Dmbt1

Summary

Gene Symbol: Dmbt1
Description: deleted in malignant brain tumors 1
Alias: Crpd, deleted in malignant brain tumors 1 protein, crp-ductin, deleted in malignant brain tumors 1 protein-like, ebnerin, hensin, pancrin
Species: rat
Products:     Dmbt1

Top Publications

  1. Li X, Snyder S. Molecular cloning of Ebnerin, a von Ebner's gland protein associated with taste buds. J Biol Chem. 1995;270:17674-9 pubmed
    ..We have identified a rat cDNA encoding a novel protein of 1290 amino acids, Ebnerin, that is specifically expressed in VEG and released onto the tongue surface along the apical region of taste buds ..
  2. Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus K, et al. DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours. Nat Genet. 1997;17:32-9 pubmed
    ..3-26.1 in a medulloblastoma cell line and have cloned a novel gene, DMBT1, spanning this deletion. DMBT1 shows homology to the scavenger receptor cysteine-rich (SRCR) superfamily...
  3. Hikita C, Vijayakumar S, Takito J, Erdjument Bromage H, Tempst P, Al Awqati Q. Induction of terminal differentiation in epithelial cells requires polymerization of hensin by galectin 3. J Cell Biol. 2000;151:1235-46 pubmed
    ..ECM) protein responsible for this activity was purified and found to be a large 230-kD protein, which we termed hensin. High density seeding caused hensin to be polymerized and deposited in the extracellular matrix, and only this ..
  4. Holmskov U, Mollenhauer J, Madsen J, Vitved L, Gronlund J, Tornoe I, et al. Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D. Proc Natl Acad Sci U S A. 1999;96:10794-9 pubmed
    ..gp-340 seems to be an alternative spliced form of DMBT1. Reverse transcription-PCR analysis showed that the main sites of synthesis of gp-340 are lung, trachea, salivary ..
  5. Elkahloun A, Powers J, Nyska A, Eisenhofer G, Tischler A. Gene expression profiling of rat pheochromocytoma. Ann N Y Acad Sci. 2006;1073:290-9 pubmed
    ..Downregulated genes included receptors and tumor-suppressor genes, including NF2 and Dmbt1. Specific genes related to neuroendocrine function were either upregulated or downregulated in subsets of tumors...
  6. De Lisle R. Characterization of the major sulfated protein of mouse pancreatic acinar cells: a high molecular weight peripheral membrane glycoprotein of zymogen granules. J Cell Biochem. 1994;56:385-96 pubmed
    ..Localization of this nonsecreted sulfated glycoprotein to exocrine secretory granule membranes suggests that gp300 may have a role in granule biogenesis. ..
  7. De Lisle R, Petitt M, Huff J, Isom K, Agbas A. MUCLIN expression in the cystic fibrosis transmembrane conductance regulator knockout mouse. Gastroenterology. 1997;113:521-32 pubmed
  8. Genter M, Burman D, Vijayakumar S, Ebert C, Aronow B. Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa. Physiol Genomics. 2002;12:35-45 pubmed
    ..Heme oxygenase was upregulated acutely and maintained elevated expression. Expression of ebnerin, related to the putative human tumor suppressor gene DMBT1, progressively increased in alachlor-treated olfactory ..
  9. Madsen J, Tornøe I, Nielsen O, Lausen M, Krebs I, Mollenhauer J, et al. CRP-ductin, the mouse homologue of gp-340/deleted in malignant brain tumors 1 (DMBT1), binds gram-positive and gram-negative bacteria and interacts with lung surfactant protein D. Eur J Immunol. 2003;33:2327-36 pubmed
    ..We conclude that CRP-ductin is the mouse homologue of human gp-340 and that its capacity to bind SP-D as well as gram-negative and gram-positive bacteria suggests a role in mucosal immune defense. ..

More Information

Publications13

  1. Boulatnikov I, De Lisle R. Binding of the Golgi sorting receptor muclin to pancreatic zymogens through sulfated O-linked oligosaccharides. J Biol Chem. 2004;279:40918-26 pubmed
    ..The behavior of Muclin fulfils the requirement of a Golgi cargo receptor to bind to regulated secretory proteins under the mildly acidic pH conditions that exist in the trans-Golgi network. ..
  2. Takito J, Al Awqati Q. Conversion of ES cells to columnar epithelia by hensin and to squamous epithelia by laminin. J Cell Biol. 2004;166:1093-102 pubmed
    ..Here, we show that mouse embryonic stem cells seeded on hensin or laminin, but not fibronectin or collagen type IV, formed hemispheric epithelial structures whose outermost ..
  3. Bisgaard H, Holmskov U, Santoni Rugiu E, Nagy P, Nielsen O, Ott P, et al. Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor 1. Am J Pathol. 2002;161:1187-98 pubmed
    ..Of these, only two, namely alpha-fetoprotein and a novel transcript with high homology to human DMBT1 (deleted in malignant brain tumor 1), were specifically associated with the emergence of ductular (oval) cell ..
  4. Tynan S, Pacia E, Haynes Johnson D, Lawrence D, D Andrea M, Guo J, et al. The putative tumor suppressor deleted in malignant brain tumors 1 is an estrogen-regulated gene in rodent and primate endometrial epithelium. Endocrinology. 2005;146:1066-73 pubmed
    Deleted in malignant brain tumors 1 (DMBT1) is a candidate suppressor of malignancies of the brain, lung, gut, and breast. We have been studying gene expression in the uterus in the presence of estrogens and their antagonists...