Drosha

Summary

Gene Symbol: Drosha
Description: drosha ribonuclease III
Alias: Etohi2, RGD1307626, Rn3, Rnasen, ribonuclease 3, drosha, ribonuclease type III, ethanol induced 2, ribonuclease III, nuclear, ribonuclease type III, nuclear
Species: rat
Products:     Drosha

Top Publications

  1. Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, et al. The nuclear RNase III Drosha initiates microRNA processing. Nature. 2003;425:415-9 pubmed
    ..Here we identify another RNase III, human Drosha, as the core nuclease that executes the initiation step of miRNA processing in the nucleus...
  2. Han J, Lee Y, Yeom K, Kim Y, Jin H, Kim V. The Drosha-DGCR8 complex in primary microRNA processing. Genes Dev. 2004;18:3016-27 pubmed
    RNase III proteins play key roles in microRNA (miRNA) biogenesis. The nuclear RNase III Drosha cleaves primary miRNAs (pri-miRNAs) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic RNase III Dicer to ..
  3. Davis B, Hilyard A, Lagna G, Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature. 2008;454:56-61 pubmed publisher
    ..of primary transcripts of miR-21 (pri-miR-21) into precursor miR-21 (pre-miR-21) by the DROSHA (also known as RNASEN) complex...
  4. Rybak A, Fuchs H, Smirnova L, Brandt C, Pohl E, Nitsch R, et al. A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol. 2008;10:987-93 pubmed publisher
  5. Krol J, Loedige I, Filipowicz W. The widespread regulation of microRNA biogenesis, function and decay. Nat Rev Genet. 2010;11:597-610 pubmed publisher
    ..Such regulation has an important role in the context-specific functions of miRNAs. ..
  6. Cesana M, Cacchiarelli D, Legnini I, Santini T, Sthandier O, Chinappi M, et al. A long noncoding RNA controls muscle differentiation by functioning as a competing endogenous RNA. Cell. 2011;147:358-69 pubmed publisher
    ..We conclude that the ceRNA network plays an important role in muscle differentiation. ..
  7. Lugli G, Larson J, Demars M, Smalheiser N. Primary microRNA precursor transcripts are localized at post-synaptic densities in adult mouse forebrain. J Neurochem. 2012;123:459-66 pubmed publisher
    ..b>Drosha and DGCR8 proteins are also expressed in synaptic fractions and PSDs, and are tightly associated with pri-miRs as ..
  8. Bhogal R, Mitchell A, Coen C. Identification of putative rat ribonuclease III by differential display: a novel rat mRNA expressed in a circadian manner in the rat suprachiasmatic nucleus. Brain Res Mol Brain Res. 2004;131:51-7 pubmed
    ..No significant changes in its expression were detected across the cycle within the supraoptic nucleus, cingulate cortex or caudate putamen. ..
  9. Chong M, Rasmussen J, Rudensky A, Rundensky A, Littman D. The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med. 2008;205:2005-17 pubmed publisher
    ..We provide genetic and in vivo evidence that the two RNaseIII enzymes, Drosha and Dicer, do indeed function in the same pathway...

More Information

Publications12

  1. Torrent M, Badia M, Moussaoui M, Sanchez D, Nogu├ęs M, Boix E. Comparison of human RNase 3 and RNase 7 bactericidal action at the Gram-negative and Gram-positive bacterial cell wall. FEBS J. 2010;277:1713-25 pubmed publisher
    ..An understanding of the interaction between antimicrobial proteins and their target at the bacterial envelope should aid in the design of alternative peptide-derived antibiotics. ..
  2. Cheloufi S, Dos Santos C, Chong M, Hannon G. A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature. 2010;465:584-9 pubmed publisher
    ..Though this microRNA is processed by Drosha (also known as Rnasen), its maturation does not require Dicer...
  3. Huang V, Place R, Portnoy V, Wang J, Qi Z, Jia Z, et al. Upregulation of Cyclin B1 by miRNA and its implications in cancer. Nucleic Acids Res. 2012;40:1695-707 pubmed publisher
    ..e. Dicer, Drosha, Ago1 and Ago2). In silico analysis identifies highly-complementary sites for 21 miRNAs in the Ccnb1 promoter...