Genomes and Genes
Gene Symbol: Dnmt3l
Description: DNA methyltransferase 3 like
Alias: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5-)-methyltransferase 3-like
- Pastor W, Stroud H, Nee K, Liu W, Pezic D, Manakov S, et al. MORC1 represses transposable elements in the mouse male germline. Nat Commun. 2014;5:5795 pubmed publisher..in a pattern that is similar to that observed for germ cells deficient for the DNA methyltransferase homologue DNMT3L. Morc1 mutants show highly localized defects in the establishment of DNA methylation at specific classes of ..
- Kovacheva V, Mellott T, Davison J, Wagner N, Lopez Coviella I, Schnitzler A, et al. Gestational choline deficiency causes global and Igf2 gene DNA hypermethylation by up-regulation of Dnmt1 expression. J Biol Chem. 2007;282:31777-88 pubmed..mRNA expression of brain and liver Dnmt3a and methyl CpG-binding domain 2 (Mbd2) protein as well as cerebral Dnmt3l was inversely correlated to the intake of choline...
- Neri F, Krepelova A, Incarnato D, Maldotti M, Parlato C, Galvagni F, et al. Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs. Cell. 2013;155:121-34 pubmed publisherThe de novo DNA methyltransferase 3-like (Dnmt3L) is a catalytically inactive DNA methyltransferase that cooperates with Dnmt3a and Dnmt3b to methylate DNA...
- Barau J, Teissandier A, Zamudio N, Roy S, Nalesso V, Herault Y, et al. The DNA methyltransferase DNMT3C protects male germ cells from transposon activity. Science. 2016;354:909-912 pubmed..is thought to be composed of three DNA methyltransferase enzymes (DNMT1, DNMT3A, and DNMT3B) and one cofactor (DNMT3L)...