Dnmt3a

Summary

Gene Symbol: Dnmt3a
Description: DNA methyltransferase 3 alpha
Alias: DNA (cytosine-5)-methyltransferase 3A, DNA (cytosine-5-)-methyltransferase 3 alpha, DNA methyltransferase 3A
Species: rat
Products:     Dnmt3a

Top Publications

  1. Walter M, Ding L, Shen D, Shao J, Grillot M, McLellan M, et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia. 2011;25:1153-8 pubmed publisher
    ..Methylation of CpG dinucleotides is mediated by DNA methyltransferases, including DNMT1, DNMT3A and DNMT3B...
  2. Lees Murdock D, Shovlin T, Gardiner T, De Felici M, Walsh C. DNA methyltransferase expression in the mouse germ line during periods of de novo methylation. Dev Dyn. 2005;232:992-1002 pubmed
    ..Use of an alternative promoter at the Dnmt3a locus produces the shorter Dnmt3a2 transcript in the germ line and postimplantation embryo only, whereas ..
  3. Hata K, Okano M, Lei H, Li E. Dnmt3L cooperates with the Dnmt3 family of de novo DNA methyltransferases to establish maternal imprints in mice. Development. 2002;129:1983-93 pubmed
    ..In this study, we demonstrate that Dnmt3L, a protein sharing homology with DNA methyltransferases, Dnmt3a and Dnmt3b, but lacking enzymatic activity, is essential for the establishment of maternal methylation imprints ..
  4. Chen T, Ueda Y, Xie S, Li E. A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. J Biol Chem. 2002;277:38746-54 pubmed
    ..However, only one form of Dnmt3a has been identified to date...
  5. Okano M, Bell D, Haber D, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999;99:247-57 pubmed
    ..Here we demonstrate that two recently identified DNA methyltransferases, Dnmt3a and Dnmt3b, are essential for de novo methylation and for mouse development...
  6. Mizuno S, Chijiwa T, Okamura T, Akashi K, Fukumaki Y, Niho Y, et al. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood. 2001;97:1172-9 pubmed
    ..Recently identified new DNA methyltransferase (DNMT) genes, DNMT3A and DNMT3B, code for de novo methyltransferases...
  7. Okano M, Xie S, Li E. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet. 1998;19:219-20 pubmed
  8. Kaneda M, Okano M, Hata K, Sado T, Tsujimoto N, Li E, et al. Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting. Nature. 2004;429:900-3 pubmed
    ..de novo DNA methyltransferases of the Dnmt3 family are implicated in maternal imprinting, the lethality of Dnmt3a and Dnmt3b knockout mice has precluded further studies...
  9. Å talekar M, Yin X, Rebolj K, Darovic S, Troakes C, Mayr M, et al. Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport. Neuroscience. 2015;293:157-70 pubmed publisher
    ..We show that Ran-binding protein 1 (RanBP1), DNA methyltransferase 3 alpha (Dnmt3a) and chromogranin B (CgB) are downregulated upon TDP-43 knockdown...

More Information

Publications70

  1. Fan H, Liu D, Qiu X, Qiao F, Wu Q, Su X, et al. A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma. BMC Med. 2010;8:12 pubmed publisher
    ..The aim of this study was to investigate the role of a DNMT3A promoter genetic variant on its transcriptional activity and to evaluate the association between DNMT3A gene ..
  2. Wu X, Sun J, Li L. Chronic cerebrovascular hypoperfusion affects global DNA methylation and histone acetylation in rat brain. Neurosci Bull. 2013;29:685-92 pubmed publisher
    ..01) compared with the sham group at 90 days after 2-VO surgery. DNMT3a expression was down-regulated to 75...
  3. Liu W, Cui Z, Ao L, Zhou Z, Zhou Y, Yuan X, et al. Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a. Toxicol Appl Pharmacol. 2011;251:70-8 pubmed publisher
    ..DNMT1 and DNMT3a protein expression increased progressively during the stages of lung carcinogenesis, whereas DNMT3b overexpression ..
  4. Blaze J, Roth T. Exposure to caregiver maltreatment alters expression levels of epigenetic regulators in the medial prefrontal cortex. Int J Dev Neurosci. 2013;31:804-10 pubmed publisher
    ..likewise affects expression levels of several genes important in regulating DNA methylation patterns (Dnmt1, Dnmt3a, MeCP2, Gadd45b, and Hdac1)...
  5. Farinelli P, Perera A, Arango Gonzalez B, Trifunovic D, Wagner M, Carell T, et al. DNA methylation and differential gene regulation in photoreceptor cell death. Cell Death Dis. 2014;5:e1558 pubmed publisher
    ..chromatin structure during retinal degeneration that coincided with an increased expression of the DNMT isozyme DNMT3a. To identify disease-specific differentially methylated DNA regions (DMRs) on a genomic level, we ..
  6. Pol Bodetto S, Carouge D, Fonteneau M, Dietrich J, Zwiller J, Anglard P. Cocaine represses protein phosphatase-1C? through DNA methylation and Methyl-CpG Binding Protein-2 recruitment in adult rat brain. Neuropharmacology. 2013;73:31-40 pubmed publisher
    ..Our data demonstrate that PP1C? is a direct MeCP2-target gene in vivo. They suggest that its repression may participate to behavioral adaptations triggered by the drug. ..
  7. Zimmermann N, Zschocke J, Perisic T, Yu S, Holsboer F, Rein T. Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels. Biochem J. 2012;448:93-102 pubmed publisher
    ..In conclusion, the present study presents a model where distinct ADs affect DNMT1 activity via G9a with important repercussions for possible novel treatment regimes. ..
  8. Tao H, Yang J, Chen Z, Xu S, Zhou X, Zhan H, et al. DNMT3A silencing RASSF1A promotes cardiac fibrosis through upregulation of ERK1/2. Toxicology. 2014;323:42-50 pubmed publisher
    ..Moreover, DNA methylation plays a central role in the maintenance of cardiac fibrosis. DNA methyltransferases 3A (DNMT3A) is a critical participant in the epigenetic silencing of regulatory genes...
  9. Zhang X, Kusumo H, Sakharkar A, Pandey S, Guizzetti M. Regulation of DNA methylation by ethanol induces tissue plasminogen activator expression in astrocytes. J Neurochem. 2014;128:344-9 pubmed publisher
    ..Furthermore, it was observed that protein levels of DNMT3A, but not DNMT1, were reduced in astrocytes after ethanol exposure...
  10. Zhang Q, Zheng R, Zhang Z, Yang L, Wang H, Ning H, et al. [Effects of bromopropane exposure on expression of DNA methyltransferases and level of histone acetylation in testis of male rats]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2013;31:92-5 pubmed
    ..The sperm count and morphology in the epididymis were evaluated. The mRNA expression of DNMT1, DNMT3a, and DNMT3b and activities of HAT and HDAC in the testis were measured by quantitative real-time PCR and ELISA...
  11. Gowher H, Jeltsch A. Enzymatic properties of recombinant Dnmt3a DNA methyltransferase from mouse: the enzyme modifies DNA in a non-processive manner and also methylates non-CpG [correction of non-CpA] sites. J Mol Biol. 2001;309:1201-8 pubmed
    ..b>Dnmt3a from mouse was cloned and expressed in Escherichia coli. It was shown to be catalytically active in E...
  12. Datta J, Majumder S, Bai S, Ghoshal K, Kutay H, Smith D, et al. Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells. Cancer Res. 2005;65:10891-900 pubmed
    b>Dnmt3a and Dnmt3b are de novo DNA methyltransferases that also act as transcriptional repressors independent of methyltransferase activity...
  13. El Ghannam D, Taalab M, Ghazy H, Eneen A. DNMT3A R882 mutations in patients with cytogenetically normal acute myeloid leukemia and myelodysplastic syndrome. Blood Cells Mol Dis. 2014;53:61-6 pubmed publisher
    ..We determined the frequency of DNMT3A mutations, their associations with clinical and molecular characteristics and outcome, in primary, cytogenetically-..
  14. Jiang J, Aitken K, Sotiropoulos C, Sotiropolous C, Kirwan T, Panchal T, et al. Phenotypic switching induced by damaged matrix is associated with DNA methyltransferase 3A (DNMT3A) activity and nuclear localization in smooth muscle cells (SMC). PLoS ONE. 2013;8:e69089 pubmed publisher
    ..Cells were fixed and stained for DNMT3A and smooth muscle actin (SMA) or smooth muscle myosin heavy chain...
  15. Kim K, Ryu H, Oh S, Oh E, Ahn J, Lee J, et al. Effect of DNA demethylation in experimental encapsulating peritoneal sclerosis. Ther Apher Dial. 2014;18:628-36 pubmed publisher
    ..DNA demethylation by 5'-azacytidine treatment improved pathologic changes of the peritoneum in experimental EPS, and was associated with reversal of increased DNMT1 expression and RASAL1 hypermethylation. ..
  16. Sehgal A, Gimotty P, Zhao J, Hsu J, Daber R, Morrissette J, et al. DNMT3A Mutational Status Affects the Results of Dose-Escalated Induction Therapy in Acute Myelogenous Leukemia. Clin Cancer Res. 2015;21:1614-20 pubmed publisher
    b>DNA methyltransferase 3A (DNMT3A) is one of the commonly mutated genes in acute myelogenous leukemia (AML)...
  17. Russler Germain D, Spencer D, Young M, Lamprecht T, Miller C, Fulton R, et al. The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers. Cancer Cell. 2014;25:442-54 pubmed publisher
    Somatic mutations in DNMT3A, which encodes a de novo DNA methyltransferase, are found in ?30% of normal karyotype acute myeloid leukemia (AML) cases...
  18. Lin J, Yao D, Qian J, Chen Q, Qian W, Li Y, et al. Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome. PLoS ONE. 2011;6:e26906 pubmed publisher
    Somatic mutations of DNMT3A gene have recently been reported in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS)...
  19. Melas P, Rogdaki M, Lennartsson A, Björk K, Qi H, Witasp A, et al. Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression. Int J Neuropsychopharmacol. 2012;15:669-79 pubmed publisher
    ..two DNA methyltransferases that have been shown to maintain DNA methylation in adult forebrain neurons (Dnmt1 and Dnmt3a)...
  20. Sun L, Zhao J, Gu X, Liang L, Wu S, Mo K, et al. Nerve injury-induced epigenetic silencing of opioid receptors controlled by DNMT3a in primary afferent neurons. Pain. 2017;158:1153-1165 pubmed publisher
    ..We show here that blocking the nerve injury-induced increase in DRG DNMT3a (a de novo DNMT) rescued the expression of Oprm1 and Oprk1 mRNAs and their respective encoding mu-opioid receptor (..
  21. Brenner C, Deplus R, Didelot C, Loriot A, Viré E, De Smet C, et al. Myc represses transcription through recruitment of DNA methyltransferase corepressor. EMBO J. 2005;24:336-46 pubmed
    ..Here we show that Myc binds the corepressor Dnmt3a and associates with DNA methyltransferase activity in vivo...
  22. Popkie A, Zeidner L, Albrecht A, D Ippolito A, Eckardt S, Newsom D, et al. Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. J Biol Chem. 2010;285:41337-47 pubmed publisher
    ..Finally, we find that N-Myc is a potent Gsk-3-dependent regulator of Dnmt3a2 expression. In summary, we have identified a signal transduction pathway that is capable of altering the DNA methylation of imprinted loci. ..
  23. Imai S, Saeki M, Yanase M, Horiuchi H, Abe M, Narita M, et al. Change in microRNAs associated with neuronal adaptive responses in the nucleus accumbens under neuropathic pain. J Neurosci. 2011;31:15294-9 pubmed publisher
    ..Acc. neurons. The expression of DNA methyltransferase 3a (DNMT3a), which is the one of the predicted targets of miR200b/429, was significantly increased in the ..
  24. Sakharkar A, Tang L, Zhang H, Chen Y, Grayson D, Pandey S. Effects of acute ethanol exposure on anxiety measures and epigenetic modifiers in the extended amygdala of adolescent rats. Int J Neuropsychopharmacol. 2014;17:2057-67 pubmed publisher
    ..The DNMT1, DNMT3a, and DNMT3b mRNA expression in the amygdala was not affected by either 1or 2 doses of 2 g/kg...
  25. Wu Y, Strawn E, Basir Z, Halverson G, Guo S. Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis. Fertil Steril. 2007;87:24-32 pubmed
    ..The aim of this study was to determine gene expression levels of DNMT1, DNMT3A, and DNMT3B, the three genes coding for DNA methyltransferases that are responsible for methylation...
  26. Vinken M, Snykers S, Fraczek J, Decrock E, Leybaert L, Rogiers V, et al. DNA methyltransferase 3a expression decreases during apoptosis in primary cultures of hepatocytes. Toxicol In Vitro. 2010;24:445-51 pubmed publisher
    ..to the hepatic in vivo situation, DNMT1, DNMT2 and DNMT3b could not be detected, whereas relatively high levels of DNMT3a protein were observed in the in vitro setting, as studied by immunoblotting...
  27. Anway M, Rekow S, Skinner M. Transgenerational epigenetic programming of the embryonic testis transcriptome. Genomics. 2008;91:30-40 pubmed
    ..The most dramatic effects were on the germ-line-associated Dnmt3A and Dnmt3L isoforms...
  28. Morey S, Smiraglia D, James S, Yu J, Moser M, Foster B, et al. DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. Cancer Res. 2006;66:11659-67 pubmed
    ..display increased cytosine DNA methyltransferase (Dnmt) activity, Dnmt1 and Dnmt3b protein expression, and Dnmt1, Dnmt3a, and Dnmt3b mRNA expression...
  29. Pandi G, Nakka V, Dharap A, Roopra A, Vemuganti R. MicroRNA miR-29c down-regulation leading to de-repression of its target DNA methyltransferase 3a promotes ischemic brain damage. PLoS ONE. 2013;8:e58039 pubmed publisher
    ..Bioinformatics indicated that DNA methyltransferase 3a (DNMT3a) is a major target of miR-29c and co-transfection with premiR-29c prevented DNMT3a 3'UTR vector ..
  30. Lees Murdock D, McLoughlin G, McDaid J, Quinn L, O Doherty A, Hiripi L, et al. Identification of 11 pseudogenes in the DNA methyltransferase gene family in rodents and humans and implications for the functional loci. Genomics. 2004;84:193-204 pubmed
    ..All except 1 rat Dnmt3b pseudogene appear to be transcriptionally silent. Dnmt3a2, a transcript variant of Dnmt3a starting at an alternative promoter, had the highest number of processed pseudogenes, while none were found for ..
  31. Ghoshal K, Li X, Datta J, Bai S, Pogribny I, Pogribny M, et al. A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats. J Nutr. 2006;136:1522-7 pubmed
    ..We investigated changes in the DNA methylation machinery, namely, de novo DNA methyltransferases (Dnmt3a and 3b), maintenance DNA methyltransferase (Dnmt1), and methyl CpG binding proteins (MBDs), in rat livers during ..
  32. Zhang Y, Yao D, Zhu X, Zhou J, Ma J, Yang J, et al. DNMT3A intragenic hypomethylation is associated with adverse prognosis in acute myeloid leukemia. Leuk Res. 2015;39:1041-7 pubmed publisher
    b>DNA methyltransferase 3A (DNMT3A), a member of de novo methyltransferases, has been found with overexpression in several cancers including acute myeloid leukemia (AML)...
  33. Liu X, Guo S. Aberrant immunoreactivity of deoxyribonucleic acid methyltransferases in adenomyosis. Gynecol Obstet Invest. 2012;74:100-8 pubmed
    ..Tissue sections were immunostained with DNMT1, DNMT3A, and DNMT3B...
  34. Tryndyak V, Muskhelishvili L, Kovalchuk O, Rodriguez Juarez R, Montgomery B, Churchwell M, et al. Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis. Carcinogenesis. 2006;27:1713-20 pubmed
    ..Protein expressions of maintenance (DNMT1) DNA methyltransferase and de novo DNA methyltransferases DNMT3a and DNMT3b were decreased at all time points...
  35. Schneider J, Kidd S, Anderson D. Influence of developmental lead exposure on expression of DNA methyltransferases and methyl cytosine-binding proteins in hippocampus. Toxicol Lett. 2013;217:75-81 pubmed publisher
    ..Western blot analyses showed significant effects of Pb exposure on DNMT1, DNMT3a, and MeCP2 expression, with effects often seen at the lowest level of exposure and modified by sex and ..
  36. Ling Y, Sankpal U, Robertson A, McNally J, Karpova T, Robertson K. Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res. 2004;32:598-610 pubmed
    The de novo DNA methyltransferase Dnmt3a is one of three mammalian DNA methyltransferases that has been shown to play crucial roles in embryonic development, genomic imprinting and transcriptional silencing...
  37. Saferali A, Berlivet S, Schimenti J, Bartolomei M, Taketo T, Naumova A. Defective imprint resetting in carriers of Robertsonian translocation Rb (8.12). Mamm Genome. 2010;21:377-87 pubmed publisher
    ..12) carriers, suggesting possible silencing of pericentromeric genes, such as the Dnmt3a gene...
  38. Kolodkin M, Auger A. Sex difference in the expression of DNA methyltransferase 3a in the rat amygdala during development. J Neuroendocrinol. 2011;23:577-83 pubmed publisher
    ..We investigated whether sex differences in the expression of DNMT1 and DNMT3a were apparent in the amygdala, preoptic area and medial basal hypothalamus at different time points during ..
  39. Valencia Antúnez C, Taja Chayeb L, Rodríguez Segura M, López Álvarez G, García Cuéllar C, Villa Treviño S. DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model. Oncol Rep. 2014;32:2093-103 pubmed publisher
    ..Changes in genomic DNA methylation patterns are established by the DNA methyltransferases (DNMTs) family: DNMT1, DNMT3a and DNMT3b. The DNMTs are known to be overexpressed in tumors...
  40. Delatte B, Deplus R, Fuks F. Playing TETris with DNA modifications. EMBO J. 2014;33:1198-211 pubmed publisher
  41. Grossmann V, Haferlach C, Weissmann S, Roller A, Schindela S, Poetzinger F, et al. The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL. Genes Chromosomes Cancer. 2013;52:410-22 pubmed publisher
    ..Here, 90 adult T-ALL cases were investigated for mutations in NOTCH1, FBXW7, PHF6, CDKN2A, DNMT3A, FLT3, PTEN, and RUNX1 using 454 next-generation amplicon sequencing and melting curve analyses...
  42. Chen T, Tsujimoto N, Li E. The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin. Mol Cell Biol. 2004;24:9048-58 pubmed
    b>Dnmt3a and Dnmt3b are responsible for the establishment of DNA methylation patterns during development...
  43. Dawson M, Kouzarides T. Cancer epigenetics: from mechanism to therapy. Cell. 2012;150:12-27 pubmed publisher
    ..This information, along with the promising clinical and preclinical results seen with epigenetic drugs against chromatin regulators, signifies that it is time to embrace the central role of epigenetics in cancer. ..
  44. Meunier L, Siddeek B, Vega A, Lakhdari N, Inoubli L, Bellon R, et al. Perinatal programming of adult rat germ cell death after exposure to xenoestrogens: role of microRNA miR-29 family in the down-regulation of DNA methyltransferases and Mcl-1. Endocrinology. 2012;153:1936-47 pubmed publisher
    ..Increased miR-29 expression resulted in a decrease in DNMT1, DNMT3a, and DNMT3b and antiapoptotic myeloid cell leukemia sequence 1 (Mcl-1) protein levels as shown in 1) germ cells of ..
  45. Li W, Gao C, Cui L, Liu S, Zhao X, Zhang R, et al. DNMT3A mutations and prognostic significance in childhood acute lymphoblastic leukemia. Leuk Lymphoma. 2015;56:1066-71 pubmed publisher
    Little is known about DNMT3A mutations in childhood acute lymphoblastic leukemia (ALL). We screened for DNMT3A mutations in exon 23 and its adjacent intron regions in diagnostic samples of 201 children with ALL...
  46. Tao J, Yang M, Chen Z, Huang Y, Zhao Q, Xu J, et al. Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura. J Clin Immunol. 2008;28:432-9 pubmed publisher
    ..DNMT1, DNMT3A, and DNMT3B mRNA expression in peripheral blood mononuclear cells (PBMCs) of adult ITP patients were analyzed by ..
  47. Park H, Yu E, Shim Y. DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma. Cancer Lett. 2006;233:271-8 pubmed
    ..Expression of DNMT1, DNMT3a and DNMT3b mRNA was detected in 33.3, 59.3, and 55.6% of HCCs and 40.7, 22...
  48. LaPlant Q, Vialou V, Covington H, Dumitriu D, Feng J, Warren B, et al. Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci. 2010;13:1137-43 pubmed publisher
    ..We found that Dnmt3a expression was regulated in mouse nucleus accumbens (NAc) by chronic cocaine use and chronic social defeat stress...
  49. Cavuoto P, Fenech M. A review of methionine dependency and the role of methionine restriction in cancer growth control and life-span extension. Cancer Treat Rev. 2012;38:726-36 pubmed publisher
    ..The application of nutritional methionine restriction and methioninase in combination with chemotherapeutic regimens is the current focus of clinical studies. ..
  50. Wong M, Gertz B, Chestnut B, Martin L. Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS. Front Cell Neurosci. 2013;7:279 pubmed publisher
    ..We show by immunoblotting that DNA methyltransferase 3A (Dnmt3a) isoform is present in pure mitochondria of adult mouse CNS, skeletal muscle, and testes, and ..
  51. Sharma D, Bhave S, Gregg E, UHT R. Dexamethasone induces a putative repressor complex and chromatin modifications in the CRH promoter. Mol Endocrinol. 2013;27:1142-52 pubmed publisher
    ..Indeed, the GR interacted with DnMT3b, but not DnMT3a. In addition, Dex-induced occupancy of the crh promoter by HDAC1, MeCP2, and DnMT3b was associated with an ..
  52. Singh R, Shiue K, Schomberg D, Zhou F. Cellular epigenetic modifications of neural stem cell differentiation. Cell Transplant. 2009;18:1197-211 pubmed publisher
    ..Furthermore, we found an outward translocation of DNA methylation marker 5-MeC, DNMT1, DNMT3a, and MBD1 in NSCs as differentiation began and proceeded; 5-MeC from homogeneous nucleus to peripheral nucleus, ..
  53. Marcucci G, Metzeler K, Schwind S, Becker H, Maharry K, Mrozek K, et al. Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia. J Clin Oncol. 2012;30:742-50 pubmed publisher
    To determine the frequency of DNMT3A mutations, their associations with clinical and molecular characteristics and outcome, and the associated gene- and microRNA-expression signatures in primary cytogenetically normal acute myeloid ..
  54. Li J, Pu M, Hirasawa R, Li B, Huang Y, Zeng R, et al. Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol Cell Biol. 2007;27:8748-59 pubmed
    DNA methylation plays an important role in gene silencing in mammals. Two de novo methyltransferases, Dnmt3a and Dnmt3b, are required for the establishment of genomic methylation patterns in development...
  55. Abzianidze E, Kvaratskhelia E, Tkemaladze T, Kankava K, Gurtskaia G, Tsagareli M. Epigenetic regulation of acute inflammatory pain. Georgian Med News. 2014;:78-81 pubmed
    ..during acute inflammatory pain induced by the application of 10% mustard oil on the tongues of rats, levels of DNMT3a and 3b were elevated markedly (36 and 42 % respectively), whereas the level of DNMT1 was not changed significantly...
  56. Feng Y, Zhao L, Hong L, Shan C, Shi W, Cai W. Alteration in methylation pattern of GATA-4 promoter region in vitamin A-deficient offspring's heart. J Nutr Biochem. 2013;24:1373-80 pubmed publisher
    ..Moreover, up-regulation of DNMT1 and down-regulation of DNMT3a and DNMT3b expression were found in this group embryo...
  57. Hiura H, Sugawara A, Ogawa H, John R, Miyauchi N, Miyanari Y, et al. A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Nucleic Acids Res. 2010;38:4929-45 pubmed publisher
    ..Methylation was dependent on DNA methyltransferase 3a (Dnmt3a), similar to H19 DMR and IG-DMR...
  58. Feng Y, Tian R, You A, Wang J, Wu Y, Wang W, et al. [Expression and significance of DNA methyltransferase in sera of patients with lung cancer]. Zhonghua Yi Xue Za Zhi. 2013;93:3822-5 pubmed
    To explore the protein expressions of DNMT1, DNMT3a and DNMT3b in sera of lung cancer patients...
  59. Liu Y, Zhang N, Wu Y, Yang L, Ding X, Zhou J, et al. DNMT3A mutation analysis in adult patients with acute lymphoblastic leukemia. J Huazhong Univ Sci Technolog Med Sci. 2015;35:337-342 pubmed publisher
    DNA methyl-transferase 3A (DNMT3A) mutation has recently been identified as an independent risk factor for patients with acute myeloid leukemia (AML)...
  60. Loree J, Koturbash I, Kutanzi K, Baker M, Pogribny I, Kovalchuk O. Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis. Int J Radiat Biol. 2006;82:805-15 pubmed
    ..Global DNA hypomethylation was paralleled by reduction in the levels of maintenance (DNMT1) and de novo (DNMT3a and 3b) DNA methyltransferases and methyl-binding protein MeCP2...
  61. Mayle A, Yang L, Rodriguez B, Zhou T, Chang E, Curry C, et al. Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation. Blood. 2015;125:629-38 pubmed
    b>DNA methyltransferase 3A (DNMT3A) is mutated in hematologic malignancies affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated with poor prognosis...