Dnmt3b

Summary

Gene Symbol: Dnmt3b
Description: DNA methyltransferase 3 beta
Alias: DNA (cytosine-5)-methyltransferase 3B, DNA (cytosine-5-)-methyltransferase 3 beta, DNA methyltransferase 3B
Species: rat
Products:     Dnmt3b

Top Publications

  1. Chen M, Lu M, Lin P, Chen P, Chen W, Lee K. The role of DNA methyltransferase 3b in esophageal squamous cell carcinoma. Cancer. 2012;118:4074-89 pubmed publisher
    ..The objective of this study was to highlight the role of DNA methyltransferase 3b (DNMT3b) in esophageal squamous cell carcinoma (SCC)...
  2. Linhart H, Lin H, Yamada Y, Moran E, Steine E, Gokhale S, et al. Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev. 2007;21:3110-22 pubmed
  3. Lee S, Jeon H, Jang J, Park S, Lee G, Lee B, et al. DNMT3B polymorphisms and risk of primary lung cancer. Carcinogenesis. 2005;26:403-9 pubmed
    DNA-methyltransferase-3B (DNMT3B) plays an important role in the generation of aberrant methylation in carcinogenesis...
  4. Li J, Pu M, Hirasawa R, Li B, Huang Y, Zeng R, et al. Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol Cell Biol. 2007;27:8748-59 pubmed
    DNA methylation plays an important role in gene silencing in mammals. Two de novo methyltransferases, Dnmt3a and Dnmt3b, are required for the establishment of genomic methylation patterns in development...
  5. Okano M, Bell D, Haber D, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999;99:247-57 pubmed
    ..Here we demonstrate that two recently identified DNA methyltransferases, Dnmt3a and Dnmt3b, are essential for de novo methylation and for mouse development...
  6. Fonseca Silva T, Oliveira M, Fraga C, Farias L, Gomes E, Barros L, et al. DNMT3B (C46359T) polymorphisms and immunoexpression of DNMT3b and DNMT1 proteins in oral lichen planus. Pathobiology. 2012;79:18-23 pubmed publisher
    To investigate the DNMT3B (C46359T) polymorphism and immunoexpression of DNMT3b and DNMT1 in oral lichen planus (OLP) compared to a control group...
  7. Gowher H, Jeltsch A. Molecular enzymology of the catalytic domains of the Dnmt3a and Dnmt3b DNA methyltransferases. J Biol Chem. 2002;277:20409-14 pubmed
    The C-terminal domains of the mammalian DNA methyltransferases Dnmt1, Dnmt3a, and Dnmt3b harbor all the conserved motifs characteristic for cytosine-C5 methyltransferases...
  8. Guo X, Zhang L, Wu M, Wang N, Liu Y, Er L, et al. Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma. Mol Biol Rep. 2010;37:219-25 pubmed publisher
    b>DNMT3B is an important enzyme to modulate the methylation status in mammalian cells...
  9. Chen T, Tsujimoto N, Li E. The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin. Mol Cell Biol. 2004;24:9048-58 pubmed
    Dnmt3a and Dnmt3b are responsible for the establishment of DNA methylation patterns during development...

More Information

Publications67

  1. Su X, Lv C, Qiao F, Qiu X, Huang W, Wu Q, et al. Expression pattern and clinical significance of DNA methyltransferase 3B variants in gastric carcinoma. Oncol Rep. 2010;23:819-26 pubmed
    The aim of this study was to detect the expression pattern of DNA methyltransferase 3B (DNMT3B) variants in primary gastric cancer (GC) and to explore the clinical significance of DNMT3B variants in gastric carcinogenesis...
  2. Van Emburgh B, Robertson K. Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants. Nucleic Acids Res. 2011;39:4984-5002 pubmed publisher
    ..is established and maintained by the coordinated action of three DNA methyltransferases: DNMT1, DNMT3A and DNMT3B, and the inactive accessory factor DNMT3L...
  3. Xie Z, Huang Y, Chen Z, Riggs A, Ding J, Gowher H, et al. Mutations in DNA methyltransferase DNMT3B in ICF syndrome affect its regulation by DNMT3L. Hum Mol Genet. 2006;15:1375-85 pubmed
    Deficiency in DNA methyltransferase DNMT3B causes a recessive human disorder characterized by immunodeficiency, centromeric instability and facial anomalies (ICF) in association with defects in genomic methylation...
  4. Khorshied M, El Ghamrawy M. DNA methyltransferase 3B (DNMT3B -579G>T) promotor polymorphism and the susceptibility to pediatric immune thrombocytopenic purpura in Egypt. Gene. 2012;511:34-7 pubmed publisher
    ..To achieve our aim, genotyping of DNMT3B -579G>T promotor polymorphism by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) ..
  5. Kim S, Park J, Choi M, Kim H, Park J, Jung Y, et al. Zinc-fingers and homeoboxes 1 (ZHX1) binds DNA methyltransferase (DNMT) 3B to enhance DNMT3B-mediated transcriptional repression. Biochem Biophys Res Commun. 2007;355:318-23 pubmed
    ..In order to gain a better insight into DNMT3B-mediated transcriptional repression, we performed a yeast two-hybrid analysis using DNMT3B as a bait...
  6. Hlady R, Nováková S, Opavska J, Klinkebiel D, Peters S, Bies J, et al. Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. J Clin Invest. 2012;122:163-77 pubmed publisher
    b>DNA methyltransferase 3B (Dnmt3b) belongs to a family of enzymes responsible for methylation of cytosine residues in mammals...
  7. Zhang C, Fang Y, Xie B, Du Y, Cheng W, Wang D, et al. [Association of DNA methyltransferase 3B gene polymorphism with early-onset schizophrenia]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010;27:697-9 pubmed publisher
    To investigate the association of DNA methyltransferase 3B (DNMT3B) gene polymorphism with the development of early-onset schizophrenia...
  8. Nam E, Kim K, Han S, Cho C, Lee J, Park J, et al. The -283C/T polymorphism of the DNMT3B gene influences the progression of joint destruction in rheumatoid arthritis. Rheumatol Int. 2010;30:1299-303 pubmed publisher
    The objective of this study is to investigate the association between the -283C/T polymorphism at the promotor of DNMT3B gene and susceptibility to rheumatoid arthritis (RA) and to evaluate the effect of the polymorphism on clinical ..
  9. Liu Z, Wang L, Wang L, Sturgis E, Wei Q. Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: a case-control study. Cancer Lett. 2008;268:158-65 pubmed publisher
    DNA-methyltransferase-3B (DNMT3B) may play an oncogenic role during tumorigenesis, and its genetic variants have been reportedly to be associated with risk of several cancers, but few studies have investigated their roles in squamous cell ..
  10. Sharma D, Bhave S, Gregg E, UHT R. Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter. Mol Endocrinol. 2013;27:1142-52 pubmed publisher
    ..Indeed, the GR interacted with DnMT3b, but not DnMT3a...
  11. Kn H, Bassal S, Tikellis C, El Osta A. Expression analysis of the epigenetic methyltransferases and methyl-CpG binding protein families in the normal B-cell and B-cell chronic lymphocytic leukemia (CLL). Cancer Biol Ther. 2004;3:989-94 pubmed
    ..Of particular note was the significant down regulation of DNMT3b. Furthermore, we observed a positive correlation between HMTaseI expression levels and stage of leukemia ..
  12. Ping J, Wang J, Liu L, Yan Y, Liu F, Lei Y, et al. Prenatal caffeine ingestion induces aberrant DNA methylation and histone acetylation of steroidogenic factor 1 and inhibits fetal adrenal steroidogenesis. Toxicology. 2014;321:53-61 pubmed publisher
    ..These effects may contribute to the inhibition of the expression of SF-1 and its associated steroidogenic enzymes and the production of corticosterone during fetal development. ..
  13. Okano M, Xie S, Li E. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet. 1998;19:219-20 pubmed
  14. Li Y, Dai Y, Wu S, Pei P, Cao X, Pu D. [The C46359T polymorphism of DNMT3B promoter gene and pathogenesis of acute leukemia]. Zhonghua Nei Ke Za Zhi. 2005;44:588-91 pubmed
    To explore the relationship between the polymorphism of C46359T in DNMT3B promoter and the pathogenesis of acute leukemia (AL)...
  15. Abzianidze E, Kvaratskhelia E, Tkemaladze T, Kankava K, Gurtskaia G, Tsagareli M. Epigenetic regulation of acute inflammatory pain. Georgian Med News. 2014;:78-81 pubmed
  16. Loree J, Koturbash I, Kutanzi K, Baker M, Pogribny I, Kovalchuk O. Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis. Int J Radiat Biol. 2006;82:805-15 pubmed
    ..The possible cellular repercussions of the observed changes in relationship to breast carcinogenesis are discussed. ..
  17. Xiong Y, Dowdy S, Xue A, Shujuan J, Eberhardt N, Podratz K, et al. Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers. Gynecol Oncol. 2005;96:601-9 pubmed
    ..were employed to measure the mRNA and protein levels of the four DNA methyltransferases, DNMT1, DNMT2, DNMT3A, and DNMT3B. Immunohistochemistry was performed to detect alterations in DNMT nuclear localization and spatial organization ..
  18. Elsner V, Lovatel G, Moysés F, Bertoldi K, Spindler C, Cechinel L, et al. Exercise induces age-dependent changes on epigenetic parameters in rat hippocampus: a preliminary study. Exp Gerontol. 2013;48:136-9 pubmed publisher
    ..In this preliminary study we investigated the effect of aging and exercise on DNA methyltransferases (DNMT1 and DNMT3b) and H3-K9 methylation levels in hippocampus from 3 and 20-months aged Wistar rats...
  19. Feng Y, Tian R, You A, Wang J, Wu Y, Wang W, et al. [Expression and significance of DNA methyltransferase in sera of patients with lung cancer]. Zhonghua Yi Xue Za Zhi. 2013;93:3822-5 pubmed
    To explore the protein expressions of DNMT1, DNMT3a and DNMT3b in sera of lung cancer patients...
  20. Qin W, Zhang K, Clarke K, Weiland T, Sauter E. Methylation and miRNA effects of resveratrol on mammary tumors vs. normal tissue. Nutr Cancer. 2014;66:270-7 pubmed publisher
    ..normal tissue after lo (P = .04) and hi (P = .007) resveratrol and Aza treatment. With hi resveratrol, DNMT3b decreased in tumor but increased normal tissue...
  21. de Vogel S, Wouters K, Gottschalk R, Van Schooten F, de Goeij A, De Bruine A, et al. Genetic variants of methyl metabolizing enzymes and epigenetic regulators: associations with promoter CpG island hypermethylation in colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2009;18:3086-96 pubmed publisher
    ..associations of genetic variants of folate metabolizing enzymes (MTHFR, MTR, and MTRR), DNA methyltransferase DNMT3b, and histone methyltransferases (EHMT1, EHMT2, and PRDM2), with colorectal cancers, with or without the CpG island ..
  22. Coppede F, Ricciardi R, Denaro M, De Rosa A, Provenzano C, Bartoccioni E, et al. Association of the DNMT3B -579G>T polymorphism with risk of thymomas in patients with myasthenia gravis. PLoS ONE. 2013;8:e80846 pubmed publisher
    ..if a common polymorphism (-579G>T: rs1569686) in the promoter of the DNMT3B gene coding for the DNA methyltransferase 3B, an enzyme that mediates DNA methylation, increases the risk to develop MG or MG-associated thymomas...
  23. Tryndyak V, Muskhelishvili L, Kovalchuk O, Rodriguez Juarez R, Montgomery B, Churchwell M, et al. Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis. Carcinogenesis. 2006;27:1713-20 pubmed
    ..Protein expressions of maintenance (DNMT1) DNA methyltransferase and de novo DNA methyltransferases DNMT3a and DNMT3b were decreased at all time points...
  24. Hirasawa R, Sasaki H. Dynamic transition of Dnmt3b expression in mouse pre- and early post-implantation embryos. Gene Expr Patterns. 2009;9:27-30 pubmed publisher
    The de novo DNA methyltransferases, Dnmt3a and Dnmt3b, are responsible for the creation of DNA methylation patterns in mouse development...
  25. Mizuno S, Chijiwa T, Okamura T, Akashi K, Fukumaki Y, Niho Y, et al. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood. 2001;97:1172-9 pubmed
    ..Recently identified new DNA methyltransferase (DNMT) genes, DNMT3A and DNMT3B, code for de novo methyltransferases...
  26. Meunier L, Siddeek B, Vega A, Lakhdari N, Inoubli L, Bellon R, et al. Perinatal programming of adult rat germ cell death after exposure to xenoestrogens: role of microRNA miR-29 family in the down-regulation of DNA methyltransferases and Mcl-1. Endocrinology. 2012;153:1936-47 pubmed publisher
    ..Increased miR-29 expression resulted in a decrease in DNMT1, DNMT3a, and DNMT3b and antiapoptotic myeloid cell leukemia sequence 1 (Mcl-1) protein levels as shown in 1) germ cells of adult rats ..
  27. Lees Murdock D, McLoughlin G, McDaid J, Quinn L, O Doherty A, Hiripi L, et al. Identification of 11 pseudogenes in the DNA methyltransferase gene family in rodents and humans and implications for the functional loci. Genomics. 2004;84:193-204 pubmed
    ..All except 1 rat Dnmt3b pseudogene appear to be transcriptionally silent...
  28. Kim S, Park J, Choi M, Park J, Kim H, Lee J, et al. DNA methyltransferase 3B acts as a co-repressor of the human polycomb protein hPc2 to repress fibroblast growth factor receptor 3 transcription. Int J Biochem Cell Biol. 2008;40:2462-71 pubmed publisher
    b>DNA methyltransferase 3B has been demonstrated to mediate gene silencing. The mechanisms how DNA methyltransferase 3B is targeted to specific regions and represses gene transcription, however, are not well understood...
  29. Chen W, Chen M, Lin P. Significance of DNMT3b in oral cancer. PLoS ONE. 2014;9:e89956 pubmed publisher
    ..The role of DNMT3b and its predictive power in the prognosis of oral cancer were identified...
  30. Dawson M, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell. 2012;150:12-27 pubmed publisher
    ..This information, along with the promising clinical and preclinical results seen with epigenetic drugs against chromatin regulators, signifies that it is time to embrace the central role of epigenetics in cancer. ..
  31. Liu X, Guo S. Aberrant immunoreactivity of deoxyribonucleic acid methyltransferases in adenomyosis. Gynecol Obstet Invest. 2012;74:100-8 pubmed
    ..Tissue sections were immunostained with DNMT1, DNMT3A, and DNMT3B. Microscopic evaluation to assess the presence and localization of DNMT1, DNMT3A, and DNMT3B throughout the ..
  32. Valencia Antúnez C, Taja Chayeb L, Rodríguez Segura M, López Álvarez G, García Cuéllar C, Villa Treviño S. DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model. Oncol Rep. 2014;32:2093-103 pubmed publisher
    ..genomic DNA methylation patterns are established by the DNA methyltransferases (DNMTs) family: DNMT1, DNMT3a and DNMT3b. The DNMTs are known to be overexpressed in tumors...
  33. Zheng Q, Zeng T, Chen J, Liu H, Zhang H, Su J. Association between DNA methyltransferases 3B gene polymorphisms and the susceptibility to acute myeloid leukemia in Chinese Han population. PLoS ONE. 2013;8:e74626 pubmed publisher
    b>DNMT3B plays a crucial role in the generation of aberrant methylation during carcinogenesis. Polymorphisms in the DNMT3B gene may influence the DNA methylation enzymatic activity of DNMT3B, thereby modulating the susceptibility to AML...
  34. Azad A, Bairati I, Samson E, Cheng D, Cheng L, Mirshams M, et al. Genetic sequence variants and the development of secondary primary cancers in patients with head and neck cancers. Cancer. 2012;118:1554-65 pubmed publisher
    ..There was a strong association of the DNA (cytosine-5-)-methyltransferase 3 beta (DNMT3B) sequence variant, DNMT3B:C149T (rs2424913) with SPC: the adjusted hazard ratio (aHR) for TT versus CC was 2.23 (1...
  35. Delatte B, Deplus R, Fuks F. Playing TETris with DNA modifications. EMBO J. 2014;33:1198-211 pubmed publisher
  36. Su P, Lin Y, Huang R, Liao Y, Lee H, Wang H, et al. Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer. Oncogene. 2013;32:15-26 pubmed publisher
    ..Here, we report evidence of the overexpression of DNA methyltransferases 3B (DNMT3B) in invasive cervical cancer and of the inhibition of metastasis by DNMT3B interference...
  37. Cavuoto P, Fenech M. A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cancer Treat Rev. 2012;38:726-36 pubmed publisher
    ..The application of nutritional methionine restriction and methioninase in combination with chemotherapeutic regimens is the current focus of clinical studies. ..
  38. Tao J, Yang M, Chen Z, Huang Y, Zhao Q, Xu J, et al. Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura. J Clin Immunol. 2008;28:432-9 pubmed publisher
    ..DNMT1, DNMT3A, and DNMT3B mRNA expression in peripheral blood mononuclear cells (PBMCs) of adult ITP patients were analyzed by real-time ..
  39. Zhang C, Fang Y, Xie B, Cheng W, Du Y, Wang D, et al. DNA methyltransferase 3B gene increases risk of early onset schizophrenia. Neurosci Lett. 2009;462:308-11 pubmed publisher
    ..b>DNA methyltransferase 3B (DNMT3B) is the key methyltransferase in DNA methylation regulations...
  40. Xu G, Bestor T, Bourc his D, Hsieh C, Tommerup N, Bugge M, et al. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature. 1999;402:187-91 pubmed
    ..Here we show that five unrelated ICF patients have mutations in both alleles of the gene that encodes DNA methyltransferase 3B (refs 5, 6)...
  41. Fan H, Zhang F, Hu J, Liu D, Zhao Z. Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study. J Exp Clin Cancer Res. 2008;27:24 pubmed publisher
    DNA-methyltransferase-3B (DNMT3B), which plays a role in DNA methylation, is usually aberrant expression involved in carcinogenesis...
  42. Li Y, Zhao M, Hou C, Liang G, Yang L, Tan Y, et al. Abnormal DNA methylation in CD4+ T cells from people with latent autoimmune diabetes in adults. Diabetes Res Clin Pract. 2011;94:242-8 pubmed publisher
    ..Genomic DNA methylation in CD4(+) T cells from LADA patients was significantly increased compared to controls. DNMT3b mRNA levels were higher in CD4(+) T cells from LADA patients than in controls...
  43. Park H, Yu E, Shim Y. DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma. Cancer Lett. 2006;233:271-8 pubmed
    ..Expression of DNMT1, DNMT3a and DNMT3b mRNA was detected in 33.3, 59.3, and 55.6% of HCCs and 40.7, 22...
  44. Wu Y, Strawn E, Basir Z, Halverson G, Guo S. Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis. Fertil Steril. 2007;87:24-32 pubmed
    ..The aim of this study was to determine gene expression levels of DNMT1, DNMT3A, and DNMT3B, the three genes coding for DNA methyltransferases that are responsible for methylation...
  45. Wang X, Meng F, Liu Z, Fan J, Hao K, Chen X, et al. Gestational hypoxia induces sex-differential methylation of Crhr1 linked to anxiety-like behavior. Mol Neurobiol. 2013;48:544-55 pubmed publisher
    ..Crhr1 DNA demethylation is more crucial in CpG island 1 than island 2 for activation of CRHR1 mRNA. DNMT3b is required for the Crhr1 DNA methylation than DNMT1 and DNMT3a in increased CRHR1 mRNA...
  46. Pol Bodetto S, Carouge D, Fonteneau M, Dietrich J, Zwiller J, Anglard P. Cocaine represses protein phosphatase-1C? through DNA methylation and Methyl-CpG Binding Protein-2 recruitment in adult rat brain. Neuropharmacology. 2013;73:31-40 pubmed publisher
    ..Our data demonstrate that PP1C? is a direct MeCP2-target gene in vivo. They suggest that its repression may participate to behavioral adaptations triggered by the drug. ..
  47. Morey S, Smiraglia D, James S, Yu J, Moser M, Foster B, et al. DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. Cancer Res. 2006;66:11659-67 pubmed
    ..primary and metastatic TRAMP tumors display increased cytosine DNA methyltransferase (Dnmt) activity, Dnmt1 and Dnmt3b protein expression, and Dnmt1, Dnmt3a, and Dnmt3b mRNA expression...
  48. Bai S, Ghoshal K, Datta J, Majumder S, Yoon S, Jacob S. DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2. Mol Cell Biol. 2005;25:751-66 pubmed
    ..The mRNA and protein levels of de novo methyltransferase Dnmt3b increased, whereas those of Dnmt3a and Dnmt1 decreased, during NGF-induced neurite outgrowth...
  49. Nguyen T, Kuo C, Nicholl M, Sim M, Turner R, Morton D, et al. Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma. Epigenetics. 2011;6:388-94 pubmed
    ..melanoma progression, whereas microRNA-29(miR-29) has been found to downregulate DNA methyltransferases DNMT3A and DNMT3B which were shown as essential to the methylation of TRGs...
  50. Xiong L, Wang F, Huang X, Liu Z, Zhao T, Wu L, et al. DNA demethylation regulates the expression of miR-210 in neural progenitor cells subjected to hypoxia. FEBS J. 2012;279:4318-26 pubmed publisher
    ..Specifically, the expression of DNMT3b decreased significantly after exposure to 0.3% O(2) ...
  51. Zhang Q, Zheng R, Zhang Z, Yang L, Wang H, Ning H, et al. [Effects of bromopropane exposure on expression of DNA methyltransferases and level of histone acetylation in testis of male rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2013;31:92-5 pubmed
    ..The sperm count and morphology in the epididymis were evaluated. The mRNA expression of DNMT1, DNMT3a, and DNMT3b and activities of HAT and HDAC in the testis were measured by quantitative real-time PCR and ELISA...
  52. Cowin P, Gold E, Aleksova J, O Bryan M, Foster P, Scott H, et al. Vinclozolin exposure in utero induces postpubertal prostatitis and reduces sperm production via a reversible hormone-regulated mechanism. Endocrinology. 2010;151:783-92 pubmed publisher
    ..These data demonstrate in utero Vinclozolin-induced male reproductive tract abnormalities are AR mediated and reversible and involve a mechanism independent of Dnmt expression. ..
  53. Hayette S, Thomas X, Jallades L, Chabane K, Charlot C, Tigaud I, et al. High DNA methyltransferase DNMT3B levels: a poor prognostic marker in acute myeloid leukemia. PLoS ONE. 2012;7:e51527 pubmed publisher
    ..The overexpression of DNMT3B/3B(NC) is (i) significantly correlated with a shorter overall survival, and (ii) inversely significantly ..
  54. Sun L, Huang L, Nguyen P, Bisht K, Bar Sela G, Ho A, et al. DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation. Cancer Res. 2008;68:2726-35 pubmed publisher
    ..These genes were used because their expression was decreased in DNMT1(-/-), DNMT3B(-/-), and double knockout cells and increased in DNMT1-overexpressing and DNMT3B-overexpressing cells...
  55. Hernández Sotelo D, García Aguilar R, Castro Coronel Y, Magaña J, Leyva Vázquez M, Alarcón Romero L, et al. The 46359CT polymorphism of DNMT3B is associated with the risk of cervical cancer. Mol Biol Rep. 2013;40:4275-80 pubmed publisher
    Abnormal methylation is related to cancer development. Since DNMT3B is an enzyme that modulates genomic methylation, we hypothesized that genetic variants of the promoter DNMT3B may be associated with an increased risk of developing ..
  56. Hata K, Okano M, Lei H, Li E. Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development. 2002;129:1983-93 pubmed
    ..In this study, we demonstrate that Dnmt3L, a protein sharing homology with DNA methyltransferases, Dnmt3a and Dnmt3b, but lacking enzymatic activity, is essential for the establishment of maternal methylation imprints and ..
  57. Pazienza V, Tavano F, Benegiamo G, Vinciguerra M, Burbaci F, Copetti M, et al. Correlations among PPAR?, DNMT1, and DNMT3B Expression Levels and Pancreatic Cancer. PPAR Res. 2012;2012:461784 pubmed publisher
    ..In this study we aimed to evaluate the expression of PPAR?, DNMT1, and DNMT3B and their correlation with clinical-pathological features in patients with pancreatic cancer (PC), and to define ..
  58. Barau J, Teissandier A, Zamudio N, Roy S, Nalesso V, Herault Y, et al. The DNA methyltransferase DNMT3C protects male germ cells from transposon activity. Science. 2016;354:909-912 pubmed
    ..DNA methylation machinery is thought to be composed of three DNA methyltransferase enzymes (DNMT1, DNMT3A, and DNMT3B) and one cofactor (DNMT3L)...