Genomes and Genes
Gene Symbol: Derl1
Description: derlin 1
Alias: RGD1311835, derlin-1, Der1-like domain family, member 1
- Altier C, Garcia Caballero A, Simms B, You H, Chen L, Walcher J, et al. The Cav? subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels. Nat Neurosci. 2011;14:173-80 pubmed publisher..Thus, Cav?? regulates the ubiquitination and stability of the calcium channel complex. ..
- El Khouri E, Le Pavec G, Toledano M, Delaunay Moisan A. RNF185 is a novel E3 ligase of endoplasmic reticulum-associated degradation (ERAD) that targets cystic fibrosis transmembrane conductance regulator (CFTR). J Biol Chem. 2013;288:31177-91 pubmed publisher..Our data thus identify RNF185 and RNF5 as a novel E3 ligase module that is central to the control of CFTR degradation. ..
- Chen C, Malchus N, Hehn B, Stelzer W, Avci D, Langosch D, et al. Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u. EMBO J. 2014;33:2492-506 pubmed publisher..Thus, we identify an ERAD complex that controls the abundance of XBP1u and thereby tunes signaling through the UPR. ..
- Kadowaki H, Nagai A, Maruyama T, Takami Y, Satrimafitrah P, Kato H, et al. Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP. Cell Rep. 2015;13:944-56 pubmed publisher..These findings demonstrate that Derlins-mediated substrate-specific rerouting and Bag6- and p97-mediated effective degradation contribute to the maintenance of ER homeostasis without the need for translocation. ..