Gene Symbol: Dstyk
Description: dual serine/threonine and tyrosine protein kinase
Alias: DustyPK, Ripk5, dual serine/threonine and tyrosine protein kinase, dusty PK, dusty protein kinase, receptor interacting protein kinase 5, receptor-interacting serine/threonine-protein kinase 5
Zha J, Zhou Q, Xu L, Chen D, Li L, Zhai Z, et al
. RIP5 is a RIP-homologous inducer of cell death. Biochem Biophys Res Commun. 2004;319:298-303 pubmed
..However, RIP5-induced apoptotic morphology is not blocked by crmA. These findings suggest that RIP5 may induce both caspase-dependent apoptosis and caspase-independent cell death. ..
Peng J, Dong W, Chen Y, Mo R, Cheng J, Hui C, et al
. Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain. Biochim Biophys Acta. 2006;1759:562-72 pubmed
..Taken together, Dusty is a unique evolutionarily selected group of divergent protein kinases that may play important functional roles in the brain and other tissues of vertebrates. ..
Sanna Cherchi S, Sampogna R, Papeta N, Burgess K, Nees S, Perry B, et al
. Mutations in DSTYK and dominant urinary tract malformations. N Engl J Med. 2013;369:621-9 pubmed publisher
..intervals, a heterozygous splice-site mutation in the dual serine-threonine and tyrosine protein kinase gene (DSTYK). This variant, which resulted in aberrant splicing of messenger RNA, was present in all affected family members...
Lee J, Hsu C, Michael M, Nanda A, Liu L, McMillan J, et al
. Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23. Am J Hum Genet. 2017;100:364-370 pubmed publisher
..further Palestinian-Jordanian SPG23 pedigree, we identified a complex homozygous 4-kb deletion/20-bp insertion in DSTYK (dual serine-threonine and tyrosine protein kinase) in all four affected family members...