Gene Symbol: Dhrs4
Description: dehydrogenase/reductase 4
Alias: PSCD, dehydrogenase/reductase SDR family member 4, DCR-AKL, NADP-retinol dehydrogenase, NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase, NADPH-dependent retinol dehydrogenase/reductase, NDRD, PHCR, carbonyl reductase, dehydrogenase/reductase (SDR family) member 4, peroxisomal short-chain alcohol dehydrogenase
Fransen M, Van Veldhoven P, Subramani S. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. Biochem J. 1999;340 ( Pt 2):561-8 pubmed
Lei Z, Chen W, Zhang M, Napoli J. Reduction of all-trans-retinal in the mouse liver peroxisome fraction by the short-chain dehydrogenase/reductase RRD: induction by the PPAR alpha ligand clofibrate. Biochemistry. 2003;42:4190-6 pubmed
..These data relate retinoid metabolism, PPAR alpha, peroxisomes, and RRD, and are consistent with a further function of CRBP(I) in retinoid metabolism...
Song X, Liang B, Liu G, Li R, Xie J, Du K, et al
. Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma. Int J Cancer. 2007;120:1618-26 pubmed
..The results presented here provide evidence that metabolic disturbances of retinal and retinoic acid, due to abnormal splicing and functional disorder of NRDR, may be involved in cervical tumorigenesis. ..
Matsunaga T, Arakaki M, Kamiya T, Endo S, El Kabbani O, Hara A. Involvement of an aldo-keto reductase (AKR1C3) in redox cycling of 9,10-phenanthrenequinone leading to apoptosis in human endothelial cells. Chem Biol Interact. 2009;181:52-60 pubmed publisher
..These results suggest that AKR1C3 is a key enzyme in the initial step of 9,10-PQ-induced cytotoxicity in HAECs. ..
Endo S, Maeda S, Matsunaga T, Dhagat U, El Kabbani O, Tanaka N, et al
. Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4). Arch Biochem Biophys. 2009;481:183-90 pubmed publisher
b>DHRS4, a member of the short-chain dehydrogenase/reductase superfamily, reduces all-trans-retinal and xenobiotic carbonyl compounds...
Su Z, Li R, Song X, Liu G, Li Y, Chang X, et al
. Identification of a novel isoform of DHRS4 protein with a nuclear localization signal. Gene. 2012;494:161-7 pubmed publisher
The DHRS4 gene encodes an NADP(H)-dependent retinol dehydrogenase/reductase (NRDR) and plays an important role in regulating the synthesis of retinoic acid...
Matsunaga T, Endo S, Maeda S, Ishikura S, Tajima K, Tanaka N, et al
. Characterization of human DHRS4: an inducible short-chain dehydrogenase/reductase enzyme with 3beta-hydroxysteroid dehydrogenase activity. Arch Biochem Biophys. 2008;477:339-47 pubmed publisher
Human DHRS4 is a peroxisomal member of the short-chain dehydrogenase/reductase superfamily, but its enzymatic properties, except for displaying NADP(H)-dependent retinol dehydrogenase/reductase activity, are unknown...