dual oxidase 2


Gene Symbol: dual oxidase 2
Description: dual oxidase 2
Alias: Thox2, dual oxidase 2, NADH/NADPH thyroid oxidase THOX2, large NOX 2, long NOX 2, thyroid oxidase 2
Species: rat
Products:     dual oxidase 2

Top Publications

  1. Moreno J, Bikker H, Kempers M, van Trotsenburg A, Baas F, de Vijlder J, et al. Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism. N Engl J Med. 2002;347:95-102 pubmed
    ..of the patients and their relatives was analyzed for mutations in the genes for thyroid oxidase 1 (THOX1 ) and 2 (THOX2 )...
  2. Dupuy C, Pomerance M, Ohayon R, Noël Hudson M, Deme D, Chaaraoui M, et al. Thyroid oxidase (THOX2) gene expression in the rat thyroid cell line FRTL-5. Biochem Biophys Res Commun. 2000;277:287-92 pubmed
    ..The predicted 1517-residue polypeptide was 82.5% identical to the human THOX2/DUOX2 and 74% similar to THOX1/DUOX1...
  3. De Marco G, Agretti P, Montanelli L, Di Cosmo C, Bagattini B, De Servi M, et al. Identification and functional analysis of novel dual oxidase 2 (DUOX2) mutations in children with congenital or subclinical hypothyroidism. J Clin Endocrinol Metab. 2011;96:E1335-9 pubmed publisher
    Congenital hypothyroidism (CH) associated with goiter or a gland of normal size has been linked to dual oxidase 2 (DUOX2) mutations in the presence of iodide organification defect...
  4. Harper R, Xu C, Eiserich J, Chen Y, Kao C, Thai P, et al. Differential regulation of dual NADPH oxidases/peroxidases, Duox1 and Duox2, by Th1 and Th2 cytokines in respiratory tract epithelium. FEBS Lett. 2005;579:4911-7 pubmed
  5. Morand S, Dos Santos O, Ohayon R, Kaniewski J, Noel Hudson M, Virion A, et al. Identification of a truncated dual oxidase 2 (DUOX2) messenger ribonucleic acid (mRNA) in two rat thyroid cell lines. Insulin and forskolin regulation of DUOX2 mRNA levels in FRTL-5 cells and porcine thyrocytes. Endocrinology. 2003;144:567-74 pubmed
    ..The presence of insulin in the culture medium converted forskolin from a stimulator to an inhibitor in FRTL-5 cells maintained in low serum conditions, but not in porcine thyrocytes in primary culture. ..
  6. Pachucki J, Wang D, Christophe D, Miot F. Structural and functional characterization of the two human ThOX/Duox genes and their 5'-flanking regions. Mol Cell Endocrinol. 2004;214:53-62 pubmed
    ..Human ThOX1 and ThOX2 genes span 75 kb and are composed of 35 and 34 exons, respectively...
  7. Geiszt M, Witta J, Baffi J, Lekstrom K, Leto T. Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense. FASEB J. 2003;17:1502-4 pubmed
    ..the catalytic core of this enzyme, were described recently; dual oxidase (Duox)1/thyroid oxidase 1 and Duox2/thyroid oxidase 2 were identified in the thyroid gland and characterized as H2O2 donors for thyroxin biosynthesis...
  8. Ameziane El Hassani R, Morand S, Boucher J, Frapart Y, Apostolou D, Agnandji D, et al. Dual oxidase-2 has an intrinsic Ca2+-dependent H2O2-generating activity. J Biol Chem. 2005;280:30046-54 pubmed
    ..These results suggest that post-translational modifications during the maturation process of Duox2 could be implicated in the mechanism of H2O2 formation by favoring intramolecular superoxide dismutation. ..
  9. Johnson K, Marden C, Ward Bailey P, Gagnon L, Bronson R, Donahue L. Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2. Mol Endocrinol. 2007;21:1593-602 pubmed
    ..Mutations in the human dual oxidase 2 gene, DUOX2, have been shown to underlie several cases of congenital hypothyroidism...

More Information


  1. Fernandez L, López Márquez A, Martínez A, Gomez Lopez G, Santisteban P. New insights into FoxE1 functions: identification of direct FoxE1 targets in thyroid cells. PLoS ONE. 2013;8:e62849 pubmed publisher
    ..Furthermore, this study points out the important role of FoxE1 in the regulation of a large number of genes in thyroid cells. ..