Dpm1

Summary

Gene Symbol: Dpm1
Description: dolichyl-phosphate mannosyltransferase subunit 1, catalytic
Alias: dolichol-phosphate mannosyltransferase subunit 1, dolichol-phosphate (beta-D) mannosyltransferase 1, dolichyl-phosphate mannosyltransferase 1, dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
Species: rat
Products:     Dpm1

Top Publications

  1. Sharma C, Radhakrishnamurthy B, Berenson G. Activation of dolichol-phosphate mannosyltransferase by dibutryl cyclic AMP in rat liver. Biochem Biophys Res Commun. 1988;155:615-21 pubmed
    ..The activation of this enzyme could be through phosphorylation/dephosphorylation mechanism involving a cAMP dependent protein kinase. ..
  2. Tomita S, Inoue N, Maeda Y, Ohishi K, Takeda J, Kinoshita T. A homologue of Saccharomyces cerevisiae Dpm1p is not sufficient for synthesis of dolichol-phosphate-mannose in mammalian cells. J Biol Chem. 1998;273:9249-54 pubmed
    ..In yeasts it also donates one mannose to the O-linked oligosaccharide. The yeast DPM1 gene encodes a Dol-P-Man synthase that is a transmembrane protein expressed in the endoplasmic reticulum...
  3. Maeda Y, Tomita S, Watanabe R, Ohishi K, Kinoshita T. DPM2 regulates biosynthesis of dolichol phosphate-mannose in mammalian cells: correct subcellular localization and stabilization of DPM1, and binding of dolichol phosphate. EMBO J. 1998;17:4920-9 pubmed
    ..The class E mutant is defective in the DPM1 gene which encodes a mammalian homologue of Saccharomyces cerevisiae Dpm1p that is a DPM synthase, whereas Lec15 is ..
  4. Maeda Y, Tanaka S, Hino J, Kangawa K, Kinoshita T. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. EMBO J. 2000;19:2475-82 pubmed
    ..In Saccharomyces cerevisiae, this enzyme is encoded by DPM1. We reported previously that mammalian DPM synthase contains catalytic DPM1 and regulatory DPM2 subunits, and that ..