Gene Symbol: Dhrs9
Description: dehydrogenase/reductase 9
Alias: Rdhl, dehydrogenase/reductase SDR family member 9, 3-alpha hydroxysteroid dehydrogenase, 3-alpha-HSD, 3alpha-HSD, dehydrogenase/reductase (SDR family) member 9, retinol dehydrogenase homolog, short-chain dehydrogenase/reductase retSDR8
Species: rat
Products:     Dhrs9

Top Publications

  1. Chetyrkin S, Belyaeva O, Gough W, Kedishvili N. Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties. J Biol Chem. 2001;276:22278-86 pubmed
    ..Thus, the new short chain dehydrogenase represents a novel type of microsomal NAD(+)-dependent 3alpha-hydroxysteroid dehydrogenase with unique catalytic properties and tissue distribution. ..
  2. Soref C, Di Y, Hayden L, Zhao Y, Satre M, Wu R. Characterization of a novel airway epithelial cell-specific short chain alcohol dehydrogenase/reductase gene whose expression is up-regulated by retinoids and is involved in the metabolism of retinol. J Biol Chem. 2001;276:24194-202 pubmed
    ..The results suggested that the novel gene represents a new member of the SDR family that may play a critical role in retinol metabolism in airway epithelia as well as in other epithelia of colon, tongue, and esophagus. ..
  3. Rexer B, Ong D. A novel short-chain alcohol dehydrogenase from rats with retinol dehydrogenase activity, cyclically expressed in uterine epithelium. Biol Reprod. 2002;67:1555-64 pubmed
    ..Consequently, this novel short-chain alcohol dehydrogenase is an excellent candidate for the retinol dehydrogenase that catalyzes the first step in retinoic acid biosynthesis that occurs in uterine epithelial cells. ..
  4. Everts H, Sundberg J, Ong D. Immunolocalization of retinoic acid biosynthesis systems in selected sites in rat. Exp Cell Res. 2005;308:309-19 pubmed
    ..This suggests that mesenchymal-epithelial interactions may be as important in the adult as they are during development and that local synthesis of RA is important in maintenance of these tissues. ..
  5. Wang C, KANE M, Napoli J. Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes. J Biol Chem. 2011;286:6542-53 pubmed publisher
    ..Knockdown of the Rdh Dhrs9 increased atRA synthesis ?40% by increasing Raldh1 expression...
  6. Napoli J. Physiological insights into all-trans-retinoic acid biosynthesis. Biochim Biophys Acta. 2012;1821:152-67 pubmed publisher
    ..and genetic data have identified specific functional outcomes for the retinol dehydrogenases, RDH1, RDH10, and DHRS9, as physiological catalysts of the first step in atRA biosynthesis, and for the retinal dehydrogenases RALDH1, ..