Genomes and Genes
Gene Symbol: Ddx6
Description: DEAD-box helicase 6
Alias: RGD1564560, DEAD (Asp-Glu-Ala-Asp) box helicase 6, DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
- Yang G, Smibert C, Kaplan D, Miller F. An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. Neuron. 2014;84:723-39 pubmed publisher..Thus, neural precursors are transcriptionally primed to generate neurons, but an eIF4E/4E-T complex sequesters and represses translation of proneurogenic proteins to determine appropriate neurogenesis. ..
- Wichroski M, Robb G, Rana T. Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. PLoS Pathog. 2006;2:e41 pubmed..Taken together, the results of this study reveal a novel link between innate immunity against retroviruses and P-bodies suggesting that APOBEC3G and APOBEC3F could function in the context of P-bodies to restrict HIV-1 replication. ..
- Kawahara C, Yokota S, Fujita H. DDX6 localizes to nuage structures and the annulus of mammalian spermatogenic cells. Histochem Cell Biol. 2014;141:111-21 pubmed publisherThe localization of DEAD (Asp-Glu-Ala-Asp) box helicase 6 (DDX6) in spermatogenic cells from the mouse, rat, and guinea pig was studied by immunofluorescence (IF) and immunoelectron microscopy (IEM)...
- Bish R, Cuevas Polo N, Cheng Z, Hambardzumyan D, Munschauer M, Landthaler M, et al. Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins. Biomolecules. 2015;5:1441-66 pubmed publisherb>DDX6 (p54/RCK) is a human RNA helicase with central roles in mRNA decay and translation repression...