Dnajc19

Summary

Gene Symbol: Dnajc19
Description: DnaJ heat shock protein family (Hsp40) member C19
Alias: RGD1560220, mitochondrial import inner membrane translocase subunit TIM14, DnaJ (Hsp40) homolog, subfamily C, member 19
Species: rat
Products:     Dnajc19

Top Publications

  1. Davey K, Parboosingh J, McLeod D, Chan A, Casey R, Ferreira P, et al. Mutation of DNAJC19, a human homologue of yeast inner mitochondrial membrane co-chaperones, causes DCMA syndrome, a novel autosomal recessive Barth syndrome-like condition. J Med Genet. 2006;43:385-93 pubmed
    ..2 Mb region of chromosome 3q26.33 was found. A disease associated mutation was identified: IVS3-1 G-->C in the DNAJC19 gene, encoding a DNAJ domain containing protein of previously unknown function (Entrez Gene ID 131118)...
  2. Elsner S, Simian D, Iosefson O, Marom M, Azem A. The mitochondrial protein translocation motor: structural conservation between the human and yeast Tim14/Pam18-Tim16/Pam16 co-chaperones. Int J Mol Sci. 2009;10:2041-53 pubmed publisher
    ..Our results show that the soluble domains of the human Tim14/Pam18 and Tim16/Pam16 proteins interact with their yeast counterparts, forming heterodimeric complexes and that these complexes interact with yeast mtHsp70. ..
  3. Taylor S, Fahy E, Zhang B, Glenn G, Warnock D, Wiley S, et al. Characterization of the human heart mitochondrial proteome. Nat Biotechnol. 2003;21:281-6 pubmed
    ..The biochemical roles of 19% of the identified proteins have not been defined. This database of proteins provides a comprehensive resource for the discovery of novel mitochondrial functions and pathways. ..
  4. Sinha D, Joshi N, Chittoor B, Samji P, D Silva P. Role of Magmas in protein transport and human mitochondria biogenesis. Hum Mol Genet. 2010;19:1248-62 pubmed publisher
    ..Magmas forms a stable subcomplex with J-protein Pam18 or DnaJC19 through its C-terminal region and is tethered to TIM23 complex of yeast and humans...
  5. Schulz C, Schendzielorz A, Rehling P. Unlocking the presequence import pathway. Trends Cell Biol. 2015;25:265-75 pubmed publisher
    ..Here, we review recent advances in understanding of the mechanisms underlying protein transport along the presequence pathway. ..