Gene Symbol: Dnmt3l
Description: DNA methyltransferase 3 like
Alias: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5-)-methyltransferase 3-like
Species: rat
Products:     Dnmt3l

Top Publications

  1. Bourc his D, Bestor T. Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L. Nature. 2004;431:96-9 pubmed
    ..Here we show that DNA methyltransferase 3-like (Dnmt3L (ref...
  2. Lees Murdock D, McLoughlin G, McDaid J, Quinn L, O Doherty A, Hiripi L, et al. Identification of 11 pseudogenes in the DNA methyltransferase gene family in rodents and humans and implications for the functional loci. Genomics. 2004;84:193-204 pubmed
    ..These results clarify the structure of a number of loci in the three species examined and provide some useful insights into the structure and evolution of this gene family. ..
  3. Xie Z, Huang Y, Chen Z, Riggs A, Ding J, Gowher H, et al. Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. Hum Mol Genet. 2006;15:1375-85 pubmed
    ..novo methylation activity of the two related methyltransferases DNMT3A and DNMT3B by regulatory factors including DNMT3L which has a stimulatory effect...
  4. Arima T, Hata K, Tanaka S, Kusumi M, Li E, Kato K, et al. Loss of the maternal imprint in Dnmt3Lmat-/- mice leads to a differentiation defect in the extraembryonic tissue. Dev Biol. 2006;297:361-73 pubmed
    ..Although the DNA methyltransferase 3-like (Dnmt3L) protein lacks DNA methylase activity, it is thought to establish the maternal imprint in combination with the ..
  5. Kim K, Ryu H, Oh S, Oh E, Ahn J, Lee J, et al. Effect of DNA demethylation in experimental encapsulating peritoneal sclerosis. Ther Apher Dial. 2014;18:628-36 pubmed publisher
    ..DNA demethylation by 5'-azacytidine treatment improved pathologic changes of the peritoneum in experimental EPS, and was associated with reversal of increased DNMT1 expression and RASAL1 hypermethylation. ..
  6. Hata K, Okano M, Lei H, Li E. Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development. 2002;129:1983-93 pubmed
    ..In this study, we demonstrate that Dnmt3L, a protein sharing homology with DNA methyltransferases, Dnmt3a and Dnmt3b, but lacking enzymatic activity, is ..
  7. Deplus R, Brenner C, Burgers W, Putmans P, Kouzarides T, De Launoit Y, et al. Dnmt3L is a transcriptional repressor that recruits histone deacetylase. Nucleic Acids Res. 2002;30:3831-8 pubmed
    The Dnmt3L protein belongs to the Dnmt3 family of DNA methyltransferases by virtue of its sequence homology in the plant homeodomain (PHD)-like motif...
  8. Anway M, Rekow S, Skinner M. Transgenerational epigenetic programming of the embryonic testis transcriptome. Genomics. 2008;91:30-40 pubmed
    ..The most dramatic effects were on the germ-line-associated Dnmt3A and Dnmt3L isoforms...
  9. Sakharkar A, Tang L, Zhang H, Chen Y, Grayson D, Pandey S. Effects of acute ethanol exposure on anxiety measures and epigenetic modifiers in the extended amygdala of adolescent rats. Int J Neuropsychopharmacol. 2014;17:2057-67 pubmed publisher
    ..However, DNMT1 and DNMT3a expression in the BNST was increased, whereas DNMT3l mRNA was decreased in the amygdala, after 2 doses of 2 g/kg ethanol...

More Information


  1. Pastor W, Stroud H, Nee K, Liu W, Pezic D, Manakov S, et al. MORC1 represses transposable elements in the mouse male germline. Nat Commun. 2014;5:5795 pubmed publisher
    ..in a pattern that is similar to that observed for germ cells deficient for the DNA methyltransferase homologue DNMT3L. Morc1 mutants show highly localized defects in the establishment of DNA methylation at specific classes of ..
  2. Kovacheva V, Mellott T, Davison J, Wagner N, Lopez Coviella I, Schnitzler A, et al. Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. J Biol Chem. 2007;282:31777-88 pubmed
    ..mRNA expression of brain and liver Dnmt3a and methyl CpG-binding domain 2 (Mbd2) protein as well as cerebral Dnmt3l was inversely correlated to the intake of choline...
  3. Neri F, Krepelova A, Incarnato D, Maldotti M, Parlato C, Galvagni F, et al. Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs. Cell. 2013;155:121-34 pubmed publisher
    The de novo DNA methyltransferase 3-like (Dnmt3L) is a catalytically inactive DNA methyltransferase that cooperates with Dnmt3a and Dnmt3b to methylate DNA...
  4. Barau J, Teissandier A, Zamudio N, Roy S, Nalesso V, Herault Y, et al. The DNA methyltransferase DNMT3C protects male germ cells from transposon activity. Science. 2016;354:909-912 pubmed
    ..is thought to be composed of three DNA methyltransferase enzymes (DNMT1, DNMT3A, and DNMT3B) and one cofactor (DNMT3L)...