Gene Symbol: Dppa3
Description: developmental pluripotency-associated 3
Alias: developmental pluripotency-associated protein 3
Sato M, Kimura T, Kurokawa K, Fujita Y, Abe K, Masuhara M, et al
. Identification of PGC7, a new gene expressed specifically in preimplantation embryos and germ cells. Mech Dev. 2002;113:91-4 pubmed
..Immunohistochemical analysis revealed that PGC7 was specifically expressed in early pre-implantation embryos, PGCs and oocytes. These results suggest that PGC7 might play an important role in the development of PGCs and oocytes. ..
Nakamura T, Arai Y, Umehara H, Masuhara M, Kimura T, Taniguchi H, et al
. PGC7/Stella protects against DNA demethylation in early embryogenesis. Nat Cell Biol. 2007;9:64-71 pubmed
..These results demonstrate that PGC7/Stella is indispensable for the maintenance of methylation involved in epigenetic reprogramming after fertilization. ..
Julaton V, Reijo Pera R. NANOS3 function in human germ cell development. Hum Mol Genet. 2011;20:2238-50 pubmed publisher
..Findings may contribute to our understanding of the basic biology of human germ cell development and may provide clinical insights regarding infertility. ..
Payer B, Saitou M, Barton S, Thresher R, Dixon J, Zahn D, et al
. Stella is a maternal effect gene required for normal early development in mice. Curr Biol. 2003;13:2110-7 pubmed
..These findings suggest a similar role for STELLA during early human development as in mice and a potential involvement in germ cell tumors. ..
Wossidlo M, Nakamura T, Lepikhov K, Marques C, Zakhartchenko V, Boiani M, et al
. 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. Nat Commun. 2011;2:241 pubmed publisher
..The maternal pronucleus seems to be largely protected against this mechanism by PGC7/Dppa3/Stella, as in PGC7 knockout zygotes 5mC also becomes accessible to oxidation into 5hmC...
Nakamura T, Liu Y, Nakashima H, Umehara H, Inoue K, Matoba S, et al
. PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos. Nature. 2012;486:415-9 pubmed publisher
..We have previously reported that the maternal factor PGC7 (also known as Dppa3, Stella) is required for the maintenance of DNA methylation in early embryogenesis, and protects 5mC from ..
Bortvin A, Goodheart M, Liao M, Page D. Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice. BMC Dev Biol. 2004;4:2 pubmed
..The function of Dppa3 (also known as Pgc7 or stella), a gene expressed in primordial germ cells at the time of their emergence in ..