatitis. Biochem Biophys Res Commun. 2000;276:680-5 pubmed
    ..Interestingly, inhibition of MKP-1 expression by Ro-31-8220 maximally induced activation of JNK but not of p38 and ERK in acutely isolated acini. These effects indicate that JNK may indeed be a preferred MKP-1 substrate in vivo. ..
  7. Jeong D, Yoon T, Kim J, Shim M, Jung S, Son J, et al. Crystal structure of the catalytic domain of human MAP kinase phosphatase 5: structural insight into constitutively active phosphatase. J Mol Biol. 2006;360:946-55 pubmed
    MAP kinase phosphatase 5 (MKP5) is a member of the mitogen-activated protein kinase phosphatase (MKP) family and selectively dephosphorylates JNK and p38...
  8. Gobert R, Joubert L, Curchod M, Salvat C, Foucault I, Jorand Lebrun C, et al. Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol Cell Biol. 2009;29:1538-53 pubmed publisher
    ..We show that a novel inhibitor for one of the identified genes, dual-specificity phosphatase DUSP10/MKP5, was also capable of inducing oligodendrocyte differentiation in primary oligodendrocyte precursors...
  9. Cuadrado A, Nebreda A. Mechanisms and functions of p38 MAPK signalling. Biochem J. 2010;429:403-17 pubmed publisher
    ..Finally, we discuss how genetic mouse models are facilitating the identification of physiological functions for p38 MAPKs, which may impinge on their eventual use as therapeutic targets. ..

More Information


  1. Papadopoulos P, Rosa Neto P, Rochford J, Hamel E. Pioglitazone improves reversal learning and exerts mixed cerebrovascular effects in a mouse model of Alzheimer's disease with combined amyloid-? and cerebrovascular pathology. PLoS ONE. 2013;8:e68612 pubmed publisher
    ..They further suggest a potential benefit of pioglitazone in managing neuroinflammation, cerebral perfusion and glucose metabolism in AD patients devoid of cerebrovascular pathology. ..
  2. Jeong D, Wei C, Ku B, Jeon T, Chien P, Kim J, et al. The family-wide structure and function of human dual-specificity protein phosphatases. Acta Crystallogr D Biol Crystallogr. 2014;70:421-35 pubmed publisher
    ..The family-wide structures of DUSPs form a basis for the understanding of phosphorylation-mediated signal transduction and the development of therapeutics. ..
  3. Kondoh K, Nishida E. Regulation of MAP kinases by MAP kinase phosphatases. Biochim Biophys Acta. 2007;1773:1227-37 pubmed
    ..Here we focus on recent findings regarding regulation and function of the MKP family members as physiological regulators of MAPK signaling. ..
  4. Zhang Y, Wu J, Wang Z. A distinct interaction mode revealed by the crystal structure of the kinase p38? with the MAPK binding domain of the phosphatase MKP5. Sci Signal. 2011;4:ra88 pubmed publisher
    ..structure of p38? in complex with the MAPK binding domain (KBD) from MAPK phosphatase 5 (MKP5) at 2.7 Å resolution...
  5. Choi H, Kim W, Kim E, Han B, Min J, Chi S, et al. Dual-specificity phosphatase 10 controls brown adipocyte differentiation by modulating the phosphorylation of p38 mitogen-activated protein kinase. PLoS ONE. 2013;8:e72340 pubmed publisher
    ..Here, we investigate the potential role of dual-specificity phosphatase 10 (DUSP10) in brown adipocyte differentiation using primary brown preadipocytes...