dual specificity phosphatase 5


Gene Symbol: dual specificity phosphatase 5
Description: dual specificity phosphatase 5
Alias: Cpg21, dual specificity protein phosphatase 5, MAP-kinase phosphatase (cpg21), MAP-kinase phosphatase CPG21, candidate plasticity-related gene 21
Species: rat

Top Publications

  1. Fu Q, McKnight R, Yu X, Callaway C, Lane R. Growth retardation alters the epigenetic characteristics of hepatic dual specificity phosphatase 5. FASEB J. 2006;20:2127-9 pubmed
  2. Wickramasekera N, Gebremedhin D, Carver K, Vakeel P, Ramchandran R, Schuett A, et al. Role of dual-specificity protein phosphatase-5 in modulating the myogenic response in rat cerebral arteries. J Appl Physiol (1985). 2013;114:252-61 pubmed publisher
  3. Ferguson B, Harrison B, Jeong M, Reid B, Wempe M, Wagner F, et al. Signal-dependent repression of DUSP5 by class I HDACs controls nuclear ERK activity and cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2013;110:9806-11 pubmed publisher
    ..These findings define unique roles for class I HDACs and DUSP5 as integral components of a regulatory signaling circuit that controls cardiac hypertrophy. ..
  4. Yan T, Zhang F, Sun C, Sun J, Wang Y, Xu X, et al. miR-32-5p-mediated Dusp5 downregulation contributes to neuropathic pain. Biochem Biophys Res Commun. 2018;495:506-511 pubmed publisher
    ..Our findings highlight a novel contribution of miR-32-5p to the process of neuropathic pain, and suggest possibilities for the development of novel therapeutic options for neuropathic pain. ..
  5. Ishibashi T, Bottaro D, Michieli P, Kelley C, Aaronson S. A novel dual specificity phosphatase induced by serum stimulation and heat shock. J Biol Chem. 1994;269:29897-902 pubmed
    ..Thus, B23 is a new human protein phosphatase which appears to be regulated in response to mitogenic signaling and at least some forms of stress. ..
  6. Hevroni D, Rattner A, Bundman M, Lederfein D, Gabarah A, Mangelus M, et al. Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms. J Mol Neurosci. 1998;10:75-98 pubmed
    ..cytoskeletal protein; cpg4--a heat-shock protein: cpg16--a protein kinase; cpg20--a transcription factor; cpg21--a dual-specificity MAP-kinase phosphatase; and cpg30 and cpg38--two new seven-transmembrane domain receptors...
  7. Ke X, McKnight R, Caprau D, O Grady S, Fu Q, Yu X, et al. Intrauterine growth restriction affects hippocampal dual specificity phosphatase 5 gene expression and epigenetic characteristics. Physiol Genomics. 2011;43:1160-9 pubmed publisher
    ..Hippocampal dual specificity phosphatase 5 (DUSP5) may be involved in these morbidities because DUSP5 regulates extracellular signal-regulated ..
  8. Fan F, Geurts A, Pabbidi M, Smith S, Harder D, Jacob H, et al. Zinc-finger nuclease knockout of dual-specificity protein phosphatase-5 enhances the myogenic response and autoregulation of cerebral blood flow in FHH.1BN rats. PLoS ONE. 2014;9:e112878 pubmed publisher
    ..1BN rats. These results indicate that Dusp5 modulates myogenic reactivity in the cerebral circulation and support the view that a mutation in Dusp5 may enhance Dusp5 activity and contribute to the impaired myogenic response in FHH rats. ..
  9. Tao H, Yang J, Hu W, Shi K, Deng Z, Li J. MeCP2 regulation of cardiac fibroblast proliferation and fibrosis by down-regulation of DUSP5. Int J Biol Macromol. 2016;82:68-75 pubmed publisher
    ..Taken together, these results indicated that MeCP2 acts as a key regulator of pathological cardiac fibrosis, promotes cardiac fibroblasts proliferation and fibrosis by down-regulation of DUSP5. ..

More Information


  1. Raghavendra Rao V, Dhodda V, Song G, Bowen K, Dempsey R. Traumatic brain injury-induced acute gene expression changes in rat cerebral cortex identified by GeneChip analysis. J Neurosci Res. 2003;71:208-19 pubmed
    ..JAK-2, STAT-3, CREM, IRF-1, SMN, silencer factor-B, ANIA-3, ANIA-4, and HES-1) and signal transduction pathways (cpg21, Narp, and CRBP) and down-regulated transmitter release mechanisms (CITRON, synaptojanin II, ras-related rab3, ..
  2. Jeong D, Wei C, Ku B, Jeon T, Chien P, Kim J, et al. The family-wide structure and function of human dual-specificity protein phosphatases. Acta Crystallogr D Biol Crystallogr. 2014;70:421-35 pubmed publisher
    ..The family-wide structures of DUSPs form a basis for the understanding of phosphorylation-mediated signal transduction and the development of therapeutics. ..