Dpysl2

Summary

Gene Symbol: Dpysl2
Description: dihydropyrimidinase-like 2
Alias: Crmp2, TOAD-64, dihydropyrimidinase-related protein 2, CRMP-2, DRP-2, collapsin response mediator protein 2, turned on after division, 64 kDa protein
Species: rat
Products:     Dpysl2

Top Publications

  1. Rogemond V, Auger C, Giraudon P, Becchi M, Auvergnon N, Belin M, et al. Processing and nuclear localization of CRMP2 during brain development induce neurite outgrowth inhibition. J Biol Chem. 2008;283:14751-61 pubmed publisher
    ..Among them, CRMP2 mediates axonal guidance by collapsing growth cones during development...
  2. Uchida Y, Ohshima T, Yamashita N, Ogawara M, Sasaki Y, Nakamura F, et al. Semaphorin3A signaling mediated by Fyn-dependent tyrosine phosphorylation of collapsin response mediator protein 2 at tyrosine 32. J Biol Chem. 2009;284:27393-401 pubmed publisher
    b>Collapsin response mediator protein 2 (CRMP2) is an intracellular protein that mediates signaling of Semaphorin3A (Sema3A), a repulsive axon guidance molecule. Fyn, a Src-type tyrosine kinase, is involved in the Sema3A signaling...
  3. Bretin S, Reibel S, Charrier E, Maus Moatti M, Auvergnon N, Thevenoux A, et al. Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain. J Comp Neurol. 2005;486:1-17 pubmed
    CRMP1, CRMP2, and CRMP5 have been identified as cytosolic proteins relaying semaphorin 3A signalling, one of the molecular cues conducting axon and dendrite growth and guidance...
  4. Zhang Z, Ottens A, Sadasivan S, Kobeissy F, Fang T, Hayes R, et al. Calpain-mediated collapsin response mediator protein-1, -2, and -4 proteolysis after neurotoxic and traumatic brain injury. J Neurotrauma. 2007;24:460-72 pubmed
    ..It is possible that the calpain-mediated truncation of CRMPs following TBI may be an inhibiting factor for post-injury neurite regeneration. ..
  5. Suzuki Y, Nakagomi S, Namikawa K, Kiryu Seo S, Inagaki N, Kaibuchi K, et al. Collapsin response mediator protein-2 accelerates axon regeneration of nerve-injured motor neurons of rat. J Neurochem. 2003;86:1042-50 pubmed
    ..CRMP-2-overexpressing motor neurons demonstrated the accelerated reprojection. The present study suggests that CRMP-2 has potent neurite elongation activity in nerve regeneration in vivo. ..
  6. Chung M, Lee J, Lee J, Ko M, Lee S, Kim H. Alteration of collapsin response mediator protein-2 expression in focal ischemic rat brain. Neuroreport. 2005;16:1647-53 pubmed
    ..These data suggest that collapsin response mediator protein-2 is an important candidate controlling ischemic stroke. ..
  7. Wang T, Wu X, Yin C, Klebe D, Zhang J, Qin X. CRMP-2 is involved in axon growth inhibition induced by RGMa in vitro and in vivo. Mol Neurobiol. 2013;47:903-13 pubmed publisher
    ..We concluded RGMa inhibits axon growth by phosphorylating CRMP-2 via both Rho-kinase and GSK-3? signaling pathways. ..
  8. Zhu L, Zheng H, Peng C, Liu D, Li H, Wang Q, et al. Protein phosphatase 2A facilitates axonogenesis by dephosphorylating CRMP2. J Neurosci. 2010;30:3839-48 pubmed publisher
    ..PP2A can dephosphorylate collapsin response mediator protein-2 (CRMP2) that implements the axon polarization, whereas constitutive expression of phosphomimic-CRMP2 abrogates the effect ..
  9. Fernandez Gamba A, Leal M, Maarouf C, Richter Landsberg C, Wu T, Morelli L, et al. Collapsin response mediator protein-2 phosphorylation promotes the reversible retraction of oligodendrocyte processes in response to non-lethal oxidative stress. J Neurochem. 2012;121:985-95 pubmed publisher
    ..Proteomics of OLG lysates with and without 3-NP treatment yielded collapsin response mediator protein 2 (CRMP-2) as a candidate effector molecule...

More Information

Publications62

  1. Liu C, Miao J, Zhang Y, Liu Y, Yu B. Effects of hypothyroidism on expression of CRMP2B and ARPC5 during development of the rat frontal cortex. Int J Biol Sci. 2013;9:209-18 pubmed publisher
    ..ARPC5 and CRMP2 are closely associated with neurite outgrowth in brain development...
  2. Nishimura T, Fukata Y, Kato K, Yamaguchi T, Matsuura Y, Kamiguchi H, et al. CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth. Nat Cell Biol. 2003;5:819-26 pubmed
    ..These results suggest that in addition to regulating microtubule assembly, CRMP-2 is involved in polarized Numb-mediated endocytosis of proteins such as L1. ..
  3. Brittain J, Chen L, Wilson S, Brustovetsky T, Gao X, Ashpole N, et al. Neuroprotection against traumatic brain injury by a peptide derived from the collapsin response mediator protein 2 (CRMP2). J Biol Chem. 2011;286:37778-92 pubmed publisher
    ..The axon guidance and outgrowth protein collapsin response mediator protein 2 (CRMP2) has been linked to NMDAR trafficking and may be involved in neuronal survival following ..
  4. Kato D, Mitake S, Mizuno M, Kanamori T, Suzuki T, Ojika K, et al. Co-localization of hippocampal cholinergic neurostimulating peptide precursor with collapsin response mediator protein-2 at presynaptic terminals in hippocampus. Neurosci Lett. 2012;517:92-7 pubmed publisher
    ..Furthermore, HCNP-pp overexpression increases synaptophysin levels. These findings suggest that HCNP-pp, in association with CRMP-2, plays an important role in presynaptic function in the hippocampus. ..
  5. Kawano Y, Yoshimura T, Tsuboi D, Kawabata S, Kaneko Kawano T, Shirataki H, et al. CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formation. Mol Cell Biol. 2005;25:9920-35 pubmed
    ..We have previously reported that collapsin response mediator protein 2 (CRMP-2) plays a critical role in axon outgrowth and axon-dendrite specification (N. Inagaki, K...
  6. Nishimura T, Yamaguchi T, Tokunaga A, Hara A, Hamaguchi T, Kato K, et al. Role of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2. Mol Biol Cell. 2006;17:1273-85 pubmed
    ..Knockdown of Numb suppressed the ephrin-B1-induced spine development and maturation. These results highlight a role of Numb for dendritic spine development and synaptic functions with intersectin and EphB2. ..
  7. Wang L, Strittmatter S. Brain CRMP forms heterotetramers similar to liver dihydropyrimidinase. J Neurochem. 1997;69:2261-9 pubmed
    ..Although purified brain CRMP does not hydrolyze several DHPase substrates, it is likely that a related activity accounts for CRMP participation in neuronal growth cone signaling. ..
  8. Yoneda A, Morgan Fisher M, Wait R, Couchman J, Wewer U. A collapsin response mediator protein 2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II. Mol Cell Biol. 2012;32:1788-804 pubmed publisher
    b>Collapsin response mediator protein 2 (CRMP-2) is known as a regulator of neuronal polarity and differentiation through microtubule assembly and trafficking...
  9. Geschwind D, Kelly G, Fryer H, Feeser Bhatt H, Hockfield S. Identification and characterization of novel developmentally regulated proteins in rat spinal cord. Brain Res Dev Brain Res. 1996;97:62-75 pubmed
    ..This expression pattern, coupled with its recently discovered homology to two proteins implicated in axon pathfinding in the chick and nematode [5,3], suggests that TOAD-64 may have a fundamental role in axon pathfinding. ..
  10. Mizuno M, Kato D, Kanamori T, Toyoda T, Suzuki T, Ojika K, et al. Phosphorylation of collapsin response mediator protein-2 regulates its localization and association with hippocampal cholinergic neurostimulating peptide precursor in the hippocampus. Neurosci Lett. 2013;535:122-7 pubmed publisher
    ..These findings suggest that HCNP-pp, in association with unphosphorylated and/or pSer522-CRMP-2, plays an important role in presynaptic function in the mature hippocampus. ..
  11. Brittain J, Piekarz A, Wang Y, Kondo T, Cummins T, Khanna R. An atypical role for collapsin response mediator protein 2 (CRMP-2) in neurotransmitter release via interaction with presynaptic voltage-gated calcium channels. J Biol Chem. 2009;284:31375-90 pubmed publisher
    ..Toxin block of Ca(2+) entry via CaV2.2 abolished this stimulated release. Thus, the CRMP-2-Ca(2+) channel interaction represents a novel mechanism for modulation of Ca(2+) influx into nerve terminals and, hence, of synaptic strength. ..
  12. Brustovetsky T, Pellman J, Yang X, Khanna R, Brustovetsky N. Collapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity. J Biol Chem. 2014;289:7470-82 pubmed publisher
    b>Collapsin response mediator protein 2 (CRMP2) is traditionally viewed as an axonal growth protein involved in axon/dendrite specification. Here, we describe novel functions of CRMP2...
  13. Indraswari F, Wong P, Yap E, Ng Y, Dheen S. Upregulation of Dpysl2 and Spna2 gene expression in the rat brain after ischemic stroke. Neurochem Int. 2009;55:235-42 pubmed publisher
    ..Dihydropyrimidinase-like 2 (Dpysl2), a protein involved in neuronal differentiation and axonal guidance, and alpha-spectrin 2 (Spna2), a protein ..
  14. Zhang Z, Majava V, Greffier A, Hayes R, Kursula P, Wang K. Collapsin response mediator protein-2 is a calmodulin-binding protein. Cell Mol Life Sci. 2009;66:526-36 pubmed publisher
    ..Take together, our data suggest that CRMP-2 is a novel CaM-binding protein and that CaM binding may play an important role in regulating CRMP-2 functions. ..
  15. Qianman B, Jialihasi A, Asilehan B, Kubai A, Aibek R, Wupuer A, et al. Active exercise promotes Achilles tendon healing and is accompanied by the upregulation of collapsin response mediator protein‑2 in rats. Mol Med Rep. 2017;16:2355-2360 pubmed publisher
    ..71±0.03; immobilization group, 0.49±0.01 nm; P<0.05). These results indicated that active mobilization may promote Achilles tendon healing via upregulation of CRMP‑2 protein expression. ..
  16. Katano T, Mabuchi T, Okuda Ashitaka E, Inagaki N, Kinumi T, Ito S. Proteomic identification of a novel isoform of collapsin response mediator protein-2 in spinal nerves peripheral to dorsal root ganglia. Proteomics. 2006;6:6085-94 pubmed
    ..These results suggest that periCRMP-2 is a C-terminal truncated isoform polarized in the peripheral side of spinal nerves and may be involved in nerve degeneration and regeneration. ..
  17. Yoshimura T, Arimura N, Kawano Y, Kawabata S, Wang S, Kaibuchi K. Ras regulates neuronal polarity via the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway. Biochem Biophys Res Commun. 2006;340:62-8 pubmed
    ..Taken together, these results suggest that Ras plays critical roles in establishing neuronal polarity upstream of the PI3-kinase/Akt/GSK-3beta/CRMP-2 pathway and mitogen-activated protein kinase cascade. ..
  18. Patrakitkomjorn S, Kobayashi D, Morikawa T, Wilson M, Tsubota N, Irie A, et al. Neurofibromatosis type 1 (NF1) tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein, CRMP-2. J Biol Chem. 2008;283:9399-413 pubmed publisher
  19. Gu Y, Hamajima N, Ihara Y. Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. Biochemistry. 2000;39:4267-75 pubmed
    ..The phosphorylation of this particular portion carboxyl-terminal to the basic region of CRMP-2 may play an important role in regulating its activity, and may be involved in the formation of degenerating neurites in AD brain. ..
  20. Brittain J, Wang Y, Eruvwetere O, Khanna R. Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2. FEBS Lett. 2012;586:3813-8 pubmed publisher
    ..Concomitant knockdown of endogenous CRMP2 and overexpression of CRMP2-S522A mutant refractory to knockdown phenocopied the reduction in Ca(2+) influx while ..
  21. Wilson S, Brittain J, Piekarz A, Ballard C, Ripsch M, Cummins T, et al. Further insights into the antinociceptive potential of a peptide disrupting the N-type calcium channel-CRMP-2 signaling complex. Channels (Austin). 2011;5:449-56 pubmed publisher
    ..A novel interaction between Cav 2.2 and collapsin response mediator protein 2 (CRMP-2) positively regulates channel function by increasing surface trafficking...
  22. Astle M, Ooms L, Cole A, Binge L, Dyson J, Layton M, et al. Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP)•collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation. J Biol Chem. 2011;286:23407-18 pubmed publisher
    ..We identify collapsin response mediator protein 2 (CRMP2), which regulates axon selection by promoting WAVE1 delivery via Kinesin-1 motors to the ..
  23. Wong C, Leung M. Effects of neonatal hypothyroidism on the expressions of growth cone proteins and axon guidance molecules related genes in the hippocampus. Mol Cell Endocrinol. 2001;184:143-50 pubmed
    ..Transcription of CRMP 1 to 4, GAP-43, G alpha o1 but not G alpha o2 and sema 3F was altered by the neonatal treatment. The only sex difference in gene expression was found in the transcription of CRMP-2 gene. ..
  24. Bork K, Karbe Y, Pollscheit J, Glaubitz N, Nöhring S, Horstkorte R. Role of collapsin response mediator protein-2 in neurite outgrowth of PC12 cells. Neuroreport. 2010;21:641-5 pubmed publisher
    ..In contrast, a PC12 cell line deficient in CRMP-2 extends neurites after the stimulation of nerve growth factor or neural cell adhesion molecule. ..
  25. Cole A, Soutar M, Rembutsu M, van Aalten L, Hastie C, McLauchlan H, et al. Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation. J Biol Chem. 2008;283:18227-37 pubmed publisher
    b>Collapsin response mediator protein 2 (CRMP2) binds to microtubules and regulates axon outgrowth in neurons...
  26. He X, Jiang L, Dan Q, Lv Q, Hu Y, Liu J, et al. Bone marrow stromal cells promote neuroplasticity of cerebral ischemic rats via a phosphorylated CRMP2-mediated mechanism. Behav Brain Res. 2017;320:494-503 pubmed publisher
    b>Collapsin response mediator protein 2 (CRMP2), an important protein involved in axonal growth and the maintenance of neuronal membrane integrity, has proved to be altered in nervous system diseases...
  27. Lee H, Joo J, Nah S, Kim J, Kim H, Kwon J, et al. Changes in Dpysl2 expression are associated with prenatally stressed rat offspring and susceptibility to schizophrenia in humans. Int J Mol Med. 2015;35:1574-86 pubmed publisher
    ..analysis revealed that the expression of dihydropyrimidinase-like 2 (Dpysl2) or collapsin response mediator protein 2 (Crmp2) was downregulated in the prefrontal cortex and hippocampus of rats in the PNS group...
  28. Yoshimura Y, Shinkawa T, Taoka M, Kobayashi K, Isobe T, Yamauchi T. Identification of protein substrates of Ca(2+)/calmodulin-dependent protein kinase II in the postsynaptic density by protein sequencing and mass spectrometry. Biochem Biophys Res Commun. 2002;290:948-54 pubmed
    ..We found 6 proteins not previously known to be substrates of CaM kinase II, namely PSD95-associated protein, SAP97, TOAD-64, TNF receptor-associated protein, insulin-receptor tyrosine kinase 58/53 kDa substrate, and homer 1b. ..
  29. Büttner B, Kannicht C, Reutter W, Horstkorte R. Novel cytosolic binding partners of the neural cell adhesion molecule: mapping the binding domains of PLC gamma, LANP, TOAD-64, syndapin, PP1, and PP2A. Biochemistry. 2005;44:6938-47 pubmed
    ..For this purpose, we performed GST pull-down experiments using cytosolic fragments of NCAM as GST-fusion proteins and cytosolic- or cytoskeleton-enriched protein fractions of rat brain. ..
  30. Minturn J, Fryer H, Geschwind D, Hockfield S. TOAD-64, a gene expressed early in neuronal differentiation in the rat, is related to unc-33, a C. elegans gene involved in axon outgrowth. J Neurosci. 1995;15:6757-66 pubmed
  31. Lin Y, Hsueh Y. Neurofibromin interacts with CRMP-2 and CRMP-4 in rat brain. Biochem Biophys Res Commun. 2008;369:747-52 pubmed publisher
  32. Rahajeng J, Giridharan S, Naslavsky N, Caplan S. Collapsin response mediator protein-2 (Crmp2) regulates trafficking by linking endocytic regulatory proteins to dynein motors. J Biol Chem. 2010;285:31918-22 pubmed publisher
    ..Here we have identified the collapsin response mediator protein-2 (Crmp2) as an interaction partner of MICAL-L1 in non-neuronal cells...
  33. Sun Y, Fei T, Yang T, Zhang F, Chen Y, Li H, et al. The suppression of CRMP2 expression by bone morphogenetic protein (BMP)-SMAD gradient signaling controls multiple stages of neuronal development. J Biol Chem. 2010;285:39039-50 pubmed publisher
    ..We have found that the BMP signaling downstream transcription factor SMAD1 and CRMP2 (collapsin response mediator protein-2) are inversely and complementarily expressed in the developing neocortex...
  34. Dustrude E, Moutal A, Yang X, Wang Y, Khanna M, Khanna R. Hierarchical CRMP2 posttranslational modifications control NaV1.7 function. Proc Natl Acad Sci U S A. 2016;113:E8443-E8452 pubmed publisher
    ..by hierarchical interactions with posttranslationally modified versions of the binding partner collapsin response mediator protein 2 (CRMP2). The binding described between CRMP2 and NaV1...
  35. Morgan Fisher M, Couchman J, Yoneda A. Phosphorylation and mRNA splicing of collapsin response mediator protein-2 determine inhibition of rho-associated protein kinase (ROCK) II function in carcinoma cell migration and invasion. J Biol Chem. 2013;288:31229-40 pubmed publisher
  36. Kimura T, Watanabe H, Iwamatsu A, Kaibuchi K. Tubulin and CRMP-2 complex is transported via Kinesin-1. J Neurochem. 2005;93:1371-82 pubmed
    ..These results indicate that the CRMP-2/Kinesin-1 complex regulates soluble tubulin transport to the distal part of the growing axon. ..
  37. Wang Y, Brittain J, Jarecki B, Park K, Wilson S, Wang B, et al. In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation. J Biol Chem. 2010;285:25296-307 pubmed publisher
    ..interacting with slow inactivated sodium channels, but the observation that LCM binds to collapsin response mediator protein 2 (CRMP-2) suggests additional mechanisms of action for LCM...
  38. Fukata Y, Itoh T, Kimura T, Menager C, Nishimura T, Shiromizu T, et al. CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. Nat Cell Biol. 2002;4:583-91 pubmed
    ..Taken together, our results suggest that CRMP-2 regulates axonal growth and branching as a partner of the tubulin heterodimer, in a different fashion from traditional MAPs. ..
  39. Ju W, Li Q, Wilson S, Brittain J, Meroueh L, Khanna R. SUMOylation alters CRMP2 regulation of calcium influx in sensory neurons. Channels (Austin). 2013;7:153-9 pubmed publisher
    The axon/dendrite specification collapsin response mediator protein 2 (CRMP2) bidirectionally modulates N-type voltage-gated Ca ( 2+) channels (CaV2.2)...
  40. Marques J, Rodrigues R, Valbuena S, Rozas J, Selak S, Marin P, et al. CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation. J Neurosci. 2013;33:18298-310 pubmed publisher
    The CRMP2 and CRMP4 proteins are strongly expressed in the developing nervous system, mediating neurite outgrowth, neuronal polarity, and axon guidance...
  41. Kobeissy F, Zhang Z, Sadasivan S, Gold M, Wang K. Methods in drug abuse neuroproteomics: methamphetamine psychoproteome. Methods Mol Biol. 2009;566:217-28 pubmed publisher
    ..These methods and protocols are discussed in the paradigm of acute model of methamphetamine drug abuse and can be applied to other models of substance abuse such as to MDMA or cocaine. ..
  42. Brittain J, Pan R, You H, Brustovetsky T, Brustovetsky N, Zamponi G, et al. Disruption of NMDAR-CRMP-2 signaling protects against focal cerebral ischemic damage in the rat middle cerebral artery occlusion model. Channels (Austin). 2012;6:52-9 pubmed publisher
    b>Collapsin response mediator protein 2 (CRMP-2), traditionally viewed as an axon/dendrite specification and axonal growth protein, has emerged as nidus in regulation of both pre- and post-synaptic Ca ( 2+) channels...
  43. Sato Y, Ishida Nakajima W, Kawamura M, Miura S, Oguma R, Arai H, et al. Hypoxia-ischemia induces hypo-phosphorylation of collapsin response mediator protein 2 in a neonatal rat model of periventricular leukomalacia. Brain Res. 2011;1386:165-74 pubmed publisher
    Collapsin response mediator protein2 (CRMP2) is a brain-specific protein involved in neuronal polarity and axonal guidance, and phosphorylation of CRMP2 regulates the function and the activity...
  44. Wilson S, Xiong W, Wang Y, Ping X, Head J, Brittain J, et al. Prevention of posttraumatic axon sprouting by blocking collapsin response mediator protein 2-mediated neurite outgrowth and tubulin polymerization. Neuroscience. 2012;210:451-66 pubmed publisher
    ..R)-lacosamide [LCM]), which acts on both voltage-gated sodium channels and collapsin response mediator protein 2 (CRMP2), an axonal growth/guidance protein...
  45. Hao G, Derakhshan B, Shi L, Campagne F, Gross S. SNOSID, a proteomic method for identification of cysteine S-nitrosylation sites in complex protein mixtures. Proc Natl Acad Sci U S A. 2006;103:1012-7 pubmed
    ..SNOSID provides the first effective tool for unbiased elucidation of the SNO proteome, identifying Cys residues that undergo reversible S-nitrosylation. ..
  46. Tan M, Cha C, Ye Y, Zhang J, Li S, Wu F, et al. CRMP4 and CRMP2 Interact to Coordinate Cytoskeleton Dynamics, Regulating Growth Cone Development and Axon Elongation. Neural Plast. 2015;2015:947423 pubmed publisher
    ..In this study, we demonstrated that CRMP2 and CRMP4 interacted with tubulin and actin in vitro and colocalized with the cytoskeleton in the transition-zone ..
  47. Xiong T, Tang J, Zhao J, Chen H, Zhao F, Li J, et al. Involvement of the Akt/GSK-3?/CRMP-2 pathway in axonal injury after hypoxic-ischemic brain damage in neonatal rat. Neuroscience. 2012;216:123-32 pubmed publisher
    ..Previous studies have shown that glycogen synthase kinase-3? (GSK-3?)/collapsin response mediator protein 2 (CRMP-2) signaling pathway could be regulated by Akt for axonal-dendritic polarity...
  48. Lee C, Jaw T, Tseng H, Chen I, Liou H. Lovastatin modulates glycogen synthase kinase-3? pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus. PLoS ONE. 2012;7:e38789 pubmed publisher
  49. Dahmen N, Jungblut P, Fischer V, Schrank M, Reuss S, Rujescu D, et al. Detection of TOAD-64 in adult rat brain as revealed by two-dimensional protein gel electrophoresis followed by MALDI mass spectrometry possible modulatory effect of chronic haloperidol treatment. Prog Neuropsychopharmacol Biol Psychiatry. 2002;26:693-8 pubmed
  50. Lee S, Kim J, Lee C, Kim J, Kim Y, Heo K, et al. Collapsin response mediator protein-2 inhibits neuronal phospholipase D(2) activity by direct interaction. J Biol Chem. 2002;277:6542-9 pubmed
    ..Taken together, our results indicate that CRMP-2 may interact directly with and inhibit neuronal PLD(2), suggesting that this inhibitory mode of regulation may play a role in neuronal pathfinding during the developmental stage. ..
  51. Liu Y, Lin D, Liu C, Zhao Y, Shen Z, Zhang K, et al. Cyclin-dependent kinase 5/Collapsin response mediator protein 2 pathway may mediate sevoflurane-induced dendritic development abnormalities in rat cortical neurons. Neurosci Lett. 2017;651:21-29 pubmed publisher
    ..CDK5/CRMP2 signaling is involved in the cortical and hippocampal dendritic development...
  52. Tsim T, Wong E, Leung M, Wong C. Expression of axon guidance molecules and their related genes during development and sexual differentiation of the olfactory bulb in rats. Neuroscience. 2004;123:951-65 pubmed
  53. Yamaguchi Y, Miyagi Y, Baba H. Two-dimensional electrophoresis with cationic detergents: a powerful tool for the proteomic analysis of myelin proteins. Part 2: analytical aspects. J Neurosci Res. 2008;86:766-75 pubmed